Yang X, Gabuzda D (November 1998). "Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein". The ... Vif1 is a 23-kilodalton protein that is essential for viral replication. Vif1 inhibits the cellular protein, APOBEC3G, from ... Vif1 seems to reduce the amount of A3 proteins (including A3D/G/F) packaged in the virion, and to slow down the action of any ... vif+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short description, Short ...

"MAP2K1 mitogen-activated protein kinase kinase 1 [Homo sapiens (human)] - Gene - NCBI". Lones MA, Raphael M, McCarthy K, ... encoding a guanylate kinase which interacts with BCL10 and activates NF-κB to regulate cell survival); 2) changes in the ... that is involved in activating T-cells), CDKN2A (encoding p16INK4a and p14arf tumor suppressor proteins) or CDKN2B (encoding ... Phosphoinositide 3-kinase inhibitors such as copanlisib, duvelisib, and idelalisib which block the phosphoinositide 3-kinase ...

"MAP2K1 mitogen-activated protein kinase kinase 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Lovisa F, Binatti ... which encodes mitogen-activated protein kinase kinase 1, an enzyme which activates the MAPK/ERK cell signaling pathway that ... alpha-induced protein 3. This protein functions to inhibit the activation of NF-κB, to block programmed cell death, and to ... which encodes the interferon regulatory factor 8 protein, a protein that contributes to the maturation and function of B-cells ...

"Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1". Colicelli J, Nicolette C, Birchmeier C, et al. ( ... This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively ... Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...

Phosphorylation is mediated by Lyn, a protein tyrosine kinase (PTK) of the Src family found in lipid rafts. After CD22 is ... Such ligands are commonly expressed on the surface of erythrocytes, monocytes, cytokine-activated endothelial cells, T cells ... the ITAM motifs provide docking sites for the SH2 domain of Lyn or other Syk kinase or Src-family tyrosine kinases. Thus, CD22 ... CD22 is a transmembrane protein with a molecular weight of 140 kDa. The extracellular part of CD22 consists of seven ...

... is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene ... "The JIP group of mitogen-activated protein kinase scaffold proteins". Molecular and Cellular Biology. 19 (10): 7245-54. doi: ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Molecular and Cellular ... "Entrez Gene: MAPK9 mitogen-activated protein kinase 9". Saleem A, Datta R, Yuan ZM, Kharbanda S, Kufe D (Dec 1995). " ...

Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... MAP Kinase Resource . Table of names for mitogen-activated kinases. MAPK cascade picture Mitogen-Activated+Protein+Kinases at ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ... Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated protein kinases (p38s) ...

Hutter D, Chen P, Barnes J, Liu Y (Nov 2000). "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by ... and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its ... "Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma". International Journal ... "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual ...

"Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1 ... Non-histone proteins such as transcription factors are also targets for acetylation with varying functional effects. ... through modulating the acetylation/deacetylation of histones and/or non-histone proteins such as transcription factors. Histone ... 23 (1): 66-84. doi:10.1089/ars.2014.5863. PMC 4492771. PMID 24512308. Gryder BE, Rood MK, Johnson KA, Patil V, Raftery ED, Yao ...

"Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete ... Wu, J. J.; Zhang, L.; Bennett, A. M. (16 May 2005). "The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase ... Wu, J. J.; Zhang, L.; Bennett, A. M. (16 May 2005). "The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase ... Camps, M. (22 May 1998). "Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase". Science. 280 ...

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene. The ... "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1". Wunderlich W, Fialka I, Teis D, Alpi A ... "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal ... "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal ...

Zheng Q, Yin G, Yan C, Cavet M, Berk BC (March 2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) ... 14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene. This gene encodes a protein belonging to ... Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ... "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem ...

"Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)". The EMBO ... including glycogen-synthase kinase-3β (GSK3β), AKT/phosphatidylinositol 3-kinase (PI3K) and NF-κB activating kinase (NAK, i.e. ... On the other hand, mitogen and stress-activated kinase 1 (MSK1) are also able to phosphorylate RELA at residue 276 under TNFα ... Phosphorylation of serine 311 by protein kinase C zeta type (PKCζ) serves the same purpose. Two residues in the TAD region are ...

This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the ... "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases". The ... Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 ... "Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein". The ...

... particularly to the activity of mitogen-activated protein kinase kinase-1 (MEK1). Studies have demonstrated that inhibition of ... "SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells". Cellular ... The expression of SMAD3 has been related to the mitogen-activated protein kinase (MAPK/ERK pathway), ... The SMAD proteins are homologs of both the Drosophila protein "mothers against decapentaplegic" (MAD) and the C. elegans ...

... are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress ... p38+Mitogen-Activated+Protein+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) P38mapkPathway ... MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to ... a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". The Journal of ...

... mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272-9. doi:10.1074/jbc.271.19.11272 ... mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272-9. doi:10.1074/jbc.271.19.11272 ... "GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin ... "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1". Schiaffino MV, ...

... and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase ... Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on ... "Entrez Gene: MAP3K3 mitogen-activated protein kinase kinase kinase 3". Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, ... "BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3". ...

... coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". ... Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly ... Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat ... 1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157-67. doi ...

"Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ... "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes ... and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746-55. doi:10.1038/sj.onc.1206185. PMID 12569367. S2CID ... ETV1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ...

... a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1 and MEK ... Mitogen-activated protein kinase kinases (MAP2Ks) are substrates for direct phosphorylation by the MAP3K1 protein kinase. The ... Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the ... "MAP3K1 mitogen-activated protein kinase kinase kinase 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved ...

... mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272-9. doi:10.1074/jbc.271.19.11272 ... mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272-9. doi:10.1074/jbc.271.19.11272 ... a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly ... a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly ...

"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909-20. doi:10.1093/ ... "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine ... "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal ...

... family of proteins that regulate growth factor-induced activation of the MAP kinase cascade. GRCh38: Ensembl release 89: ... Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 ... kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543-51. doi:10.1074/jbc.M405189200 ... "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical ...

The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. ... Human proteins, Proteins, Hematopathology, Neuro-cardio-facial-cutaneous syndromes). ... Sprouty-related, EVH1 domain-containing protein 1 (Spread-1) is a protein that in humans is encoded by the SPRED1 gene located ... This mutation may result in a truncated nonfunctional protein. Blast cells analysis displayed the same abnormality as germline ...

"The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". The EMBO Journal. 16 (8): 1909-1920. ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". The EMBO Journal. 16 (8): 1909-1920. ... "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Molecular and ...

... is also known as MEK1 (see Mitogen-activated protein kinase kinase). MEK1 is a meiotic chromosome-axis-associated kinase ... The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mitogen-activated ... Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. ... "Entrez Gene: MAP2K1 mitogen-activated protein kinase kinase 1". "MAP2K1 - My Cancer Genome". Goldfarb T, Lichten M (2010). " ...

"Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast ... a MNK kinase inhibitor for blood cancers and a PORCN inhibitor for solid tumours. Other molecules discovered by his group have ... "Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and ... 67 (1): 8-18. doi:10.1006/geno.2000.6226. ISSN 0888-7543. PMID 10945465. Lee, Bernett T.K.; Song, Chun Meng; Yeo, Boon Huat; ...

"Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress ... Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B (2004). "Programmed Cell Death Protein 4 (PDCD4) Acts As a ...

"Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1". Yasuda, J; Whitmarsh A J; Cavanagh J; Sharma M ... 2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/ ... "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ... "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): ...

This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This ... Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is ... Nemoto S, DiDonato JA, Lin A (1998). "Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 ... "Entrez Gene: MAP3K14 mitogen-activated protein ki kinase kinase 14". Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E (May ...