Gardini, G. P.; Palla, G.; Scapini, G.; Cesaroni, M. R. (2006). "Convenient Synthesis of N-Benzyl-N′-acyl-piperazines". ... Fipexide (Attentil, Vigilor) is a psychoactive drug of the piperazine chemical class which was developed in Italy in 1983. It ... PTC alkylation of piperazine (1) with 2 equivalents of piperonyl chloride [25054-53-9] (2) in the presence of cetrimonium ... Substituted piperazine Befuraline Piberaline Missale C, Pasinetti G, Govoni S, Spano PF, Trabucchi M (February 1983). "[ ...
1994). "Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse ... Piperazines, Aminopyridines, All stub articles, Antiinfective agent stubs). ... of the pyridylpiperazine moiety starts by aromatic displacement of chlorine from 2-chloro-3-nitropyridine by piperazine to give ...
A known use has been in the synthesis of L-745,870. Substituted piperazine "www.emcdda.europa.eu" (PDF).[dead link] Fuller RW, ... It has been encountered in illicit capsules as a recreational drug similarly to other piperazines like mCPP. Scientific ... Snoddy HD (July 1980). "Comparative effects of p-chloroamphetamine and 1-(p-chlorophenyl)piperazine on 5-hydroxyindole ...
"Synthesis of natural fragrance jasminaldehyde using silica-immobilized piperazine as organocatalyst". Catalysis Science & ...
February 2003). "Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles ... August 2001). "Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element ... The changes that were made on the left hand side of the lead compound and the addition of a methyl group on the piperazine ... October 2001). "Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]- ...
Younes, S (2000). "Synthesis and structure-activity relationships of novel arylalkyl 4-benzyl piperazine derivatives as σ site ... Efficient Synthesis ofN-(Heteroarylcarbonyl)-N′-(arylalkyl) piperazines". Chemistry - A European Journal. 10 (3): 746-757. doi: ... Substituted piperazine Befuraline Fipexide Tekes K, Tóthfalusi L, Malomvölgyi B, Hermán F, Magyar K (1987). "Studies on the ... Piberaline (EGYT-475; Trelibet) is a psychoactive drug and member of the piperazine chemical class which was developed in the ...
New Conjugated Systems Derived from Piperazine-2,5-dione. Molecules 2000, 5, 629-636 Cara E. Humphrey, Markus Furegati, Kurt ... In one study the Erlenmeyer amino acid synthesis was used in the heart of an L-m-tyrosine synthesis Dakin-West reaction Perkin ... 3-8. G. E. VandenBerg, J. B. Harrison, H. E. Carter, B. J. Magerlein (1973). "2-Phenyl-2-oxazolone". Organic Syntheses.{{cite ... 5, p. 946 H. B. Gillespie, H. R. Snyder (1934). "dl-β-Phenylalanine". Organic Syntheses.; Collective Volume, vol. 2, p. 489 ...
An N-alkylation of the piperazine ring with 3-methylbenzylchloride completes the synthesis. Alternatively, the last step can be ... Synthesis, Patents, Applications (4th ed.). Thieme. ISBN 3-13-115134-X. "Guidelines on the Use of INNs for Pharmaceutical ... Fuhrkop JH, Li G (2003). Organic Synthesis. Concepts and Methods. Wiley. p. 237. ISBN 978-3-527-30272-7. US 2709169, Morren H, ... Meclizine is a first-generation antihistamine (nonselective H1 antagonist) of the piperazine class. It is structurally and ...
... piperazine. Substituted piperazine Phenylpiperazine Leś A, Badowska-Rosłonek K, Łaszcz M, Kamieńska-Duda A, Baran P, Kaczmarek ... It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is ... Caccia S (August 2007). "N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines ... Ł (2010). "Optimization of aripiprazole synthesis". Acta Poloniae Pharmaceutica. 67 (2): 151-7. PMID 20369792. ...
Substituted piperazine Fipexide Piberaline Boksay IJ, Popendiker K, Weber RO, Söder A (1979). "Synthesis and pharmacological ... Befuraline (DIV-154) is a psychoactive drug and member of the piperazine chemical class which was developed in Germany in the ... Piperazines, Benzofuran-2-carboxamides, Serotonin-norepinephrine-dopamine releasing agents, All stub articles, Psychoactive ...
"Stereocontrolled Synthesis of Trisubstituted Cyclopropanes: Expedient, Atom-Economical, Asymmetric Syntheses of (+)-Bicifadine ... 4-disubstituted piperazines and piperidines as triple reuptake inhibitors". Bioorganic & Medicinal Chemistry. 25 (7): 2266-2276 ... Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19( ... Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors. Eur J Med Chem. 2012 ...
February 2008). "Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as ... December 2008). "Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 ( ... September 2005). "Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232 ...
... piperazine [303-26-4] (4). Alkylation of the remaining nitrogen with Cinnamyl Bromide [4392-24-9] (5) completed the synthesis ... Venkat Narsaiah A, Narsimha P (April 2012). "Efficient synthesis of antihistamines clocinizine and chlorcyclizine". Medicinal ... DE 2220242, Kato H, Kurata S, "Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart ... Alkylation with one equivalent of piperazine gives 1-(4-Chlorobenzhydryl) ...
J. Jones, Amino Acid and Peptide Synthesis, 2nd edn., Oxford University Press, 2002 Wuts, P; Green, T (2006); "Greene's ... Ralhan, Krittika; KrishnaKumar, V. Guru; Gupta, Sharad (8 December 2015). "Piperazine and DBU: a safer alternative for rapid ... The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile protecting group used in organic synthesis. Fmoc ... piperazine, 1% DBU and 1% formic acid in DMF. This method avoids the use of strictly controlled piperidine. No side product was ...
Opening of the epoxide with o-anisyl-piperazine [35386-24-4] (4) completes the synthesis of enciprazine (5). Acaprazine ... Narsaiah, A., & Nagaiah, B. (2010). A simple and efficient asymmetric synthesis of anxiolytic drug enciprazine. Synthesis, 2010 ... "New chemical and chemo-enzymatic routes for the synthesis of (RS)- and (S)-enciprazine". Tetrahedron: Asymmetry. 23 (17): 1272- ... piperazines, Pyrogallol ethers, All stub articles, Psychoactive drug stubs). ...
The alkylation of 2-chloropyridine (1) with piperazine gives 1-(pyridin-2-yl)piperazine [67980-77-2] (2). The attachement of ... Soudijn, W.; van Wijngaarden, I. (1968). "A rapid and convenient method for the synthesis of labelled tertiary amines". Journal ... "Improved Method for the Total Synthesis of Azaperone and Investigation of Its Electrochemical Behavior in Aqueous Solution". ... the sidechain by reaction with 4-chloro-4'-fluorobutyrophenone [3874-54-2] (3) completed the synthesis of azaperone (4). ...
Substituted piperazine Sunifiram Power JD, Scott KR, Gardner EA, Curran McAteer BM, O'Brien JE, Brehon M, Talbot B, Kavanagh PV ... January 2014). "The syntheses, characterization and in vitro metabolism of nitracaine, methoxypiperamide and mephtetramine". ... Methoxypiperamide (also known as MeOP and MEXP) is a psychoactive drug of the piperazine class that has been sold online as a ...
"Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic ... It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such as MT-45 and AD-1211, but ... piperazine derivatives and compositions containing the same.", issued 21 March 1978, assigned to Dainippon Pharmaceutical Co ...
"Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic ... It is chemically a 1-substituted-4-prenyl-piperazine derivative, which is structurally unrelated to most other opioid drugs. ... piperazine and its enantiomorph in experimental animals". The Journal of Pharmacy and Pharmacology. 32 (9): 635-42. doi:10.1111 ...
2018). "Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly ... Nozaki M, Niwa M, Imai E, Hori M, Fujimura H (1983). "(1,2-Diphenylethyl) piperazines as potent opiate-like analgesics; the ... Nakamura H, Shimizu M (May 1976). "Comparative study of 1-cyclohexyl-4-(1,2-diphenylethyl)-piperazine and its enantiomorphs on ... Natsuka K, Nakamura H, Nishikawa Y, Negoro T, Uno H, Nishimura H (October 1987). "Synthesis and structure-activity ...
WY-46824, a piperazine-containing derivative, has shown norepinephrine and dopamine reuptake inhibition. Further synthesis and ... December 2006). "Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H- ... April 2008). "Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition". ... improper synthesis?] Most SNRIs function alongside primary metabolites and secondary metabolites in order to inhibit reuptake ...
Piezo1 has been shown to sense RNA in the gut and relay this information through serotonin synthesis to the bone by acting as a ... piperazine (PAPP)". Journal of Agricultural and Food Chemistry. 58 (5): 2624-2629. doi:10.1021/jf902640u. PMID 20000410. ... Cai M, Li Z, Fan F, Huang Q, Shao X, Song G (March 2010). "Design and synthesis of novel insecticides based on the serotonergic ... In plants serotonin synthesis seems to be associated with stress signals. Despite its longstanding prominence in pharmaceutical ...
... synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel ... Kiyoi T, York M, Francis S, Edwards D, Walker G, Houghton AK, Cottney JE, Baker J, Adam JM (August 2010). "Design, synthesis, ... 2010). "Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 ... "Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand ...
... synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel ... derived by cyclisation around the indole or piperazine rings. LBP-1 Org 28611 Adam, J. M.; et al. (2010). "Design, synthesis, ... Kiyoi T, York M, Francis S, Edwards D, Walker G, Houghton AK, Cottney JE, Baker J, Adam JM (August 2010). "Design, synthesis, ...
Suzuki S, Masui Y, Ohnuki M, Miyakoda G, Mori T, Nakajima K, Sato M (Apr 2007). "Induction of metallothionein synthesis by ... "Indanyl piperazines as melatonergic MT2 selective agents". Bioorganic & Medicinal Chemistry Letters. 13 (6): 1199-202. doi: ... "Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ... synthesis, and pharmacological characterization of a new class of melatonin receptor ligands". Journal of Medicinal Chemistry. ...
Multiple syntheses of phantasmidine have been proposed, some of which have been included below. The general mechanism for the ... The final step involves reacting this product with BH3 in THF, then reacting the product with piperazine in MeOH at reflux. 6- ... The syntheses of phantasmidine result in racemic mixtures, making it difficult to synthesize an individual enantiomer of ... "Synthesis of Amphibian Indolizidine Alkaloids and Related Compounds from Enaminone Precursors" (PDF). University of the ...
"An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan piperazine intermediate". Tetrahedron Letters. ... Ma Z, Xiang Z, Luo T, Lu K, Xu Z, Chen J, Yang Z (2006). "Synthesis of functionalized quinolines via Ugi and Pd-catalyzed ... September 2004). "Concise synthesis of isoquinoline via the Ugi and Heck reactions". Organic Letters. 6 (18): 3155-8. doi: ... Short KM, Mjalli AM (1997). "A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams". ...
March 1986). "Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine ... Synthesis and antipsychotic activity of N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cis- ...
Piperazine System. Syntheses, Structures, and Characterization of Zero-Dimensional (C4N2H12)UO2F4·3H2O, One-Dimensional ( ...
... cleanly gives the corresponding chiral piperazines. For example, cyclo(L-Phe-L-Phe) 1 gives the chiral piperazine (2S,5S)- ... In addition to the many methods of peptide synthesis, the Ugi reaction can be applied. Dipeptides with an ester terminus ... doi:10.1016/S0040-4039(01)00232-5. Peng J, Clive DL (December 2008). "Asymmetric Synthesis of the ABC-Ring System of the ... Chaignaud M, Gillaizeau I, Ouhamou N, Coudert G (August 2008). "New highlights in the synthesis and reactivity of 1, 4- ...