"Computational prediction of RNA structural motifs involved in post-transcriptional regulatory processes". Proc. Natl. Acad. Sci ... PCFGs have application in areas as diverse as natural language processing to the study the structure of RNA molecules and ... The RNA analysis package Infernal uses such profiles in inference of RNA alignments. The Rfam database also uses CMs in ... Since RNAs preserve their structures over their primary sequence; RNA structure prediction can be guided by combining ...

However, protein abundance is governed by the complex interplay between RNA expression and post-transcriptional processes. ... Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X (April 2015). "RNA imaging. Spatially resolved, highly multiplexed RNA ... proteomics it is not as accurate at determining gene expression in cells as it does not take into account post-transcriptional ... is still important as studying the difference between RNA levels and protein levels could give insight on which genes are post- ...

Trypanosomatid protists and other kinetoplastids have a novel post-transcriptional mitochondrial RNA modification process known ... Guide RNAs binds to the anti sense RNA sequence and regulates the RNA modification. It is observed that small interfering RNA ( ... Adenosine deaminase acts on RNA bringing post transcriptional modification by altering the codons and different protein ... A guide RNA (gRNA) is a piece of RNA that functions as a guide for RNA- or DNA-targeting enzymes, with which it forms complexes ...

... the processing of micro-RNAs that are involved in RNA silencing and post-transcriptional regulation of gene expression; and 3) ... the splicing of pre-messenger RNA into mature messenger RNA, and the transport of these RNAs between different areas of their ... They are RNA-binding proteins. By binding to their RNA targets, they contribute to the regulation of: a) the transcription of ... "EWSR1 EWS RNA binding protein 1 [Homo sapiens (Human)] - Gene - NCBI". "FUS FUS RNA binding protein [Homo sapiens (Human)] - ...

Micro RNAs up- or downregulate expression levels of mRNAs by the process of RNA interference at the post-transcriptional level ... The RNA purification process is different for short and long RNAs. This step is usually followed by an assessment of RNA ... RNA integrity can also be analyzed quantitatively comparing the ratio and intensity of 28S RNA to 18S RNA reported in the RNA ... Ribosomal RNA/rRNA: Usually the most abundant RNA in the transcriptome. Long non-coding RNA/lncRNA: Non-coding RNA transcripts ...

In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing ... This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, ...

The 5-HT2C receptors are the only G-protein coupled receptors known to undergo a post-transcriptional process of RNA editing. ... This process of RNA editing generates 14 unique receptor isoforms of the 5-HT2C receptor that differ in three amino acids in ... This gene product undergoes an RNA editing process leading to a decrease in agonist binding affinity, however antagonist ... In the drug discovery process of a 5-HT2C agonist, a pharmacophore module has been used to discover novel 5-HT2C receptor ...

Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post- ... RNA can be an important regulator of gene activity, e.g. by microRNA (miRNA), antisense-RNA, or long non-coding RNA (lncRNA). ... chromatin domains Transcription Post-transcriptional modification RNA transport Translation mRNA degradation In eukaryotes, the ... Three prime untranslated regions (3'-UTRs) of messenger RNAs (mRNAs) often contain regulatory sequences that post- ...

tRNA processing is an important post-transcriptional modification necessary for tRNA maturation because it locates and removes ... These non-coding RNA molecules form tRNA molecules after being processed, and this is dependent on tRNA-intron lyase to splice ... This is regulator is thought to limit or interfere with the continuation of RNA processing. Mutations in specific subunits of ... Thompson LD, Brandon LD, Nieuwlandt DT, Daniels CJ (January 1989). "Transfer RNA intron processing in the halophilic ...

... identification of targets of RNA decay and provides insight into the dynamics of transcriptional and post-transcriptional gene ... Thus, sequencing this degradome offers a method for studying and researching the process of RNA degradation. This process is ... a precious resource for deciphering RNA processing and regulation codes in plants". RNA Biology. 17 (9): 1223-1227. doi:10.1080 ... Degradome sequencing is a complex process which includes multiple steps such as isolating RNA fragments in a given sample as ...

