... treatment and the resulting ER calcium depletion inhibits autophagy independent of the UPR. Thapsigargin is useful ... Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin ... Thapsigargin raises cytosolic (intracellular) calcium concentration by blocking the ability of the cell to pump calcium into ... A prodrug of thapsigargin, mipsagargin, is currently undergoing clinical trials for the treatment of glioblastoma. The ...

The chemical compound thapsigargin has been isolated from Thapsia garganica. A synthetic prodrug of thapsigargin called "G-202 ... This same chemical compound thapsigargin is now being looked at as an antiviral to use against SARS-coV-2, the coronavirus ... in San Antonio, TX is studying methods of delivering thapsigargin directly to cancer cells, avoiding damage to other cells in ... "Thapsigargin prodrug G-202". NCI Cancer Dictionary. Kristen Philipkoski (2 February 2012). "Scientists Transform Deadly Plant ...

An example of a Grob-like fragmentation in organic synthesis is the expansion of the Wieland-Miescher ketone to thapsigargin: ... "Synthesis of the thapsigargins". Proceedings of the National Academy of Sciences. 101 (33): 12073-12078. Bibcode:2004PNAS.. ...

Thapsigargin coated intraocular lenses inhibit human lens cell growth. Nature Medicine: 3, 1028-1030. DX Xie, BF Feys, S James ...

It is a thapsigargin-based prodrug with cytotoxic activity used to reduce blood flow to the tumor during treatment. Results ... phyton (2016-08-22). "Phyton Biotech Achieves Manufacturing Milestone with Thapsigargin, the Active Agent in Mipsagargin". ...

For experimental purposes, SERCA can be inhibited by thapsigargin and induced by istaroxime. SERCA function is upregulated in ...

... increases agonist and thapsigargin releasable Ca2+ storage in the Golgi". The Journal of Cell Biology. 145 (2): 279-89. doi: ...

CPA also binds to SERCA ATPase at the same site as another inhibitor, thapsigargin (TG). In this way, CPA lowers the ability of ... for thapsigargin and cyclopiazonic acid". Biochemistry. 38 (47): 15522-7. doi:10.1021/bi991523q. PMID 10569935. Voss KA (May ...

... thapsigargin, arsenite and heat-shock treatments". Experimental Cell Research. 315 (6): 968-80. doi:10.1016/j.yexcr.2009.01.012 ...

... thapsigargin, arsenite and heat-shock treatments". Experimental Cell Research. 315 (6): 968-980. doi:10.1016/j.yexcr.2009.01. ... thapsigargin), proteasome inhibition (MG132), hyperosmotic stress, ultraviolet radiation, inhibition of eIF4A (pateamine A, ...

... can reduce calcium influx through inhibition of the fMLP, AlF4−, and thapsigargin G-protein pathways. Honokiol has ...

... thapsigargin leads to ER Ca2+ depletion due to inhibition of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA). A23187 ...

This is effected by its inhibiting thrombin and thapsigargin, two activators of SOCE that increase intracellular free calcium. ...

Catalyzed Allenic Pauson-Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on ... which enable the enantioselective synthesis of compounds such as thapsigargin. Her approach includes collaborations with ...

Ca2+ uptake usually occurs via a thapsigargin-insensitive pathway (therefore precluding SERCA involvement) and appears to be ... thapsigargin). This is a blanket term that encompasses a spectrum of acidic vesicles that include endosomes, lysosomes, and ... thapsigargin) whereas the exchanger exploit the H+ gradient to drive Ca2+ uptake against its concentration gradient. The genes ...

Thapsigargin kills cells irrespective of the rate of cell division, which may provide an effective approach to kill both fast- ... The objective of the collaboration was to chemically alter thapsigargin to a derivative that could be linked to peptides, thus ... The active ingredient in G-202 is a chemotherapeutic agent derived from thapsigargin, a plant-based cytotoxin that kills by ... GenSpera's prodrug delivery system keeps the thapsigargin inactive in the body until it finds cells that it has been programmed ...

... thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): ...

... thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096-106. doi: ... Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096-106. doi: ...

Their effects are mimicked by the pharmacological agent, thapsigargin, which is sometimes used in fluid secretion assays when a ...

TcK6 causes modest suppression of thapsigargin-triggered IFN-g production by sheep T cells, suggesting that the parasite use ...

... and both are inhibited by the tumor-promoting agent thapsigargin, which does not affect the plasma membrane Ca2+ pumps. Active ...

Thapsigargin, cyclopamine, Thiostrepton, Staurosporine, Mithramycin, Midostaurin, Wortmannin, K252a, Geldanamycin and its ...

Thapsigargin, a sesquiterpene lactone and tumor promoter Thyroglobulin, a protein Transgenic, referring to genetic material ...

... thapsigargin MeSH D02.455.849.765.850 - trichothecenes MeSH D02.455.849.765.850.870 - t-2 toxin MeSH D02.455.849.765.850.900 - ...

Tetracycline Thapsigargin Thaumatin Thiamine (vitamin B1) - C12H17ClN4OS·HCl Threonine Thrombopoietin Thromboxane Thymidine ...

One of these prodrugs termed G202 consists of an analog of the highly toxic natural product thapsigargin coupled to a peptide ...

... thapsigargin, epothilone A, antascomicin B, bengazole A and rapamycin. His total synthesis of azadirachtin, completed in 2007, ...

The addition of thapsigargin (the SERCA pump inhibitor that stimulates SOCE by passive depletion of intracellular Ca2+ stores) ...

... and 3 to thapsigargin and other inhibitors". J. Biol. Chem. 281 (11): 6970-6. doi:10.1074/jbc.M510978200. PMID 16410239. ...