Nasal administrationOsmotic controlled-release oral delivery system: OROS (Osmotic [Controlled] Release Oral [Delivery] System) is a controlled release oral drug delivery system in the form of a tablet. The tablet has a rigid water-permeable jacket with one or more laser drilled small holes.Appointment on Route 17: Appointment on Route 17 is the fiftieth episode and the fifteenth episode of the third season (1988–89) of the television series The Twilight Zone.Lung receptor: Lung receptors sense irritation or inflammation in the bronchi and alveoli.Gross pathology: Gross pathology refers to macroscopic manifestations of disease in organs, tissues, and body cavities. The term is commonly used by anatomical pathologists to refer to diagnostically useful findings made during the gross examination portion of surgical specimen processing or an autopsy.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingIontocaineImmunologic adjuvant: In immunology, an adjuvant is a component that potentiates the immune responses to an antigen and/or modulates it towards the desired immune responses. The word “adjuvant” comes from the Latin word adiuvare, meaning to help or aid.ImmunizationSubcutaneous injectionIferanserin: Iferanserin (INN; VEN-309) is a drug which acts as a selective 5-HT2A receptor antagonist. It is under development as an intra-rectal formulation for the treatment of hemorrhoid disease, and as of February 2012, is in phase IIb clinical trials.First pass effect: The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.Red Noses: Red Noses is a comedy about the black death by Peter Barnes, first staged at Barbican Theatre in 1985. It depicted a sprightly priest, originally played by Antony Sher, who travelled around the plague-affected villages of 14th century France with a band of fools, known as God's Zanies, offering holy assistance.VaccinationAfrin (nasal spray): Afrin is a brand of nasal spray used to ease nasal congestion and sinusitis that is available over the counter in the USA, distributed by Merck Consumer Care.Global Vaccines: Global Vaccines, Inc is a mission-driven non-profit company applying state-of-the-art science and innovative business strategies to design and develop affordable vaccines for people in poor countries.AB5 toxin: The AB5 toxins are six-component protein complexes secreted by certain pathogenic bacteria known to cause human diseases such as cholera, dysentery, and hemolytic-uremic syndrome. One component is known as the A subunit, and the remaining five components make up the B subunit.CD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.Immunization during pregnancy: Immunization during pregnancy, that is the administration of a vaccine to a pregnant woman, is not a routine event as it is generally preferred to administer vaccines either prior to conception or in the postpartum period. When widespread vaccination is used, the risk for an unvaccinated pregnant patient to be exposed to a related infection is low, allowing for postponement, in general, of routine vaccinations to the postpartum period.Placebo-controlled study: Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham "placebo" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment.Liver sinusoid: A liver sinusoid is a type of sinusoidal blood vessel (with fenestrated, discontinuous endothelium) that serves as a location for the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.SIU SOM Histology GIFlu season: Flu season is an annually recurring time period characterized by the prevalence of outbreaks of influenza (flu). The season occurs during the cold half of the year in each hemisphere.Periarteriolar lymphoid sheaths: Periarteriolar lymphoid sheaths (or periarterial lymphatic sheaths, or PALS) are a portion of the white pulp of the spleen. They are populated largely by T cells and surround central arteries within the spleen; the PALS T-cells are presented with blood borne antigens via myeloid dendritic cells.Aerosolization: Aerosolization is the process or act of converting some physical substance into the form of particles small and light enough to be carried on the air i.e.BentazepamOvalbumin: Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor.Proinflammatory cytokine: A proinflammatory cytokine is a cytokine which promotes systemic inflammation.Besins HealthcareMidazolamHydrophile: A hydrophile is a molecule or other molecular entity that is attracted to, and tends to be dissolved by, water.Liddell, H.Somnoplasty: Somnoplasty (composed of the Latin root somnus, meaning sleep, and the Greek word plastia, meaning molding or formation) is a medical treatment approved by the Food and Drug Administration (FDA) to treat three conditions: habitual snoring, chronic nasal obstruction, and obstructive sleep apnea (OSA) using radiofrequency ablation to shrink the tissues that are causing the problem.Sneeze: A sneeze, or sternutation, is a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa. A sneeze expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane.Drug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.Kennel clubAllergic rhinitis: wide.Honeymoon rhinitis: Honeymoon rhinitis is a condition in which the sufferer experiences nasal congestion during sexual intercourse.OxatomideAllergen immunotherapy: Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for some types of allergies. It is useful for environmental allergies, allergies to insect bites, and asthma.Multiple cloning site: A multiple cloning site (MCS), also called a polylinker, is a short segment of DNA which contains many (up to ~20) restriction sites - a standard feature of engineered plasmids. Restriction sites within an MCS are typically unique, occurring only once within a given plasmid.Septicemic plague: Septicemic (or septicaemic) plague is one of the three main forms of plague. It is caused by Yersinia pestis, a gram-negative species of bacterium.Influenza Research Database: The Influenza Research Database (IRD)IRD Influenza Research Database BRCSquires, R.B.Progressive vaccinia: Progressive vaccinia (also known as "Vaccinia gangrenosum," and "Vaccinia necrosum") is a rare cutaneous condition caused by the vaccinia virus, characterized by painless, but progressive, necrosis and ulceration.New Zealand rabbitAortic pressure: Central aortic blood pressure (CAP or CASP) is the blood pressure at the root of aorta. Studies have shown the importance of central aortic pressure and its implications in assessing the efficacy of antihypertensive treatment with respect to cardiovascular risk factors.Topical decongestant: Topical decongestants are decongestants applied directly to the nasal cavity. By applying them directly to the site of action, topical decongestants relieve nasal congestion while reducing the side effects associated with systemically-acting decongestants, such as high blood pressure.Eva Engvall: Eva Engvall, born 1940, is one of the scientists who invented ELISA in 1971.Eva Engvall, The Scientist 1995, 9(18):8Median toxic dose: ==Introduction==Kidney: The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates. They remove excess organic molecules from the blood, and it is by this action that their best-known function is performed: the removal of waste products of metabolism.Intravaginal administration: Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration.Peptide vaccine: A peptide vaccine is any peptide which serves to immunize an organism against a pathogen. Peptide vaccine are often synthetic and mimic naturally occurring proteins from pathogens.Opioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.