Eldstrom J, Doerksen KW, Steele DF, Fedida D (November 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS ... Manganas LN, Trimmer JS (September 2000). "Subunit composition determines Kv1 potassium channel surface expression". The ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 ...

Eldstrom J, Doerksen KW, Steele DF, Fedida D (November 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS ... With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact ... Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. It plays ... and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051-63. doi:10.1074/jbc. ...

Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS ... Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Kv1.5+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNA5+protein,+human at the U. ...

Eldstrom J, Doerksen KW, Steele DF, Fedida D (November 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS ... Voltage-gated potassium channel Voltage-gated potassium-channel Kv1.4 IRES GRCh38: Ensembl release 89: ENSG00000182255 - ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the KCNA4 ...

Eldstrom J, Doerksen KW, Steele DF, Fedida D (2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Lett. 531 ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene. It contributes ... Kv4.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCND2+protein,+human at the U. ...

Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and ... channel ancillary or β subunits. KCNE4 is best known for modulating the KCNQ1 Kv α subunit, but it also regulates KCNQ4, Kv1.x ... but this varies depending on the channel subtype. KCNE4 strongly inhibits the KCNQ1 potassium channel, which is known to play ... "Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4". Abbott GW, Sesti F, Splawski I, Buck ME, ...

Potassium channels are required for the activation of T-cells. Pharmacological inhibition of Potassium channels can be useful ... "Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system ... Margatoxin blocks potassium channels Kv1.1 Kv1.2 en Kv1.3. Kv1.2 channel regulates neurotransmitter release associated with ... Pharmacological studies suggest that functional potassium channels are required in the activation of T- and B-cells. KV channel ...

Gu C, Jan YN, Jan LY (2003). "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels". Science ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene. ... Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ...

Kv1) K+ channels. HgTX1 shows high affinity with Kv1.1, Kv1.2, Kv1.3 voltage-gated potassium channels, but much lower affinity ... Hongotoxin (HgTX) is an ion channel toxin, which blocks Shaker-type (Kv1) K+ channels. The toxin is derived from the venom of ... HgTX4 and HgTX5 are potent selective inhibitors of Kv1 voltage-gated potassium channels (By similarity). ND, not determined. ... Potassium channel inhibitor family. Alpha-KTx 2 subfamily. There are five subtypes known of the hongotoxin peptide. HgTX1 is 39 ...

... is the first toxin (Tx1) from this scorpion (Hge). HgeTx1 belongs to the α-KTx potassium channel toxin category, and is ... 2005). "Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels". J Pept Sci. 11 (2): 65 ... 2015). "Diversity of Potassium Channel Ligands: Focus on Scorpion Toxins". Biochemistry (Moscow). 80 (13): 1764-99. doi:10.1134 ... "Kalium: Scorpion Toxins Active on Potassium Channels". Kalium Database. Retrieved 3 October 2016. Ménez, A. (1998). "Functional ...

BcsTx3, also known as Kappa-actitoxin-Bsc4a, is a neurotoxin that blocks voltage-gated potassium channel (Kv1/KCNA). It is ... and 94.25 nM for the Drosophila Shaker IR channels. Competitive interaction with another voltage-gated potassium channel ... October 2013). "BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker". The FEBS Journal. 280 ( ... Unlike the four subtypes of previously identified sea anemone voltage-gated potassium channel toxins, BcsTx3 exhibits 4 ...

"A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino ... Calcium entry through the CRAC channel is promoted by potassium efflux through the Kv1.3 and KCa3.1 potassium channels. ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans ...

"Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... LGI1 has been shown to be the major target of human autoantibodies which immunoprecipitate voltage-gated potassium channel ... 52 (3): 364-7. doi:10.1002/ana.10280. PMID 12205652. S2CID 2957451. Pizzuti A, Flex E, Di Bonaventura C, Dottorini T, Egeo G, ... 53 (3): 396-9. doi:10.1002/ana.10492. PMID 12601709. S2CID 26216565. Fertig E, Lincoln A, Martinuzzi A, Mattson RH, Hisama FM ( ...

Amino acid residues only found in Kv1.3 pore regions and not in other Kv1.x channel family members, could potentially explain ... Abdel-Mottaleb Y, Clynen E, Jalali A, Bosmans F, Vatanpour H, Schoofs L, Tytgat J (November 2006). "The first potassium channel ... It belongs to the α-KTx family, and selectively blocks the voltage-gated potassium channel Kv1.3 (KCNA3). Odonthobuthus doriae ... Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures". The Journal of ...

The stoichiometry of toxin binding to the potassium channel is 1:1. Discrepin specifically blocks the IA currents (fast ... where other K+ channel blockers (Kv1-, Kv3.4-, Kv4.2/4.3 family blockers) were unable to compete with this toxin. These results ... Discrepin blocks voltage-gated Shal-type (Kv4.x) K+ channels in cerebellar granular cells. These A-type K+ channels regulate ... "Structure and function of Kv4-family transient potassium channels". Physiological Reviews. 84 (3): 803-33. doi:10.1152/physrev. ...

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... Although it has no known effects on hERG (Kv11.1) or Kv1.x family channel activity, KCNE5 inhibits Kv2.1 activity 50% and ... are potassium channel regulatory subunits that do not pass currents themselves but alter the properties of potassium channel ... "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell. 97 (2): 175-87. doi:10.1016/ ...