... introduces a cryptic splice site that is used instead of the wild-type splice site during post-transcriptional RNA processing. ... The process is called mechanoelectrical transduction and ultimately results in the perception of sound. Intact tip links and ... Since the change in the RNA sequence is not a multiple of three, the mRNA contains a frameshift and a premature stop codon ...

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of ... stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 ... Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated ... v t e (RNA, RNA interference, All stub articles, Molecular biology stubs). ...

... and are then processed into 21-nucleotide-long RNA duplexes with overhangs. These segments are incorporated into an RNA-induced ... that repress gene expression through post-transcriptional gene silencing in land plants. Precursor transcripts from TAS loci ... RDR6 then converts the transcript into a double strand RNA fragment which then gets processed by DCL4 to generate the 21-nt ... "Identification of trans-acting siRNAs in moss and an RNA-dependent RNA polymerase required for their biogenesis". Plant J. 48 ( ...

Her work has revealed the mechanism by which plants remember they have experienced winter, demonstrated novel RNA processing ... Her discoveries have broad significance in the fields of epigenetics, post-transcriptional regulation and molecular evolution. ... This acceleration of flowering by prolonged cold is a classic epigenetic process called vernalisation. FLC regulation involves ... transcription and non-coding RNAs. Her goal is to understand the chromatin dynamics that enable switching between epigenetic ...

... post-transcriptional gene silencing (PTGS), and quelling. The detailed study of each of these seemingly different processes ... "RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing". Nature Genetics. 36 ... Hammond S, Bernstein E, Beach D, Hannon G (2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in ... RNAi is an RNA-dependent gene silencing process that is controlled by RISC and is initiated by short double-stranded RNA ...

Genomic approaches for studying transcriptional and post-transcriptional processes. 67 (1): 13-19. doi:10.1016/j.ymeth.2013.11. ... This technique provides insight into the post-transcriptional gene regulation which occurs between RNA and RNA binding proteins ... CLIP: The RNA binding protein is cross-linked to the RNA via the use of UV light prior to lysis, which is followed by RNA ... RNA-Binding Protein Immunoprecipitation-Microarray Profiling", Post-Transcriptional Gene Regulation, Methods In Molecular ...

Lipshitz studies embryonic development and post-transcriptional regulation of gene expression in Drosophila with a focus on ... stability and localization during the Maternal to zygotic transition and the role of RNA-binding proteins in this process. With ... "Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic ... RNA. 22 (4): 636-655. doi:10.1261/rna.055186.115. PMC 4793217. PMID 26847261. Laver, John D.; Li, Xiao; Ancevicius, Kristin; ...

... the protein complex specialized for carrying out RNA splicing during the process of post-transcriptional modification. The ... RNA 4:85-100. Gooding C, Roberts GC, Moreau G, Nadal-Ginard B, Smith CW. (1994). Smooth muscle-specific switching of alpha- ... The polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, ...

... rna processing, post-transcriptional MeSH G05.315.700.225 - rna 3' end processing MeSH G05.315.700.225.710 - polyadenylation ... protein processing, post-translational MeSH G05.315.670.600.400 - protein isoprenylation MeSH G05.315.670.600.700 - protein ... MeSH G05.315.700.250 - rna editing MeSH G05.315.700.700 - rna splicing MeSH G05.315.700.700.100 - alternative splicing MeSH ... rna interference MeSH G05.315.425 - genomic imprinting MeSH G05.315.670 - protein modification, translational MeSH G05.315. ...

Polypyrimidine tract Valcárcel J, Gebauer F (November 1997). "Post-transcriptional regulation: the dawn of PTB". Current ... Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a ... splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. Two ...

Annotation of eukaryotic genomes has an extra layer of difficulty due to RNA splicing, a post-transcriptional process in which ... December 2008). "The RNA WikiProject: community annotation of RNA families". RNA. 14 (12): 2462-2464. doi:10.1261/rna.1200508. ... Noncoding RNA (ncRNA), produced by RNA genes, is a type of RNA that is not translated into a protein. It includes molecules ... The RNA WikiProject seeks to write articles that describe individual RNAs and RNA families in an accessible way. Gene Ontology ...

