Anaplastic large cell lymphoma may show RS-like cells as well. They are named after Dorothy Reed Mendenhall and Carl Sternberg ... Reed-Sternberg cells (also known as lacunar histiocytes for certain types) are distinctive, giant cells found with light ... Seen against a sea of B cells, they give the tissue a moth-eaten appearance. Reed-Sternberg cells are large (30-50 microns) and ... Despite having the genetic signature of a B cell, the Reed-Sternberg cells of classical Hodgkin lymphoma fail to express most B ...

Idiopathic giant cell myocarditis Large cell Reed-Sternberg cell Subependymal giant cell astrocytoma Syncitium Giant+Cells at ... Types include foreign-body giant cells, Langhans giant cells, Touton giant cells, Giant-cell arteritis, and Reed-Sternberg ... This giant cell is often found in tissue because of medical devices, prostheses, and biomaterials. Reed-Sternberg cells are ... and virus-infected cells. Similar to other MGCs, Reed-Sternberg cells are large and are either multinucleated or have a bilobed ...

The Reed-Sternberg cell is named after him and American physician Dorothy Reed Mendenhall. Sternberg studied medicine at the ... It was through his studies of tuberculosis that he discovered a novel cell that is today called the Reed-Sternberg cell. ... Sternberg returned to teaching after the war. Sternberg's research focused mostly on tuberculosis and leukemia. ... In 1908, Sternberg moved to Brünn where he taught as a professor until 1926. During World War I, he served as a military ...

... a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. ... Cell. 7 (12): 1977-93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159. Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, ... Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells ... Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through ...

2004). "Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells". J. Pathol. 201 (3): 413-20. doi:10.1002/path ... Cell. Biol. 14 (4): 2593-603. doi:10.1128/mcb.14.4.2593. PMC 358627. PMID 8139561. Kumar S, Gélinas C (1993). "I kappa B alpha- ... Cell. Biol. 17 (10): 6184-90. doi:10.1128/mcb.17.10.6184. PMC 232469. PMID 9315679. Spiecker M, Darius H, Liao JK (2000). "A ... Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986. Rual JF, Venkatesan K, Hao T, et al. (2005). " ...

October 1999). "Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with ... Hyperplastic germinal centers and Reed-Sternberg-like cells can also be seen. AITL typically has the phenotype of a mixture of ... Polyclonal plasma cells and CD21+ follicular dendritic cells are also seen. Clonal T-cell receptor gene rearrangements are ... plasma cells, and follicular dendritic cells. In addition, blast-like B-cells are occasionally seen. A classic morphological ...

"Detection of ebv gene expression in reed-sternberg cells of Hodgkin's disease". International Journal of Cancer. 46 (5): 801- ... The abundance of EBER targets in cells with latent EBV infection cells and ease of non-isotopic methodology in formalin-fixed ... The Epstein-Barr virus-encoded small RNAs (EBERs) are small non-coding RNAs localized in the nucleus of human cells infected ... Yamamoto N, Takizawa T, Iwanaga Y, Shimizu N, Yamamoto N (November 2000). "Malignant transformation of B lymphoma cell line ...

Dorothy Reed Mendenhall, American physician, and Carl Sternberg, Austrian pathologist - Reed-Sternberg cell. Rehoboam, Hebrew ... Langerhans cell, Langerhans cell histiocytosis. Samuel Pierpont Langley, American astronomer and physicist - langley a ... Friedrich Carl Alwin Pockels, German physicist - Pockels effect, Pockels cell. Joel Roberts Poinsett, American politician and ... Jan Evangelista Purkyně, Czech anatomist and physiologist - Purkinje cell, Purkinje effect, Purkinje shift, Purkinje images, ...

"Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". ... CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma. CD30 is the target of the FDA approved ... Lee SY, Park CG, Choi Y (Feb 1996). "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic ... types of CD30-positive B cell lymphomas Various types of CD30-positive T cell lymphomas CD30-positive cases of the NK cell ...

... mast cells, the L1236 Reed-Sternberg cell line derived from Hodgkin's lymphoma, and certain other tissues. These cells produce ... umbilical cord-derived mast cells, nasal polyps from allergic subjects, airway epitheleal cells, and L1236 Reed-Sternberg cells ... These products were formed by the L1236 Reed Sternberg cell line presented with anandamide; human platelets presented with ... "Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the ...

