FGFR4 was observed to be significantly associated with nodal involvement and overall survival in patients with different types ... 1992). "A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor ... "Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor ... Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as ...

... hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 ... Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ (September 2003). "ALK2 functions as a BMP type I receptor and ... 2002). "A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved". Hum. Genet. 111 (4-5): ... 2003). "Identification of a mutation in the Indian Hedgehog (IHH) gene causing brachydactyly type A1 and evidence for a third ...

... fibroblast growth factor receptor 1), TfR (transferrin receptor), IL-13R. Most human meningiomas massively expresses IL-4 ... Type 2 receptors consist of an IL-4Rα subunit bound to a different subunit known as IL-13Rα1. These type 2 receptors have the ... and medulloblastoma overexpress receptors for various growth factors including epidermal growth factor receptor, FGFR-1 ( ... This receptor exists in 3 different complexes throughout the body. Type 1 receptors are composed of the IL-4Rα subunit with a ...

... receptor, fibroblast growth factor, type 1 MeSH D12.776.543.750.060.092 - receptor, fibroblast growth factor, type 2 MeSH ... receptor, fibroblast growth factor, type 1 MeSH D12.776.543.750.750.400.370.750 - receptor, fibroblast growth factor, type 2 ... fibroblast growth factor, type 3 MeSH D12.776.543.750.060.116 - receptor, fibroblast growth factor, type 4 MeSH D12.776.543.750 ... fibroblast growth factor, type 3 MeSH D12.776.543.750.750.400.370.937 - receptor, fibroblast growth factor, type 4 MeSH D12.776 ...

Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth ... growth factors and as "promiscuous" growth factors due to their multiple actions on multiple cell types. Promiscuous refers to ... Wikimedia Commons has media related to Fibroblast growth factors (FGF). Fibroblast+Growth+Factors at the U.S. National Library ... "acidic fibroblast growth factor" (FGF1) and "basic fibroblast growth factor" (FGF2). These proteins had a high degree of ...

... stimulates phosphorylation of fibroblast growth factor receptor substrate 2 and ERK1/2 in the liver. Acute FGF21 ... composed of an FGF receptor protein (FGFR) and a (β-) klotho co-receptor. Klotho co-receptors of three types have been ... "Entrez Gene: FGF21 fibroblast growth factor 21". "Fgf21 fibroblast growth factor 21 [Mus musculus (house mouse)] - Gene - NCBI ... July 2012). "Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol- ...

"The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which ... Vajo, Zoltan; Francomano CA; Wilkin DJ (2000). "The molecular and genetic basis of fibroblast growth factor receptor 3 ... It can be associated with missense mutations in fibroblast growth factor receptor-3. It is inherited in an autosomal dominant ... and type I thanatophoric dysplasia is more common than type II thanatophoric dysplasia. Infants with type 1 thanatophoric ...

The exact pathways and elements activated depend on the cell type being stimulated plus other factors such as the stimulated ... Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine ... with eosinophil such as those caused by Platelet-derived growth factor receptor A or platelet-derived growth factor receptor B ... FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, which in addition to FGFR1, includes FGFR2, FGFR3, ...

... synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts ... type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor ... Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor". Nucleic Acids Res. 17 ( ... Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. ...

This factor is thought to be expressed in the peritubular cells in human testes. Fibroblast growth factor (FGF2) is another ... Chemokine (C-X-C motif) ligand 12 (CXCL12) signaling via its receptor C-X-C chemokine receptor type 4 (CXCR4) is also involved ... Short-term in vitro propagation of these cells has been carried out in Stem-Pro 34 media supplemented by growth factors. Long- ... Kubota, Hiroshi; Avarbock, Mary R.; Brinster, Ralph L. (2004-11-23). "Growth factors essential for self-renewal and expansion ...

... the point mutation G380R located on the fibroblast growth factor receptor 3(FGFR-3) gene leads to achondroplasia, a type of ... The non-mutated FGFR-3 gene is responsible for the expression of fibroblast growth factors(FGFs) which has to maintain a ... and fibroblast growth factor 2(FGF2) have been seen to influence the amount of differentiation into chondrocytes. Both proteins ... Primary cilia work as centers for wingless type (Wnt) and hedgehog signaling and contain mechanosensitive receptors. The number ...

Insulin regulates adipogenesis through insulin-like growth factor 1 (IGF1) receptor signaling. Insulin/IGF1 promotes the ... The growth arrest followed by the earliest events, including a morphological change of preadipocyte from the fibroblast-shape ... July 1998). "Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and ... T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), GATA2/3, retinoic acid receptor α, and SMAD6/7 don't affect the ...

March 1995). "Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3". ... a receptor for fibroblast growth factors. Perlecan binds to growth factors involved in growth plate development. Perlecan ... a receptor for fibroblast growth factors. In yet another mouse knockout model, the perlecan gene was mutated by homologous ... Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (March 2001). "Fibroblast growth factor-binding protein is a novel ...

... intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". ... 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by ... "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3". Lim YP, Low BC, Lim J, et al. (1999). "Association of ...

... kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors". The ... Zinc finger MYM-type protein 2 is a protein that in humans is encoded by the ZMYM2 gene. Chromosome 13 (human) ... "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)". Proceedings of the ... "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome". ...

The protein also contains type II repeats with epidermal growth factor-like homology and type III repeats that contain an RGD ... The amino-terminal end contains a tryptophan-rich motif that blocks fibroblast growth factor (FGF-2 or bFGF) driven ... It has been suggested that activating the CD36 receptor causes an increase in ECs sensitivity to apoptotic signals. Type I ... can activate transforming growth factor beta 1 (TGFβ1) and inhibit endothelial cell migration, angiogenesis, and tumor growth. ...

"Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling". FASEB J. ... It is overexpressed and amplified in several cancer types, including prostate cancer. FRS2 has been shown to interact with: CBL ... intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". ... intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". ...

"Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2". Nature Medicine. 5 (1): ... Summerford C, Bartlett JS, Samulski RJ (January 1999). "AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 ... aVβ5 integrin and fibroblast growth factor receptor 1 (FGFR-1). The first functions as a primary receptor, while the latter two ... and AAV5 was shown to enter cells via the platelet-derived growth factor receptor. There have been many efforts to engineer and ...

... on chromosome 8 or the fibroblast growth factor receptor 2 (FGFR2) gene on chromosome 10. These genes code for fibroblast ... There are three main types of Pfeiffer syndrome: type I is the mildest and most common; type II is the most severe, with ... Pfeiffer syndrome is caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped ... 1994). "A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome". Nat Genet. 8 (3): 269-74. doi: ...

"Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at ... "Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor". EMBO J ... Davis RJ, Czech MP (1985). "Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor ... Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an ...

"The basic fibroblast growth factor-saporin mitotoxin acts through the basic fibroblast growth factor receptor". Journal of ... There are different classes of mitotoxins, each acting on a different type of cell or system. The mitotoxin classes that have ... epidermal growth factor-based, nerve growth factor-based, insulin-like growth factor-I-based, and fibroblast growth factor- ... Growth factor-targeted cytotoxic molecules". Progress in Growth Factor Research. 2 (4): 223-236. doi:10.1016/0955-2235(90)90020 ...

The FGF (Fibroblast Growth Factor) pathway stimulation leads to Smad4 phosphorylation by Erk of the canonical MAPK site located ... Once the type II receptor is activated by the binding of TGF-β, it phosphorylates a type I receptor. Type I receptor is also a ... In the TGF-β pathway, TGF-β dimers are recognized by a transmembrane receptor, known as type II receptor. ... "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine & Growth ...

... to their fibroblast growth factor receptors, is promoted via their interactions as co-receptors with β-klotho. Loss of β-Klotho ... Transgenic mice that overexpress Klotho live longer than wild-type mice. The α-klotho gene is located on chromosome 13, and is ... PMID 15161545.[permanent dead link] Helsten T, Schwaederle M, Kurzrock R (September 2015). "Fibroblast growth factor receptor ... Mice lacking either fibroblast growth factor 23 or the α-klotho enzyme display premature aging due to hyperphosphatemia. Many ...

Vajo Z, Francomano CA, Wilkin DJ (February 2000). "The molecular and genetic basis of fibroblast growth factor receptor 3 ... "Insulin and analogue effects on protein degradation in different cell types. Dissociation between binding and activity". ... and research on the molecular and genetic background of skeletal dysplasias and fibroblast growth factor receptor 3 disorders, ... "The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal ...

Angiogenic factors such as vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF-1), fibroblast growth ... also known as tumour-associated fibroblast; carcinogenic- associated fibroblast; activated fibroblast) is a cell type within ... "Effects of cytokines derived from cancer-associated fibroblasts on androgen synthetic enzymes in estrogen receptor-negative ... Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) and other chemokines to stimulate angiogenesis and ...

Fibroblast growth factor 2 (basic fibroblast growth factor) FGFR3: fibroblast growth factor receptor 3 (achondroplasia, ... Thanatophoric dysplasia Type 1 Type 2 Wolfram syndrome Wolf-Hirschhorn syndrome G-banding ideograms of human chromosome 4 " ... fibroblast growth factor receptor-like 1 FRG1: FSHD region gene 1 FRYL: encoding protein FRY like transcription coactivator ... Kinase insert domain receptor (Vascular endothelial growth factor receptor 2) KIAA1530: UV stimulated scaffold protein A LCORL ...

FGFR types 1-2 and PDGFR alpha/beta. Tumor types such as breast carcinoma show amplification of fibroblast growth factor ... platelet-derived growth factor receptor), RAF kinase, FLT3 (Fms-like tyrosine kinase-3) and KIT (stem cell factor receptor). ... The other receptors in the family are VEGFR-1 and VEGFR-3. These receptors are a type of transmembrane kinase receptors and ... "Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and new inhibitors". Journal of Medicinal Chemistry. 55 (24): 10797- ...

"Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor ... "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6". Knee RS, Pitcher SE, Murphy PR (1995). "Basic ... 2001). "The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production ... Sheng Z, Lewis JA, Chirico WJ (2004). "Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by ...

This process requires the precise integration of a variety of signaling pathways such as the transforming growth factor type β ... Upon FGF binding to its receptor, FGFR, the receptor pair dimerizes and is transphosphorylated, enabling it to recruit proteins ... Fibroblast growth factor signaling during early vertebrate development. Endocr Rev 26(1):63-77. 10. Halpern ME, Ho RK, Walker C ... Fibroblast growth factor contributes to this process not only by promoting mesoderm formation, but also by inhibiting ...

It inhibits the three main vascular endothelial growth factor receptors VEGFR1, 2 and 3, as well as fibroblast growth factor ... As lenvatinib moderately prolongs QT time, addition of other drugs with this property could increase the risk of a type of ... platelet-derived growth factor receptor (PDGFR) alpha, c-Kit, and the RET proto-oncogene. Some of these proteins play roles in ... node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor ...