ZASP is a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino ... Dec 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". The Journal of Biological Chemistry ... LIM domain binding 3 (LDB3), also known as Z-band alternatively spliced PDZ-motif (ZASP), is a protein which in humans is ... The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also ...

THOC 3 and 6 both contains WD40 repeat motifs that allow interaction with other THO proteins. THOC5 and THOC7 binds tightly and ... is a multi-domain protein composed of one conserved N-terminal RNA recognition and four leucine-rich repeat motifs, a central ... and a C-terminal ubiquitin associated domain that mediates interactions with nucleoporins. The NTF2-like domain is able to form ... The N and C-termini of ALYREF both contain UAP56-bonding motifs (UBMs), which are necessary for its interaction with UAP56. ...

CaaX motifs) or additional domains that are thought to operate in protein-protein or protein-membrane interactions. Some GBPs ... domains that resemble those found within the inflammasome-related proteins: Apoptosis-associated speck-like protein containing ... IPR003191 This article incorporates text from the public domain Pfam and InterPro: IPR015894 (Protein domains). ... terminal helical domain. In addition, some members of the GBPs family harbor motifs (e.g., ...

... the interaction of proline-rich motifs in signaling proteins with their cognate domains". FASEB Journal. 14 (2): 231-41. doi: ... tend to more frequently produce proteins that are involved in protein-protein interactions than many other general types of ... so the confidence of protein-protein interaction with PRP36 isn't very high. Phobius predicted protein location for human PRP36 ... STRING predicted protein interactions for human PRP36. PRP36 has medium scores for predicted interaction with two other ...

... the interaction of proline-rich motifs in signaling proteins with their cognate domains". FASEB Journal. 14 (2): 231-41. doi: ... Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene ... It has a proline rich C terminus and contains putative SH3 and WW domains. This C terminus is believed to be critical in its ... It contains an asparagine residue at position 51 which is important for its interactions with DNA base pairs. NOBOX is a ...

January 2008). "PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains". ... linear motifs or minimotifs are short stretches of protein sequence that mediate protein-protein interaction. The first ... Protein structural motifs, Protein domains, Short linear motifs). ... Linear motif mediated protein-protein interactions have shown promise in recent years as novel drug targets. Success stories ...

"A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. ... The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role ... 2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer". EMBO Rep. 5 (2): 189-94. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...

"A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. ... Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene. TNRC6B has been ... It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197-205. doi: ...

This domain recruits receptor-interacting protein (RIP1) and RIP3 through the RIP homotypic interaction motif. Cells deficient ... TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF ... Destruction of these motifs reduced the activation of NF-κB, a transcription factor that is also activated by the carboxy- ... TICAM1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short description ...

In addition, the ALP subfamily contains a specific 34 amino acid domain named the ALP-like motif, containing protein kinase C ... identification of a domain interaction between PDZ and spectrin-like repeat motifs". The Journal of Cell Biology. 139 (2): 507- ... Actin-associated LIM protein (ALP), also known as PDZ and LIM domain protein 3 is a protein that in humans is encoded by the ... "Protein sequence for human PDZ and LIM domain protein 3 (Uniprot: Q53GG5)". Cardiac Organellar Protein Atlas Knowledgebase ( ...

These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif. They dimerize with other HLH ... containing proteins through an HLH-HLH interaction. There are typically four vertebrate MRF paralogues which are homologous to ... Barndt R, Zhuang Y (1999). "Controlling lymphopoiesis with a combinatorial E-protein code". Cold Spring Harb Symp Quant Biol. ...

The WW domains interact with proline rich PPxY motifs in target proteins to mediate interactions with substrates and adaptors. ... 3-4 WW protein-protein interaction domains, and a carboxyl-terminal catalytic HECT ubiquitin ligase domain. The C2 domain ... In the case of NEDD4, viral proteins mimic the PPxY recognition motif of WW domains that are part of NEDD4. GRCh38: Ensembl ... The NDFIP1 and NDFIP2 proteins function as adaptor proteins that can facilitate NEDD4 binding to substrates that lack PY motifs ...

... the interaction of proline-rich motifs in signaling proteins with their cognate domains. The FASEB Journal. 2000, 14, 231-241. ... the Pin1 Domain protein is shown to the left as an example. Proteins that are β-sheet rich, also called WW domains, function by ... is a simple protein structural motif involving two beta strands that look like a hairpin. The motif consists of two strands ... The β-hairpin loop motif can be found in many macromolecular proteins. However, small and simple β-hairpins can exist on their ...

... asymmetric dimethylation of arginine residues in close proximity to proline-rich motifs can inhibit the binding to SH3 domains ... The arginine methylation of proteins can either inhibit or promote protein-protein interactions depending on the type of ... as with phosphorylated proteins, is the role this modification plays in the regulation of protein-protein interactions. ... The opposite effect is seen with interactions between the survival of motor neurons protein and the snRNP proteins SmD1, SmD3 ...

... protein-protein interactions, and signal transduction pathways. Zinc finger domain motifs aid in gene transcription, cell ... Myristoylation sites are found in the protein sequence 17 times, and a zinc finger domain motif occurs once. The presence of ... "MyHits Motif Scan". SIB MyHits. "Prediction of Coiled Coil Regions in Proteins". Prediction of Coiled Coil Regions in Proteins ... There are no charge runs, hydrophobic segments, or transmembrane domains. There are two different motifs present in ...

