MAP kinase MAP kinase kinase MAP kinase kinase kinase kinase List of unusual biological names "Global Identification, ... is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP ... These MAP kinases include the extracellular regulated kinases (ERKs), the c-Jun N-terminal Kinases (JNKs), and the p38 MAP ... MAP+Kinase+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 2.7.11.25 Portal: Biology ...
"MAP kinase-kinase", thus qualifying as a "MAP kinase kinase kinase". The MAP kinase-kinase, which activates ERK, was named " ... MAP) kinase through MAP kinase kinase". Proceedings of the National Academy of Sciences of the United States of America. 90 (3 ... In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein ... The Extracellular Signal-Regulated Kinases MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. Extracellular+Signal ...
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ... MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. This article incorporates text from the United States National ... Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases". Cell. 103 (2): 239-52. doi:10.1016/S0092-8674(00)00116- ... This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, ...
"Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277-282. PMID 2156206. "Entrez ... This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families. This ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of ... Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1. GRCh38: Ensembl release 89: ...
1992). "Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24". Mamm. Genome. 3 (1): 36- ... Janus kinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, ... Janus+Kinase+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Genes on human ... JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the ...
MAP kinase signaling specificity". Science. 296 (5577): 2345-2347. doi:10.1126/science.1073344. PMID 12089430. S2CID 93194160. ... Chadee DN, Yuasa T, Kyriakis JM (February 2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by ... Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members are: A-RAF B-RAF c-Raf ... RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse ...
"Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773 (8 ... "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773 (8 ... "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773 (8 ... "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773 (8 ...
Each of these mutations maps to the kinase domain of DBT gene. The short- and long-period alleles of DBT enhance or attenuate, ... Casein kinase 2 - a distinct protein kinase family Eide EJ, Virshup DM (May 2001). "Casein kinase I: another cog in the ... Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ... By the late 1960s, cyclic AMP-dependent protein kinase had been purified, and most attention was centered on kinases and ...
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (January 2003). "Erbin suppresses the MAP kinase pathway". The Journal of Biological ... Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) ... Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ... Peles E, Levy RB, Or E, Ullrich A, Yarden Y (August 1991). "Oncogenic forms of the neu/HER2 tyrosine kinase are permanently ...
activators of the MAP kinase pathway. In 2019, the first SOS1 inhibitor, BAY-293, was published which met the quality criteria ... November 1997). "Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases". The ... Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D (October 1996). "Identification of the mitogen-activated protein kinase ... May 1993). "Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling". ...
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (January 2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. 278 (2): ... Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. 278 (2): 1108-14. ... Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis ... 539 (1-3): 167-73. doi:10.1016/s0014-5793(03)00155-8. PMID 12650946. S2CID 7429554. Izawa I, Nishizawa M, Tomono Y, Ohtakara K ...
When activated by the second messengers such as cAMP and calcium ions, enzymes such as PKA and MAP kinase can translocate to ... Treisman, R. (1996). Regulation of transcription by MAP kinase cascades. Current Opinion in Cell Biology, 8(2), 205-215. Nguyen ... roles for the ERK MAP kinase cascade in memory. Annual Review of Pharmacology and Toxicology, 42(1), 135-163. ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ...
Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the ... Nemo-like kinase: atypical MAPK) ERK1/2 kinases ERK1/2 pathway JNK kinases p38 MAP kinases MEKK2 (MAP3K2) ASK1 (MAP3K5) Pearson ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ...
... "cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically ... 14 Suppl 1: 9-13. doi:10.1111/j.1463-1326.2011.01507.x. PMID 22118705. S2CID 7446914. Takahashi H, Shibasaki T, Park JH, Hidaka ... 98 (1): 331-6. doi:10.1073/pnas.021541098. PMC 14590. PMID 11134533. Zhong N, Zucker RS (Jan 2005). "cAMP acts on exchange ... 587 (Pt 1): 101-13. doi:10.1113/jphysiol.2008.157461. PMC 2670026. PMID 19001039. Métrich M, Lucas A, Gastineau M, Samuel JL, ...
Kohorn BD, Johansen S, Shishido A, Todorova T, Martinez R, Defeo E, Obregon P (December 2009). "Pectin activation of MAP kinase ... Kohorn BD, Johansen S, Shishido A, Todorova T, Martinez R, Defeo E, Obregon P (December 2009). "Pectin activation of MAP kinase ... Cell wall associated kinases are receptor-like protein kinases, found in plant cell walls, that have the capability to transmit ... Wall-Associated Kinases (WAKs) are a subfamily of receptor-like kinases (RLKs) associated with the cell wall. They were ...
"Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2". Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, ... Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene. EMK (ELKL Motif Kinase) is a ... "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833-43. doi: ... Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were ...
2008) Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus. EMBO J. 27(16). ... 2002) MAP kinase signalling cascade in Arabidopsis innate immunity. Nature. 415(6875). 977-983 Deslandes, Olivier, Peeters, ... 2005) Tobacco Transcription Factor WRKY1 Is Phosphorylated by the MAP Kinase SIPK and Mediates HR-Like Cell Death in Tobacco. ... While kinases phosphorylating WRKY transcription factors are known, phosphatases removing phosphate groups have yet to be ...
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene. MARK3 has been shown to ... "Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A ... Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H (1998). "C-TAK1 protein kinase ... Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR (2007). "Regulation of the polarity kinases PAR-1/MARK ...
Zarubin, Tyler; Han, Jiahuai (January 2005). "Activation and signaling of the p38 MAP kinase pathway". Cell Research. 15 (1): ... "Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1". Journal of Biological ... "Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual ... 1] Google Scholar Author page, Accessed Oct.27 2021 Han Jiahuai publications indexed by Google Scholar (CS1 uses Chinese- ...
... a scaffold for the ERK-MAP kinase cascade". EMBO Reports. 5 (5): 484-489. doi:10.1038/sj.embor.7400140. PMC 1299052. PMID ... Dystroglycan has been shown to interact with FYN, C-src tyrosine kinase, Src, NCK1, Grb2, Caveolin 3 and SHC1. Dystrophin- ... Skynner MJ, Gangadharan U, Coulton GR, Mason RM, Nikitopoulou A, Brown SD, Blanco G (January 1995). "Genetic mapping of the ... 15 (1): 115-126. doi:10.1016/0896-6273(95)90069-1. PMID 7619516. S2CID 589282. Yang B, Jung D, Motto D, Meyer J, Koretzky G, ...
"Entrez Gene: MARK1 MAP/microtubule affinity-regulating kinase 1". Drewes G, Trinczek B, Illenberger S, et al. (1995). " ... 2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833-43 ... Yang SD, Yu JS, Shiah SG, Huang JJ (1994). "Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation ... 2003). "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1". EMBO J. 22 (19): 5090-101. doi:10.1093/ ...
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ... In addition, one substrate of p38 MAPK, MAP kinase-activated protein kinase 2 (MAPAK2 or MK2) can modulate and direct p38α MAPK ... The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the ... for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The ...
MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the ... "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4". Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E ( ... MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in ... Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and ...
"PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell. 1 (2): 239-50. doi:10.1016/s1534-5807(01)00035-1. PMID ... "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell. 1 (2): 239-50. doi:10.1016/S1534-5807(01)00035-1. PMID ... by protein kinase C and calcium/calmodulin kinase II in vitro". J. Neurochem. 71 (3): 1307-14. doi:10.1046/j.1471-4159.1998. ... "Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action". Mol. Cell. Biol. 23 (13): 4511 ...
Yang-Feng TL, Zheng K, Kopatz I, Naiman T, Canaani D (February 1992). "Mapping of the human casein kinase II catalytic subunit ... Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as ... Ahn BH, Kim TH, Bae YS (October 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target ... Allende JE, Allende CC (1995). "Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling ...
Slattery ML, Lundgreen A, Wolff RK (2012). "MAP kinase genes and colon and rectal cancer". Carcinogenesis. 33 (12): 2398-408. ... Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on ... "Entrez Gene: MAP3K3 mitogen-activated protein kinase kinase kinase 3". Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, ... pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". The Journal of Biological ...
Mishra, N.; Tuteja, R.; Tuteja, N. (2006). "Signaling through MAP kinase networks in plants". Arch. Biochem. Biophys. 452 (1): ... A second magnesium ion is critical for ATP binding in the kinase domain. The presence of Mg2+ regulates kinase activity. It is ... Phosphorylation of a protein by a kinase can activate a cascade such as the mitogen-activated protein kinase cascade. ATP is ... phosphoglycerate kinase (PGK) and pyruvate kinase. Two equivalents of nicotinamide adenine dinucleotide (NADH) are also ...
"Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523-4. doi:10.1007/s004390050861 ... Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. This gene encodes a member of the ... "Entrez Gene: CLK1 CDC-like kinase 1". Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (Oct 1996). "SRPK1 ... Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (1996). "SRPK1 and Clk/Sty protein kinases show distinct ...
YopJ acetylates MAPK kinases at serines and threonines that are normally phosphorylated during activation of the MAP kinase ... YopO is a protein kinase also known as Yersinia protein kinase A (YpkA). YopO is a potent inducer of human macrophage apoptosis ... "Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways". PLOS ONE. 3 (1): e1375. Bibcode:2008PLoSO... ... Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K (May 2006). "Yersinia YopJ acetylates and inhibits kinase ...
MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene. MNK2 has ... "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2". Scheper GC, Parra JL, Wilson M, Van Kollenburg B, ... "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high ... "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine ...