Transplant rejection
Current research tends to focus[citation needed] on Th1 and Th17 which mediate allograft rejection via the CD4 and CD8 T cells ... particularly in telltale ratios, (2) structural compromise of tissue anatomy, varying by tissue type transplanted, and (3) ... whereas acute rejection episodes with return to function back to baseline do not have major effects on graft survival. Chronic ... December 2008). "A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy". The Journal of ...
Ankylosing spondylitis
The association of AS with HLA-B27 suggests the condition involves CD8 T cells, which interact with HLA-B. This interaction is ... The BASFI is not usually used as a diagnostic tool, but rather as a tool to establish a current baseline and subsequent ... Over 85% of people that have been diagnosed with AS are HLA-B27 positive, although this ratio varies from population to ... including possibly an ability to interact with T cell receptors in association with CD4 (usually CD8+ cytotoxic T cell with ...
Regulatory T cell
All T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell ... Unlike conventional T cells, regulatory T cells do not produce IL-2 and are therefore anergic at baseline. A number of ... it is now widely recognized that the ratio of Treg to effector T cells in the tumor microenvironment is a determining factor in ... If they receive these signals, they proliferate and express both CD4 and CD8, becoming double-positive cells. The selection of ...
Pathology of multiple sclerosis
CD4, CD8, CD20, and/or CD138) These markers are specific for the different processes that drive the formation of plaques: ... This would image the high-gyromagnetic-ratio hydrogen nucleus instead of the low-gyromagnetic-ratio nucleus that is bonded to ... April 2009). "Retinal vessels in patients with multiple sclerosis: baseline diameter and response to flicker light stimulation ... In particular, B-cell to monocyte ratio looks promising. The anti-MOG antibody has been investigated and finally led to the ...