The stronger a protein's interaction with DNA, the higher the salt concentration needed to elute that protein. Planar ... ISBN 978-0-632-02017-1. Bourgeois S, Pfahl M (1976). "Repressors". In Anfinsen CB, Edsall JT, Richards FM (eds.). Advances in ... It is often used in biochemistry in the purification of proteins bound to tags. These fusion proteins are labeled with ... Fast protein liquid chromatography (FPLC), is a form of liquid chromatography that is often used to analyze or purify mixtures ...

The lacI gene codes for a protein called "the repressor" or "the lac repressor", which functions to repressor of the lac operon ... The lacI gene synthesizes LacI repressor protein. The LacI repressor protein represses lacZYA by binding to the operator ... An example of a repressor protein is the methionine repressor MetJ. MetJ interacts with DNA bases via a ribbon-helix-helix (RHH ... A repressor that binds with a co-repressor is termed an aporepressor or inactive repressor. One type of aporepressor is the trp ...

... the Cro repressor family is a family of repressor proteins in bacteriophage lambda that includes the Cro repressor. ... The crystal structure of the lambda Cro repressor reveals a HTH DNA-binding protein with an alpha/beta fold that differs from ... Ohlendorf DH, Tronrud DE, Matthews BW (July 1998). "Refined structure of Cro repressor protein from bacteriophage lambda ... Together the Cro and cI repressors form a helix-turn-helix (HTH) superfamily. The lambda Cro repressor binds to DNA as a highly ...

Fe(II)-regulated proteins contain an SH3-like domain as a C-terminal extension, which is absent in Mn(II)-regulated mntR. Metal ... In molecular biology, the iron dependent repressors are a family of bacterial and archaeal transcriptional repressors. At their ... Several proteins are known to contain a dtxR-type HTH domain. These include: Corynebacterium diphtheriae dtxR, a diphtheria ... The dtxR protein regulates the expression of diphtheria toxin in response to environmental iron concentrations. Furthermore, ...

The lac repressor (LacI) is a DNA-binding protein that inhibits the expression of genes coding for proteins involved in the ... More information on the lac repressor molecule Archived 2010-05-28 at the Wayback Machine on protein database Lac Repressor in ... The lac repressor was first isolated by Walter Gilbert and Benno Müller-Hill in 1966. They showed that in vitro the protein ... This bound repressor can reduce transcription of the Lac proteins by occluding the RNA polymerase binding site or by prompting ...

"The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members ... Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. The Jun dimerization protein is a ... Other proteins such as interferon regulatory factor-2-binding protein-1 (IRF2BP1). CCAAT/enhancer-binding protein gamma (C/EBPγ ... "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Molecular and Cellular Biology. ...

... the other human protein that is a member of that family is Nuclear receptor co-repressor 2. Nuclear receptor co-repressor 1 has ... The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1 ... is a protein that in humans is encoded by the NCOR1 gene. NCOR1 is a transcriptional coregulatory protein which contains ... "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Hum. Mol. ...

Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". ... KCNIP2, a protein that in humans is encoded by the KCNIP2 gene. KCNIP3, more commonly known as Calsenilin, a protein that in ... KCNIP4, a protein that in humans is encoded by the KCNIP4 gene. Burgoyne RD (2007). "Neuronal calcium sensor proteins: ... Kv channel interacting proteins are members of a family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, ...

The Krüppel protein is a transcription factor, and has been shown to act as a repressor. It functions in collaboration with ... Licht JD, Grossel MJ, Figge J, Hansen UM (July 1990). "Drosophila Krüppel protein is a transcriptional repressor". Nature. 346 ... December 1986). "A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel ... Knirps acts as a repressor to inhibit expression. This results in Krüppel being expressed in a stripe in the center of the ...

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor- ... the other human protein that is a member of that family is Nuclear receptor co-repressor 1. SMRT was initially cloned and ... "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". The EMBO Journal. 19 (16): 4342-50 ... Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). "SKIP, a CBF1-associated protein, ...

This protein is also part of a co-repressor complex which is an important component of transcriptional silencing. This gene is ... CREB-binding protein, also known as CREBBP or CBP, is a protein that is encoded by the CREBBP gene in humans. The CREB protein ... Proteins RbAp48 is a key player in the assembly of nucleosomes. RbAp48 protein is a subunit of the chromatin-assembly factor-1 ... RbAp48 protein is also found in numerous other protein complexes for regulation of chromatin structure. Studies show that ...

The Bicoid protein is a morphogen as well. The Nanos protein is a translational repressor protein. Bicoid has a DNA-binding ... Nanos protein forms a gradient at the posterior end. The Bicoid protein blocks translation of caudal mRNA so Caudal protein is ... and Caudal proteins is in the transcriptional regulation of other zygotically expressed proteins. Many of these are the protein ... Nanos protein, in complex with Pumilio protein, binds to the hunchback mRNA and blocks its translation in the posterior end of ...

This second pathway is regulated by repressor protein DesT. DesT is also a repressor of fabAB expression for anaerobic ... Two DesR-P proteins will dimerize and bind to the DNA promoters of the des gene and recruit RNA polymerase to begin ... It acts as an activator of fabA and fabB transcription and as a repressor for the β-oxidation regulon. In contrast, FabR acts ... Another pathway uses two proteins, DesC and DesB, together to act as a Δ9-desaturase, which inserts a double bond into a ...

Then there's the repressor protein that turns genes off. The inducer can remove this repressor, turning genes back on. The ... Lastly, the regulatory gene is the gene for the repressor protein. An example of inducible enzyme is COX-2 which is synthesized ... operator is a section of DNA where the repressor binds to shut off certain genes; the promoter is the section of DNA where the ...

Saier MH, Ramseier TM (June 1996). "The catabolite repressor/activator (Cra) protein of enteric bacteria". Journal of ... Gupta V, Bamezai RN (November 2010). "Human pyruvate kinase M2: a multifunctional protein". Protein Science. 19 (11): 2031-44. ... Heterogenous ribonucleotide proteins (hnRNPs) can act on the PKM gene to regulate expression of M1 and M2 isoforms. PKM1 and ... Allosteric regulation is the binding of an effector to a site on the protein other than the active site, causing a ...

Capicua transcriptional repressor is a protein that in humans is encoded by the CIC gene. Capicua functions as a ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... DUX4 - chimeric CIC-DUX4 proteins are found in tumors. FOXO4 - chimeric CIC-FOXO4 proteins are found in tumors. NUTM1 - ... chimeric CIC-NUTM1 proteins are found in tumors. LEUTX - chimeric CIC-LEUTX proteins are found in tumors. GRCh38: Ensembl ...

1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605-10. Bibcode:1999PNAS ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have ... 2003). "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1". Mol. Biol. Cell. 14 (1 ...

The NHL repeat has also been used to design a family of fully symmetrical 6-blade beta-propeller proteins called "Pizza". These ... Edwards TA, Wilkinson BD, Wharton RP, Aggarwal AK (October 2003). "Model of the brain tumor-Pumilio translation repressor ... The NHL repeats are also found in serine/threonine protein kinase (STPK) in diverse range of pathogenic bacteria. These STPK ... The arthropod 'Brain Tumor' protein (Brat; Q8MQJ9) is one such growth regulator that contains a 6-bladed NHL-repeat beta- ...

The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Two ... Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene. The protein encoded by this gene is a ... Halford S, Mattei MG, Daw S, Scambler PJ (Jul 1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273-81. doi: ...

... regulator genes often code for repressor proteins. Repressor proteins bind to operators or promoters, preventing RNA polymerase ... a gene which binds repressor proteins thus inhibiting the translation of RNA to protein via RNA polymerase). In prokaryotes, ... Inducers cause repressor proteins to change shape or otherwise become unable to bind DNA, allowing RNA polymerase to continue ... An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operator ( ...

This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the ... Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene. The protein encoded by this gene is ... It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the ... Cdx protein family DNA-binding protein Inhibitor of DNA-binding protein Mapper(2) Nuclear receptor, a class of ligand activated ... Pairs of transcription factors and other proteins can play antagonistic roles (activator versus repressor) in the regulation of ... Chadwick LH, Wade PA (April 2007). "MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?". ...

This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ... AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to ... Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene. AP-2 beta is a ...

KaiC belongs to a larger family of proteins; it performs autophosphorylation and acts as its own transcriptional repressor. It ... The cyanobacterial clock proteins comprise three proteins: KaiA, KaiB and KaiC. The kaiABC complex may act as a promoter- ... The KaiA protein from Anabaena sp. (strain PCC 7120) lacks the N-terminal CheY-like domain. KaiB adopts an alpha-beta meander ... In both systems the circadian period is dependent on the interactions between proteins within the cell, and when the genes for ...

This protein is likely a transcriptional repressor from the E-box binding factors family TR4/TR2 - These proteins are part of a ... The proteins encoded by the TMPIT proteins are predicted to be transmembrane proteins. However, there is lack of literature to ... It encodes a protein from a family of bacterial proteins with no known function. FHAD1 contains the forkhead-associated domain ... Forkhead-associated domain containing protein 1 (FHAD1) is a protein encoded by the FHAD1 gene. As the name suggests, it has a ...

"Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735-8. doi:10.1038/nature01550 ... Zinc finger protein 516 is a protein that in humans is encoded by the ZNF516 gene. Zinc-finger proteins bind nucleic acids and ... This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in ... "Entrez Gene: Zinc finger protein 516". Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil ...

These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and ... Protein SSX1 is a protein that in humans is encoded by the SSX1 gene. The product of this gene belongs to the family of highly ... "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM ... 1995). "Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human ...

These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and ... Protein SSX5 is a protein that in humans is encoded by the SSX5 gene. The product of this gene belongs to the family of highly ... "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear ... protein, SSX2IP". Genes, Chromosomes & Cancer. 34 (3): 285-98. doi:10.1002/gcc.10073. PMID 12007189. S2CID 11734893. Güre AO, ...

These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and ... Protein SSX4 is a protein that in humans is encoded by the SSX4 gene. The product of this gene belongs to the family of highly ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... 2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel ...

These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and ... SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene. This gene belongs to the family of ... highly homologous synovial sarcoma X (SSX) breakpoint proteins. ...