... s do not express immunoglobulins and are unable to respond to the follicular dendritic cell antigens present in the ... However, they are able to promote the secretion of immunoglobulins though CD27/CD70 interactions. B cells begin expressing CD27 ... allowing the B cell receptor to potentially gain stronger affinity for an antigen. In the absence of FDC and helper T cell ...

... on activated antigen presenting cells (APC) including dendritic cells and B cells binds to CD27 on T lymphocytes and ... CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for ... Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation. Also, CD70 can be ... CD70 is also found to be overexpressed in some types of solid tumors. This overexpression of CD70 in cancer cells has been ...

Borst J, Hendriks J, Xiao Y (June 2005). "CD27 and CD70 in T cell and B cell activation". Current Opinion in Immunology. 17 (3 ... CD27: This molecule supports antigen-specific expansion of naïve T cells and is vital for the generation of T cell memory. CD27 ... The ligand for GITR is mainly expressed on antigen presenting cells. Antibodies to GITR have been shown to promote an anti- ... CD40: This molecule, found on a variety of immune system cells including antigen presenting cells has CD40L, otherwise known as ...

B1b cells seem to recognize more types of antigens including intracellular antigens. Previously, B1b cell antigen recognition ... Human B1 cells have been found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been ... making antibodies against antigens and acting as antigen-presenting cells. These B1 cells are commonly found in peripheral ... Hence, there appears to be a role for self or foreign antigen in shaping the repertoire of the B-1 B cell compartment. B1 cells ...

Borst, Jannie; Hendriks, Jenny; Xiao, Yanling (June 2005). "CD27 and CD70 in T cell and B cell activation". Current Opinion in ... that recognizes a common epitope on the human T cell receptor for antigen". Journal of Immunology. 135 (3): 1922-1928. doi: ... The identification of TNF receptor CD27 and CD70 ligand as important costimulatory system on T cells LUMC. "Prof. Jannie Borst ... Church, J. A. (2004-08-01). "Lethal T Cell Immunodeficiency Induced by Chronic Costimulation via CD27-CD70 Interactions". ...

CD70. In normal lymphoid tissues CD27 and its ligand CD70 have a restricted expression pattern, but a 1999 study found CD70 on ... B-cells that have not encountered an antigen are called naive B cells. When naïve B-cells encounter an antigen, one of the ... that bind to a specific antigen. Once activated by an antigen, B-cells proliferate and further differentiate into plasma cells ... Follicular dendritic cells and T cells help to select the B-cells that have a high affinity to the antigen for further ...

"PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway". Bosnian ... "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor ...

... which is a glycoprotein that serves as a ligand for macrophage-1 antigen (Mac-1) and lymphocyte function-associated antigen 1 ( ... "Glioblastomas Induce T-Lymphocyte Death by Two Distinct Pathways Involving Gangliosides and CD70". Cancer Research. 65 (12): ... which is a glycoprotein that serves as a ligand for macrophage-1 antigen (Mac-1) and lymphocyte function-associated antigen 1 ( ... July 2008). "Antigen-specific T-cell induction by vaccination with a recombinant Sendai virus vector even in the presence of ...

... +Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD27 genome location and CD27 gene ... When CD27 binds CD70, a signaling cascade leads to the differentiation and clonal expansion of T cells. The cascade also ... Lens SM, de Jong R, Hintzen RQ, Koopman G, van Lier RA, van Oers RH (June 1995). "CD27-CD70 interaction: unravelling its ... It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. ...

... pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen ... Held-Feindt J, Mentlein R (2002). "CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors". Int. J. ...

... is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... Lutfi, Forat; Wu, Long; Sunshine, Sarah; Cao, Xuefang (2021-09-22). "Targeting the CD27-CD70 Pathway to Improve Outcomes in ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... This additional binding makes the B cells 100- to 10,000-fold more sensitive to antigen. CR2 on mature B cells forms a complex ...

OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as ... CD70, and 4-1BBL on dendritic cells". Blood. 113 (11): 2451-60. doi:10.1182/blood-2008-05-157123. PMID 19029446. S2CID 43707862 ...

When T cells are activated by Antigen Presenting Cells (APCs), CD137 becomes embedded in CD4+ and CD8+ T cells. CD137 is a ... Shulzhenko N, Morgun A, Chinellato AP, Rampim GF, Diniz RV, Almeida DR, Gerbase-DeLima M (March 2002). "CD27 but not CD70 and 4 ...