RNA binding protein) plays a crucial role. Post-transcriptional modifications due to various enzymes like methyltransferase ... TRAMP complex is involved in processing and surveillance of various RNAs and degrade abnormal RNAs. Different type of RNA ... small nucleolar RNAs (snoRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), Long transcripts of RNA polymerase II (Pol ... TRAMP complex also affects various other RNA processes either directly or indirectly. It is involved in RNA export, Splicing, ...

Post-transcriptional modification RNA-binding protein Cook, Kate B.; Kazan, Hilal (2010). "RBPDB: a database of RNA-binding ... RNA-binding proteins ( RBPs ) play critical role during this process. All RBPs can bind to RNA depends on different ... Glisovic, Tina; Bachorik, Jennifer L. (2008). "RNA-binding proteins and post-transcriptional gene regulation". FEBS Letters. ... "Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression". Briefings in Functional ...

... or post-translational processing. It is also different from the multifunctionality of the protein, in which the protein has ... For example, a ribosome is made up of 90 proteins and RNA. A number of the currently known moonlighting proteins are ... The fact that similar transcriptional factors such as Pax-6, and retinoic acid receptors, regulate different crystalline genes ... Multifunctionality could also be as a consequence of differential post translational modifications (PTMs). In the case of the ...

"RITS acts in cis to promote RNA interference-mediated transcription and post-transcriptional silencing". Nature Genetics. 36 ( ... This process is called RNA interference (RNAi) and it is found in many eukaryotes; it is a key process in defense against viral ... RNA-induced transcriptional silencing (RITS) RNA interference Pratt AJ, MacRae IJ (2009). "The RNA-induced silencing complex: A ... "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells". Nature. 404 (6775): 293-296. ...

... ncRNAs also control various aspects of post-transcriptional mRNA processing. Similar to small regulatory RNAs such as microRNAs ... Noncoding RNAs act upon different aspects of this process, targeting transcriptional modulators, RNA polymerase (RNAP) II and ... small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. Given ... potentially affecting any step in post-transcriptional gene expression including pre-mRNA processing and splicing, transport, ...

The cleavage is the first step in adding a polyadenine tail to the pre-mRNA, which is one of the necessary post-transcriptional ... untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule in the process of gene transcription. ... Stumpf, G; Domdey, H (1996). "Dependence of yeast pre-mRNA 3'-end processing on CFT1: a sequence homolog of the mammalian ... Ustyantsev, I. G.; Golubchikova, J. S.; Borodulina, O. R.; Kramerov, D. A. (9 May 2017). "Canonical and noncanonical RNA ...

The 5′-end of nascent messenger RNA is the site at which post-transcriptional capping occurs, a process which is vital to ... The 3′-end of nascent messenger RNA is the site of post-transcriptional polyadenylation, which attaches a chain of 50 to 250 ... but it was discovered to be transcribed into RNA and quickly removed during processing of the primary transcript to form the ... The 5′-end (pronounced "five prime end") designates the end of the DNA or RNA strand that has the fifth carbon in the sugar- ...

... s' transcriptional and post-transcriptional regulation of RNA has a role in regulating the patterns of gene ... plays a critical role in RNA processing, RNA localization, RNA interference, RNA editing, and translational repression. All ... As nuclear RNA emerges from RNA polymerase, RNA transcripts are immediately covered with RNA-binding proteins that regulate ... Glisovic T, Bachorik JL, Yong J, Dreyfuss G (June 2008). "RNA-binding proteins and post-transcriptional gene regulation". FEBS ...

... splicing but also makes complex mechanisms such as the RNA post-transcriptional to cooperate with the splicing-mRNA processing ... On the one hand, SON protein is required to maintain the genome stability in order to ensure an efficient RNA processing of ... It also facilitates the interaction of SR proteins with RNA polymerase II and is required for processing of weak constitutive ... Specifically, these results revealed that the serine-arginine-rich protein involved in the RNA splicing process, could suppress ...