G protein-coupled receptor kinase 3
GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family". The Journal of ...
G protein-coupled receptor kinase 2
... beta-adrenergic receptor kinase 1) at Wikimedia Commons beta-Adrenergic+Receptor+Kinase at the U.S. National Library of ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... GRK2 was initially called Beta-adrenergic receptor kinase (βARK or βARK1), and is a member of the G protein-coupled receptor ... Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ (1989). "Beta-adrenergic receptor kinase: primary structure delineates ...
Adrenergic receptor
Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 There is no α1C receptor. There was a subtype known as C, but ... and β-Adrenergic Receptors Theory of receptor activation Desensitization of β1 receptors (Webarchive template wayback links, ... There are also α2 receptors on the nerve terminal membrane of the post-synaptic adrenergic neuron. Actions of the α2 receptor ... Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective beta 3-adrenergic receptor ...
Arrestin beta 2
Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the ... "Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in ...
SAG (gene)
... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause ... 1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic ... "Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, ...
AKAP5
... receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1 ... adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409-12. doi:10.1016/S0960- ... A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene. The A-kinase anchor proteins (AKAPs) are a ... The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase ...
MAGI2
2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase ... "Identification and characterization of a PDZ protein that interacts with activin type II receptors". J Biol Chem. 275 (8): 5485 ... Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase ... "Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2". Wood, J D; Yuan J; Margolis R L; ...
G protein-coupled receptor kinase
Dorn GW 2nd, Liggett SB (2008). "Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart ... "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2". Cell. 129 (3): 511 ... protein kinase A, protein kinase G, protein kinase C) group of kinases. Like all AGC kinases, GRKs use ATP to add phosphate to ... and was originally called the beta adrenergic receptor kinase (βARK, or ββARK1). GRK2 is overexpressed in heart failure, and ...
Beta-1 adrenergic receptor
"G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological ... of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". ... "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by ... "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 ( ...
Photorelaxation
... it is regulated by Beta adrenergic receptor kinase type 1 (βARK or BARK) also called G protein coupled receptor kinase 2 (GRK2 ... The research by Sikka et al concluded that there light-sensing receptors, melanopsin receptors, are present in blood vessels ... but not cGMP-dependent protein kinase or Protein Kinase G (PKG). Furthermore, ... and involves vascular hyperpolarization, and this receptor pathway could be targeted for wavelength-specific light-based ...
DLGAP2
2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 ( ... 1998). "A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell ... These kinases are a family of signaling molecules expressed at various submembrane domains and contain the PDZ, SH3 and the ... Ying Z, Bingaman W, Najm IM (2004). "Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human ...
Martin J. Lohse
"Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart". Circulation ... He discovered that beta-1 adrenergic receptors and their regulatory G protein-coupled receptor kinases are dysregulated in ... that increased β1-adrenergic receptor levels and signaling cause long-term cardiac damage contributed to the use of beta- ... a Protein that Regulates β-adrenergic Receptor Function". Science. American Association for the Advancement of Science (AAAS). ...
Prostaglandin DP1 receptor
... also known as β-Adrenergic receptor kinase 2 [BARK1]) and arrestin 2 (also known as Arrestin beta 1 [ARRB1]). These agents act ... Prostaglandin receptors Prostanoid receptors Prostaglandin DP2 receptor Eicosanoid receptor GRCh38: Ensembl release 89: ... is primarily a receptor for prostaglandin D2 (PGD2). The receptor is a member of the Prostaglandin receptors belonging to the ... The Prostaglandin D2 receptor 1 (DP1), a G protein-coupled receptor encoded by the PTGDR1 gene (also termed PTGDR), ...
G protein-coupled receptor kinase 7
"The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase ... members of the family of G protein-coupled receptors that recognize light of various wavelengths (red, green, blue). ... G-protein-coupled receptor kinase 7 (EC 2.7.11.14, GRK7, cone opsin kinase, iodopsin kinase) is a serine/threonine-specific ... GRK7 is a member of the family of G protein-coupled receptor kinases, and is officially named G protein-coupled receptor kinase ...
Arrestin beta 1
... is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated ... Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... January 1999). "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes". Science. 283 ( ... "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta- ...
AKAP12
Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases ... cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 ... scaffold binding to the beta2-adrenergic receptor". EMBO J. 22 (24): 6419-29. doi:10.1093/emboj/cdg628. PMC 291823. PMID ... Shih M, Lin F, Scott JD, Wang HY, Malbon CC (1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and ...
Rhodopsin kinase
"The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase ... a member of the family of G protein-coupled receptors that recognizes light. Phosphorylated, light-activated rhodopsin binds to ... Rhodopsin kinase (EC 2.7.11.14, rod opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, opsin kinase, opsin ... "Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase". Nature. 321 (6073): 869-72. Bibcode:1986Natur ...
