Beta-2 adrenergic receptor
"Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... "Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta- ... In contrast, Beta-1 adrenergic receptors are coupled only to Gs, and stimulation of these results in a more diffuse cellular ...
Beta-adrenergic-receptor kinase
... beta-adrenergic-receptor] kinase, beta-adrenergic receptor-specific kinase, beta-AR kinase, beta-ARK, beta-ARK 1, beta-ARK 2, ... beta-adrenergic receptor] Thus, the two substrates of this enzyme are ATP and beta-adrenergic receptor, whereas its two ... beta-adrenergic receptor] phosphotransferase. Other names in common use include ATP:beta-adrenergic-receptor phosphotransferase ... beta-receptor kinase, GRK2, GRK3, beta-adrenergic-receptor kinase (phosphorylating), beta2ARK, betaARK1, beta-adrenoceptor ...
Beta-1 adrenergic receptor
"The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by ... "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1- ... "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic ...
Adrenergic receptor
Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 There is no α1C receptor. There was a subtype known as C, but ... and β-Adrenergic Receptors Theory of receptor activation Desensitization of β1 receptors (Webarchive template wayback links, ... Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective beta 3-adrenergic receptor ... Sep 2010). "Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice". ...
G protein-coupled receptor kinase 3
GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase ... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family". The Journal of ... and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family". The Journal of ...
G protein-coupled receptor kinase 2
... beta-adrenergic receptor kinase 1) at Wikimedia Commons beta-Adrenergic+Receptor+Kinase at the U.S. National Library of ... GRK2 was initially called Beta-adrenergic receptor kinase (βARK or βARK1), and is a member of the G protein-coupled receptor ... Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ (1989). "Beta-adrenergic receptor kinase: primary structure delineates ... 1991). "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor ...
Discovery and development of beta2 agonists
Beta2-adrenergic agonist Alpha-adrenergic agonist Asthma Beta blocker Beta-1 adrenergic receptor Beta-2 adrenergic receptor ... β1 receptors make up to 75% of all beta receptors and are predominantly located in the heart. β2 receptors are found in ... It also influences the specificity for the β-receptor subtypes. Direct-acting analog binds the β-adrenergic receptors directly ... β-receptors are membrane-bound receptors coupled to G-proteins. Three types of β-receptors have been identified by molecular ...
AKAP12
Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases ... AKAP12 has been shown to interact with Beta-2 adrenergic receptor. GRCh38: Ensembl release 89: ENSG00000131016 - Ensembl, May ... Shih M, Lin F, Scott JD, Wang HY, Malbon CC (1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and ... scaffold binding to the beta2-adrenergic receptor". EMBO J. 22 (24): 6419-29. doi:10.1093/emboj/cdg628. PMC 291823. PMID ...
Lung
... adrenergic receptor function, response, and regulation". The Journal of Allergy and Clinical Immunology. 117 (1): 18-24, quiz ... ISBN 978-0-07-179313-1. Johnson M (January 2006). "Molecular mechanisms of beta(2)- ... Pulmonary stretch receptors in the smooth muscle of the airways initiate a reflex known as the Hering-Breuer reflex that ... The lungs also have a sympathetic tone from norepinephrine acting on the beta 2 adrenoceptors in the respiratory tract, which ...
Vascular smooth muscle
The adrenergic receptors exert opposite physiologic effects in the vascular smooth muscle under activation: alpha-1 receptors. ... Agonism of beta-2 receptors causes vasodilation and low blood pressure (i.e. the effect is opposite of the one resulting from ... Vascular smooth muscle is innervated primarily by the sympathetic nervous system through adrenergic receptors (adrenoceptors). ... Under NE binding alpha-1 receptors cause vasoconstriction (contraction of the vascular smooth muscle cells decreasing the ...
Hyperkalemia
Beta2-adrenergic agonists act on beta-2 receptors to drive potassium into the cells. Therefore, beta blockers can raise ... Examples of medications that can cause hyperkalemia include ACE inhibitors, angiotensin receptor blockers, non-selective beta ... Examples of drugs that can raise the serum potassium are non-selective beta-blockers such as propranolol and labetalol. Beta-1 ... Note that 12-40% of patients do not respond to salbutamol therapy for reasons unknown, especially if on beta-blockers, so it ...
ATG10
Feldman RD, Hunninghake GW, McArdle WL (1987). "Beta-adrenergic-receptor-mediated suppression of interleukin 2 receptors in ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). " ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using ...
Dopexamine
Beta-adrenergic agonists, Cardiac stimulants, Catecholamines, D1-receptor agonists, D2-receptor agonists, Norepinephrine ... Effects of depexamine may be suppressed by concomitant use with ß2-adrenergic and dopamine receptor antagonists requires ... July 1985). "Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". British Journal of ... It is not an α-adrenergic agonist, does not cause vasoconstriction, and is not a pressor agent. As of 2004 there was some ...
Beta-adrenergic agonist
"The beta-adrenergic receptors". PMID 12439640. Yoo, B.; et al. "Beta1-adrenergic receptors stimulate cardiac contractility and ... In general, pure beta-adrenergic agonists have the opposite function of beta blockers: beta-adrenoreceptor agonist ligands ... Lowell, B.B.; Flier, J.S. (1997). "Brown adipose tissue, beta 3-adrenergic receptors, and obesity". Annu. Rev. Med. Vol. 48. pp ... Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, causing widening of the airways ...
ARF6
... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45 ... A pseudogene of this gene is located on chromosome 7. ARF6 can interact with βarrestin upon receptor activation. ARF6 has been ... D'Souza-Schorey C, Li G, Colombo MI, Stahl PD (1995). "A regulatory role for ARF6 in receptor-mediated endocytosis". Science. ... "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. 278 (36): 33818-30 ...
Beta-2 adrenergic antagonist
... is an adrenergic antagonist which blocks the beta-2 adrenergic receptors of cells, with either high specificity (an antagonist ... ICI-118,551 Butaxamine Propranolol Betablocker Beta-2 adrenergic receptor Beta2-adrenergic agonist Bilski, AJ; Halliday, SE; ... Fitzgerald, JD; Wale, JL (1983). "The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551)". J Cardiovasc ... A Beta-2 adrenergic antagonist (β2-adrenoceptor antagonist) ...
CYTH2
... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45 ... links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor ... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45 ... Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (Sep 1996). "Alpha L beta 2 integrin/LFA-1 binding ...
Arrestin beta 1
... is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated ... Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta- ... January 1999). "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes". Science. 283 ( ...
Beta-3 adrenergic receptor
... has been shown to interact with Src. Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 ... The beta-3 adrenergic receptor (β3-adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the ... adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Beta blocker GRCh38: Ensembl release 89: ... "Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes". ...
Energy expenditure
Adrenergic agonists, especially those that work on the beta-2 adrenergic receptor, increase energy expenditure. Although some ... 5 (2): 151-154. doi:10.1016/j.jshs.2016.04.001. Christoffersen, Berit Østergaard; Sanchez‐Delgado, Guillermo; John, Linu Mary; ... 68 (2): 146-152. doi:10.1038/ejcn.2013.253. ISSN 1476-5640. Blundell, John E; Gibbons, Catherine; Beaulieu, Kristine; Casanova ... Two of the earliest weight loss drugs, 2,4-dinitrophenol and thyroid hormone, increase energy expenditure, but both were ...
Anti-obesity medication
Adrenergic agonists, especially those that work on the beta-2 adrenergic receptor, increase energy expenditure. Although some ... It reduces appetite by activating a type of serotonin receptor known as the 5-HT2C receptor in a region of the brain called the ... Cannabinoid receptor antagonists were developed to treat obesity because researchers noticed that cannabinoid agonists (such as ... Setmelanotide is an agonist of the melanocortin 4 receptor and is used in people with certain rare genetic conditions that ...
Falintolol
... is a beta-adrenergic receptor antagonist. Conti P, Dallanoce C, De Amici M, De Micheli C, Klotz KN (April 1998). " ... Beta blockers, Cyclopropanes, Ketoximes, Secondary alcohols, Amines, Tert-butyl compounds, All stub articles, Cardiovascular ... "Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor ...
Formaldehyde dehydrogenase
... increased beta adrenergic receptor numbers in lung and heart, diminished tachyphylaxis to β2-adrenergic receptor agonists, ... "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2". Cell. 129 (3): 511 ... J. 331 (2): 659-68. doi:10.1042/bj3310659. PMC 1219401. PMID 9531510. Hedberg JJ, Griffiths WJ, Nilsson SJ, Höög JO (March 2003 ...
Frizzled-1
... adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives ... DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (May 2002). "The Frizzled-1/(beta(2))- ... "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... G protein-coupled receptors, All stub articles, Transmembrane receptor stubs). ...
Asthma trigger
... or beta-adrenergic antagonists, may also induce bronchial constriction and block the action of other beta-receptor targeted ... As the FceRI receptors on mast cells capture the IgE antibodies produced by Th2 cells, they become sensitive to the specific ... Long-acting beta-agonists such as salmetrol had been used in combination with corticosteroids to control asthma symptoms. They ... Oral use of leukotriene receptor antagonist such as Zafirlukast may also be used as a long term control for asthma in addition ...
AKAP5
... receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1 ... adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409-12. doi:10.1016/S0960- ... The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase ... 2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107-19. doi:10.1016/S0896-6273( ...
60S acidic ribosomal protein P2
2002). "Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal ... 150 (2): 243-250. doi:10.1016/0378-1119(94)90433-2. PMID 7821789. Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5 ... 35 (2): 203-211. doi:10.1016/S1357-2725(02)00133-4. PMID 12479870. Shu H, Chen S, Bi Q, et al. (2004). "Identification of ... 3.0.CO;2-5. PMID 10508479. Tchórzewski M, Boldyreff B, Issinger O, Grankowski N (2000). "Analysis of the protein-protein ...
Vesicular monoamine transporter 2
"VMAT2 gene expression and function as it applies to imaging beta-cell mass". J. Mol. Med. 86 (1): 5-16. doi:10.1007/s00109-007- ... Receptors, Signal transduction, Solute carrier family, Articles containing video clips). ... "Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4 ... 117 (1-2): 87-97. doi:10.1016/j.jad.2008.12.021. PMID 19328558. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman ...
Flestolol
... is a short-acting beta adrenergic receptor antagonist. Acylation of glycidol (2) with the acid chloride 1 produces ... 1. Novel .beta.-blockers with ultrashort duration of action". Journal of Medicinal Chemistry. 27 (8): 1007. doi:10.1021/ ... Beta blockers, Fluoroarenes, Benzoate esters, Ureas, All stub articles, Cardiovascular system drug stubs). ...
Arrestin beta 2
... like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the ... Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... "beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this ...