... activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. ... Calcineurin induces transcription factors (NFATs) that are important in the transcription of IL-2 genes. IL-2 activates T- ... Shibasaki F, Kondo E, Akagi T, McKeon F (1997). "Suppression of signalling through transcription factor NF-AT by interactions ... The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, ...
"Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". ... Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology ... where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role ... "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun". Nature. 365 (6444): 352- ...
"Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". ... Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune ... Kinoshita S, Su L, Amano M, Timmerman LA, Kaneshima H, Nolan GP (Mar 1997). "The T cell activation factor NF-ATc positively ... The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This ...
shows that some of the phenotypes associated with Down syndrome can be related to the disregulation of transcription factors ( ... preventing NFATc from activating the transcription of target genes and thus the production of certain proteins (Epstein 583). ... "Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts". Mutat. Res. 780: 15- ...
The product of this gene is a member of the nuclear factors of activated T cells (NFAT) family of transcription factors. ... Subsequent analysis revealed that NFAT5 is a member of the Rel family, which also consists of NF-κB and NFATc proteins. The ... Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription ... 2000). "Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 ...
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 352(3668): 803-807, 1991. ... calcineurin preventing the entry of the NFATc proteins into the nucleus. NFAT proteins activate a large group of genes ... in the human genome and to discover the HNF1 transcription factor. In 1982 Crabtree discovered that one gene could produce more ... BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature. 366( ...
... sensitive factor that regulates the transcription of various cytokines. The upregulated expression of specific cytokine genes ... NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding". The Journal of Experimental Medicine. 182 ... Furthermore, targeting extrinsic factors such as FasL or TRAIL to the tumor cell surface triggers death receptors, inducing ... This CD16-induced expression of cytokine mRNA in NK cells is mediated by the nuclear factor of activated T cells (NFATp), a ...
Kinoshita, S.; Su, Lu; Amano, M.; Timmerman, L.A.; Kanesima, H.; Nolan, G.P. (1997). "The T cell activation factor NF-ATc ... He also developed cloning of the RELA transcription factor, a key regulator in immune response genes and a principal cellular ... proof that the NFAT transcription factor is both a REL protein and a key determinant in HIV replication, and development of ... NF-AT components define a family of transcription factors targeted in T-cell activation (1994) Episomal vectors rapidly and ...