... , also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is ... Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ... April 2007). "Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity". The Journal of Biological ... January 2001). "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction". The ...

... is a protein that in humans is encoded by the DACT2 gene. GRCh38: Ensembl ... "Entrez Gene: Dishevelled binding antagonist of beta catenin 2". Retrieved 2017-09-10. Koga Y, Yao T, Hirahashi M, Kumashiro Y, ... "Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different ... "DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon ...

... (Dact1, previously known as Dapper, Dpr1, Frodo) is a protein that in humans ... "DACT1 dishevelled binding antagonist of beta catenin 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved ... "Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals". Developmental ... a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation". Developmental Cell. 2 ...

Takemaru, Ken-Ichi (2006). "Catenin, beta". AfCS-Nature Molecule Pages. doi:10.1038/mp.a000506.01. Rousseau, Simon (2011). "P38 ...

CTNNB1 (beta-catenin; a transcription gene) mutations are found in 14-44% of endometrial cancers and may indicate a good ... Beta-catenin mutations are commonly found in endometrial cancers with squamous cells. FGFR2 mutations are found in ... The CTNNB1 (beta-catenin) gene is most commonly mutated in the squamous subtype of endometrioid adenocarcinoma. Serous ...

Wnt/beta-catenin Pathway. The role of Tbx2 in Wnt signaling has yet to be confirmed; however, up-regulation of Tbx2 in the beta ... catenin signaling pathway leads to loss of the adhesion molecule E-cadherin. This returns cells to a mesenchymal state, and ...

"Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta- ... beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879-88. doi:10.1074/jbc.M306421200. PMID ... catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369-87. doi:10.1016/j.yexcr.2004.04.036. ...

Beta-catenin is phosphorylated and degraded. An important protein in the cell cycle, Cyclin D, is inhibited by inactivated GSK- ... and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811-1815. Bibcode:1995Sci ...

"Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development". Cell ... found the transcripts of hormone genes for LH beta (LHb) and FSH beta (FSHb), and GnRH receptor (GnRHR) were nearly absent or ... The Pitx2 gene plays a role in lung adenocarcinoma that is dependent on activating the Wnt/β-catenin signaling pathway. When ... cVg1 is a Transforming growth factor beta signal that is expressed posteriorly before the formation of the embryo germ layers. ...

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene ... "Entrez Gene: CTNNBL1 catenin, beta like 1". Human CTNNBL1 genome location and CTNNBL1 gene details page in the UCSC Genome ... In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein ...

Yang F, Li X, Sharma M, Sasaki CY, Longo DL, Lim B, Sun Z (March 2002). "Linking beta-catenin to androgen-signaling pathway". ... Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP (October 2004). "Recruitment of beta-catenin by wild- ... Amir AL, Barua M, McKnight NC, Cheng S, Yuan X, Balk SP (August 2003). "A direct beta-catenin-independent interaction between ... Androgen receptor has been shown to interact with: AKT1, BAG1, Beta-catenin, BRCA1, C-jun, Calmodulin 1, Caveolin 1, CDK9, ...

... and increased levels of active beta-catenin. Since each of these contribute to regulating cell proliferation, deletion of HDAC7 ... "Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin". Circulation Research. 106 (7): 1202 ... One study showed that HDAC7 suppresses proliferation and β-catenin activity in chondrocytes. This was shown by knocking out ... Overall, this study demonstrated that HDAC7 once again interacts with β-catenin to keep endothelial cells in a low ...

Wong NA, Pignatelli M (Feb 2002). "Beta-catenin--a linchpin in colorectal carcinogenesis?". The American Journal of Pathology. ... GSK-3β, inhibited in some cancer, regulates the stability of β-catenin in cytoplasm and subsequently, cytosolic β-catenin moves ... Ectopic CD97 expression upregulates the expression of N-cadherin and β-catenin in HT1080 fibrosarcoma cells leading to enhanced ... Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. ...

"Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development". Cell ...

alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex. J Biol Chem ... alpha-1-catenin (also called alpha-E-catenin) CTNNA2, alpha-2-catenin (also called alpha-N-catenin) CTNNA3, alpha-3-catenin ( ... Simply put, in the cadherin-catenin complex, cadherin molecules are linked through beta-catenin to α-Catenin, which then binds ... has been shown to have both beta-catenin and α-catenin homologues named Aardvark and Ddα-catenin respectively.34 Additionally, ...

