... , also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc ... Proto-oncogene tyrosine-protein kinase Src) at the PDBe-KB. Portal: Biology (Articles with short description, Short description ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. When src is activated, it ... Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. Once the oncogene is ...
Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation. Proto-oncogenes are often involved ... a proto-oncogene becomes a tumor-inducing agent, an oncogene. Examples of proto-oncogenes include RAS, WNT, MYC, ERK, and TRK. ... Wikimedia Commons has media related to Proto-oncogene proteins. Drosophila Oncogenes and Tumor Suppressors - The Interactive ... The resultant protein encoded by an oncogene is termed oncoprotein. Oncogenes play an important role in the regulation or ...
Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C (2000). "The protein encoded by the proto-oncogene DEK changes ... Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C (2001). "Subcellular localization of the human proto-oncogene protein DEK ... The human DEK gene encodes the DEK protein. This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK v t e (Articles with ...
NCBI (April 2015). "MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]". {{cite journal}}: Cite ... Glutamate-rich protein 3, also known as Uncharacterized Protein C1orf173, is a protein encoded by the ERICH3 gene. ERICH3 was ... The C1orf173 protein has been predicted or experimentally observed to interact with the following proteins: CRISPLD2 GIMAP4 ... C1orf173 is predicted to be a nuclear protein based on PSORT II analysis and the suggested protein interactions found between ...
... proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is ... Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA". Mol. Cell ... This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly ... "Identification and characterization of the protein encoded by the human N-myc oncogene". Science. 232 (4751): 768-72. Bibcode: ...
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. ... Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward- ... "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1". Ogorodnikov A, Levin M, Tattikota S, ...
The DBL proto-oncogene is a protein that in humans is encoded by the MCF2 gene. The commonly-used name DBL is derived from " ... Nishida K, Kaziro Y, Satoh T (October 1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits ... Ron D, Tronick SR, Aaronson SA, Eva A (August 1988). "Molecular cloning and characterization of the human dbl proto-oncogene: ... July 2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene. 253 (1 ...
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS ... Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene. ... Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor ... 2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium ...
Wnt1 is a proto-oncogene protein (Wingless-type MMTV integration site family, member 1). This gene was originally thought to ... Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing ...
"Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY". Science. 325 (5941): 753-6. ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... the YccA protein of Escherichia coli and the YetJ protein of Bacillus subtilis. These proteins are about 200-250 residues in ... These proteins are distantly related to the ionotropic glutamate-binding protein of the N-methyl D-aspartate (NMDA) receptor of ...
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Fyn is a member of the Src-family of kinases (SFK), the first proto-oncogene to be identified. The discovery of the Src-family ...
... is a protein that in humans is encoded by the MYBL1 gene. GRCh38: Ensembl release 89: ENSG00000185697 ... "Entrez Gene: MYB proto-oncogene like 1". Retrieved 2016-11-15. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, ...
Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. Members of the extended ... Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene". Oncogene. 9 (1 ... MYB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drosophila Myb oncogene-like - The ...
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a ... Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology ... Bustelo XR, Barbacid M (1992). "Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells". Science. 256 ...
... is a proto-oncogene, meaning that mutations of this protein can lead to cancer. Mutations of the FLT3 receptor can lead ... receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 ... Overview of all the structural information available in the PDB for UniProt: P36888 (Receptor-type tyrosine-protein kinase FLT3 ... Cluster of differentiation cytokine receptor receptor tyrosine kinase tyrosine kinase oncogene hematopoiesis Lymphopoiesis# ...
"Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase". Biochemical and Biophysical Research ... "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of ... This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by ...
Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene. The protein encoded by this gene belongs to the ... Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to ... Saitoh T, Mine T, Katoh M (2002). "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer". Int. J. Oncol. 20 ... 2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase ...
Raf is a proto-oncogene because mutations in this protein have been found in many cancers. The Rho GTPase Vav1, which can be ... GEFs are multi-domain proteins and interact with other proteins inside the cell through these domains. Adaptor proteins can ... G protein-coupled receptors are trans-membrane receptors that act as GEFs for their cognate G proteins upon binding of a ligand ... This 200 amino acid region is homologous to the yeast Sec7p protein. GEFs are often recruited by adaptor proteins in response ...
"SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): ... Degenhardt YY, Silverstein S (2001). "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human ... SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein ... and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator- ...
"Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins". Molecular and Cellular Biology. 15 ... RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are called K-homology or ... Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein ... The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the ...
Interestingly, uORFs were found in two thirds of proto-oncogenes and related proteins. 64-75% of experimentally found ... If transcription were to cease before the stop codon, an incomplete protein would be made during translation. In eukaryotic ... Long ORFs are often used, along with other evidence, to initially identify candidate protein-coding regions or functional RNA- ... Pearson WR, Wood T, Zhang Z, Miller W (November 1997). "Comparison of DNA sequences with protein sequences". Genomics. 46 (1): ...
Gupta K, Chevrette M, Gray DA (1994). "The Unp proto-oncogene encodes a nuclear protein". Oncogene. 9 (6): 1729-31. PMID ... 1995). "Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors". Oncogene. 10 (11): 2179-83. PMID ... "Entrez Gene: USP4 ubiquitin specific peptidase 4 (proto-oncogene)". Gilchrist CA, Gray DA, Baker RT (December 1997). "A ... 2001). "The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein". Oncogene. 20 (39): 5538-5542. doi:10.1038/ ...
Proto-oncogene tyrosine-protein kinase Src Myristoylation SH2 domain SH3 domain Parsons SJ, Parsons JT (October 2004). "Src ... It allows for weak protein-protein and protein-lipid interactions. Myristoylation aids in the membrane association of Src ... Src family kinases interact with many cellular cytosolic, nuclear and membrane proteins, modifying these proteins by ... Myristoylation and fusion proteins work together to localize Src to cellular membranes. Src kinases transduce signals related ...
Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene. The WNT gene family consists of ... It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". ...
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB ... "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70 ... "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon". Oncogene. 4 (7): 935-42. PMID 2666912. ... Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro". Oncogene. 7 (3): 567-72. ...
The SKI protein is a nuclear proto-oncogene that is associated with tumors at high cellular concentrations. SKI has been shown ... The name SKI comes from the Sloan-Kettering Institute where the protein was initially discovered. The SKI proto-oncogene is ... The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Smad-3 and CReB ... The SnoN protein was identified as a similar protein and is often discussed in conjugation with the Ski protein in publications ...
1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 ... "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): ... Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene. This gene is a member of the ... The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin ...
Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of ... Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the ... 1990). "The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase ... Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". ...
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly ... The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function ... protein; it is encoded by the c-ros oncogene and was first identified in 1986. The exact role of the ROS1 protein in normal ... Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (July 1987). "Human ros1 and mas1 oncogenes located in regions ...
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of ... "Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase". Iwase T, Tanaka M, Suzuki M, Naito Y, Sugimura H, Kino I (July 1993 ... "Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia". Clinical Cancer Research. 12 (9 ... Weier HU, Fung J, Lersch RA (Jun 1999). "Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ ...