Platelet membrane glycoprotein
Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. The Journal of Biological Chemistry ... Platelet membrane glycoproteins Platelet+membrane+glycoproteins at the U.S. National Library of Medicine Medical Subject ... Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis ... platelet membrane glycoproteins interact with the extracellular matrix. Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV ...
Arginylglycylaspartic acid
Pytela, R.; Pierschbacher, M. D.; Ginsberg, M. H.; Plow, E. F.; Ruoslahti, E. (1986-03-28). "Platelet membrane glycoprotein IIb ... These drugs block activation of the integrin responsible for aggregation of platelets (αIIbβ3, also known as glycoprotein IIb/ ... King, Shawn; Short, Marintha; Harmon, Cassidy (2016-03-01). "Glycoprotein IIb/IIIa inhibitors: The resurgence of tirofiban". ... "Chemical structures and mode of action of intravenous glycoprotein IIb/IIIa receptor blockers: A review". Experimental & ...
Abciximab
... is made from the Fab fragments of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane. ... EPIC Investigators (April 1994). "Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in ... It is a glycoprotein IIb/IIIa inhibitor. While abciximab has a short plasma half-life, due to its strong affinity for its ... Abciximab, a glycoprotein IIb/IIIa receptor antagonist manufactured by Janssen Biologics BV and distributed by Eli Lilly under ...
List of MeSH codes (D23)
... platelet membrane glycoprotein iib MeSH D23.050.301.264.035.590 - proto-oncogene proteins c-kit MeSH D23.050.301.264.035.595 - ... platelet membrane glycoprotein iib MeSH D23.101.100.110.590 - proto-oncogene proteins c-kit MeSH D23.101.100.110.595 - receptor ... lysosomal-associated membrane protein 1 MeSH D23.050.301.264.035.531 - lysosomal-associated membrane protein 2 MeSH D23.050. ... lysosomal-associated membrane protein 1 MeSH D23.101.100.110.531 - lysosomal-associated membrane protein 2 MeSH D23.101.100.110 ...
Thromboxane
Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of ... Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets ... If the cap of a vulnerable plaque erodes or ruptures, as in myocardial infarction, platelets stick to the damaged lining of the ... The mechanism of secretion of thromboxanes from platelets is still unclear. They act in the formation of blood clots and reduce ...
Coagulation
... activate platelets in the bloodstream, leading to attachment of platelets' membrane receptors (e.g. glycoprotein IIb/IIIa) to ... Activation of platelets and platelet plug formation: Platelet activation: Platelet activators, such as platelet activating ... and the fibrinogen cross-links with glycoprotein IIb/IIIa aid in aggregation of adjacent platelets, forming a platelet plug and ... Charo, I. F.; Bekeart, L. S.; Phillips, D. R. (25 July 1987). "Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial ...
List of MeSH codes (D12.776.543)
... platelet membrane glycoprotein iib MeSH D12.776.543.750.705.408.200 - integrin beta chains MeSH D12.776.543.750.705.408.200.249 ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.750.705.675.784 - platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.785 - platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.800.790 - receptor, par-1 MeSH D12.776.543.550.625.800.800 - ...
Integrin alpha 2b
"Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". Kato, Atsushi; Kawamata ... Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes ... Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): ... Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary ...
Integrin alpha 5
... localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and ... Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ...
Antiphospholipid syndrome
A low platelet count and positivity for antibodies against β2-glycoprotein 1 or phosphatidylserine may also be observed in a ... lupus anticoagulant present alone IIb: anti-cardiolipin IgG and/or IgM present alone in medium or high titers IIc: anti-β2 ... react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common ... The use of testing for antibodies specific for individual targets of aPL such as β2 glycoprotein 1 and phosphatidylserine is ...
Integrin beta 3
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): ... The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. ... Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as ... localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and ...
Integrin alpha V
... localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and ... ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a ... Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends ...
Disintegrin
... sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of ... ADAM7 (Mammalian epididymial apical protein 1, EAP I). ADAM7 is associated with the sperm membrane and may play a role in sperm ... fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting ... serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in ...
