Genetically modified mice are the most common genetically engineered animal model. They have been used to study and model ... Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M (June 2010). "20 years of gene therapy for SCID". Nature Immunology. 11 (6): ... Rudolf Jaenisch created the first GM animal when he inserted foreign DNA into a mouse in 1974. The first company to focus on ... Mouse hybridomas, cells fused together to create monoclonal antibodies, have been adapted through genetic engineering to create ...

Spontaneous Pneumocystis carinii pneumonia in immunodeficient mutant scid mice. Natural history and pathobiology. American ... "Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice". Journal ... The fungus is transmitted between mice via inhalation or through the shedding of P. murina from one host to another. It serves ... P. murina is particularly notable for its exclusive infection of laboratory mice and its role as an important model for ...

Moreover, SCID mice and Mongolian gerbil can be experimentally infected. The life cycle is basically similar to those of other ...

Myles MH, Livingston RS, Franklin CL (October 2004). "Pathogenicity of Helicobacter rodentium in A/JCr and SCID mice". ... Its type strain is MIT 95-1707 (= ATCC 700285). Its name refers to the species first being isolated from mice. Shen, Z.; Fox, J ... Feng, S.; Ku, K.; Hodzic, E.; Lorenzana, E.; Freet, K.; Barthold, S. W. (2005). "Differential Detection of Five Mouse-Infecting ... nov., a Urease-Negative Helicobacter Species Isolated from Laboratory Mice". International Journal of Systematic Bacteriology. ...

"bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice". Janssen. February 1, 1998. Retrieved 24 November 2019. " ... "Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections". Science ...

SCID chimeric mice.". 28th Cologne workshop on Dope Analysis (Manfred Donike workshop). Vol. 18. pp. 52-61. "World Anti-Doping ...

"Biological half-life of normal and truncated human IgG3 in scid mice". Eur J Immunol. 21 (5): 1319-22. doi:10.1002/eji. ...

The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson ... 2008). "A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in ... Fulop, GM; Phillips, RA (1990). "The Scid Mutation in Mice Causes a General Defect in DNA Repair". Nature. 347 (6292): 479-482 ... NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells. NSG branded mice are also deficient in multiple ...

"Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora". Infection and Immunity. 65 (11): 4858- ... 2000]. H. rappini has also been isolated from the feces of healthy people, dogs, and mice, as well as from patients with ... Like Helicobacter hepaticus, it colonizes the bile, liver, and intestine of mice, and is associated with multifocal chronic ... nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice". Journal of Clinical ...

"High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid ... "A cell initiating human acute myeloid leukaemia after transplantation into SCID mice". Nature. 367 (6464): 645-648. Bibcode: ... Mouse models of breast cancer metastasis Marusyk, A; Polyak, K (2010). "Tumor heterogeneity: Causes and consequences". ...

Dick developed an in vivo repopulation assay using the NOD/SCID mouse. This technique of using an immune-deficient mouse to ... "Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene ... "A cell initiating human acute myeloid leukaemia after transplantation into SCID mice". Nature. 367 (6464): 645-8. Bibcode: ... Dick is also known for his demonstration of a blood stem cell's ability to replenish the blood system of a mouse, his ...

1980 Discovery of the SCID mouse, a mouse strain with no natural immunity, by Melvin Bosma. The SCID mouse is an essential ... 1981 Beatrice Mintz's laboratory is one of the first to introduce a cloned gene into fertilized mouse eggs and prove that it is ... 1979 Beatrice Mintz shows that a fatal genetic anemia of mice can be prevented in utero by injecting normal blood-forming stem ... 1993 Beatrice Mintz produces the first mouse model of human malignant melanoma, in which the disease resembles the human ...

... a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model". Journal of Autoimmunity. 55: 63 ... "The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model". The Journal of Investigative Dermatology. 131 (1 ... In a mouse model of diet-induced obesity, ShK-186 counteracted the negative effects of increased caloric intake. It reduced ... In a mouse model of brain radiation, ShK-170 reversed neurological deficits, and protected neurons from radiation-induced brain ...

"Modeling human lymphoid precursor cell gene therapy in the SCID-hu mouse". Blood. 84 (5): 1393-1398. doi:10.1182/blood.V84.5. ...

"Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice". Nature Medicine. 3 (4 ... the lymph node metastasis of a male patient with hormone refractory prostate cancer which was then xenografted into SCID mice ...

Cancer Infectious Diseases Regenerative Medicine Hematology Humanized mouse Nude mouse SCID mouse M. Ito and, et al. (2002). " ... such as nude mouse and NOD/scid mouse. Thus, the mouse can be the best model as a highly efficient recipient of human cells to ... A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for ... "NOD/SCID/γnull mouse: an excellent recipient mouse model for engraftment of human cells". Blood. 100 (9): 3175-3182. doi: ...

"Gene therapy for human immunodeficiency virus infection in the humanized SCID mouse model". The Israel Medical Association ... After having created a mouse with a human immune system, Touraine used it to test several gene therapies for HIV/AIDS. The ...

Natural analogs of this knockout happen in mice, horses and dogs, also causing SCID. Human SCID usually have other causes, but ... DNA-PKcs deficient mice have a shorter lifespan and show an earlier onset of numerous aging related pathologies than ... DNA-PKcs knockout mice have severe combined immunodeficiency due to their V(D)J recombination defect. ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Sipley JD, ...

"Establishment of a Human Cutaneous T-Cell Lymphoma in C.B-17 SCID Mice". Journal of Investigative Dermatology. 94 (3): 381-384 ...

1985 - Started producing BALB/c mice. 1991 - Became the first commercial provider of the C.B-17 SCID mouse model. 1994 - ... "Mice in microgravity: how rodent research in space accelerates study timelines". outsourcing-pharma.com. Retrieved 9 June 2017 ... They continue to supply NCI with BDF1 mice. 1975 - Began offering the SHR hypertensive rat and the WKY control strain. 1980 - ... 1949 - Robert Phelan began shipping mice from his garage in Canajoharie, NY. 1952 - Taconic Farms is officially founded in ...

KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice. Journal of Clinical ...

While HIV normally cannot infect mice, SCID mice have been used to study HIV. Prior to the use of humanized SCID mice, ape ... Some examples include SCID-hu Thy/Liv mice, which are given human fetal thymus and liver cells, hu-SRC-SCID mice, which are ... NOD/SCID IL2Rγ mice have also been used to study human melanoma. SCID mice can serve many functions in research, particularly ... This failure to create antibodies prevents most SCID mice from rejecting non-self tissues. Some SCID mice are shown to reject ...

S1P has protected ovarian tissue xenografts in SCID mouse models from radiation induced atresia. In animal models these ... Fukuda, Yu; Kihara, Akio; Igarashi, Yasuyuki (12 September 2003). "Distribution of sphingosine kinase activity in mouse tissues ... September 2002). "Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in ... September 2006). "Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through ...

"DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts". Chromosoma. 126 (2): 287- ... However, in mice there is no increase in mutation in the brain with aging. Mice defective in a gene (Pms2) that ordinarily ... One or two months after inducing DNA double-strand breaks in the livers of young mice, the mice showed multiple symptoms of ... mutant mice defective in Ku70, or Ku80, or double mutant mice deficient in both Ku70 and Ku80 exhibit early aging. The mean ...

"Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice". PLOS ONE. 2 (11): e1251. Bibcode: ...

"DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts". Chromosoma. 126 (2): 287- ... Tian M, Jones DA, Smith M, Shinkura R, Alt FW (2004). "Deficiency in the nuclease activity of xeroderma pigmentosum G in mice ... Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE (2015). "NRMT1 knockout mice exhibit ... Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (February 2003). "Aging and genome maintenance: lessons from the mouse ...

All NHEJ mutant mice show a SCID phenotype, sensitivity to ionizing radiation, and neuronal apoptosis. A system was developed ... NHEJ efficiency could be compared across tissues of the same mouse and in mice of different age. Efficiency was higher in the ... SCID) due to defective V(D)J recombination. Loss-of-function mutations in Artemis also cause SCID, but these patients do not ... Many NHEJ genes have been knocked out in mice. Deletion of XRCC4 or LIG4 causes embryonic lethality in mice, indicating that ...

Myeloma cells overexpressing Sulf1 and 2 were subcutaneously injected in severe combined immunodeficient (SCID) mice. Enhanced ... deficient mice, BMP deficient mice and hypermorphic Fgfr1 and 3 mice. This provides evidence that Sulf1 and 2 is linked to HS ... Sulf null mice and other model systems implicated Sulfs in other developmental and disease systems. For example, studies ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: SULF1 ...

"Development of an orthotopic SCID mouse-human tumor xenograft model displaying the multidrug-resistant phenotype". Cancer ... WEINSTEIN, R (1972). "Effects of continuous inhalation of dichloromethane in the mouse: Morphologic and functional observations ...

... administration of the antibody prolonged survival of SCID mice implanted with JOK-1 cells. Apoptosis induction appears to be ... In a mouse model of multiple myeloma, tumor metastasis to bone was decreased in CD47-deficient mice compared with wild type ... CD47 knockout mice show reduced recruitment of blood T cells as well as neutrophils and monocytes in areas of inflammation. ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: CD47 ...