Activator protein Transcription factor Hess J, Angel P, Schorpp-Kistner M (December 2004). "AP-1 subunits: quarrel and harmony ... Lee W, Mitchell P, Tjian R (June 1987). "Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements". ... activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1", which "defines the ... Ahn JD, Morishita R, Kaneda Y, Lee KU, Park JY, Jeon YJ, Song HS, Lee IK (June 2001). "Transcription factor decoy for activator ...
All three transcription factors are needed to activate the transcription of interleukin-2(IL2) gene. NFAT activation depends on ... AP-1 then acts as transcription factor. Raf is activated via the second messenger DAG, SOS, and Ras. DAG recruits among other ... Transcription factors involved in T-cell signalling pathway are the NFAT, NF-κB and AP1, a heterodimer of proteins Fos and Jun ... Upon binding to pMHC, the TCR initiates a signalling cascade, involving transcription factor activation and cytoskeletal ...
"Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 ... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 ... c-jun transcription is autoregulated by its own product, Jun. The binding of Jun (AP-1) to a high-affinity AP-1 binding site in ...
Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF ... The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of ... "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon ... Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor ...
"JUN - Transcription factor AP-1 - Homo sapiens (Human) - JUN gene & protein". www.uniprot.org. Retrieved 2018-05-01. Serra RW, ... The presence of multiple y-box binding transcription factors and SRY transcription factor binding sites suggest that C18orf63 ... In the regulatory sequence missense mutations occur at two transcription factor binding sites. Transcription factors affected ... SRY testis determining factors, Y-box binding transcription factors, and glucocorticoid responsive elements. The JUN protein ...
Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor ... "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 ... Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. ... Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper ...
"The AP-1 transcription factor c-Jun is required for efficient axonal regeneration." Neuron 43.1 (2004): 57-67. Raivich, ... "Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in ...
Hypoxia also activates transcription factor AP-1, which is involved in MET transcription. MET pathway plays an important role ... "Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway". ... ETS1 activates MET transcription in vitro. MET transcription is activated by hypoxia-inducible factor 1 (HIF1), which is ... MET transcription is activated by HGF and several growth factors. MET promoter has four putative binding sites for Ets, a ...
"Activation of Transcription Factors AP-1 and NF- B in Murine Chagasic Myocarditis". Infection and Immunity. 71 (5): 2859-67. ... It was found that within seven days the concentration of AP-1 was significantly higher in T. cruzi-infected mice when compared ... Huang, Huan; Petkova, Stefka B.; Cohen, Alex W.; Bouzahzah, Boumediene; Chan, John; Zhou, Jian-nian; Factor, Stephen M.; Weiss ... AP-1, and NF-κB. Also, the mitotic regulator for G1 progression, cyclin D1 was found to be activated. Although there was no ...
"FOSB FosB proto-oncogene, AP-1 transcription factor subunit [Homo sapiens (Human)] - Gene - NCBI". "WikiGenes - Collaborative ... 39 (1): 4-6. doi:10.1016/j.ro.2003.10.001. PMID 14976833. Vlaic J, Fattorini MZ, Dukaric N, Tomas D (September 2020). " ... Individuals commonly present within 1-3 weeks or, rarely, longer times (e.g. 3 months) of noticing a rapidly growing, small (. ... that increase in size over several weeks and often regress over the ensuing 1-3 months. The lesions in PF/PM are typically ...
PLC activates 3 major transcription factors and their pathways: NFAT, NFkB and AP-1. In addition and after costimulation from ... It cooperates with other transcription factors including NFkB and Oct. NFkB is translocated to the nucleus after costimulation ... This phosphorylation recruits STAT transcription factors, predominantly STAT5, which dimerize and migrate to the cell nucleus ... AP-1 is a dimer and is composed of c-Jun and c-Fos proteins. ... 712 The key factor was isolated from cultured mouse cells in ...
This adduct interferes with the binding of transcription factors to DNA which can trigger apoptosis or result in deletion ... AP endonuclease then cleaves the AP site, and the single-strand break is either processed by short-patch BER to replace a ... There are two broad causes of nucleic acid lesions, endogenous and exogenous factors. Endogenous factors, or endogeny, refer to ... transcription factor". Biochemistry. 41 (25): 8093-8102. doi:10.1021/bi012180a. ISSN 0006-2960. PMID 12069602. Esterbauer, H.; ...
It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors. COP9 constitutive ... November 2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. ... June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22 ... June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22 ...
"Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in ... Jin C, Li H, Murata T, Sun K, Horikoshi M, Chiu R, Yokoyama KK (July 2002). "JDP2, a repressor of AP-1, recruits a histone ... "The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and ... It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF- ...
"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Transcription factor JunD is a protein that in humans is encoded by the JUND gene. The protein encoded by this intronless gene ...
PKR is induced via the transcription factor AP-1 and activated independently of PACT. In this context, PKR has been shown to be ... PKR also has pro-inflammatory functions, as it can mediate the activation of the transcription factor NF-kB, by phosphorylating ... This leads to the expression of adhesion molecules and transcription factors that activate them, which induce inflammation ... eIF2a phosphorylation then induces activation of transcription factor 4 (ATF4), which induces apoptosis and nuclear ...
PEMT gene expression is regulated by transcription factors including activator protein 1 (AP-1) and Sp1. Sp1 is a negative ... Estrogen has also been shown to be a positive regulator of hepatocyte PEMT transcription. Ablation of the estrogen binding site ... regulator of PEMT transcription, yet is it is a positive regulator of choline-phosphate cytidylyltransferase (CT) transcription ... 1348 (1-2): 142-50. doi:10.1016/s0005-2760(97)00108-2. PMID 9370326. Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono ...
"Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1". Biochem. Biophys ... 345 (1): 495-501. doi:10.1016/j.bbrc.2006.04.123. PMID 16684505. ITGA10 Info with links in the Cell Migration Gateway Archived ... The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 1, Webarchive template ...
... transcription factor consisting of cFOS and Cjun). This results in the activation of caspases as well. ROS also causes a ... JNK is phosphorylated, which leads to the phosphorylation of AP-1 ( ... When the mitochondrial membrane potential changes, apoptosis-inducing factors (AIFs) are also released. These trigger apoptosis ... 242 (1): 161-6. doi:10.1016/0014-5793(88)81007-x. PMID 2462511. S2CID 1400091. Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch- ...
... a key transcription factor involved in inflammation. Retinoic acid products also reduce sebum secretion, a nutrient source for ... The retinoid-receptor complex competes for coactivator proteins of AP-1, ... The "accessory factors" were termed "fat soluble" in 1918, and later "vitamin A" in 1920. In 1919, Harry Steenbock (University ... Given the weak quality of the clinical evidence, an uncertainty factor of 5 was used, and with rounding, the UL was set at ...
... a key transcription factor involved in inflammation. Retinoids also down-regulate expression of toll-like receptor (TLR)-2, ... The retinoid-receptor complex competes for coactivator proteins of AP-1, ... Dictionary transcriptions also include /ˌtrɪˈtɪnoʊɪn/ (tri-TIN-oh-in) and /ˈtrɛtɪnɔɪn/. Tretinoin has been explored as a ... The epoxide is attacked by water to form diol in site 1. NADH, as a reduction agent, reduce the alcohol group to aldehydes. ...
Pospelov VA, Pospelova TV, Julien JP (February 1994). "AP-1 and Krox-24 transcription factors activate the neurofilament light ... 143 (1): 1-4. doi:10.1083/jcb.143.1.1. PMC 2132816. PMID 9763415. Beaudet L, Charron G, Julien JP (May 1992). "Origin of the ... 67 (1): 37-46. doi:10.1086/302962. PMC 1287099. PMID 10841809. De Jonghe P, Mersivanova I, Nelis E, Del Favero J, Martin JJ, ... 909 (1): 10-20. doi:10.1016/0167-4781(87)90041-8. hdl:1765/2408. PMID 3034332. Hurst J, Flavell D, Julien JP, Meijer D, ...
Hu Y, Jin X, Snow ET (July 2002). "Effect of arsenic on transcription factor AP-1 and NF-κB DNA binding activity and related ... hydroxylation of fatty acids and the inhibition of pro-inflammatory transcription factors (NF-κB and AP-1), pro-inflammatory ... December 2009 Arsenic has also been shown to induce cardiac hypertrophy by activating certain transcription factors involved in ... Increased AP-1 and NF-κB obviously also result in an up-regulation of mdm2 protein, which decreases p53 protein levels. Thus, ...
... its presence was detected in the cytoplasm and it was associated with activation of the AP-1 transcription factor. LYPD6B is ... 29 (1): 39-50. doi:10.1111/exd.14047. PMID 31602702. v t e (Articles with short description, Short description matches Wikidata ...
Activation of the IRAK/MAPK pathway leads to the stimulation of the transcription factors NF-kappaB and AP-1. These ... transcription factors cause the upregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression ... Neiman, J. (Oct 1998). "Alcohol as a risk factor for brain damage: neurologic aspects". Alcohol. Clin. Exp. Res. 22 (7 Suppl): ... 44 (1): 15-26. doi:10.1016/j.alcohol.2009.10.003. PMID 20113871. Blanco Am, V. S. S.; Vallés, S. L.; Pascual, M.; Guerri, C. ( ...
The p38 pathway leads to the activation of AP-1 transcription factor c-Fos and the ERK1/2 pathway. The ERK1/2 pathway then ... This toxin is a fungal example of a classical virulence factor. Hyphal morphogenesis in C. albicans is associated with damage ... Examples of pro-inflammatory cytokines that can activate the p38 MAP Kinase include tumor necrosis factor, Interleukin-1, and ... MAPK phosphatase 1 is the founding member of the family of MAPK phosphatases which is a group of 11 phosphatases. The N- ...
2003). "Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16". J. ... Transcription factors, All stub articles, Human chromosome 1 gene stubs). ... Johnstone RW, Kerry JA, Trapani JA (1998). "The human interferon-inducible protein, IFI 16, is a repressor of transcription". J ... localization sequence of the interferon-induced nuclear factor IFI 16". Biochem. J. 353 (Pt 1): 69-77. doi:10.1042/0264-6021: ...
In SARS-CoV, ORF3b protein reportedly activates the transcription factor AP-1 through the JNK and ERK signaling pathways. ... Varshney B, Lal SK (June 2011). "SARS-CoV accessory protein 3b induces AP-1 transcriptional activity through activation of JNK ... 12 (1): 2642. Bibcode:2021NatCo..12.2642J. doi:10.1038/s41467-021-22905-7. hdl:1721.1/130581. PMC 8113528. PMID 33976134. Lu R ...
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... 1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 ( ... 1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. ... Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper ...
Most important in T cells is PKC-θ, critical for activating the transcription factors NF-κB and AP-1. IP3 is released from the ... NFAT is a transcription factor that activates the transcription of a pleiotropic set of genes, most notable, IL-2, a cytokine ... Both subsets require the expression of the transcription factor FOXP3 which can be used to identify the cells. Mutations of the ... Last known factors that can play a role in T cell exhaustion are regulatory cells. Treg cells can be a source of IL-10 and TGF- ...