... has trinucleotide repeats that occur in the exons of the affected genes. Some of the problems in trinucleotide repeat syndromes ... Trinucleotide repeats are a subset of a larger class of unstable microsatellite repeats that occur throughout all genomes. The ... Three categories of trinucleotide repeat disorders and related microsatellite (4, 5, or 6 repeats) disorders are described by ... Trinucleotide repeat disorders and the related microsatellite repeat disorders affect about 1 in 3,000 people worldwide. ...
... trinucleotide repeat expansion can also occur during DNA repair. When a DNA trinucleotide repeat sequence is damaged, it may be ... This (CTG)n trinucleotide repeat is located within leukocytes; the length of the repeat and the age of the individual have been ... In trinucleotide repeat expansion there is a certain threshold or maximum amount of repeats that can occur before a sequence ... A trinucleotide repeat expansion, also known as a triplet repeat expansion, is the DNA mutation responsible for causing any ...
"Entrez Gene: Trinucleotide repeat containing 18". Retrieved 2016-10-22. "trinucleotide repeat-containing gene 18 protein [Homo ... GeneCards lists five aliases for TNRC18, Long CAG Trinucleotide Repeat-Containing Gene 79 Protein, Trinucleotide Repeat- ... Trinucleotide repeat containing 18 is a protein that in humans is encoded by the TNRC18 gene. The exact function of TNRC18 is ... "TNRC18 trinucleotide repeat containing 18 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-05-01. " ...
It is caused by an expanded number of trinucleotide repeats in the polyglutamine tract of the ATXN1 gene, which encodes the ... July 1993). "Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1". Nature Genetics. 4 (3): 221- ... Cummings CJ, Zoghbi HY (September 2000). "Trinucleotide repeats: mechanisms and pathophysiology". Annual Review of Genomics and ... For repeat lengths within the range where interruptions are relevant, assays like CE and PAGE will not determine if the strain ...
Orr HT, Zoghbi HY (July 2007). "Trinucleotide repeat disorders". Annual Review of Neuroscience. 30 (1): 575-621. doi:10.1146/ ... Almeida B, Fernandes S, Abreu IA, Macedo-Ribeiro S (2013). "Trinucleotide repeats: a structural perspective". Frontiers in ...
... however the polyglutamine repeat region is similar to genetic precursors in trinucleotide repeat disorders. An increase in the ... Orr HT, Zoghbi HY (2007). "Trinucleotide repeat disorders". Annual Review of Neuroscience. 30: 575-621. doi:10.1146/annurev. ... C9orf43 contains DUF 4647 and a polyglutamine repeat region although protein function is not well understood. C9orf43 is ... length of the polyglutamine repeat region is seen in diseases such as Huntington's disease and Spinocerebellar ataxia. GRCh38: ...
Trinucleotide Repeat Protocols. Methods in Molecular Biology. Vol. 1010. pp. 95-109. doi:10.1007/978-1-62703-411-1_7. ISBN 978- ... Repeated developmental work also shed light on improving the chemical composition of the RNA molecule to reduce the immune ...
"Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q". Diabetes ...
Part of this gene is a repeated section called a trinucleotide repeat expansion - a short repeat, which varies in length ... HD is one of several trinucleotide repeat disorders that are caused by the length of a repeated section of a gene exceeding a ... instead of reproducing an exact copy of the trinucleotide repeat. This causes the number of repeats to change in successive ... Trinucleotide CAG repeats numbering over 28 are unstable during replication, and this instability increases with the number of ...
Huntington's disease is one of several trinucleotide repeat disorders which are caused by the length of a repeated section of a ... known as a trinucleotide repeat. CAG is the genetic code for the amino acid glutamine, so a series of them results in the ... HTT contains a sequence of three DNA bases-cytosine-adenine-guanine (CAG)-repeated multiple times (i.e. ... CAGCAGCAG ...), ... "Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain". Human ...
PolyQ is a biological database of polyglutamine repeats in disease and non-disease associated proteins. Trinucleotide repeat ... a database describing the sequence and domain context of polyglutamine repeats in proteins". Nucleic Acids Res. England. 39 ( ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ... studies of genes with triplet repeats expressed in skeletal muscle". Diabetologia. 39 (6): 725-30. doi:10.1007/BF00418545. PMID ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ... Normal alleles usually have 22 or 23 repeats, but can contain up to 31 repeats. Longer expansions can cause spinocerebellar ... "Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2". Nature Genetics. 14 (3): 269 ... The disease allele usually contains 34-52 CAG repeats, but can contain as few as 32 or more than 100, and can expand in size ...
"Entrez Gene: TNRC15 trinucleotide repeat containing 15". Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of ... "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ... Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch ... a WD40-repeat protein linked to deafness". Genes & Development. 14 (9): 1048-57. doi:10.1101/gad.14.9.1048. PMC 316569. PMID ... a WD40-repeat protein linked to deafness". Genes & Development. 14 (9): 1048-57. doi:10.1101/gad.14.9.1048. PMC 316569. PMID ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ... Manke IA, Lowery DM, Nguyen A, Yaffe MB (October 2003). "BRCT repeats as phosphopeptide-binding modules involved in protein ... Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene. This gene encodes a ... "Entrez Gene: TNRC6A trinucleotide repeat containing 6A". Yamagata K, Takeda J, Menzel S, et al. (1996). "Searching for NIDDM ... "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ... member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing ...
This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind ... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
The MED15 gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in ... "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ... "Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and ...
... "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114-22. doi:10.1007/s004390050476. PMID ...
The JPH3 gene contains a CAG/CTG trinucleotide repeat segment. This segment's expansion is associated with several ... July 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114-122. doi:10.1007/ ... December 2001). "A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2". Nature ... March 2002). "CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients". ...
Hearne CM, Todd JA (1991). "Trinucleotide repeat polymorphism at the CRYG1 locus". Nucleic Acids Res. 19 (19): 5450. doi: ... "Two human gamma-crystallin genes are linked and riddled with Alu-repeats". Gene. 38 (1-3): 197-204. doi:10.1016/0378-1119(85) ...
This region is called a trinucleotide repeat. The usual CAG repeat count is between seven and 35 repeats. The HTT gene is ... Nance MA, Mathias-Hagen V, Breningstall G, Wick MJ, McGlennen RC (Jan 1999). "Analysis of a very large trinucleotide repeat in ... The key sequence which is found in Huntington's disease is a trinucleotide repeat expansion of glutamine residues beginning at ... This makes it part of a class of neurodegenerative disorders known as trinucleotide repeat disorders or polyglutamine disorders ...
Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene. TNRC6B has been ... "Entrez Gene: TNRC6B trinucleotide repeat containing 6B". Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, ...
Hearne CM, Todd JA (October 1991). "Trinucleotide repeat polymorphism at the CRYG1 locus". Nucleic Acids Research. 19 (19): ... "Two human gamma-crystallin genes are linked and riddled with Alu-repeats". Gene. 38 (1-3): 197-204. doi:10.1016/0378-1119(85) ... "Two human gamma-crystallin genes are linked and riddled with Alu-repeats". Gene. 38 (1-3): 197-204. doi:10.1016/0378-1119(85) ...
The process of DNA mismatch repair plays a prominent role in the formation of direct trinucleotide repeat expansions. Such ... Tandem repeats (tandem repeat sequences) are repeated copies which lie adjacent to each other. These can also be direct or ... Flanking (or terminal) repeats (terminal repeat sequences) are sequences that are repeated on both ends of a sequence, for ... Inverted repeat Ussery, David W.; Wassenaar, Trudy; Borini, Stefano (2008-12-22). "Word Frequencies, Repeats, and Repeat- ...