Cao PR, Bernhardt R (June 1999). "Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 ... "Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase". J. Clin ... June 2015). "Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency". The Journal of Clinical Endocrinology and Metabolism ... February 2008). "Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli". The ...
Peter M, Dubuis JM, Sippell WG (1999). "Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies". ... beta)". The Journal of Biological Chemistry. 264 (35): 20961-7. doi:10.1016/S0021-9258(19)30030-4. PMID 2592361. Martsev SP, ... Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase ... steroids, and other lipids. Aldosterone synthase is the enzyme that has steroid 18-hydroxylase activity as well as steroid 11 ...
November 1982). "Late-onset steroid 21-hydroxylase deficiency: a variant of classical congenital adrenal hyperplasia". The ... "A case of late-onset congenital adrenal hyperplasia due to partial 3 beta-hydroxysteroid dehydrogenase deficiency". Endocrine ... November 2018). "Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical ... "Determination of functional effects of mutations in the steroid 21-hydroxylase gene (CYP21) using recombinant vaccinia virus". ...
... a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase". Hormone and Metabolic Research. 35 (5): 273 ... is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta ... 8 (11): 841-5. CiteSeerX 10.1.1.326.9619. doi:10.1007/s003359900589. PMID 9337397. S2CID 8557603. Shang J, Li X, Ring HZ, ... 17 (11): 6673-82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431. Tremblay JJ, Drouin J (April 1999). "Egr-1 ...
This particular oxidation/reduction system is involved in the synthesis of steroid hormones in steroidogenic tissues. In ... "Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel ... Martsev SP, Chashchin VL, Akhrem AA [in Belarusian] (1985). "[Reconstruction and study of a multi-enzyme system by 11 beta- ... hydroxylase steroids]". Biokhimiia. 50 (2): 243-57. PMID 3872685. Geren LM, Millett F (1981). "Fluorescence energy transfer ...
Other names in common use include steroid 11beta-hydroxylase, steroid 11beta/18-hydroxylase, and oxygenase, steroid 11beta - ... HAYANO M, DORFMAN RI (1954). "On the mechanism of the C11 beta-hydroxylation of steroids". J. Biol. Chem. 211 (1): 227-35. PMID ... In enzymology, a steroid 11beta-monooxygenase (EC 1.14.15.4) is an enzyme that catalyzes the chemical reaction a steroid + ... GRANT JK, BROWNIE AC (1955). "The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation". Biochim. Biophys. Acta. 18 ...
18-hydroxylase from porcine adrenal". Journal of Steroid Biochemistry. 29 (6): 665-675. doi:10.1016/0022-4731(88)90167-7. PMID ... This enzyme participates in c21-steroid hormone metabolism. "ENZYME - 1.14.15.5 corticosterone 18-monooxygenase". enzyme.expasy ... Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. ... Yanagibashi K, Shackleton CH, Hall PF (June 1988). "Conversion of 11-deoxycorticosterone and corticosterone to aldosterone by ...
November 2018). "Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical ... GeneReviews/NCBI/NIH/UW entry on 21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia OMIM entry on 21-Hydroxylase-Deficient ... the major steroid 21-hydroxylase related to congenital adrenal hyperplasia". Journal of Biomolecular Structure & Dynamics. 38 ( ... Steroids. 77 (4): 342-6. doi:10.1016/j.steroids.2011.12.009. PMC 3638754. PMID 22186144. Feingold, K. R.; et al. (2000). ...
... steroid 21-hydroxylase MeSH D08.811.682.690.708.292 - dopamine beta-hydroxylase MeSH D08.811.682.690.708.392 - fatty acid ... steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 - steroid 16-alpha-hydroxylase MeSH D08.244.453.915.748 - steroid 17- ... steroid 12-alpha-hydroxylase MeSH D08.811.682.690.708.170.915.737 - steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.170. ... steroid 12-alpha-hydroxylase MeSH D08.811.682.690.708.783.737 - steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.783.745 ...
... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ... beta-crystallin a chain MeSH D12.776.306.366.300.200 - beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate ... Type XI collagen MeSH D12.776.860.300.250.400 - non-fibrillar collagens MeSH D12.776.860.300.250.400.100 - Type IV collagen ... steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 - steroid 21-hydroxylase MeSH D12.776.422.512.380.440 - ...
All of the forms of CAH involve excessive or defective production of sex steroids and can prevent or impair development of ... When it occurs it resembles the salt-wasting of severe 21-hydroxylase deficient CAH: poor weight gain and vomiting in the first ... Because the enzyme defect does not affect sex steroid synthesis, gonadal function at puberty and long-term fertility should be ... These androgens produce effects that are similar to those of 21-hydroxylase deficient CAH. In the severe forms, XX (genetically ...
