Precursor B-cell lymphoblastic leukemia
... as designated leukemia/lymphoma. ALL is the most prevalent childhood malignancy, with precursor B-cell ALL (B-ALL) accounting ... Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white ... Precursor B-lymphoblastic leukemia entry in the public domain NCI Dictionary of Cancer Terms v t e v t e (Articles with short ... It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, ...
Acute leukemia
Types of T-cell acute lymphoblastic leukemia include adult T-cell leukemia/lymphoma and (precursor) T-lymphoblastic leukemia/ ... a rare form of which is acute erythroid leukemia. Acute lymphoblastic leukemia including T-cell acute lymphoblastic leukemia. ... T-lymphoblastic cells of acute leukemia in the bone marrow Acute erythroid leukemia, a rare form of acute myeloid leukemia ... Litzow, Mark R.; Ferrando, Adolfo A. (2015-08-13). "How I treat T-cell acute lymphoblastic leukemia in adults". Blood. 126 (7 ...
Brexucabtagene autoleucel
... is a cell-based gene therapy medication for the treatment of mantle cell lymphoma (MCL) and acute lymphoblastic leukemia (ALL ... It is also indicated for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia. ... Efficacy for adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia was evaluated in ZUMA-3 ( ... "FDA approves brexucabtagene autoleucel for relapsed or refractory B-cell precursor acute lymphoblastic leukemia". U.S. Food and ...
Acute lymphoblastic leukemia
"FDA approves brexucabtagene autoleucel for relapsed or refractory B-cell precursor acute lymphoblastic leukemia". U.S. Food and ... DeAngelo DJ, Pui C. Acute lymphoblastic leukemia and lymphoblastic lymphoma. Chapter 19 of American Society of Hematology Self- ... Because precursor B cell and precursor T cells look the same, immunophenotyping can help differentiate the subtype of ALL and ... Larson RA (2 January 2018). "Managing CNS disease in adults with acute lymphoblastic leukemia". Leukemia & Lymphoma. 59 (1): 3- ...
Biphenotypic acute leukaemia
"Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. ... "Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. ... the acute leukemia could be acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). According to the original EGIL ... Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to ...
List of cancer types
... tissue lymphoma Mycosis fungoides Nodal marginal zone B cell lymphoma Non-Hodgkin lymphoma Precursor B lymphoblastic leukemia ... cell lymphoma Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell ... leukemia Cutaneous T-cell lymphoma Diffuse large B-cell lymphoma Follicular lymphoma Hairy cell leukemia Hepatosplenic T-cell ... myeloid dendritic cell leukemia AIDS-related lymphoma Anaplastic large cell lymphoma Angioimmunoblastic T-cell lymphoma B-cell ...
Lymphoid leukemia
The most common T-cell leukemia is precursor T-cell lymphoblastic leukemia. It causes 15% of acute leukemias in childhood, and ... Other types include: Large granular lymphocytic leukemia Adult T-cell leukemia/lymphoma T-cell prolymphocytic leukemia In ... cell leukemia T-cell leukemia NK-cell leukemia The most common type of lymphoid leukemia is B-cell chronic lymphocytic leukemia ... Acute lymphoblastic leukemia, mature B-cell type 9833/3 - B-cell prolymphocytic leukemia 9940/3 - Hairy cell leukemia T-cell ...
B-cell leukemia
Precursor B lymphoblastic leukemia 9940/3 - Hairy cell leukemia T-cell leukemia B-cell lymphoma "B-Cell Leukemia (Concept Id: ... B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma 9826/3 - Acute lymphoblastic leukemia, mature B-cell type 9833/3 ... A B-cell leukemia is any of several types of lymphoid leukemia which affect B cells. Types include (with ICD-O code):[citation ...
B cell
... acute lymphoblastic leukemia (ALL), hairy cell leukemia, follicular lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, and ... Malignant transformation of B cells and their precursors can cause a host of cancers, including chronic lymphocytic leukemia ( ... B-2 cell FO B cells and MZ B cells. Follicular (FO) B cell (also known as a B-2 cell) Most common type of B cell and, when not ... T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a ...
Follicular lymphoma
... precursor B-cell lymphoblastic leukemia, plasmablastic lymphoma, the high grade subtype of B-cell lymphoma, Hodgkin lymphoma of ... the high grade subtype of B-cell lymphoma, Hodgkin lymphoma of the B-cell type, chronic lymphocytic leukemia/small cell ... or in rare cases exhibit the histology resembling precursor B-cell lymphoblastic leukemia, plasmablastic lymphoma, ... FL may be confused with marginal zone B-cell lymphoma, mantle cell lymphoma, and the small lymphocytic lymphoma variant of ...
CAR T cell
... present in B-cell-derived cancers such as acute lymphoblastic leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL). There ... marketed by Novartis originally for B-cell precursor acute lymphoblastic leukemia (B-ALL), and axicabtagene ciloleucel ( ... a protein expressed by normal B cells as well as B-cell leukemias and lymphomas, by investigators at the NCI, University of ... CAR T cells that target lymphoma cells), there are other potential uses for this technology. T cells can also mediate tolerance ...