Up to 97% of the Reed-Sternberg cells of Hodgkin's lymphoma express Pax-5. PAX5 has been shown to interact with TLE4 and Death ... cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter". The ... "Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors". Nature. 401 (6753): 603-6. ... "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas". Nature. 412 (6844): 341-6. Bibcode:2001Natur ...

... the cell composition around the Reed-Sternberg cell(s)). Presence of EBV in Reed-Sternberg cells is most commonly found in the ... the Reed-Sternberg cells are infected by the Epstein-Barr virus. Characteristics of classic Reed-Sternberg cells include large ... and plasma cells. The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an ... Reed-Sternberg cells are usually of B cell origin. Although Hodgkin's is now frequently grouped with other B-cell malignancies ...

"Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas". Blood. 103 (6): 2351 ... thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to ... Serrano M, Hannon GJ, Beach D (1993). "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/ ... Lapointe J, Lachance Y, Labrie Y, Labrie C (1996). "A p18 mutant defective in CDK6 binding in human breast cancer cells". ...

Detection of Sternberg-Reed- and Hodgkin cell specific antigen on atypical cells in lymphomatoid papulosis. 2nd Internat. ... A.; Wiede, J. (1991). A Subcutaneous Delta-Positive T-Cell Lymphoma That Produces Interferon Gamma. N. Engl J Med 325:1078-1081 ... Dummer, R.; Schäfer, E.; Eilles, C.; Börner, W.; Burg, G., (1991). Lymphokine-activated killer-cell traffic in metastatic ... Then, pattern-diagnostic of lymphoproliferative skin infiltrates (T- and B-cell pattern), and Characterization of CD 30- ...

... induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotype. Blood, 95 ... Generation of cells with Hodgkin's and Reed-Sternberg phenotype through downregulation of CD99 (Mic2). Blood, 92:4287-4295, ... LMP1-induced downregulation of CD99 molecules in Hodgkin and Reed-Sternberg cells. Leuk Lymphoma, 42:587-94, 2001 Lee I-S, Kim ... T cell-T cell, so called T-T) interaction is really present and T cells can be developed by the interaction in vivo. After ...

... of the entire nucleus - a finding in Reed-Sternberg cells in individuals with Hodgkin's lymphoma. Owl's ... The owl's eye appearance has a relationship with Reed-Sternberg cells in regards to cytomegalovirus infection. Owl's eye ... In 2007, a journal wrote about the presence of owls' eye appearance as cells found in a transplant to a patient. The owl's eye ... It was stated that the owl's eye had a characteristic of a clear halo that extended towards the cell membrane's nucleus. The ...

370 as well as Reed-Sternberg-like cells.: 370 There are two subtypes: one with monotonous large cells, the other with numerous ... Adam P, Bonzheim I, Fend F, Quintanilla-Martínez L (2011). "Epstein-Barr virus-positive diffuse large B-cell lymphomas of the ... Ok CY, Papathomas TG, Medeiros LJ, Young KH (2013). "EBV-positive diffuse large B-cell lymphoma of the elderly". Blood. 122 (3 ... Epstein-Barr virus positive diffuse large B-cell lymphoma, not otherwise specified (also termed: EBV positive diffuse large B ...

"Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the ... a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". ... a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". The EMBO ... supporting a function-based concept of Hodgkin and Reed-Sternberg cells". Blood. 100 (12): 4139-45. doi:10.1182/blood.V100.12. ...

... protein in the Reed-Sternberg cells of Hodgkin's disease". Leukemia & Lymphoma. 43 (7): 1435-40. doi:10.1080/1042819022386725. ... Expressed on red blood cell surfaces, these variants make up the Augustine blood group system. This gene is a member of the ... in renal epithelial cells". American Journal of Physiology. Renal Physiology. 284 (5): F902-10. doi:10.1152/ajprenal.00215.2002 ... "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport ...

Hodgkin lymphoma is characterised by a particular type of cell, called a Reed-Sternberg cell, visible under microscope. It is ... as the primary site for cells relating to adaptive immune system including T-cells and B-cells. Cells in the lymphatic system ... Mature T cells then join B cells in search of pathogens. The other 95% of T cells begin a process of apoptosis, a form of ... to produce immune cells to fight antigens to remove particulate matter and aged blood cells, mainly red blood cells to produce ...