Radiotherapy and chemotherapy reduced tumor and beta-hCG levels normalized. In a study using neonatal melatonin on rats, ... Central precocious puberty can be treated by suppressing the pituitary hormones that induce sex steroid production. The ... Symptoms are usually as a sequelae from adrenal hyperplasia (because of 21-hydroxylase deficiency or 11-beta hydroxylase ... Secondary sexual development induced by sex steroids from other abnormal sources is referred to as peripheral precocious ...
25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans ... possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes". J. Steroid Biochem. Mol. Biol. 104 ( ... "CYP7B generates a selective estrogen receptor beta agonist in human prostate". J. Clin. Endocrinol. Metab. 89 (6): 2928-35. doi ... Tang W, Norlin M (2006). "Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells". ...
In 21-hydroxylase deficiency, progesterone and 17α-hydroxyprogesterone accumulate and are the substrates of steroid 11β- ... In normal conditions, 21-hydroxylase has higher activity on progesterone than steroid 11β-hydroxylase (CYP11B1) and aldosterone ... can be used as marker for adrenal 21-hydroxylase deficiency, another 21-carbon steroid - 21-deoxycortisol (produced from 17α- ... Journal of Steroid Biochemistry. 26 (1): 145-50. doi:10.1016/0022-4731(87)90043-4. PMID 3546944. Fiet J, Gueux B, Raux-DeMay MC ...
It may be increased in 17α-hydroxylase (CYP17A1) deficiency, in aldosterone synthase (CYP11B2) deficiency, in primary ... is an endogenous steroid and a mineralocorticoid. It is a hydroxylated metabolite of 11-deoxycorticosterone. In rats, ... beta. Chemical synthesis and structural analysis by 1H NMR". Biochemistry. 23 (12): 2558-64. doi:10.1021/bi00307a004. PMID ... Steroid hormones, All stub articles, Steroid stubs). ... 18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18, ...
3 beta-HSD), 17 alpha-hydroxylase and 17,20 lyase by progestins and danazol". Endocrinologia Japonica. 36 (3): 387-394. doi: ... "Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data". J. Steroid Biochem. Mol. ... Arakawa S, Mitsuma M, Iyo M, Ohkawa R, Kambegawa A, Okinaga S, Arai K (June 1989). "Inhibition of rat ovarian 3 beta- ... Tamaya T, Fujimoto J, Watanabe Y, Arahori K, Okada H (1986). "Gestrinone (R2323) binding to steroid receptors in human uterine ...
The deficiency of the 21-hydroxylase enzyme leads to excess of 17α-hydroxyprogesterone, a 21-carbon (C21) steroid. This excess ... November 2018). "Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical ... "Steroid biomarkers for identifying non-classic adrenal hyperplasia due to 21-hydroxylase deficiency in a population of PCOS ... "Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency". The Journal of Clinical Endocrinology and Metabolism. 100 (6): ...
This type can be treated with steroid medications called glucocorticoids, so it is also known as glucocorticoid remediable ... The CYP11B1 gene provides instructions for making an enzyme called 11-beta-hydroxylase. This enzyme helps produce hormones ...
The precursor of steroids synthesized in the adrenal cortex is cholesterol that is stored in vesicles. Cholesterol can be ... The zona reticularis has more of the cofactors required for the 17,20-lyase activity of 17α-hydroxylase than zona fasciculata. ... The steps up to this point occur in many steroid-producing tissues. Subsequent steps to generate aldosterone and cortisol, ... Rainey WE, Nakamura Y (February 2008). "Regulation of the adrenal androgen biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3 ...
Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations". J. Biol. Chem. 247 (6): 1727-34. PMID ... Mitoma C, Udenfriend S (1962). "Aryl-4-hydroxylase". Methods Enzymol. 5: 816-819. doi:10.1016/s0076-6879(62)05318-5. Napoli JL ... Haugen DA, Coon MJ (1976). "Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone- ... Nebert DW, Gelboin HV (1968). "Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and ...
Joh, T. H.; Hwang, O. (1987). "Dopamine Beta-Hydroxylase: Biochemistry and Molecular Biology". Annals of the New York Academy ... ventricular tachycardia History of catecholamine research Hormone Julius Axelrod Peptide hormone Phenethylamines Steroid ... The enzyme dopamine hydroxylase requires copper as a cofactor (not shown in the diagram) and DOPA decarboxylase requires PLP ( ... The enzyme tyrosine hydroxylase (TH) converts the amino acid L-tyrosine into 3,4-dihydroxyphenylalanine (L-DOPA). The ...
Wolkowitz OM, Lupien SJ, Bigler ED (June 2007). "The "steroid dementia syndrome": a possible model of human glucocorticoid ... Regardless of the adenoma's location, most patients require steroid replacement postoperatively at least in the interim, as ... "Iatrogenic Cushing's syndrome with inhaled steroid plus antidepressant drugs". Multidisciplinary Respiratory Medicine. 7 (1): ... "How many people are affected by or at risk for Cushing's syndrome?". 2012-11-30. Archived from the original on 2 April 2015. ...
Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer. Adv. Pharmacol. 74:223-62, 2015. GRCh38: Ensembl release 89: ... steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this ... omega-hydroxylates Vitamin Ks including menaquinone in a metabolic step which is essential for their further metabolism by beta ... Johnson AL, Edson KZ, Totah RA, Rettie AE (2015). "Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer". Cytochrome P450 ...
... which is the rate-limiting step in the production of steroid hormones. It is primarily present in steroid-producing cells, ... Recent findings suggest that StAR may also traffic cholesterol to a second mitochondrial enzyme, sterol 27-hydroxylase. This ... and 3 beta hydroxysteroid dehydrogenase (3βHSD). StAR was found to have an anti-apoptotic effect on the fibroblasts, which may ... StAR has thus far been found in all tissues that can produce steroids, including the adrenal cortex, the gonads, the brain and ...
21-hydroxylase, 17α-hydroxylase, 11β-hydroxylase and 3β-hydroxysteroid dehydrogenase), lipoid CAH due to deficiency of StAR and ... Lifelong, continuous steroid replacement therapy is required, with regular follow-up treatment and monitoring for other health ... and beta-lipotropin. The subunit ACTH undergoes further cleavage to produce alpha-MSH, the most important MSH for skin ... Addison's disease arises from problems with the adrenal gland such that not enough of the steroid hormone cortisol and possibly ...
attributed the urinary metabolites to the androgen backdoor pathway from 17-OHP to DHT in patients with steroid 21-hydroxylase ... 17 beta-diol". Proceedings of the National Academy of Sciences of the United States of America. 97 (22): 12256-12259. Bibcode: ... from the steroid nucleus, converting a C21 steroid (a pregnane) to C19 steroid (an androstane or androgen). AST is 17β-reduced ... pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis". The Journal of Clinical ...
Its binding site is located in the transmembrane section of this receptor between the beta and alpha subunits (β+α−). β3- ... Other authors advise giving a prophylactic dose of steroids (e.g. hydrocortisone) if etomidate is used, but only one small ... etomidate has also been found to directly inhibit the enzymatic biosynthesis of steroid hormones, including corticosteroids in ... an enzyme important in adrenal steroid production; it leads to primary adrenal suppression. Using a continuous etomidate ...
The steroid is known to compete with catecholamines for binding to catechol O-methyltransferase and tyrosine hydroxylase and to ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ... The steroid is only very weakly estrogenic, and is able to antagonize the estrogenic effects of estradiol, indicating that its ... 2-Hydroxyestradiol (2-OHE2), also known as estra-1,3,5(10)-triene-2,3,17β-triol, is an endogenous steroid, catechol estrogen, ...
A critical role for nuclear liver X receptors alpha and beta". The Journal of Biological Chemistry. 277 (35): 31900-8. doi: ... Steroids. 68 (7-8): 685-91. doi:10.1016/S0039-128X(03)00100-4. PMID 12957674. S2CID 6023862. NR1H3 human gene location in the ... X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase ... 11 (1): 37-44. doi:10.1038/gene.2009.63. PMID 19798078. Brendel C, Gelman L, Auwerx J (Jun 2002). "Multiprotein bridging factor ...
4-Hydroxyamphetamine has been shown to be metabolized into 4-hydroxynorephedrine by dopamine beta-hydroxylase (DBH) in vitro ... The Journal of Steroid Biochemistry and Molecular Biology. 186: 212-225. doi:10.1016/j.jsbmb.2018.10.016. PMID 30381248. S2CID ... Taylor KB (January 1974). "Dopamine-beta-hydroxylase. Stereochemical course of the reaction" (PDF). Journal of Biological ... Dopamine-β-hydroxylase catalyzed the removal of the pro-R hydrogen atom and the production of 1-norephedrine, (2S,1R)-2-amino-1 ...