John Theurer Cancer Center
... multiple myeloma and pediatric B-Cell precursor acute lymphoblastic leukemia: Yescarta, Tecartus (brexucabtagene autoleucel), ... Other areas of concentration include bone marrow transplants, stem cell transplantation, lymphoma, leukemia, multiple myeloma, ... "Dr Andre Goy on Predictive Biomarker Use for CAR T-Cell Therapy Response in Patients With Large B-Cell Lymphoma". AJMC. 12 ... Goy, Andre (2022-11-14). "Andre H. Goy, MD, on Unresolved Questions in Mantle Cell Lymphoma". Oncology. 36 (11): 651-653. " ...
Tisagenlecleucel
... is indicated for the treatment of those under 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is ... large B-cell lymphoma after two or more lines of systemic therapy including diffuse large B-cell lymphoma (DLBCL) not otherwise ... is a CAR T cells medication for the treatment of B-cell acute lymphoblastic leukemia (ALL) which uses the body's own T cells to ... The T cells are engineered to target a protein called CD19 that is common on B cells. A chimeric T cell receptor ("CAR-T") is ...
ETV6
... a wide range of acquired mutations in hematological precursor cells that lead to various types of leukemia and/or lymphoma. It ... chronic myelomonocytic leukemia, acute myelocytic leukemia, B cell acute lymphoblastic leukemia, mixed phenotype acute leukemia ... Sanchez-Martin M, Ferrando A (March 2017). "The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia". Blood. 129 (9 ... of adult T cell Acute lymphoblastic leukemia cases. These mutations involve insertions or deletions in the gene that lead to ...
Myeloproliferative neoplasm
... the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma. ... Chronic eosinophilic leukemia (not otherwise specified) MPN, unclassifiable (MPN-U) MPNs arise when precursor cells (blast ... Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or ... Chronic neutrophilic leukemia (CNL) is characterized by a mutation in the CSF3R gene and an exclusion of other causes of ...
Mir-17 microRNA precursor family
... of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia ... DNA sequencing of miR-17-92 cluster at chromosome 13q31-q32 in mantel cell lymphoma cell lines]". Zhongguo Shi Yan Xue Ye Xue ... amplification in human mantle cell lymphoma". Leuk Lymphoma. 48 (2): 410-2. doi:10.1080/10428190601059738. PMID 17325905. S2CID ... amplification in human mantle cell lymphoma". Leuk Lymphoma. 48 (2): 410-2. doi:10.1080/10428190601059738. PMID 17325905. S2CID ...
Inotuzumab ozogamicin
... is used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia. It is administered ... In May 2013, a phase III trial in patients with relapsed or refractory CD22+ aggressive non-Hodgkin lymphoma (NHL) who were not ... is an antibody-drug conjugate medication used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia ( ... and the FDA for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia ...
Mir-223
Hepatocellular carcinoma Chronic lymphocytic leukemia Acute lymphoblastic leukemia Acute myeloid leukemia gastric MALT lymphoma ... "Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and ... Page for mir-223 microRNA precursor family at Rfam (Articles with short description, Short description with empty Wikidata ... acute lymphoblastic leukemia, acute myeloid leukemia, gastric MALT lymphoma, and recurrent ovarian cancer. Integrative analysis ...
Clonal hypereosinophilia
B-cell lymphoma, T-cell lymphomas, T cell leukemias, and Langerhans cell histiocytosis. Other hematological diseases are ... Hematopoietic stem cells give rise to: 1) myeloid precursor cells that differentiate into red blood cells, mast cells, blood ... acute myelogenous leukemia, acute lymphoblastic leukemia, or T lymphoblastic lymphoma. These patients usually respond well to ... Such mutations occur in hematological stem cells and/or their daughter myeloid precursor and lymphoid precursor cells; commonly ...
Mir-19 microRNA precursor family
T-cell acute lymphoblastic leukemia * B-cell lymphomas * Cell lines * Cerebellum * Purkinje cells * HeLa cells Finally they ... MiR-19 is sufficient to induce T-cell lymphoblastic leukemia activating Notch1 and accelerate the disease. Its targets are: * ... which provides new clues for sustained activation of NF-kB in T-cell acute lymphoblastic leukemia. ... demonstrated that the expression of endogenous miR-17-92 is required to suppress apoptosis in Myc-driven B-cell lymphomas. More ...
CD79
However, tumor cells in some cases of T-lymphoblastic leukemia/lymphoma and AML has shown to potentially react positively with ... expressed by B-cell and plasma cell precursors is a candidate that induces apoptosis as well as inhibition of B-cell receptor ( ... "Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma". Nature. 463 (7277): 88-92. Bibcode:2010Natur.463 ... CD79 serves to be a pan-B cell marker for the detection of B-cell neoplasms. ...