A Hodgkin lymphoma is marked by the presence of a type of cell called the Reed-Sternberg cell. Non-Hodgkin lymphomas, which are ... B cells, T cells, NK cells, and histiocytic-dendritic cells in which one or more of these cell types is infected with the ... cell neoplasms T-cell prolymphocytic leukemia T-cell large granular lymphocyte leukemia Aggressive NK cell leukemia Adult T- ... cell leukemia/lymphoma Extranodal NK/T-cell lymphoma, nasal type Enteropathy-associated T-cell lymphoma Hepatosplenic T-cell ...

It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands.[ ... citation needed] The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into " ... November 2007). "A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell- ...

In 2018, Falini's group analyzing the genome of thousands microdissected Hodgkin and Reed-Sternberg tumor cells discovered ... "In vivo targeting of Hodgkin and Reed‐Sternberg cells of Hodgkin's disease with monoclonal antibody Ber‐H2 (CD30): ... Tiacci E, Falini B. Genomics of hairy cell leukemia. J Clin Oncol. 35:1002-1010, 2017. Sportoletti P, Sorcini D, Falini B. BCOR ... Falini B, Martelli MP, Tiacci E. BRAF V600E mutation in hairy cell leukemia: from bench to bedside. Blood. 128:1918-1927, 2016 ...

... mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells ... LL-100 panel cell lines cover the full spectrum of human leukemia and lymphoma including T-cell, B-cell and myeloid ... "Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens". ... NCI-60, 60 human cancer cell lines used by the NCI List of breast cancer cell lines Quentmeier, H; Pommerenke, C; Dirks, WG; ...

... with Reed-Sternberg-like cells vs Classic Hodgkin lymphoma transformation of CLL: does this distinction matter?". Blood Cancer ... hairy cell leukemia, or a high grade T cell lymphoma such as anaplastic large-cell lymphoma or angioimmunoblastic T-cell ... The histopathology of the involved tissues in HL-RT is diagnosed based of the presence of Reed-Sternberg cells (here termed RS ... Reed A, Sommerhalder D (December 2019). "The Use of R-Hyper-CVAD in a Rare Case of Primary Bone Marrow Diffuse Large B-Cell ...

... in the form of IL-5 secreted by Reed-Sternberg cells. In primary cutaneous T cell lymphoma, blood and dermal eosinophilia are ... CD7 positive T cells, CD3 negative, CD4 positive T cells, or CD3 positive, CD4 negative, CD8 negative T cells) and is thought ... These cytokines may be released by the diseased cells or the diseased cells may cause the release of these cytokines by non- ... aberrant population of a particular T-cell phenotype. The disorder is clonal with regard to the production of abnormal T-cell ...

The presence of these cells is diagnostic of Hodgkin's lymphoma. Reed-Sternberg cells display a characteristic pattern of ... the latter does not stain Reed-Sternberg cells, but does stain almost all other lymphoid cells. Sialyl-Lewisx is also present ... CD15 is present on almost all Reed-Sternberg cells, including their rare mononuclear variants, and, as such, can be used in ... It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which an egg attracts sperm; ...

Glutathione conjugates of 14,15-HxA3 and 14,15-HxB3 have also been detected the human Hodgkin disease Reed-Sternberg cell line ... The insulin-secreting actions of HxA3 and HxB3 on isolate rat pancreatic islet cells involves their ability to increase or ... Hepoxilins have various biological activities in animal models and/or cultured mammalian (including human) tissues and cells. ... Cultured rat RINm5F pancreatic islet cells undergoing oxidative stress secrete HxB3; HxB3 (and HxA3) in turn upregulates ...

... and Reed-Sternberg cells (HRS cells, also termed Hodgkin Reed-Sternberg cells) into lymphoid and other tissues. HRS cells are ... These Reed-Sternberg-like cells are EBV+ B cells that express the tumor marker cell surface membrane protein, CD30, the B cell ... activated B cells), plasma cells, and Reed-Sternberg-lide cells. The EBV+ cells in CAEB express primarily LMP1, LMP2, and EBNA1 ... CD4+ T cells (i.e. T helper cells), CD8+ cells (i.e. cytotoxic T cells), NK cells (i.e. natural killer cells). The mechanism by ...

2006). "Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: ... Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the ... 2005). "Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma". Leuk. Lymphoma. 45 ( ... IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro". Mol. Hum. Reprod. 8 (9): 841-8. doi: ...