"OMIM Entry - # 613551 - AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6; AIS6". Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, ... Genetic defects in SIAE have been associated with multiple autoimmune diseases. Loss of function mutations in SIAE are much ... Genetic variants and polymorphisms associated with the SIAE gene have been implicated in susceptibility to Autoimmune Disease 6 ... and other autoimmune diseases. Individuals harboring rare heterozygous loss-of-function variants or homozygous defective ...
Autoimmune diseases most commonly associated to Hashimoto's thyroiditis include celiac disease, type 1 diabetes, vitiligo, and ... They can present thyroid autoantigens and initiate autoimmune thyroid disease. Susceptibility alleles are not consistent in ... Aging-associated diseases, Autoimmune diseases, Endocrine diseases, Wikipedia medicine articles ready to translate, Wikipedia ... Those that already have an autoimmune disease are at greater risk of developing Hashimoto's as the diseases generally coexist ...
"Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?". FEBS Letters. 585 (23): 3689-98. doi:10.1016/j. ... possibly due to their higher prevalence of related autoimmune diseases. Vitamin D deficiency and smoking are risk factors for ... disease inflammatory bowel disease Whipple's disease systemic lupus erythematosus polyarteritis nodosa Kawasaki's disease ... Uveitis may arise spontaneously, have a genetic component, or be associated with an autoimmune disease or infection. While the ...
This list includes conditions that are not diseases but signs common to autoimmune disease. Some, such as chronic fatigue ... "A New Gene Linked to Vitiligo and Susceptibility to Autoimmune Disorders - Journal Watch Dermatology". Archived from the ... This list of autoimmune diseases is categorized by organ and tissue type to help locate diseases that may be similar. Overview ... "Celiac Disease". Archived from the original on 2009-07-20. Meize-Grochowski R (2005). "Celiac disease: a multisystem autoimmune ...
... is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely ... Human MHC mediated diseases, Genes on human chromosome 6, MHC class II). ... Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an ... By looking at the change of disease association with improved testing we can see how HLA nomenclature has evolved over time. ...
... is a description of the autoimmune diseases that affect women; it seems that these diseases are ... It is possible that female susceptibility to autoimmune disease may be understood through antibody function; furthermore, this ... Women with autoimmune diseases can safely have children. There are some risks for the mother or baby, depending on the disease ... Although most autoimmune diseases cannot be cured, it is possible to manage the disease and participate in same activities that ...
"Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility". Tissue ... further evidence of increased predisposition to immune diseases". Annals of the Rheumatic Diseases. 69 (1): 309-11. doi:10.1136 ... June 2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 ( ... July 2009). "Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20". ...
The MHC determines donor compatibility for organ transplant, as well as one's susceptibility to autoimmune diseases. In a cell ... In 2007 low MHC diversity was attributed a role in disease susceptibility in the Tasmanian devil (Sarcophilus harrisii), native ... Having some MHC molecules increases the risk of autoimmune diseases more than having others. HLA-B27 is an example. It is ... Disease states occur when this principle is disrupted. Antigen presentation: MHC molecules bind to both T cell receptor and CD4 ...
... is one of the genes thought to influence susceptibility to several autoimmune diseases in humans. Its decreased function ... Family of Leukocyte FcR in Health and Disease". Frontiers in Immunology. 10: 464. doi:10.3389/fimmu.2019.00464. PMC 6433993. ... FCGR2B may be a target for monoclonal antibody therapy for autoimmune diseases as well as malignancies. CD32 GRCh38: Ensembl ... is associated with systemic lupus erythematosus, rheumatoid arthritis, Goodpasture's disease, multiple sclerosis and others. ...
... where multiple autoimmune diseases are seen, e.g.: inflammatory bowel disease, autoimmune thrombocytopenia and autoimmune ... Certain individuals are genetically susceptible to developing autoimmune diseases. This susceptibility is associated with ... Although this route to autoimmune disease may underlie various degenerative disease states, no diagnostics for this disease ... γδ T-cells in the pathogenesis of autoimmune disease are under investigation. Autoimmune diseases can be broadly divided into ...
Once this regulation is disrupted, it may lead to a higher susceptibility to inflammatory and autoimmune diseases. Some ... cardiovascular disease, and lupus nephritis (a complication usually occurring along with SLE). These SNPs are: rs1143679 (R77H ... further drive the inflammation during this disease causing more tissue damage and creation of immune complexes. Hence, CD11b ... "β2 Integrins-Multi-Functional Leukocyte Receptors in Health and Disease". International Journal of Molecular Sciences. 21 (4): ...
It is because of these that they are often implicated in a wide range of diseases such as cancer, HIV, autoimmune disease, ... have increased susceptibility to autoimmune diseases. GnTV is the enzyme required to synthesise polylactosamine chains, which ... Trypanosoma cruzi infection of cardiac cells, the cause of heart involvement in Chagas disease, is reduced by galectin-1, which ... PLOS Neglected Tropical Diseases. 9 (10): e0004148. doi:10.1371/journal.pntd.0004148. PMC 4599936. PMID 26451839. e0004148. Liu ...
... including cardiovascular disease and autoimmune disorders. Gender and sex are both components of health disparity in the male ... Rates of diarrheal diseases and tuberculosis are also significantly greater in this population (16 and 15 times greater ... Sex and gender can both be considered sources of health disparity; both contribute to men and women's susceptibility to various ... lung disease, and heart disease across all income levels.: Figure 13.2 This is also true of the difference between mortality ...
As with other autoimmune diseases, susceptibility to Sjögren's syndrome is greatly influenced by the human leukocyte antigen. ... Lundin KE, Wijmenga C (Sep 2015). "Coeliac disease and autoimmune disease-genetic overlap and screening". Nat Rev Gastroenterol ... Autoimmune diseases, Connective tissue diseases, Hepatitis C virus-associated diseases, Wikipedia medicine articles ready to ... Though the disease commonly begins in middle age, people of any age can be affected. Among those without other autoimmune ...
Underactive factor H may result in increased complement activity on healthy host cells - resulting in autoimmune diseases. It ... Binding of FH permits the bacteria to proliferate in the bloodstream and cause disease. The ability of Factor H to exert its ... Overactive factor H may result in reduced complement activity on pathogenic cells - increasing susceptibility to microbial ... GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome GeneReviews/NCBI/NIH/UW entry on Dense Deposit Disease/ ...
... variation in regulatory elements expressed by CD4+ cells determines susceptibility to a broad class of autoimmune diseases. Th ... Cellular auto-immune disease occurs because the host antigen recognition systems fail, and the immune system believes, by ... Many auto-immune diseases are more complex. A well-known example is rheumatoid arthritis, where both antibodies and immune ... For example, studies have suggested that lupus (SLE) and other auto-immune diseases of similar nature can be linked to the ...
... and susceptibility to infections. Individuals also develop autoimmune diseases at a young age. Autoimmune polyendocrinopathy- ... The disease is characterized by hypogammaglobulinemia, frequent infections and the occurrence of autoimmune diseases. In ... Omenn syndrome manifests as GVHD (graft versus host disease)-like autoimmune disease. Immune dysregulation is caused by ... Various other autoimmune diseases or hypersensitivity are common in other individuals with IPEX syndrome. In addition to ...
... determine susceptibility to autoimmune thyroid disease". Human Molecular Genetics. 13 (19): 2221-2231. doi:10.1093/hmg/ddh245. ... LncRNAs such as HEAT2 or KCNQ1OT1 have been shown to be regulated in the blood of patients with cardiovascular diseases such as ... "Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on ... The discovery that long ncRNAs function in various aspects of cell biology has led to research on their role in disease. Tens ...
Additionally, it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto- ... Immunosuppressants may be prescribed when a normal immune response is undesirable, such as in autoimmune diseases. Steroids ... Immunosuppressive drugs have the potential to cause immunodeficiency, which can increase susceptibility to opportunistic ... Chandrashekara, S. (2012). "The treatment strategies of autoimmune disease may need a different approach from conventional ...
Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/ ... "Unit Of Diseases And Diversity". www.iend.org. Archived from the original on 10 October 2018. Retrieved 1 June 2018. "Sudan: ... Her doctoral research, "The role of Host Genetics in Susceptibility to Kala-azar in The Sudan", was under the supervision of ... She was awarded the 2007 Royal Society Pfizer Award for her research into the disease, which is transmitted by sandfly bites. ...
"Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/ ... Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and ... polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility ... inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Alternatively spliced variants that encode different ...
... common autoimmune and inflammatory diseases arise from combinatorial interactions of common non-disease specific loci, disease ... Jampol and Becker insinuate that 'common susceptibility genes' are present in patients affected by white dot syndromes. The ... He suggested these diseases represent one disease due to common factors such as a high occurrence in females, unexplained ... aspect of this hypothesis pertains to the existence of common non-disease genes that predispose patients to autoimmune diseases ...
... in enzymes involved in the glycosylation of the CD22 ligand may also lead to the susceptibility to autoimmune diseases. ... Single-nucleotide polymorphisms in the CD22 gene lead to a higher likelihood of autoimmune disease. Specifically, some studies ... CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases ... show that polymorphisms in the CD22 gene are associated with susceptibility to systemic lupus erythematosus (SLE) and cutaneous ...
Huntington's disease, Creutzfeldt-Jakob disease, and motor neuron diseases, polyglutamine (PolyQ) diseases, Muscular ... cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to ... Basler M, Lauer C, Beck U, Groettrup M (Nov 2009). "The proteasome inhibitor bortezomib enhances the susceptibility to viral ... including Alzheimer's disease, Parkinson's disease and Pick's disease, Amyotrophic lateral sclerosis (ALS), ...
Huntington's disease, Creutzfeldt-Jakob disease, and motor neuron diseases, polyglutamine (PolyQ) diseases, Muscular ... cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to ... Basler M, Lauer C, Beck U, Groettrup M (Nov 2009). "The proteasome inhibitor bortezomib enhances the susceptibility to viral ... including Alzheimer's disease, Parkinson's disease and Pick's disease, Amyotrophic lateral sclerosis (ALS), ...
Huntington's disease, Creutzfeldt-Jakob disease, and motor neuron diseases, polyglutamine (PolyQ) diseases, Muscular ... cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to ... Basler M, Lauer C, Beck U, Groettrup M (Nov 2009). "The proteasome inhibitor bortezomib enhances the susceptibility to viral ... including Alzheimer's disease, Parkinson's disease and Pick's disease, Amyotrophic lateral sclerosis (ALS), ...
Huntington's disease, Creutzfeldt-Jakob disease, and motor neuron diseases, polyglutamine (PolyQ) diseases, Muscular ... The clinical relevance of the PSMB9 protein can be found mostly in the areas of infectious diseases, autoimmune diseases and ... Basler M, Lauer C, Beck U, Groettrup M (Nov 2009). "The proteasome inhibitor bortezomib enhances the susceptibility to viral ... cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to ...
and for some of them an association with susceptibility to various infectious diseases and to some autoimmune diseases like ... Netea MG, Wijmenga C, O'Neill LA (May 2012). "Genetic variation in Toll-like receptors and disease susceptibility". Nature ... It also interacts functionally with amyloid formation and behavior in a transgenic mouse model of Alzheimer's disease. A ... January 2014). "The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis". ...
... selected during evolution offer a balance between susceptibility to infection and our capacity to avoid autoimmune diseases. ... List of autoimmune diseases "Autoimmune diseases". Office on Women's Health. U.S. Department of Health and Human Services. 22 ... Autoimmune Diseases. National Academies Press (US). "Autoimmune Disease List • AARDA". AARDA. 2016-06-01. Retrieved 2019-03-21 ... of the population were affected by an autoimmune disease. Women are more commonly affected than men. Autoimmune diseases ...
... and susceptibility to autoimmune diseases is a reason to consider the STAT4 as general autoimmune disease susceptibility locus ... STAT4 is involved in several autoimmune and cancer diseases in animal models humans, significantly in the disease progression ... Rönnblom L (November 2011). "The type I interferon system in the etiopathogenesis of autoimmune diseases". Upsala Journal of ... September 2012). "Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis". Molecular Biology ...