Antibody-drug conjugate
"U.S. FDA Approves Inotuzumab Ozogamicin for Treatment of Patients with R/R B-cell precursor Acute Lymphoblastic Leukemia". ADC ... and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma". Nat ... "BESPONSA® Approved in the EU for Adult Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia". 30 ... monotherapy for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia ...
Adoptive cell transfer
... large-cell lymphomas, chronic lymphocytic leukemia and acute lymphoblastic leukemia. Toxicity against CD19 results in B cell ... though the expression of these molecules on normal precursors can lead to prolonged myeloablation. BCMA is a tumor necrosis ... Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... CD4+ T cells can also promote tumor rejection. CD4+ T cells enhance CD8+ T cell function and can directly destroy tumor cells. ...
Eosinophilia
... malignancy Acute lymphoblastic leukemia Chronic myelogenous leukemia Eosinophilic leukemia Clonal eosinophilia Hodgkin lymphoma ... Maintenance of these levels results from a balance between production of eosinophils by bone marrow eosinophil precursor cells ... In primary cutaneous T cell lymphoma, blood and dermal eosinophilia are often seen. Lymphoma cells have also been shown to ... chronic myelomonocytic leukemia, and certain cases of T-lymphoblastic leukemia/lymphoma-associated or myelodysplastic- ...
FIP1L1
... cell linages present with signs and symptoms respectively of acute myeloid leukemia or lymphoma T-lymphoblastic leukemia/ ... occurs in lymphoid precursor cells to promote the proliferation and differentiation of precursor cells along the lymphoid ... while occurring in myeloid precursor cells, promotes proliferation and differentiation of precursor cells along the neutrophil ... the success of Gleevec in treating the myeloproliferative neoplasm/myeloblastic leukemia or T-lymphoblastic leukemia/lymphoma ...
Mir-16 microRNA precursor family
Downregulation of miR16 (as well as miR15) was observed in diffuse large B-cell lymphoma. miR16 has been shown to bind to a ... "Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant ... Caligaris-Cappio F, Hamblin TJ (1999). "B-cell chronic lymphocytic leukemia: a bird of a different feather". J Clin Oncol. 17 ( ... "Accumulation of miR-155 and BIC RNA in human B-cell lymphoma". Proc Natl Acad Sci U S A. 102 (10): 3627-3632. doi:10.1073/pnas. ...
TRD (gene)
"Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells". ... "Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 gammadelta T cells in nasal T-cell lymphoma and chronic active ... positive childhood T-cell acute lymphoblastic leukemia". European Journal of Haematology. 77 (1): 27-34. doi:10.1111/j.0902- ... "Entrez Gene: TRD@ T cell receptor delta locus". Chien YH, Iwashima M, Kaplan KB, Elliott JF, Davis MM (1987). "A new T-cell ...
List of gene therapies
"FDA approves brexucabtagene autoleucel for relapsed or refractory B-cell precursor acute lymphoblastic leukemia". U.S. Food and ... treatment for mantle cell lymphoma and acute lymphoblastic leukemia Cambiogenplasmid (Neovasculgen): treatment for vascular ... treatment for B cell lymphoblastic leukemia Valoctocogene roxaparvovec (Roctavian): treatment for hemophilia A Voretigene ... "FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma". U.S. Food and Drug Administration ...
Patrick A. Baeuerle
... which is approved by the US FDA for treatment of relapsed/refractory acute lymphoblastic leukemia. He has invented various ... "Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor". Cell. 53 (2): 211 ... Perkel, Jeffrey (14 August 2008). "New Lymphoma Drug Shows Promise". Washington Post. "TCR2 Therapeutics Unveils New Cancer ... University of Konstanz Max-Planck Institute of Molecular Cell Biology and Genetics Max-Planck Institute for Neurobiology EMBL ...
Sialyl-Lewis X
... some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. CD15 is ... The presence of these cells is diagnostic of Hodgkin's lymphoma. Reed-Sternberg cells display a characteristic pattern of ... and ST3GAL6 participate in the synthesis of the Sialyl-Lewis X precursor. Sialyl-Lewisx is important in leukocyte tethering and ... It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which an egg attracts sperm; ...
Lymphoma
... cell lymphoma Precursor lymphoid neoplasms B-lymphoblastic leukemia/lymphoma not otherwise specified B-lymphoblastic leukemia/ ... T-cell large granular lymphocyte leukemia Aggressive NK cell leukemia Adult T-cell leukemia/lymphoma Extranodal NK/T-cell ... large B-cell lymphoma ALK+ large B-cell lymphoma Plasmablastic lymphoma Primary effusion lymphoma Large B-cell lymphoma arising ... lymphoma, nasal type Enteropathy-associated T-cell lymphoma Hepatosplenic T-cell lymphoma Blastic NK cell lymphoma Mycosis ...