Catch bond
"Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF". Journal of ... Coated outside the membrane of leukocytes are microvilli, which have various types of adhesive molecules, including P-selectin ... and integrin alpha IIb beta 3 with fibronectin or fibrinogen. Sivasankar and his research team have found that the mechanism ... platelet glycoprotein Ib and von Willebrand factor, and integrin alpha 5 beta 1 and fibronectin. Emphasizing their importance ...
Glycoprotein
... glycoprotein IIb/IIIa, an integrin found on platelets that is required for normal platelet aggregation and adherence to the ... Glycoproteins are also often important integral membrane proteins, where they play a role in cell-cell interactions. It is ... Glycoprotein-41 (gp41) and glycoprotein-120 (gp120) are HIV viral coat proteins. Soluble glycoproteins often show a high ... The two most common linkages in glycoproteins are N-linked and O-linked glycoproteins. An N-linked glycoprotein has glycan ...
Glanzmann's thrombasthenia
... in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for ... "Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membrane". Nature. 257 (5527): 599-600. ... formerly known as glycoprotein IIb/IIIa (GpIIb/IIIa), which is an integrin aggregation receptor on platelets. This receptor is ... Nurden AT,Caen JP (1974). "An abnormal platelet glycoprotein pattern in three cases of Glanzmann's thrombasthenia". British ...
Vitamin B6
Also, PLP influences expression of glycoprotein IIb by interacting with various transcription factors; the result is inhibition ... "Vitamin B6 is a nutrient that helps produce energy from protein and helps maintain healthy skin and mucous membranes." In 2010 ... of platelet aggregation. Plant synthesis of vitamin B6 contributes to protection from sunlight. Ultraviolet-B radiation (UV-B) ...
Outline of immunology
Beta subunits B1 B2 B3 B4 B5 B6 B7 B8 Dimers Cytoadhesin receptor Integrin alpha6beta4 Glycoprotein IIb/IIIa - Heterodimer: ... Pattern recognition receptor Membrane-bound PRRs Toll-like receptors (TLRs) TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TLR10 ... Platelets) Erythropoiesis Proerythroblast Normoblast Reticulocyte CFU-Mast Mast cell precursors B cells Antigen receptor - B ... C5a C3-convertase C5-convertase Late stage Membrane attack complex (MAC) C6 C7 C8 C9 Complement pathway inhibitors C1-inhibitor ...
Plasma gelsolin
A 2020 Phase IIb placebo-controlled efficacy study has been approved for acute severe pneumonia due to COVID-19. The primary ... PIP2, a phospholipid component of cell membranes, competes with ATP and actin for pGSN binding, and will dissociate F-Actin- ... Scarborough, Victoria D.; Bradford, Harvey R.; Ganguly, Pankaj (1981-06-16). "Aggregation of platelets by muscle actin. A ... "Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin". Journal of Cellular and Molecular ...
Immunoglobulin E
July 2014). "Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production ... Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans. There are two types of Fcε ... An anti-M1' humanized antibody, quilizumab, is in phase IIb clinical trial. In 2002, researchers at the Randall Division of ... Glycoproteins, Antibodies). ... platelets, and some T cells. The IgE isotype has co-evolved ...
Preclinical imaging
... microbubbles can be conjugated to markers such as activated glycoprotein IIb/IIIa (GPIIb/IIIa) receptors on platelets and clots ... Deng CX, Sieling F, Pan H, Cui J (April 2004). "Ultrasound-induced cell membrane porosity". Ultrasound in Medicine & Biology. ... to allow for imaging of single cells and localizing cellular location on the cell membrane, endosomes, cytoplasm, or nuclei ( ...
List of OMIM disorder codes
PAI1 Platelet disorder, familial, with associated myeloid malignancy; 601399; RUNX1 Platelet glycoprotein IV deficiency; 608404 ... type IIB; 608634; HSPB1 Neuropathy, distal hereditary motor, type V; 600794; BSCL2 Neuropathy, distal hereditary motor, type V ... epithelial basement membrane; 121820; TGFBI Corneal dystrophy, Fuchs endothelial, 1; 136800; COL8A2 Corneal dystrophy, Fuchs ... type IIb; 606056; GCS1 Congenital disorder of glycosylation type IIc; 266265; SLC35C1 Congenital disorder of glycosylation, ...