Platelet factor 4
Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ... Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif ... "Entrez Gene: PF4 platelet factor 4 (chemokine (C-X-C motif) ligand 4)". Lasagni L, Francalanci M, Annunziato F, Lazzeri E, ... Platelet+factor+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
CXCL7
1988). "Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human ... 1986). "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta- ... Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992). "Genes for beta-thromboglobulin and platelet factor 4 are closely linked and ... Comparison with the gene for platelet factor 4". J Biol Chem. 266 (9): 5785-9. doi:10.1016/S0021-9258(19)67665-9. PMID 1826003 ...
Linda Holloway
McLaren, Kathryn M.; Holloway, Linda; Pepper, Duncan S. (1980). "Human platelet factor 4 and tissue mast cells". Thrombosis ... 43 (4): 39. Retrieved 15 July 2019. Rudd, Allison (1 August 2009). "All but two from Otago opt for titles". Otago Daily Times ... doi:10.1016/0049-3848(80)90431-4. ISSN 0049-3848. PMID 6449755. Bethwaite, Peter; Yeong, Mee Ling; Holloway, Linda; Robson, ...
Helge Stormorken
Day, HJ; Stormorken, H; Holmsen, H (1973). "Subcellular localization of platelet factor 3 and platelet factor 4". Scandinavian ... lack of platelet aggregatory response to adrenaline and lack of secondary aggregation to ADP and platelet activating factor ( ... Gogstad, GO; Stormorken, H; Solum, NO (15 July 1983). "Platelet alpha 2-antiplasmin is located in the platelet alpha-granules ... "Characterization of a factor VII molecule carrying a mutation in the second epidermal growth factor-like domain". Thrombosis ...
Protein C
... may be up-regulated by platelet factor 4. This cytokine is conjectured to improve activation of protein C by forming ... Factor VIIIa augments Factor X activation by a factor of around 200,000. Because of its importance in clotting, Factor VIII is ... It acts as a serine protease zymogen: APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor Va and Factor ... Factor VII, Factor IX and Factor X.: 1215 Protein C synthesis occurs in the liver and begins with a single-chain precursor ...
Embolic and thrombotic events after COVID-19 vaccination
June 2021). "Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination". N Engl J Med. 384 (23): 2202-11. ... an antibody against platelet factor 4 has been identified. This phenomenon is mostly encountered in some people who have been ... the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance". Blood. 109 (7): 2832-2839. doi: ... which includes a platelet count) as the initial investigation. If the platelet count is decreased, determination of the D-dimer ...
Β-Thromboglobulin
It is a type of chemokine (C-X-C motif) ligand 7. Along with platelet factor 4 (PF4), β-TG is one of the best-characterized ... Kaplan KL, Owen J (February 1981). "Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet ... Cella G, Scattolo N, Girolami A, Sasahara AA (1984). "Are platelet factor 4 and beta-thromboglobulin markers of cardiovascular ... β-TG and PF4 are stored in platelet alpha granules and are released during platelet activation. As a result, they are useful ...
Neurobiological effects of physical exercise
"Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged ... In 2023 platelet factor 4 (FF4) has been proposed as an exerkine. Sibley and Etnier (2003) performed a meta-analysis that ... and brain-derived neurotrophic factor (BDNF). These factors play crucial roles in promoting cellular survival, neuroprotection ... July 2020). "Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain". Science. ...
Platelet-derived growth factor
VEGFD Platelet-activating factor Platelet-derived growth factor receptor atheroma platelet involvement in smooth muscle ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... "Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family". Biochemical and ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ...
Duffy antigen system
The binding of platelet factor 4 (CXCL4) appears to be critical for the platelet induced killing of P. falciparum. The Duffy ... CXCL1 Platelet factor 4 - CXCL4 ENA-78 - CXCL5 Neutrophil activating peptide-2 (NAP-2) - CXCL7 Interleukin-8 (IL-8) - CXCL8 ... "Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum". Science. 338 (6112): 1348-51. ... "Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum". Science. 338 (6112): 1348-51. ...
Apafant
Kato M, Imoto K, Miyake H, Oda T, Miyaji S, Nakamura M (August 2004). "Apafant, a potent platelet-activating factor antagonist ... is a drug which acts as a potent and selective inhibitor of the phospholipid mediator platelet-activating factor (PAF). It was ... pharmacokinetics and safety profile of the new platelet-activating factor antagonist apafant in man". Arzneimittel-Forschung. ... 95 (4): 435-442. doi:10.1254/jphs.fp0040265. PMID 15286429. S2CID 34872524. v t e (Articles with short description, Short ...
Platelet-activating factor
... receptor Platelet-derived growth factor Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM (May ... Platelet Activating Factor) Platelet+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH ... cytoplasmic platelet-activating factor acetylhydrolase 2, and platelet-activating factor acetylhydrolase 1b. Cations are one ... an enzyme that catabolizes platelet-activating factor. It is an important mediator of bronchoconstriction. It causes platelets ...
Platelet-activating factor receptor
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is ... "Entrez Gene: PTAFR platelet-activating factor receptor". Correa-Costa M (Apr 2014). "Activation of platelet-activating factor ... Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl- ... platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article ...
Platelet
Platelets also secrete platelet-derived growth factor (PDGF). Platelets modulate neutrophils by forming platelet-leukocyte ... platelet-derived epidermal growth factor, and vascular endothelial growth factor. Local application of these factors in ... "Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in ... The platelets from rats were conclusively shown to express tissue factor protein and also it was proved that the rat platelets ...
Platelet-derived growth factor receptor
"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B (March 1992). "Platelet-derived growth factor: ...
MEIS1
"Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12 ... Wang Y, Yin L, Hillgartner FB (Jun 2001). "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid ... "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding ... Transcription factors, All stub articles, Human chromosome 2 gene stubs). ...
PBX2
"Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12 ... Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene. This gene encodes a ... 19 (4): 3051-61. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572. Monica K, Galili N, Nourse J, Saltman D, Cleary ML (Dec ... 19 (4): 3051-61. doi:10.1128/MCB.19.4.3051. PMC 84099. PMID 10082572. Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, ...
Coagulation activation marker
Markers of platelet activation (primary hemostasis) include platelet factor 4 (PF4), β-thromboglobulin (β-TG), and P-selectin. ... Gurney D, Lip GY, Blann AD (June 2002). "A reliable plasma marker of platelet activation: does it exist?". Am J Hematol. 70 (2 ... 33 (4): 333-42. doi:10.1111/j.1751-553X.2011.01345.x. PMID 21692994. S2CID 30451755. Kyrle PA, Rosendaal FR, Eichinger S ( ... 30 (4): 459-71. doi:10.1007/s11239-010-0460-x. PMID 20213258. S2CID 23806848. Merlini PA, Ardissino D (1995). "Laboratory ...
CXCL5
2001). "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene ... Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". ... "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets". Gene. 151 (1-2): 333-4. ... It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. ...
CXCL9
Farber JM (July 1990). "A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 ... and acts as functional receptor for platelet factor 4". The Journal of Experimental Medicine. 197 (11): 1537-49. doi:10.1084/ ... 81 (3-4): 271-2. doi:10.1159/000015043. PMID 9730616. S2CID 46846304. Jenh CH, Cox MA, Kaminski H, Zhang M, Byrnes H, Fine J, ... 74 (4): 255-8. doi:10.1159/000134428. PMID 8976378. O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC ...
Syndecan-2
Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by ... Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor ... Lyon M, Deakin JA, Mizuno K, Nakamura T, Gallagher JT (1994). "Interaction of hepatocyte growth factor with heparan sulfate. ... "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Soussi-Yanicostas N, ...
Migrainous infarction
Administration of aspirin in patients with MA has been shown to be effective in reducing platelet factor 4 (PF4) concentration ... Zeller, J. A.; Frahm, K.; Baron, R.; Stingele, R.; Deuschl, G. (2004-07-01). "Platelet-leukocyte interaction and platelet ... Additionally, platelet activation is enhanced in patients with MA, even during aura-free and headache-free periods. Moreover, ... Enhanced platelet activation during MA has been observed which directly increases the risk of developing thrombosis. ...
TIAL1
1997). "An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene". Biochem ... Involvement of divergent RNA-binding factors HuR, KSRP and TIAR". Int. J. Cancer. 113 (6): 911-9. doi:10.1002/ijc.20675. PMID ...
Leonard R. Stephens
Hawkins, P.T.; Jackson, T.R.; Stephens, L.R. (1992). "Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by ... Later, they showed that PtdIns(3,4,5)P3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore ... Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of ... They - in parallel with Dario Alessi - identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link ...
CD32
... A is also linked to autoimmunity; for example, the production of antibodies against platelet factor 4 (PF4) bound to CD32A ... CD32A is an activating subtype of CD32 that can be found on a variety of immune cells - notably, CD32A is found on platelets, ... CD32A also plays an important role in platelet activation, adhesion, and aggregation in response to injured blood vessels. When ... Hamzeh-Cognasse H, Damien P, Chabert A, Pozzetto B, Cognasse F, Garraud O (2015-02-26). "Platelets and infections - complex ...
Fibrin scaffold
... platelet-rich fibrin gels are ideal since they have a high concentration of platelet releasing growth factors and bioactive ... transforming growth factor beta 1, transforming growth factor beta 2, nerve growth factor, brain derived neurotrophic factor ... Another study to assess if fibrin glue enriched with platelet is better than just platelet rich plasma (PRP) on bone formation ... neural cell adhesion molecule and platelet factor 4, respectively. Heparin-binding growth factors can be attached to heparin ...
Granule (cell biology)
... platelet factor 4 [PF4] and fibrinogen). Proteomic studies have identified more than 300 soluble proteins that are involved in ... Other platelet granules have been described. Platelets contain about 1-3 lysosomes per platelet and peroxisomes, the platelet- ... α-Granules are unique to platelets and are the most abundant of the platelet granules, numbering 50-80 per platelet 2. These ... Dense granules (also known as δ-granules) are the second most abundant platelet granules, with 3-8 per platelet. They measure ...
Interleukin 8
... resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily". Hum. Genet. 84 (2): 185- ... "Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an ... IL-8 has also been implied to have a role in colorectal cancer by acting as an autocrine growth factor for colon carcinoma cell ... IL-8 and other inflammatory cytokines form a vicious cycle with the transcription factor NF-κB in cystic fibrosis. NF-κB ...
Interleukin
... resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily". Hum. Genet. 84 (2): 185- ... T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, ... These include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis ... Schindler R, Dinarello CA (1990). "Interleukin 1". In Habenicht A (ed.). Growth Factors, Differentiation Factors, and Cytokines ...
Discovery and development of direct thrombin inhibitors
Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets, ... which results from a platelet-activating immune response triggered by the interaction of heparin with platelet factor 4 (PF4). ... factor VII comes into contact with tissue factors which starts a process called the blood coagulation cascade. Its purpose is ... Most of those drugs are in the class of direct factor Xa inhibitors, but there is one DTI called AZD0837, which is a follow-up ...