... works by inhibiting Na+/Cl− ion reabsorption from the distal tubules of the kidneys. In addition, ... trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general ...
The distal tubules of the kidneys secrete large amounts of uromucoid (Tamm-Horsfall protein). This is the dominant protein in ... of large amounts of immunoglobulin light chains through the kidneys may cause inflammation or blockage of the kidney tubules.[ ... the light chains enter the distal tubules and can appear in the urine (Bence Jones protein). The passage ... flows through the glomeruli and is completely processed by the proximal tubules. If the proximal tubules of the nephrons are ...
2006). "Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease". ...
... which can be found in the distal convoluted tubule of the kidney. Disease-causing variants in SLC12A3 lead to a loss of NCC ... "Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney". Acta Physiologica. 231 (2 ... Loss of SLC12A3 has been shown to lead to a shorter distal convoluted tubule, at least in mice. Therefore, other functions of ... It participates in the control of ion homeostasis at the distal convoluted tubule of the nephron. Thus, loss of NCC function ...
Renal tubular epithelial cells (RTEs) line the collecting ducts and the distal and proximal tubules of the kidney. They can be ... The filtrate proceeds into the loop of Henle, then flows through the distal convoluted tubule to the collecting duct. The ... Blood enters the kidney though the renal artery and flows through the kidney's vasculature into the glomerulus, a tangled knot ... as it suggests that the kidneys have lost the ability to control urine concentration. It is not possible for the kidneys to ...
... in the distal tubules of the kidneys. In this disorder, a gain of function mutation decreases ENaC degradation leading to ... Hypertension may be asymptomatic or may lead to symptoms such as headache, dizziness, vision changes, or kidney disease. ...
"The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney". The ... kidney and epididymis". PLOS ONE. 4 (2): e4471. Bibcode:2009PLoSO...4.4471V. doi:10.1371/journal.pone.0004471. PMC 2637605. ...
The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is ... "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863-9. ...
Neer undertook independent research on the biochemical mechanisms of vasopressin's action on kidney's distal tubules. She ...
Use of carbenicillin can cause hypokalemia by promoting potassium loss at the distal convoluted tubule of the kidney.[citation ...
... inhibits adenylate cyclase activity required for antidiuretic hormone effect on the distal convoluted tubule of the kidney. ... 281 Those with impaired kidney function are more susceptible to adverse effects.: 292 The kidney injury is characterised by ... Thus, patients with chronic kidney disease will maintain serum fluoride for longer period of time, leading to increased risk of ... Fluoride induced nephrotoxicity is kidney injury due to toxic levels of serum fluoride, commonly due to release of fluoride ...
It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. ...
... a thiazide medication which inhibits reabsorption of sodium and chloride ions from the distal convoluted tubules of the kidneys ... It is also used for the prevention of kidney stones in those who have high levels of calcium in their urine. Multiple studies ... Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those ... Thiazides decrease mineral bone loss by promoting calcium retention in the kidney, and by directly stimulating osteoblast ...
Specifically, it binds receptors of cells that comprise the distal tubules of the kidneys which then stimulate ion channels to ... For example, aldosterone functions to raise blood sodium levels and lower blood potassium levels by targeting the kidneys. ... These hormones also function in regulating the conservation of water by the kidneys and glucose metabolism, respectively. ...
However, in the kidney, glucose is reabsorbed from the filtrate in the tubule lumen, where it is at a relatively low ... Close to the loop of Henle and in the distal convoluted tubule of the nephron where much glucose has been reabsorbed into the ... There are two types of secondary active transporter found within the kidney tubule; close to the glomerulus, where glucose ... passes through the simple cuboidal epithelia lining the kidney tubule, and into the bloodstream where glucose is at a ...
Studies in mice indicate that FP mRNA and/or protein is expressed in diverse tissues including the kidney (distal tubules), ... 2005). "Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that ...
... protein is highly expressed in the distal convoluted tubule (DCT) and the cortical collecting duct (CDD) of the kidney. ... elevated WNK4 kinase activity is the increase of NCC-mediated sodium reabsorption in the distal convoluted tubule of the kidney ... WNK4 plays a critical role in the regulation of various transporters and channels in the kidney. PHAII-causing mutations in ... In addition to NCC, WNK4 also regulates multiple ions channels and cotransporters in the kidney through various mechanisms. ...
The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting tubule. It is ... 2 proximal tubule, 3 distal tubule Transverse section of pyramidal substance of kidney of pig, the bloodvessels of which are ... Sodium absorption by the distal tubule is mediated by the hormone aldosterone. Aldosterone increases sodium reabsorption. ... The DCT is lined with simple cuboidal cells that are shorter than those of the proximal convoluted tubule (PCT). The lumen ...
