Low-dose spironolactone is generally very well tolerated. Even higher doses of spironolactone, such as 100 mg/day, are well ... Spironolactone may be more effective than birth control pills in the treatment of acne, and the combination of spironolactone ... Spironolactone is also used to treat Bartter's syndrome due to its ability to raise potassium levels. Spironolactone has ... Also, spironolactone is immunosuppressive in the treatment of sarcoidosis. Most of the side effects of spironolactone are dose- ...

Spironolactone does not inhibit 5α-reductase. [...] The progestational activity of spironolactone is variable. The drug ... In accordance, replacement of spironolactone with canrenone in male patients has been found to reverse spironolactone-induced ... Keleştimur F, Everest H, Unlühizarci K, Bayram F, Sahin Y (March 2004). "A comparison between spironolactone and spironolactone ... Another study that directly compared the affinities of spironolactone and canrenone reported that spironolactone had 5-fold ...

"Spironolactone". Archived from the original on 2016-06-30. Retrieved 2017-07-04. "Spironolactone , C24H32O4S , ChemSpider". v t ... Spironolactone is the derivative of this compound in which the acetyl group at the C17β position has been cyclized with the C17 ... which is similar to that of spironolactone and its active metabolite 7α-thiomethylspironolactone. The drug has also been ...

Overdiek HW, Merkus FW (1987). "The metabolism and biopharmaceutics of spironolactone in man". Rev Drug Metab Drug Interact. 5 ... Cashman JR, Peña S (1989). "Canrenone formation via general-base-catalyzed elimination of 7 alpha-(methylthio)spironolactone S- ... Abshagen, U.; Rennekamp, H.; Luszpinski, G. (1976). "Pharmacokinetics of spironolactone in man". Naunyn-Schmiedeberg's Archives ... Spironolactone. Analytical Profiles of Drug Substances and Excipients. Vol. 29. pp. 261-320. doi:10.1016/S1075-6280(02)29009-6 ...

Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of spironolactone have ... relative to that of spironolactone. The affinity of 7α-TS, 7α-TMS, and spironolactone for the rat prostate AR is about 3.0 to ... Doggrell SA, Brown L (2001). "The spironolactone renaissance". Expert Opin Investig Drugs. 10 (5): 943-54. doi:10.1517/ ... Other important metabolites of spironolactone include 7α-thiospironolactone (7α-TS; SC-24813), 6β-hydroxy-7α- ...

Analgesic doses of aspirin decrease sodium loss induced by spironolactone in the urine, however this does not reduce the ... Furthermore, antiplatelet doses of aspirin are deemed too small to produce an interaction with spironolactone. Aspirin is known ... Hollifield JW (August 1976). "Failure of aspirin to antagonize the antihypertensive effect of spironolactone in low-renin ... Baxter K, Preston CL (eds.). "Aspirin and Spironolactone". MedicinesComplete: Stockley's Drug Interactions. Royal ...

Spironolactone (SC-9420; Aldactone), another spirolactone, followed and had both good oral bioavailability and potency, and was ...

... and spironolactone (Aldactone). Pravastatin is cleared by the kidneys, giving it a distinct advantage over other statins when a ...

Spironolactone is described as a relatively weak antiandrogen. It is widely used in the treatment of acne, excessive hair ... Spironolactone is an antiandrogen as a secondary and originally unintended action. It works as an antiandrogen mainly by acting ... Spironolactone has been found to decrease the bioavailability of high doses of oral estradiol. Although widely employed, the ... Spironolactone, another antiandrogen, was first used in transgender women by 1986. These agents were described as allowing the ...

Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of spironolactone have ... relative to that of spironolactone. The affinity of 7α-TS, 7α-TMS, and spironolactone for the rat prostate AR is about 3.0 to ... A study assessed the interaction of spironolactone and 7α-TS with sex hormone-binding globulin and found that they had very low ... Gardiner P, Schrode K, Quinlan D, Martin BK, Boreham DR, Rogers MS, Stubbs K, Smith M, Karim A (1989). "Spironolactone ...

Spironolactone (SC-9420; Aldactone) followed and had both good oral bioavailability and potency, and was the first synthetic ... Similarly to other spirolactones like canrenone and spironolactone, SC-5233 has some antiandrogenic activity and antagonizes ...

Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of spironolactone have ... Gardiner P, Schrode K, Quinlan D, Martin BK, Boreham DR, Rogers MS, Stubbs K, Smith M, Karim A (1989). "Spironolactone ... Doggrell SA, Brown L (2001). "The spironolactone renaissance". Expert Opin Investig Drugs. 10 (5): 943-54. doi:10.1517/ ... Other important metabolites of spironolactone include 7α-thiospironolactone (7α-TS; SC-24813), 7α-thiomethylspironolactone (7α- ...

The steroidal antiandrogen spironolactone is first synthesized 1960: Spironolactone is first introduced for medical use, as an ... spironolactone, bicalutamide, and ketoconazole. Spironolactone and bicalutamide require combination with an aromatase inhibitor ... Spironolactone has been marketed in Italy in the form of a topical cream under the brand name Spiroderm for the treatment of ... However, spironolactone was introduced in 1959, although its antiandrogen effects were not recognized or taken advantage of ...

Spironolactone, an aldosterone antagonist. This has two actions, firstly, as a potassium-sparing diuretic, although its ...

SC-9420 for spironolactone). The spirolactones include the marketed drugs spironolactone (SC-9420; Aldactone), canrenone (SC- ... Spironolactone is a derivative of SC-5233 with a 7α-acetylthio group (that is, SC-5233 is 7α-desthioacetylspironolactone). 7α- ... spironolactone as an antiandrogen, and drospirenone as a progestin). The spirolactones were developed by G. D. Searle & Company ...

... or decreased renal function that may occur with spironolactone treatment. In women, unlike CPA and spironolactone, bicalutamide ... Unlike spironolactone, bicalutamide has no antimineralocorticoid activity, and for this reason, has no risk of hyperkalemia ( ... As such, although bicalutamide has not been compared head-to-head to CPA or spironolactone in the treatment of androgen- ... However, some of them, namely CPA and spironolactone, are still commonly used in the management of certain androgen-dependent ...

Diuretics: hydrochlorothiazide, spironolactone, chlortalidone. ACE inhibitors: captopril, enalapril. Other drugs: digoxin, ...

Greenblatt DJ, Koch-Weser J (July 1973). "Adverse reactions to spironolactone. A report from the Boston Collaborative Drug ... In contrast to the SAA spironolactone, bicalutamide does not have antimineralocorticoid effects, and hence is not associated ... In women, unlike CPA and spironolactone, bicalutamide does not produce menstrual irregularity or amenorrhea and does not ...

In addition, spironolactone, a steroidal antimineralocorticoid that was introduced for medical use in 1959, was discovered to ... Ober KP, Hennessy JF (November 1978). "Spironolactone therapy for hirsutism in a hyperandrogenic woman". Annals of Internal ... "Anti-androgenic activity of spironolactone". Steroids. 14 (4): 449-450. doi:10.1016/S0039-128X(69)80007-3. PMID 5344274. ...

Tremblay RR (May 1986). "Treatment of hirsutism with spironolactone". Clinics in Endocrinology and Metabolism. 15 (2): 363-371 ...

Thus, spironolactone is currently used. [...] In our opinion, [spironolactone] has a weak antiandrogenic activity. Tommaso ... Spironolactone (up to 100 mg twice daily), a diuretic with antiandrogenic properties, has similar effects and is widely ... In one study, it decreased acne scores by 80% within 3 months, whereas the SAA spironolactone decreased symptoms by only 40% in ... Bicalutamide with anastrozole is considered to be superior to the combination of spironolactone and testolactone in peripheral ...

Like spironolactone, flutamide is typically only used by women. Bicalutamide is another option for the treatment of female ... There is tentative support for spironolactone in women. Due to its feminising side effects and risk of infertility it is not ... Other options include topical or systemic spironolactone or flutamide, although they have a high incidence of feminising side ... Other medications include ketoconazole, and in female androgenic alopecia spironolactone and flutamide. In June 2022, the FDA ...

Important antimineralocorticoids are spironolactone and eplerenone. List of corticosteroids Baker ME, Katsu Y (July 2020). " ...

Spironolactone is an effective treatment for acne in adult women. Unlike combined birth control pills, it is not approved by ... Spironolactone is an aldosterone antagonist and is a useful acne treatment due to its ability to additionally block the ... The effectiveness of spironolactone for acne appears to be dose-dependent. High-dose cyproterone acetate alone reportedly ... Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. ...

... spironolactone, protected them from aldosterone-induced cardiac necrosis. The same year, 1959, spironolactone was launched as a ... Spironolactone has shorter half-life (t1/2 = 1.3-1.4 hours) than eplerenone (t1/2 = 4-6 hours). Eplerenone goes through rapid ... 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease ... Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism (including Conn's syndrome ...

... differs structurally from spironolactone only in that the C7α acetyl thio substitution of spironolactone has been ... Spironolactone] was synthesized after the demonstration of the natriuretic effect of progesterone (Landau et al., 1955). ... ISBN 978-0-12-817783-9. In addition to spironolactone, which is a derivative of progesterone [...] Hu X, Li S, McMahon EG, Lala ... The medication is an analog of the drug spironolactone. Drospirenone is taken by mouth. Common side effects include acne, ...

After the fight Alves tested positive for spironolactone. He was fined $5,500 by the NSAC and suspended for eight months. Alves ...

Canrenone Drospirenone Spironolactone J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, ... Animal research found that it was 3.3-fold more potent as an antimineralocorticoid relative to spironolactone. In addition to ... It is 2- to 3-fold as potent as spironolactone as a progestogen and antigonadotropin but its antiandrogenic activity is ... is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed. ...

Some birth control pills and spironolactone reduce androgen levels. The primary characteristic of all forms of hypertrichosis ...

Spironolactone acts by competitively inhibiting the action of aldosterone. NSAIDs such as ibuprofen, naproxen, or celecoxib ... A number of medications can also cause high blood potassium including spironolactone, NSAIDs, and angiotensin converting enzyme ...