... von Hippel-Lindau Disease Von+Hippel-Lindau+Tumor+Suppressor+Protein at the U.S. National Library of Medicine Medical Subject ... VHL von Hippel-Lindau tumor suppressor". Czyzyk-Krzeska MF, Meller J (April 2004). "von Hippel-Lindau tumor suppressor: not ... The Von Hippel-Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations ... Lolkema MP, Mehra N, Jorna AS, van Beest M, Giles RH, Voest EE (December 2004). "The von Hippel-Lindau tumor suppressor protein ...
"The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1". J. Biol. Chem. 277 (42): 39887-98. ... binding to the von Hippel-Lindau (VHL) tumor suppressor gene product". Cancer Res. 56 (13): 2881-5. PMID 8674032. Zhou MI, Wang ... Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. Actin-binding protein, or filamin, is a 280-kD ... The protein structure includes an actin binding N terminal domain, 24 internal repeats and 2 hinge regions. Filamin has been ...
"Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation ... "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1". The Journal of Biological Chemistry ... "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1". The Journal of Biological Chemistry ... "Identification of the von Hippel-Lindau disease tumor suppressor gene". Science. 260 (5112): 1317-20. Bibcode:1993Sci... ...
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B ... The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two ... "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex". Proc. Natl ... "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. ...
"Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein". The Journal of ... Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that ... protein contains a basic helix-loop-helix protein dimerization domain as well as a domain found in signal transduction proteins ... and leads to protein stabilization and pseudohypoxic signaling. In addition, these neuroendocrine tumors release erythropoietin ...
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B ... "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex". Proc. Natl ... "Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes ... Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD (1997). "The von Hippel-Lindau tumor-suppressor gene ...
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B ... The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. TCEB1 ... "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex". Proc. Natl ... "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. ...
"Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Research. 63 ... MutS protein homolog 5 is a protein that in humans is encoded by the MSH5 gene. This gene encodes a member of the mutS family ... This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing- ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
"Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Research. 63 ... "Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Research. 63 ... MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene. The MSH4 and MSH5 proteins form a hetero- ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
"Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. ... "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. ... USP33 has been shown to interact with DIO2, SELENBP1 and Von Hippel-Lindau tumor suppressor. GRCh38: Ensembl release 89: ... "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. ...
"Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein". Journal of ... The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt-Hogg-Dubé syndrome protein, which functions ... syndromes von Hippel-Lindau syndrome and tuberous sclerosis complex can develop kidney cysts in addition to kidney tumors, ... Experimental evidence supports a role for FLCN as a tumor suppressor gene. In BHD-associated kidney tumors, the inherited FLCN ...
"Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein". The EMBO ... proline residue of HIF1A is then recognized and buried in the hydrophobic core of von Hippel-Lindau tumor suppressor protein ( ... factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene ... contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein". Nature Genetics. 35 (3): 229-37. doi:10.1038 ...
... nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein". Molecular and ... Moreover, a truncated form of the eEF1A1 protein, prostate tumour inducing gene 1 (PTI-1), has been detected in prostate ... The eEF1A1 protein is an isoform of the eEF-1 complex alpha subunit, an elongation factor protein, a GTPase, and an actin ... This protein can also act as a membrane receptor for the cryptic antiadhesive site of fibronectin, thus inhibiting cell ...
"Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation ... Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene. DEC1 encodes a basic ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... BHLHB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook BHLHE40 Human BHLHE40 ...
The von Hippel-Lindau tumour suppressor protein (pVHL) ubiquitinates hypoxia-inducible factor 1α (HIF1α) when cell oxygen ... Kondo K, Kaelin WG (Mar 2001). "The von Hippel-Lindau tumor suppressor gene". Experimental Cell Research. 264 (1): 117-25. doi: ... "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochemical and ... "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochemical and ...
"Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function". ... NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in saccharomyces cerevisiae this protein is known as Rub1) ... This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called ... Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K (March 2004). "Nedd8 on cullin: building an expressway to protein destruction". ...
Von Hippel-Lindau tumor suppressor Von Hippel-Lindau disease Eugen von Hippel Arvid Lindau "UniProt". beta.uniprot.org. ... also Von Hippel-Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel-Lindau protein and ... Tsuchiya H, Iseda T, Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor ... von+Hippel-Lindau+binding+protein+1,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e ( ...
Kaelin Jr on Nobelprize.org including the Nobel Lecture 7 December 2019 The von Hippel-Lindau Tumor Suppressor Protein: ... His major work has been on the retinoblastoma, von Hippel-Lindau, and p53 tumor suppressor genes. His work has been funded by ... He had become interested in Von Hippel-Lindau disease (VHL). VHL tumors, caused by gene mutation, were known to be angiogenic, ... His laboratory studies tumor suppressor proteins. In 2016, Kaelin received the Albert Lasker Award for Basic Medical Research ...
The von Hippel-Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation. GRCh38 ... 2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... Elongin A is a protein that in humans is encoded by the ELOA gene. Elongin A is a subunit of the transcription factor B (SIII) ...
Von Hippel-Lindau tumor suppressor - Mammalian protein found in Homo sapiens Information on VHL disease VHL Family Alliance ( ... biography of Arvid Lindau) Arvid Vilhelm Lindau @ Who Named It Hippel-Lindau disease @ Who Named It (Articles with ISNI ... and today the disease is named Von Hippel-Lindau disease. Studien über Kleinhirncysten. Bau, Pathogenese und Beziehungen zur ... Arvid Vilhelm Lindau (23 July 1892 - 7 September 1958) was a Swedish pathologist and bacteriologist born in Malmö. Lindau ...
... cullin proteins MeSH D08.811.464.938.750.875 - von hippel-lindau tumor suppressor protein MeSH D08.811.520.224.062 - aldehyde ... proto-oncogene proteins c-cbl MeSH D08.811.464.938.750.562 - proto-oncogene proteins c-mdm2 MeSH D08.811.464.938.750.750 - skp ... gtp-binding protein alpha subunits MeSH D08.811.277.040.330.300.200.100.100 - gtp-binding protein alpha subunits, g12-g13 MeSH ... gtp-binding protein alpha subunit, gi2 MeSH D08.811.277.040.330.300.200.100.300 - gtp-binding protein alpha subunits, gq-g11 ...
The von Hippel-Lindau tumor suppressor protein (pVHL, human GeneID: 7428) complex binds the hyperphosphorylated large subunit ... "VHL von Hippel-Lindau tumor suppressor [ Homo sapiens ]". Liao S, Zhang J, Jeffery DA, et al. (2002). "A kinase-cyclin pair in ... "Von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif ... Protein interference is the process where in some signaling protein interacts, either with the promoter or with some stage of ...
... and endolymphatic sac tumors. It is caused by genetic mutations in the Von Hippel-Lindau tumor suppressor gene. The VHL protein ... Von Hippel-Lindau disease is a dominantly inherited cancer syndrome that significantly increases the risk of various tumors. ... The APC gene is a tumor suppressor. Its protein product is involved in many cellular processes. Inactivation of the APC gene ... Tuberin and hamartin inhibit the mTOR protein in normal cellular physiology. Inactivation of the TSC tumor suppressors causes ...
The von-Hippel Lindau tumor suppressor (pVHL) is a part of protein complex known as E3 ubiquitin ligase and targets hypoxia- ... Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G (April 2003). "The VHL protein recruits a novel KRAB-A domain protein to ... It is reported that there is a new protein that was discovered that interacts with the pVHL protein and helps it with its job. ... "KRBA1 Gene - GeneCards , KRBA1 Protein , KRBA1 Antibody". www.genecards.org. Retrieved 2020-05-02. "CDD Conserved Protein ...
The von Hippel-Lindau tumor suppressor gene generally has a germline mutation. This suppressor gene is also called elongin ... binding protein and G7 protein. The VHL protein is involved in up-regulation of hypoxic response via the [[hypoxia inducible ... The vast majority of patients with an endolymphatic sac tumor have von Hippel-Lindau syndrome. Tumors range from several ... usually do so because of other tumors within the von Hippel-Lindau complex rather than from this tumor. Surgery is the primary ...
A specific step identified was the binding of proteins expressed by the Von Hippel-Lindau tumor suppressor gene (VHL) to ... the VHL protein then ubiquitylates the HIF protein which ultimately leads to the HIF protein's destruction. When oxygen levels ... Ratcliffe found that the VHL protein can bind a hydroxylated residues of HIF when oxygen is present at acceptable levels; ...
... von Hippel-Lindau tumor suppressor ZMYND10: zinc finger MYND-type containing 10 ZNF197: encoding protein Zinc finger protein ... encoding protein Zinc finger protein 620 ZNF621: encoding protein Zinc finger protein 621 ZNF717: encoding protein Zinc finger ... encoding protein QRICH1, also known as Glutamine-rich protein 1, RBM6: RNA-binding protein 6 RPP14: Ribonuclease P protein ... encoding protein F-box protein 40 FILIP1L: encoding protein Filamin A interacting protein 1 like GYG1: Glycogenin-1 HACD2 ...
Promyelocytic leukemia protein, Retinoid X receptor alpha, and Von Hippel-Lindau tumor suppressor. GRCh38: Ensembl release 89: ... Lee MO, Kang HJ, Cho H, Shin EC, Park JH, Kim SJ (November 2001). "Hepatitis B virus X protein induced expression of the Nur77 ... In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells. ... Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, ...
... a human eye disease named after Lindau and German ophthalmologist Eugen von Hippel von Hippel-Lindau tumor suppressor, a ... mutations of which may cause the above disease von Hippel-Lindau binding protein 1, a human chaperone protein that transports ... Zurich Lindau (surname) Arvid Lindau (1892-1958), Swiss pathologist and bacteriologist von Hippel-Lindau disease or familial ... Lindau may also refer to: Lindau (Anhalt), a town in the district Anhalt-Zerbst, Saxony-Anhalt Lindau (Katlenburg-Lindau), a ...
... has been shown to interact with HIF1A and Von Hippel-Lindau tumor suppressor. Additionally, asparaginyl hydroxylation of ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... "Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau". J. Biol. ... Mahon PC, Hirota K, Semenza GL (Oct 2001). "FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of ...