The underlying genetic defect leads to increased sodium chloride reabsorption in the distal tubule in the kidney, leading to ... The hyperkalemia found in PHA2 is proposed to be a function of diminished sodium delivery to the cortical collecting tubule ( ... A renal form with autosomal dominant inheritance exhibiting salt loss mainly from the kidneys, and a multi-system form with ... autosomal recessive form exhibiting salt loss from kidney, lung, and sweat and salivary glands. The hereditary lack of ...
The effect of vasopressin on the kidney tubules is to reabsorb water from the distal convoluted tubules and collecting ducts, ... Aldosterone acts primarily on the distal convoluted tubules and collecting ducts of the kidneys, stimulating the excretion of ... It is very probable that the renal tubular cells of the distal convoluted tubules are themselves sensitive to the pH of the ... Aldosterone's action on the kidney tubules prevents sodium loss to the extracellular fluid (ECF). So there is no change in the ...
... in the distal convoluted tubule of the kidney. Hypercalciuric hypomagnesemic syndromes, which encompass the syndromes caused by ... Adrenergics, displace magnesium into the cell Cisplatin, stimulates kidney excretion Ciclosporin, stimulates kidney excretion ... The kidneys are very efficient at maintaining body levels; however, if the diet is deficient, or certain medications such as ... Normal plasma Mg is 1.7-2.3 mg/dL (0.69-0.94 mmol/L). The kidneys regulate the serum magnesium. About 2400 mg of magnesium ...
Because NCC is located at the apical membrane of the distal convoluted tubule of the nephron, it faces the lumen of the tubule ... the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal ... Nephron Distal convoluted tubule Electrolytes, such as sodium and chloride Cotransporter, including symporter Blood pressure ... Using the sodium gradient across the apical membrane of the cells in distal convoluted tubule, the sodium-chloride symporter ...
... dysfunction because they rely on aerobic metabolism and they are in a more oxidized state as compared to the distal tubules. ... The duration of kidney ischemia does not affect kidney function either in the short term or long term. In patients who get a ... In acute kidney ischemia, the proximal tubules are vulnerable to mitochondrial ... The level of cystatin C is used to determine whether the kidney is functioning well or not since it is removed from the kidney ...
... transporters increase sodium reabsorption and potassium excretion in the distal tubule and the collecting duct of the kidneys. ... 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease ... When aldosterone is secreted from the adrenal glands, it binds to the mineralocorticoid receptor in the renal tubule cell and ... They decrease sodium reabsorption, which leads to increased water excretion by the kidneys. By regulating water excretion, ...
... ions from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na+-Cl− symporter. The term "thiazide ... Thiazide diuretics also increase calcium reabsorption at the distal tubule. By lowering the sodium concentration in the tubule ... The thiazide receptor is a sodium-chloride transporter that pulls NaCl from the lumen in the distal convoluted tubule. Thiazide ... Thiazides increase the uptake of calcium in the distal tubules, to moderately reduce urinary calcium. Thiazides combined with ...
... deposit selectively in the kidney's proximal tubule to cause light chain proximal tubulopathy or in the kidneys distal tubule ... MGRS can be caused by the deposition of a monoclonal immunoglobulin in, and consequent injury to, the kidneys. The diagnosis of ... 2 gram/deciliter due to myeloma protein-induced kidney damage; A = Anemia, as defined by a blood hemoglobin level >2 gram/ ... At the time of diagnosis, 30% to 50% of light chain multiple myeloma patients have severe renal dysfunction or kidney failure ...
... by acting on the distal convoluted tubule of kidney nephrons to: increase sodium reabsorption, increase potassium excretion, ... renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid ...
AVPR2 are expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, in fetal lung ... In the kidney, AVPR2's primary function is to respond to arginine vasopressin by stimulating mechanisms that concentrate the ... V1Rs are found in kidney, where they occur in high density on medullary interstitial cells, vasa recta, and epithelial cells of ... The increased intracellular cAMP in the kidney in turn triggers fusion of aquaporin-2-bearing vesicles with the apical plasma ...
... to a continuous region of the kidney tubule running from the medullary thick descending limb to the distal convoluted tubule. ... In particular, Claudin-16 allows the selective reuptake of Mg2+ in the human kidney. Some patients with mutations in the CLDN19 ... This localisation was consistent with the earlier reports for the location of Mg2+ re-uptake by the kidney. Following the ... Ponting CP (Mar 1997). "CBS domains in CIC chloride channels implicated in myotonia and nephrolithiasis (kidney stones)". ...
Distal convoluted tubule Uriniferous tubule Tubular fluid, the fluid in the tubules of the kidney This disambiguation page ...