It binds to several subclasses of voltage-gated potassium channels (Kv channels), including Kv1.1, Kv1.6, and less potently to ... Bessone, R; Martin-Eauclaire, MF; Crest, M; Mourre, C (2004). "Heterogeneous competition of Kv1 channel toxins with kaliotoxin ... By blocking potassium channels, the MCD peptide can increase the duration of action potentials and increase neuronal ... This toxicity is caused by the blockage of voltage-gated potassium channels by the MCD peptide. However, there is no toxicity ...

2010). "Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin- ... The voltage-gated potassium channel (VGKC), like other ion channels, belong to a multiprotein complex. Some of the proteins ... Anti-VGKC-complex encephalitis are caused by antibodies against the voltage gated potassium channel-complex (VGKC-complex) and ... 2004). "Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic ...

Two other voltage-gated potassium channels inhibited by GxTX-1 are the Kv2.2 and Kv4.3 channels. Kv2.2 is located predominantly ... "Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion". Molecular Endocrinology. 15 (8 ... By inhibiting Kv2.1 potassium channels, GxTX-1E boosts action potentials of pancreatic β-cells causing mainly increased glucose ... Swartz KJ, MacKinnon R (October 1995). "An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean ...

Gu C, Jan YN, Jan LY (2003). "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels". Science ... human K+ channel I), RBK1 (rubidium potassium channel 1), MBK (mouse brain K+ channel), voltage gated potassium channel HBK1, ... Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel ... KCNA1 potassium voltage-gated channel". "KCNA1 - Potassium voltage-gated channel subfamily A member 1 - Homo sapiens (Human) - ...

The human homologues of shaker B channels are the Kv1 channels. The affinity of the Pi3 for shaker B voltage- gated potassium ... The Pi3 toxin is a potent inhibitor of the Kv1.2 potassium channel, encoded by the KCNA2 gene and a less potent blocker of ... It is a potent blocker of voltage-gated potassium channel, Kv1.3 and is closely related to another peptide found in the venom, ... As a blocking agent, it is used to analyze the structure and function of the voltage-gated potassium channels, to identify the ...

"A potassium channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels - revision of the amino ... BgK and ShK attenuate K+ channels in the neurons of rat dorsal ganglia, in vitro. AsKs stops potassium channel currents that ... This combination appear to form the core residues that are the site of binding of all Kv1 channel blockers from sea anemones. ... BgK competes with I-α-dendrotoxin, a known probe used to indicate the presence of certain potassium channels, over binding to ...

... cardiac potassium channel. The neuronal Kv1.1 channel and the T lymphocyte Kv1.3 channel are most potently inhibited by ShK. ... "A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions". ... The prodomain traps the voltage-gated potassium channel KV1.3, but not the closely related KV1.2 channel, in the endoplasmic ... channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3". The ...

Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that ... Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential, ... the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ ... Sansom MS (2000). "Potassium channels: watching a voltage-sensor tilt and twist". Curr. Biol. 10 (5): R206-9. doi:10.1016/S0960 ...

Rash JE, Vanderpool KG, Yasumura T, Hickman J, Beatty JT, Nagy JI (April 2016). "KV1 channels identified in rodent myelinated ... directly apposed to equally abundant immunogold-labeled Kv1.1 potassium channels, both in the juxtaparanodal axolemma and along ... In both PNS and CNS myelinated axons, Cx29 is precisely colocalized with Kv1.2 voltage-gated K+ channels, where both proteins ... Gap junction gamma-3, also known as connexin-29 (Cx29) or gap junction epsilon-1 (GJE1), is a protein that in humans is encoded ...

It is believed that antibodies to the Shaker-type K+ channels (the Kv1 family) are the type of potassium channel most strongly ... Antibodies against voltage-gated potassium channels (VGKC), which are detectable in about 40% of patients with acquired ... peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels". Brain. 124 ... 2006-03-13). "Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates ...

"SK channel" stands for a small conductance calcium activated potassium channel, and the channels are found in the heart. SK ... The four types are Kv1, Kv2, Kv3 and Kv4. The Kv1 channel primarily influences the repolarization of the axon. The Kv2 channel ... Another type of K+ channel that helps to mediate repolarization in the human atria is the SK channel, which are K+ channels ... Other voltage gated K+ channels which contribute to repolarization include A-type channels and Ca2+-activated K+ channels. ...

Potassium channels are vital in conducting the presynaptic action potential. The calyx contains several types of potassium ... showed that the density of the Kv1 and Kv3 low threshold channels increases, which in turn affect the kinetics of the channels ... There is a calcium activated potassium channel expressed in the calyx, however this type of channel does not contribute to ... The low-threshold potassium channels of the postsynaptic neuron reduce the excitability of the neuron in order to restrict its ...

4-AP works as a potassium channel blocker. Strong potassium currents decrease action potential duration and amplitude, which ... It is a relatively selective blocker of members of Kv1 (Shaker, KCNA) family of voltage-activated K+ channels. However, 4-AP ... Judge SI, Bever CT (July 2006). "Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of ... It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage ...