The sarcolemma (sarco (from sarx) from Greek; flesh, and lemma from Greek; sheath) also called the myolemma, is the cell ... The sarcolemma generally maintains the same function in muscle cells as the plasma membrane does in other eukaryote cells. It ... At each end of the muscle fiber, the surface layer of the sarcolemma fuses with a tendon fiber, and the tendon fibers, in turn ... Biology portal Sarcolemma at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Ripa, Rashelle; George, Tom ...
The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural ... "Glycoprotein complex anchoring dystrophin to sarcolemma". J. Biochem. 108 (5): 748-52. doi:10.1093/oxfordjournals.jbchem. ...
"Entrez Gene: SLMAP sarcolemma associated protein". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, ...
... and the cell membrane in a muscle cell is termed the sarcolemma. The sarcolemma receives and conducts stimuli. Skeletal muscle ... In skeletal muscle, at the end of each muscle fiber, the outer layer of the sarcolemma combines with tendon fibers at the ... When the acetylcholine is released it diffuses across the synapse and binds to a receptor on the sarcolemma, a term unique to ... Actin filaments are anchored by dense bodies (similar to the Z discs in sarcomeres) to the sarcolemma. A myoblast is an ...
DHPRs are located on the sarcolemma (which includes the surface sarcolemma and the transverse tubules), while the RyRs reside ... The cell membrane is called the sarcolemma with the cytoplasm known as the sarcoplasm. In the sarcoplasm are the myofibrils. ... The costamere attaches the sarcomere to the sarcolemma. Every single organelle and macromolecule of a muscle fiber is arranged ... Pressed against the inside of the sarcolemma are the unusual flattened myonuclei. Between the myofibrils are the mitochondria. ...
Many nuclei are present in each muscle cell placed at regular intervals beneath the sarcolemma. Based on their contractile and ... Each muscle fiber contains sarcolemma, sarcoplasm, and sarcoplasmic reticulum. The functional unit of a muscle fiber is called ...
Roostalu U, Strähle U (2012). "In vivo imaging of molecular interactions at damaged sarcolemma". Dev. Cell. 22 (3): 515-29. doi ... or sarcolemma, as efficiently as healthy muscle can, and that most of the dysferlin in healthy muscle is concentrated in the ... consistent with a role for dysferlin in regulating fusion of repair vesicles with the sarcolemma during membrane repair. ...
It overlies the muscle fiber's cell membrane: the sarcolemma. Endomysium is the deepest and smallest component of muscle ...
The DGC consists of peripheral and integral proteins that physically traverse the sarcolemma and connect the ECM to the F-actin ... They physically couple force-generating sarcomeres with the sarcolemma in striated muscle cells and are thus considered one of ... They are also responsible for the lateral transmission of the sarcomere-generated contractile force to the sarcolemma and the ... These proteins are thought to play an important role in maintaining the structural integrity of sarcolemma during contraction ...
This potential travels along the surface of the sarcolemma. The sarcolemma is an excitable membrane that surrounds the ... Depolarizing blocking agents: These agents act by depolarizing the sarcolemma of the skeletal muscle fiber. This persistent ... that connects the sarcolemma and center of the fibre. Later, action potential reaches the sarcoplasmic reticulum which stores ...
Sarcolemma in muscle cells: Sarcolemma is the name given to the cell membrane of muscle cells. Although the sarcolemma is ... It has also been found that the average sarcolemma is 10 nm thick as opposed to the 4 nm thickness of a general cell membrane. ... For instance, the sarcolemma transmits synaptic signals, helps generate action potentials, and is very involved in muscle ... Unlike other cell membranes, the sarcolemma makes up small channels called T-tubules that pass through the entirety of muscle ...
2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma". J. Neuropathol. Exp. Neurol. 64 (4): 334-40. doi: ...
have shown that TMEM43 is mainly localized at the sarcolemma. Mutations in TMEM43 are associated with ARVD and EDMD7. GRCh38: ...
The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. This protein may ... "Dystrobrevin deficiency at the sarcolemma of patients with muscular dystrophy". Hum. Mol. Genet. 6 (7): 1185-91. doi:10.1093/ ...
PKG also activates the sarcolemma calcium pump to remove activating calcium. PKG acts on K+ channels to promote K+ efflux and ...
Satellite cells are described as quiescent myoblasts and neighbor muscle fiber sarcolemma. They are crucial for the repair of ...
Bu G, Adams H, Berbari EJ, Rubart M (March 2009). "Uniform action potential repolarization within the sarcolemma of in situ ... Action potentials result from the depolarization of the cell membrane (the sarcolemma), which opens voltage-sensitive sodium ... the sarcolemma) of the muscle fiber. However, the acetylcholine does not remain bound; rather, it dissociates and is hydrolyzed ...
These action potentials travel along the cell membrane (sarcolemma), as impulses, passing from one cell to the next through ... located in the sarcolemma and the t-tubule membrane of cardiac cells. This activates a protein, called a G-protein and results ... on the sarcolemma of both SAN cells and ventricular cells. This again activates a G-protein. However this G-protein works by ... Certain regions of the sarcolemma penetrate deep into the cell. These are known as transverse-tubules (t-tubules); which are ...
The sarcolemma (membrane) from adjacent cells bind together at the intercalated discs. They consist of desmosomes, specialized ... T (transverse) tubules are deep invaginations from the sarcolemma (cell membrane) that penetrate the cell, allowing the ...
Damage to the sarcolemma and sarcoplasmic reticulum from direct trauma or high force production causes a high influx of calcium ... Exertional rhabdomyolysis results from damage to the intercellular proteins inside the sarcolemma. Myosin and actin break down ...
Bu G, Adams H, Berbari EJ, Rubart M (March 2009). "Uniform action potential repolarization within the sarcolemma of in situ ...
... with alpha1-syntrophin at the sarcolemma". Microsc. Res. Tech. 55 (3): 164-70. doi:10.1002/jemt.1167. PMID 11747091. S2CID ...
... with alpha1-syntrophin at the sarcolemma". Microsc. Res. Tech. 55 (3): 164-70. doi:10.1002/jemt.1167. PMID 11747091. S2CID ...
The costamere is a different component that connects the sarcomere to the sarcolemma. Two of the important proteins are myosin ...
Also, the breakdown of the sarcolemma causes additional calcium to enter the cytosol. The calcium activates the formation of ...
2009). "Uniform action potential repolarization within the sarcolemma of in situ ventricular cardiomyocytes". Biophysical ...
In the human fetus during muscle differentiation, utrophin is found at the sarcolemma. It disappears when the fetus begins to ...
Buchthal, F.; Weis-Fogh, T. (1956). "Contribution of the Sarcolemma to the Force Exerted by Resting Muscle of insects". Acta ...
Located in the sarcolemma of smooth muscle cells are receptors, called dihydropyridine receptors (DHPR). In skeletal and ... Electrical impulses, known as action potentials, travel along the cell membrane (sarcolemma) of muscle cells. ...
In myocytes, sarcomeres adhere to the sarcolemma via costameres, which align at Z-discs and M-lines. The two primary ... Rybakova IN, Patel JR, Ervasti JM (Sep 2000). "The dystrophin complex forms a mechanically strong link between the sarcolemma ... myofibril-to-sarcolemma attachment sites". Cell Motility. 3 (5-6): 449-62. doi:10.1002/cm.970030513. PMID 6420066. Pardo JV, ... mark sites of attachment between myofibrils and sarcolemma". Proceedings of the National Academy of Sciences of the United ...