... (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells. In ... Acute promyelocytic leukemia can be distinguished from other types of AML based on microscopic examination of the blood film or ... Acute promyelocytic leukemia was first characterized in 1957 by French and Norwegian physicians as a hyperacute fatal illness, ... Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) ...

Because acute promyelocytic leukemia has the highest curability and requires a unique form of treatment, it is important to ... "Acute Myeloid Leukemia Staging". Retrieved 26 August 2011. Mihova D. "Leukemia acute - Acute myeloid leukemia with minimal ... Acute leukemias of ambiguous lineage (also known as mixed phenotype or biphenotypic acute leukemia) occur when the leukemic ... "acute leukemia" in 1889 to differentiate rapidly progressive and fatal leukemias from the more indolent chronic leukemias. The ...

Acute promyelocytic leukemia Keratoconjunctivitis sicca Xerophthalmia Schwartz, Robert. "Dermatologic manifestations of Vitamin ...

Subtypes of AML include acute promyelocytic leukemia, acute myeloblastic leukemia, and acute megakaryoblastic leukemia. Chronic ... Nearly all leukemias appearing in pregnant women are acute leukemias. Acute leukemias normally require prompt, aggressive ... There are four main types of leukemia-acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic ... Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and ...

In 2009, Bible was diagnosed with acute promyelocytic leukemia. He retired from coaching on February 12, 2021. Served as ...

... acute promyelocytic leukemia) and new "nonrandom chromosomal translocations" of leukemia. Based on her discoveries, she ... Wang, Zhen-Yi; Chen, Zhu (2008-03-01). "Acute promyelocytic leukemia: from highly fatal to highly curable". Blood. 111 (5): ... She has made important discoveries in the pathogenesis of leukemia and developed therapies to treat acute promyelocytic ... leukemia (APL) and other types of leukemia. Chen was born in May 1951 in Yinzhou District, Ningbo, Zhejiang, China. During the ...

Acute promyelocytic leukemia (APL) is a specific type of AML. In this leukemia promyelocytes are produced and build up in the ... Another type of acute leukemia is acute myelogenous leukemia (AML). AML accounts for most of the remaining cases of leukemia in ... The vast majority of childhood leukemia is acute, and chronic leukemias are more common in adults than in children. Acute ... the most common being acute lymphoblastic leukemia (ALL) followed by acute myeloid leukemia (AML). Survival rates vary ...

Abnormal promyelocytes with multiple Auer rods, called faggot cells, occur in acute promyelocytic leukemia. Blast cell Blast ... Adams, Julia; Nassiri, Mehdi (2015). "Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations". ... occur in chronic myelomonocytic leukemia and acute leukemias of monocytic origin. Monocyte counts may be decreased ( ... When seen on the blood smear, blast cells are an abnormal finding and may be indicative of acute leukemia or other serious ...

Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all. Leuk Lymphoma. 2019 Dec;60(13):3107-3115. doi ... Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ (February 1996). "The t(5;17) variant of acute promyelocytic leukemia expresses ... doi: 10.1038/nri2378 Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Acute Promyelocytic Leukemia: A ... Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Acute Promyelocytic Leukemia: A Constellation of Molecular ...

"Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all". Leukemia & Lymphoma. 60 (13): 3107-3115. doi: ... "Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene". Cancers. 12 (3): 624. ... "A dual functional ruthenium arene complex induces differentiation and apoptosis of acute promyelocytic leukemia cells". ... the most common of which is a condition known as Acute Promyeloid Leukemia (APL) caused by a somatic mutation described by the ...

Treatment of acute promyelocytic leukemia was first introduced at Ruijin Hospital in Shanghai by Wang Zhenyi in a 1988 clinical ... May 2015). "Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer". Nature ... Tretinoin is used to induce remission in people with acute promyelocytic leukemia (APL) who have a mutation (the t(15;17) ... August 1988). "Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia" (PDF). Blood. 72 (2): 567-72. ...

As2S3 and As4S4 have been investigated as treatments for acute promyelocytic leukemia (APL). Arsenic trisulfide manufactured ...

It is used in realgar/Indigo naturalis, a medication for acute promyelocytic leukemia. Indirubin exerts its effects on the ... However, it is being studied for treatment of small-cell lung cancer, glioblastoma, and chronic myeloid leukemia, either alone ...

2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc ... "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. ... degradation and apoptosis in acute promyelocytic leukemia. GRCh38: Ensembl release 89: ENSG00000182179 - Ensembl, May 2017 ... The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) ...

ATO has been approved by the FDA for the treatment of acute promyelocytic leukemia. Further, it has been shown to be effective ... Arsenic trioxide, an inhibitor of GLI transcription factors, is being used for the treatment of acute promyelocytic leukemia. ... and acute myeloid leukemia. Sonidegib was created by Novartis. It is a SMO antagonist that can induce arrest of cell division ... Leukemia. 2003 Aug;17(8):1499. Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes & development. 2008 Sep 15;22( ...

... and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J Biol Chem. 276 (25): 22375-81. doi ... Rossi V, Levati L, Biondi A (2006). "Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative ... "Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR". Methods Mol. Med. 125: ... a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). PRAM1 has been shown to ...

Translocations between this 17q21.2 locus and several other loci have been associated with acute promyelocytic leukemia. Three ... RARA gene loci are associated with two cases of acute promyelocytic leukemia and one case of juvenile myelomonocytic leukemia. ... signs and symptoms respectively of acute myeloid leukemia or lymphoma T-lymphoblastic leukemia/lymphoma or lymphocytic leukemia ... a variant translocation in acute promyelocytic leukemia". Haematologica. 96 (10): 1565-6. doi:10.3324/haematol.2011.047134. PMC ...

October 1998). "Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion ... In promyelocytic leukemia (PML), the oncogenic PML-retinoic acid receptor alpha (RARalpha) chimera disrupts the normal ... Nuclear bodies include Cajal bodies, the nucleolus, and promyelocytic leukemia protein (PML) nuclear bodies (also called PML ... "Resistance to virus infection conferred by the interferon-induced promyelocytic leukemia protein". Journal of Virology. 72 (2 ...

"Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". ... Leukemia & Lymphoma. 44 Suppl 3: S5-12. doi:10.1080/10428190310001621588. PMID 15202519. S2CID 25565667. Jardin F, Ruminy P, ... Leukemia & Lymphoma. 43 (7): 1375-81. doi:10.1080/10428190290033305. PMID 12389616. S2CID 27096971. Niu H (December 2002). "The ...

"Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene". Cancers. 12 (3): 624. ... medulloblastoma and in some acute leukemias. Further, mouse knock-out studies strongly support SMARCB1 as a tumor suppressor ... and in other haematological malignancies PML-RARA fusion protein in acute myeloid leukemia recruits histone deacetylases. This ... Leukemia. 34 (10): 2722-2735. doi:10.1038/s41375-020-0919-5. ISSN 1476-5551. PMID 32576963. Andrades, Alvaro; Peinado, Paola; ...

"Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". ... "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". ...

De Thé H, Chomienne C, Lanotte M, Degos L, Dejean A (1990). "The translocation of acute promyelocytic leukemia fuses the ... translocation in acute promyelocytic leukemia encodes a functionally altered RAR". Cell. 66 (4): 675-684. doi:10.1016/0092-8674 ... she then discovered the PML-RARa oncoprotein as the genetic defect responsible for acute promyelocytic leukemia (APL) and ... "Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells". Cell. 76 (2): ...

Wang's research has led to the improved survival of patients with acute promyelocytic leukemia (APML). Wang is the author of ... He is most well known for discovering the cure for acute promyelocytic leukemia while working with Laurent Degos in France, ... Chen Zhu Yuet Wai Kan Hematology Acute myeloid leukemia American Society of Hematology Charles Rodolphe Brupbacher Foundation ...

"All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells". ... Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ (March 1999). "CRKL binding to BCR-ABL and BCR-ABL transformation". Leukemia & ... Leukemia. 11 (3): 376-85. doi:10.1038/sj.leu.2400590. PMID 9067577. Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, ... Leukemia & Lymphoma. 28 (1-2): 65-72. doi:10.3109/10428199709058332. PMID 9498705. Bai RY, Jahn T, Schrem S, Munzert G, Weidner ...

... s are cells normally found in the hypergranular form of acute promyelocytic leukemia (FAB - M3). These promyelocytes ...

Chim CS, Chan WW, Pang A, Kwong YL (2006). "Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia ... Simon M, Grandage VL, Linch DC, Khwaja A (2005). "Constitutive activation of the Wnt/beta-catenin signalling pathway in acute ... an independent poor prognostic factor". Leukemia. 20 (5): 907-9. doi:10.1038/sj.leu.2404176. PMID 16525492. Urakami S, Shiina H ...

Anna Fitzgerald's older sister, Kate, suffers from acute promyelocytic leukemia, a blood and bone marrow cancer. Anna was born ... Kate Fitzgerald - A frail teenage girl who was diagnosed with promyelocytic leukemia at a young age. She is the older sister of ... who is suffering from acute leukemia. The story takes place in the fictional town of Upper Darby, Rhode Island in 2004. ... He is diagnosed with myeloid leukemia and meets her at the hospital while undergoing chemotherapy. Kate has some of her ...

Fantastichini died of acute promyelocytic leukemia in Naples on 1 December 2018, at the age of 63. 1983: Fuori dal giorno 1984 ...

... how the therapeutic effect of arsenic trioxide on acute promyelocytic leukemia was discovered". Science China Life Sciences. 56 ... investigated the potential use of the traditionally used substance arsenic trioxide to treat acute promyelocytic leukemia (APL ... Liu X, Zhang M, He L, Li Y (October 2012). Li Y (ed.). "Chinese herbs combined with Western medicine for severe acute ... Chinese herbal medicine has been a major cause of acute liver failure in China. The harvesting of guano from bat caves ( ...

May 2015). "Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer". Nature ...