Phosphatidylinositol 4,5-bisphosphate
... stabilizes GRK2 and also orients it in a way that allows for more efficient phosphorylation of the beta adrenergic receptor, a ... a membrane-bound enzyme activated through protein receptors such as α1 adrenergic receptors. PIP2 regulates the function of ... PIP2 has been shown to recruit G protein-coupled receptor kinase 2 (GRK2) to the membrane by binding to the large lobe of GRK2 ... "Effect of Lipid Composition on Membrane Orientation of the G protein-coupled Receptor Kinase 2-Gβ1γ2 Complex". Biochemistry. 55 ...
Beta-2 adrenergic receptor
Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases ... "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... "Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta- ...
Protein kinase C
"Excitatory alpha1-adrenergic receptors predominate over inhibitory beta-receptors in rabbit dorsal detrusor". The Journal of ... the vitamin D3 receptor VDR, Raf kinase, calpain, and the epidermal growth factor receptor. Upon activation, protein kinase C ... membrane-bound receptor for activated protein kinase C proteins). The protein kinase C enzymes are known for their long-term ... Anderson PW, McGill JB, Tuttle KR (Sep 2007). "Protein kinase C beta inhibition: the promise for treatment of diabetic ...
Alpha-2A adrenergic receptor
... the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor ... is an α2 adrenergic receptor, and also denotes the human gene encoding it. α2 adrenergic receptors include 3 highly homologous ... receptor". Hein, Lutz; Altman, John D.; Kobilka, Brian K. (1999). "Two functionally distinct α2-adrenergic receptors regulate ... Adrenergic receptors, Biology of attention deficit hyperactivity disorder, All stub articles, Transmembrane receptor stubs). ...
List of MeSH codes (D08)
... beta-adrenergic-receptor kinase MeSH D08.811.913.696.620.682.700.150.150 - cyclic gmp-dependent protein kinases MeSH D08.811. ... receptor, platelet-derived growth factor beta MeSH D08.811.913.696.620.682.725.400.925 - receptors, tie MeSH D08.811.913.696. ... map kinase kinase kinase 1 MeSH D08.811.913.696.620.682.700.559.200 - map kinase kinase kinase 2 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 - map kinase kinase kinase 4 MeSH D08.811.913.696.620.682. ...
Beta-3 adrenergic receptor
... has been shown to interact with Src. Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 ... "Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation". J. Biol. Chem. 275 ... The beta-3 adrenergic receptor (β3-adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the ... adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Beta blocker GRCh38: Ensembl release 89: ...
G beta-gamma complex
"Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors". ... "Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts". Circulation. 109 (13 ... "Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted ... "Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling ...
Octopamine
OctβR (beta-adrenergic-like), are structurally and functionally similar to noradrenergic beta receptors in mammals. There are ... "The octopamine receptor OAMB mediates ovulation via Ca2+/calmodulin-dependent protein kinase II in the Drosophila oviduct ... OctαR (OCTOPAMINE1 receptors) are more closely related to α-adrenergic receptors, while OctβR (OCTOPAMINE2 receptors) are more ... and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations". PLOS Genetics. ...
GRB2
"Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ... "Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". ... Granulocyte colony-stimulating factor receptor, HER2/neu, HNRNPC, Huntingtin, INPP5D, IRS1, ITK, Janus kinase 1, Janus kinase 2 ... EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand, GAB1, GAB2, Glycoprotein ...
GRK5
"G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein ... "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase- ...
Tedral
Thereby, leading to alpha- and beta-adrenergic stimulation. The stimulation of alpha-1-adrenergic receptors in vascular smooth ... This is accomplished by acting on GABA-A receptor subunits. When phenobarbital binds to these receptors, the chloride ion gates ... which then activates protein kinase A, and inhibits TNF-alpha, and leukotriene synthesis. Thereby, suppressing inflammation and ... Direct stimulation of beta-1 receptors by ephedrine and norepinephrine also increases cardiac chronotropy and inotropy. Lastly ...
G protein-coupled receptor
The longer the receptor remains active the more kinases are activated and the more receptors are phosphorylated. In β2- ... Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ (June 1990). "beta-Arrestin: a protein that regulates beta-adrenergic ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors ( ... receptor domain by protein kinases. Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain ...
Vasodilation
Schindler, C; Dobrev, D; Grossmann, M; Francke, K; Pittrow, D; Kirch, W (January 2004). "Mechanisms of beta-adrenergic receptor ... Some sympathetic stimulation of arterioles in skeletal muscle is mediated by epinephrine acting on β-adrenergic receptors of ... "Regulation of Na+-K+-ATPase by cAMP-dependent protein kinase anchored on membrane via its anchoring protein". American Journal ... Angiotensin II receptor blockers ACE inhibitors Calcium channel blockers Drugs that appear to work by activating the α2A ...