"Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular ... In its GTP-bound form, RhoA exposes regions that allow it to interact with downstream targets. Rnd3 contains a region which is ... "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular ... By binding to ROCK1, Rnd3 inhibits it from phosphorylating downstream targets necessary for stress fiber formation. Rnd3 is ...

Though RhoA is most easily recognized from its unique contributions in actin-myosin contractility and stress fiber formation, ... Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium ... p75NTR without a ligand bound activates RhoA and limits actin assembly, but neurotrophin binding to p75NTR can inactivate RhoA ... RhoA acquires both inactive GDP-bound and active GTP-bound conformational states; these states alternate between the active and ...

RhoA regulates the actin cytoskeleton and forms stress fibers and focal adhesions. When RhoA is inactivated via TcdA, its ... Just I, Selzer J, von Eichel-Streiber C, Aktories K (March 1995). "The low molecular mass GTP-binding protein Rho is affected ... These target molecules include RhoA, Rac, and Cdc42, which are regulatory proteins of the eukaryotic actin cytoskeleton and ... The glucosylation prevents proper binding of GTP and blocks activation. TcdA acts preferentially on the GDP-bound form of the ...

A mouse embryo cDNA library was screened to identify a RhoA-GTP-binding protein using a yeast two-hybrid system. Further it was ... Stress fibers are bundles of about 20 actin filaments linked via non-muscle myosin II. In vitro studies showed that mDia1 ... Profilin as a ubiquitous actin-binding protein is associated with most actin monomers in cells. Interactions between profilin- ... Rho-GTP binds to the GDB domain and disrupts the DAD-DID-interaction thus promoting actin assembly. But this requires high ...

The activity of RhoA regulates the formation of actin stress fibers and focal adhesions - complexes of many proteins located at ... functions to enhance the GTPase activity of the Rho-GTPase proteins RhoA and Cdc42, promoting the hydrolysis of their bound GTP ... its ability to enhance activated GTP-bound Rho-GTPases' (specifically, RhoA and Cdc42) intrinsic ability to convert their GTP ... the termini of actin stress fibers which link the actin cytoskeleton with integrin extracellular matrix receptors. Therefore, ...

... domain for the RhoA small GTP-binding protein. A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is guanine ... "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation". The Journal of ... In particular, active Rho is a major regulator of the cell actin cytoskeleton. AKAP13 is a member of a group of four RhoGEF ... In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate ...

Alternatively, Rif can induce the formation of actin stress fibers in epithelial cells, which is dependent on the activity ... Specifically, the interaction is between the GTP from Rif and the GTPase binding domain (GBD) of mDia2. Rif's function in ... of ROCK proteins since the absence of ROCK activity would mean Rif would be unable to stimulate the growth of stress fibers. ... This process is regulated by FARP1, a type of activator for RhoA GTPases. ...

... putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7 ... Surks HK, Riddick N, Ohtani K (2006). "M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain ... "p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis". Mol. ... putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7 ...

Thus in both cases, ROCK activation by Rho induces the formation of actin stress fibers, actin filament bundles of opposing ... The kinase activity is switched on when Rho-GTP binds to the Rho-binding domain of ROCK, disrupting the autoinhibitory ... Leung T, Chen XQ, Manser E, Lim L (October 1996). "The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is ... glial fibrillaric acidic protein), NF-L (neurofilament L protein) F-actin binding proteins: Adducin, EF-1α (elongation factor, ...

G-protein RhoE binds to the N-terminus of ROCK1 and inhibits its activity by preventing RhoA binding. Small G-proteins, Gem and ... Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, ... When a substrate such as GTP-bound RhoA binds to the Rho-binding region of the coiled-coil domain, the interactions between the ... ROCK1 is activated when bound to the GTP-bound form of RhoA. The human ROCK1 gene is located on human chromosome 18 with ...

"The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth ... RhoA (sometimes referred to as just 'Rho') is responsible for the formation of stress fibers, and its activity in stress fiber ... "The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth ... there are three main types of stress fibers: ventral stress fibers, transverse arcs, and dorsal stress fibers. Ventral stress ...

In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate ... "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation". The Journal of ... for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But ... In particular, active Rho is a major regulator of the cell actin cytoskeleton. RhoGEF12 is a member of a group of four RhoGEF ...

In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate ... "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation". Journal of Biological ... for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But ... In particular, active Rho is a major regulator of the cell actin cytoskeleton. RhoGEF11 is a member of a group of four RhoGEF ...

In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate ... "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation". The Journal of ... for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But ... In particular, active Rho is a major regulator of the cell actin cytoskeleton. RhoGEF1 is a member of a group of four RhoGEF ...

"The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth ... Downregulation of RhoA in the HBE cell lines using siRNAs showed a lack of apical junction formation in contrast with the ... another Ras-related GTP-binding protein, is implicated in the regulation of the actin organisation in presence of extracellular ... In 1993, Alan Hall was awarded the Feldberg Foundation Prize for his work on the role GTP-binding proteins played on signal ...

"Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952 ... Chardin P (1991). "Small GTP-binding proteins of the ras family: a conserved functional mechanism?". Cancer Cells. 3 (4): 117- ... "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106-15. doi:10.1016/s0960-9822(03) ... "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. 22 (9): 2952 ...

RhoA signaling is largely responsible for the neuronal response to neuronal inhibitory proteins and the regeneration (or lack ... The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the ... Further more it binds to BDNF receptor and TrkB inhibiting the activation of TkrB by binding of BNDF after the induction of ... RhoA kinase) which, in turn, stimulates LIM kinase, which then stimulates cofilin, which effectively reorganizes the actin ...

"AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation". J. Biol. Chem. 276 ( ... It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction ... Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape and motility. RhoC can activate formins ... Wheeler AP, Ridley AJ (2004). "Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility". Exp. Cell Res. 301 (1): 43-9. doi: ...

The binding to receptors activates a signaling pathway involving some proteins of the small GTPase system (Cdc42, Rac, RhoA, ... the cellular actin cytoskeleton is changed and subjected to remodeling with the formation of stress fibers that are collected ... controlled by small GTPase RhoA and its effector, ROCK kinase. This GTPase belongs to the superfamily of small GTP hydrolases, ... It was shown that ZEB1 and ZEB2 proteins with a zinc finger domain are able to directly bind to promoters, thereby inducing the ...

G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but ... transforming activity and actin stress fiber formation". FEBS Letters. 478 (1-2): 173-7. doi:10.1016/S0014-5793(00)01845-7. ... Jin S, Exton JH (Nov 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research ... Active GTP-bound G12 alpha subunit interacts with and activates ARHGEF1, ARHGEF11, and ARHGEF12. These ARHGEF proteins function ...