Wnt/beta-catenin pathway: modulating anticancer immune response. J Hematol Oncol 10, 101 (2017). doi:10.1186/s13045-017-0471-6 ... TMED5 has been found to interact with WNT7B, activating the canonical WNT-CTNNB1/β-catenin signaling pathway. This pathway is ... The structure of TMED5 isoform 1 consists of beta strands making up the lumenal region, disparate coil-coiled regions, alpha ... to numerous cancers because upregulation of the Wnt/β-catenin signaling pathway leads to cytosolic accumulation of β-catenin, ...

"Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation". Molecular Cell ... "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex". Genes & ... "A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of ... "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway". Genes & Development. 16 ( ...

Graham TA, Weaver C, Mao F, Kimelman D, Xu W (Dec 2000). "Crystal structure of a beta-catenin/Tcf complex". Cell. 103 (6): 885- ... Balaz P, Plaschke J, Krüger S, Görgens H, Schackert HK (Aug 2010). "TCF-3, 4 protein expression correlates with beta-catenin ... These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the ... "Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling". ...

Ge X, Jin Q, Zhang F, Yan T, Zhai Q (Jan 2009). "PCAF acetylates {beta}-catenin and improves its stability". Mol. Biol. Cell. ... Asano Y, Czuwara J, Trojanowska M (November 2007). "Transforming growth factor-beta regulates DNA binding activity of ...

... and stabilize beta-catenin. Mutant of presenilin-1 that reduces the ability to stabilize beta-catenin complex leads to ... presenilin-1 was also found to play a role in beta-catenin phosphorylation. Beta-catenin is coupled by presenilin-1 and ... "Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in ... Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE (December 1998). "Abrogation of the presenilin 1/beta-catenin interaction ...

Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ... αE-catenin has been shown to interact with: APC, Beta-catenin, CDH1, CDH2, CDH3 Plakoglobin, and VE-cadherin. Alpha-catenin ... αE-catenin has no homology to established actin-binding proteins. The N-terminus of αE-catenin binds β-catenin or γ-catenin/ ... "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". J ...

... "alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion". J Cell Sci. 114 (17 ... Catenin alpha-3, also known as αT-catenin, is a α-catenin protein that in humans is encoded by the CTNNA3 gene Janssens B, ... "Entrez Gene: CTNNA3, catenin alpha 3". v t e (Articles with short description, Short description matches Wikidata, Protein ...

December 2002). "Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations". The American Journal of ...

... has been shown to interact with Beta-catenin. GRCh38: Ensembl release 89: ENSG00000152104 - Ensembl, May 2017 GRCm38: ... "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular ... "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular ...

"Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". ... "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity ... "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin". The ... "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin". The ...

"Analysis of beta-catenin aggregation and localization using GFP fusion proteins: nuclear import of alpha-catenin by the beta- ... Tang W, Dodge M, Gundapaneni D, Michnoff C, Roth M, Lum L (July 2008). "A genome-wide RNAi screen for Wnt/beta-catenin pathway ... PDB: 2GL7​; Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (October 2006). "Crystal structure of a beta-catenin/ ... Sun P, Xiong H, Kim TH, Ren B, Zhang Z (February 2006). "Positive inter-regulation between beta-catenin/T cell factor-4 ...

Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". ... "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer ... "Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway". Nat Commun. 2: 548. doi:10.1038/ ...

Another study shows FAM158A responds to Beta-catenin depletion. Although there are no known beta-catenin binding sites in the ... there is a NeuroD site and NeuroD responds to beta-catenin. The paralog to FAM158A is commonly known as Cox4NB and is located ... "Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression". Blood. 114 (13): 2699-708. ...

Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (November 2001). "Regulation of beta-catenin function by ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation ... Sakurai H, Miyoshi H, Toriumi W, Sugita T (April 1999). "Functional interactions of transforming growth factor beta-activated ... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Ninomiya- ...

These include Wnt/beta-catenin through direct protein interaction; Smad3, through an unknown mechanism of protein stabilisation ... March 2019). "BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells". ... drive a cancer stem cell phenotype through enhancing β-catenin signalling, drive the COX-2 mediated response to inflammatory ...