... motif and two proline-rich (PR) regions. The other protein interaction domains of Tec kinase include Src homology (SH) domains ... Tec kinase contains five protein interaction domains. The characteristic feature of Tec family kinases is a pleckstrin homology ... PH) domain on the N-terminus of the molecule followed by a Tec homology (TH) domain. The TH domain of Tec kinase contains a Btk ... TEC produces two protein isoforms that differ in the SH3 domain through alternative splicing. Type IV isoform has a full length ...

Most of cingulin protein interactions are through the globular head domain. Cingulin interacts with ZO-1 through an N-terminal ... ZO-1 interacting motif (ZIM) in its head region. The rod domain is involved in dimerization and interaction with the RhoA ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ... domain, a long α-helical coiled-coil "rod" domain and a small globular C-terminal "tail" region. This organization is highly ...

A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et ... Zinc finger protein 208 is a protein that in humans is encoded by the ZNF208 gene. Zinc finger proteins (ZNFs), such as ZNF208 ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. v t e ( ... Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. ...

These domains are one of the most common protein-protein interaction platforms in nature. They occur in a large number of ... ankyrin tandem repeats mediate protein-protein interactions and are among the most common structural motifs in known proteins. ... and involved mainly in mediating protein-protein interactions. An artificial protein design based on a consensus sequence ... Ankyrin repeat proteins, though absent in most viruses, are common among poxviruses. Most proteins that contain the motif have ...

... which can mediate interactions with other proteins. P1 motif is the most important among them, because it is crucial for ... CSK binds two prolin-rich motifs (P1 and P2) in the structure of PTPN22 through its SH3 domain and the P1 motif is more ... is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is ... Another interaction partner of the PTPN22 is TRAF3. This protein bind the PTPN22 and regulate its translocalization to a plasma ...

CAS proteins have an amino terminal SH3 domain enabling interaction with poly-proline motif-containing proteins such as FAK. ... which when tyrosine-phosphorylated allow interaction with SH2 domain containing proteins. Further to the carboxy-terminus, they ... this motif is conserved among the other three CAS family proteins and is an important binding site for the Src SH2 domain. ... Using a yeast two-hybrid approach, the CASS4 protein SH3 domain was shown to interact with the FAK C-terminus, despite the ...

Leucine-rich repeats are typically involved in protein-protein interactions, and form a characteristic α/β horseshoe fold. An ... In total, there are 4 conserved domains within LRRIQ3: 3 leucine-rich repeats and 1 IQ calmodulin-binding motif. ... "LRRIQ3 - Leucine-rich repeat and IQ domain-containing protein 3 - Homo sapiens (Human) - LRRIQ3 gene & protein". www.uniprot. ... Ren J, Wen L, Gao X, Jin C, Xue Y, Yao X (February 2009). "DOG 1.0: illustrator of protein domain structures". Cell Res. 19 (2 ...

Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. ... There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly ... belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 ... are actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins ...

Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. ... There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly ... a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling ... "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta". Biochem. J ...

Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. ... There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly ... "Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain". ... belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The ...

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. ... and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ... WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene. The globular WW domain is composed of 38 ... 2006). "WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and ...

The 119 amino-terminal cytoplasmic domain of LMP2A has several motifs that mediate interactions between proteins, including ... "The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases". Virology. ... Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein-Barr virus. LMP2A/LMP2B are ... The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as ...

"A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting ... Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene. IWS1 is ... Yoh SM, Cho H, Pickle L, Evans RM, Jones KA (Jan 2007). "The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA ... Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein ...

... residues of the core motif and additional arginine and lysine residues of the WRKY domain are responsible for interaction with ... The WRKY protein domain is 60 to 70 amino acids long type of DNA binding domain. The domain is characterized by a highly ... The WRKY protein domain is a globular shape composed of five anti-parallel β-strands. The core WRKYGQK motif is found on the ... Eighteen amino acids are highly conserved in the WRKY protein domain, including the core motif, zinc-finger binding cysteines ...

"A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting ... The 80 or so N-terminal residues form a protein interaction domain containing a conserved motif, which has been called the LW ... The N-terminal domain of MED26 is a protein fold known as a TFIIS N-terminal domain (or TND). It is a compact five-helix bundle ... This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which ...

The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. ... There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three- ... is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions". ... This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of ...

... with the characteristic GxGxxG motif present. The third domain, C-terminal, is responsible for the protein-membrane interaction ... The structure/fold from these proteins may be divided into three domains: first dinucleotide binding domain (green in the ... The third domain, together with part of the first domain, is also partially responsible for the binding of the electron ... figure), second dinucleotide binding domain (orange in the figure) and C-terminal domain (blue in the figure). The first domain ...

... and PXXP motifs represent potential sites of interaction for SH3 domain-containing proteins. Myopodin contains a novel actin ... Myopodin protein, also called Synaptopodin-2 is a protein that in humans is encoded by the SYNPO2 gene. Myopodin is expressed ... Myopodin contains one PPXY motif, multiple PXXP motifs, and two potential nuclear localization sequences (one N-terminal and ... "Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) -- Protein Information". heartproteome.org. "SYNPO2 - Synaptopodin-2 - ...

Linear motifs are short disordered segments of proteins that mediate functional interactions with other proteins or other ... Flexible linkers allow the connecting domains to freely twist and rotate to recruit their binding partners via protein domain ... for example Short Linear Motifs are over-represented in disordered proteins. Disordered proteins and short linear motifs are ... proteins or protein domains, relatively rapid and efficient refolding can be observed in vitro. As stated in Anfinsen's Dogma ...