... hibernation and ischemic preconditioning". Tidsskr. Nor. Laegeforen. (in Norwegian). 121 (4): 440-4. PMID 11255859. Vaidya Y ( ... Myocardial stunning or transient post-ischemic myocardial dysfunction is a state of mechanical cardiac dysfunction that can ... Some evidence suggests that brief, repetitive episodes of myocardial ischemia may result in chronic myocardial stunning and ... Clinical situations associated with myocardial stunning include: acute myocardial infarction (AMI) with early reperfusion ...

"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning". Am ... Ischemic preconditioning (IPC) is an experimental technique for producing resistance to the loss of blood supply, and thus ... The control animals had no such period of "ischaemic preconditioning" and had much larger infarct sizes compared with the dogs ... Murry, CE; Jennings, RB; Reimer, KA (November 1986). "Preconditioning with ischemia: a delay of lethal cell injury in ischemic ...

"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning". ... Cardioprotection includes strategies that are implemented before an ischemic event (preconditioning, PC), during an ischemic ... remote ischemic PostC and remote ischemic PerC. Classical (local) preconditioning has an early phase with an immediate onset ... Murry, CE; Jennings, RB; Reimer, KA (November 1986). "Preconditioning with ischemia: a delay of lethal cell injury in ischemic ...

"Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury ... significant threat to myocardial function that arises with the reintroduction of blood flow to the heart following an ischemic ... The mitochondria has been known to protect the heart from ischemic-reperfusion injury through the opening of the ATP-sensitive ... A major topic of research is the impact of hydrogen sulfide on reducing myocardial ischemia-reperfusion injury. Reperfusion ...

Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through ... Murry CE, Jennings RB, Reimer KA (November 1986). "Preconditioning with ischemia: a delay of lethal cell injury in ischemic ... Mullane K (January 1993). "Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury". ... The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 ...

... and block the cardiac dysfunction caused by extensive tissue ischemia in animal models of remote ischemic preconditioning. TP ... In addition, TP receptor antagonists lessen myocardial infarct size in various animal models of this disease ... High levels of isoprostanes form in ischemic or otherwise injured blood vessels and acting through TP, can stimulate arterial ... Aggarwal S, Randhawa PK, Singh N, Jaggi AS (2016). "Preconditioning at a distance: Involvement of endothelial vasoactive ...

"Remote ischemic preconditioning reduces contrast-induced acute kidney injury in patients with ST-elevation myocardial ... "Remote Ischemic Preconditioning Reduces Myocardial Injury in Patients Undergoing Coronary Stent Implantation". Canadian Journal ... "Remote Ischemic Conditioning Reduces Myocardial Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial ... The phenomenon of ischemic preconditioning (IPC) was discovered in 1986 by C. E. Murry and colleagues, who observed that ...

Fryer, R. M., Eells, J. T., Hsu, A. K., Henry, M. M., & Gross, G. J. (2000). Ischemic preconditioning in rats: role of ... Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. Circ Res 84, 973−979. ... Activation of the KATP channels on cardiac mitochondria is involved in ischemic preconditioning that results in protection for ... 50(3):552-560 Wilde, A. A. M. (1993). Role of ATP-sensitive K+ channel current in ischemic arrhythmias. Cardiovasc Drugs Ther 7 ...

Xu CF, Yu CH, Li YM (December 2009). "Regulation of hepatic microRNA expression in response to ischemic preconditioning ... Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM (February 2009). "MicroRNA-320 expression in myocardial microvascular ...

... specifically in myocardial mitochondria) to survive ischemic stress conditions. This is done by adapting myocardial cells to ... This has made meldonium a possible pharmacological agent for ischemic preconditioning. The mechanisms underlying the central ... Myocardial ischemia. Mayo Clinic (25 July 2015). Retrieved on 28 May 2016. Zvejniece L, Svalbe B, Makrecka M, Liepinsh E, ... It is also used in cases of cerebral ischemia, ocular ischemic syndrome and other ocular disease caused by disturbed arterial ...

... influences the tissue's later response to a prolonged ischaemic exposuret. Thus is known as ischaemic preconditioning, and it ... The most common causes of death in an aging population include myocardial infarction, stroke and cancer. These diseases share a ... This is called 'ischemic hypoxia'. Ischemia can be caused by an embolism, a heart attack that decreases overall blood flow, ... Hypoxic ischemic encephalopathy (HIE) is a condition that occurs when the entire brain is deprived of an adequate oxygen supply ...

... such as during ischemic preconditioning of the heart. Although a large burst of ROS is known to lead to cell damage, a moderate ... Using a MnSOD gene silencing approach, reported that prevention of the ExTr-induced increase in myocardial MnSOD resulted in a ... can play a significant triggering role in the signal transduction pathways of ischemic preconditioning leading to reduction of ... also known as ischemic heart disease). Ischemic heart disease, which results from an occlusion of one of the major coronary ...

Multicenter Myocardial Ischemia Research Group". American Heart Journal. 138 (3 Pt 1): 577-85. doi:10.1016/s0002-8703(99)70163- ... Nakamura Y, Moss AJ, Brown MW, Kinoshita M, Kawai C (September 1999). "Long-term nitrate use may be deleterious in ischemic ... Gori T, Parker JD (July 2008). "Nitrate-induced toxicity and preconditioning: a rationale for reconsidering the use of these ...

... such as during ischemic preconditioning of the heart. Although a large burst of ROS is known to lead to cell damage, a moderate ... Braunwald E, Kloner RA (November 1985). "Myocardial reperfusion: a double-edged sword?". The Journal of Clinical Investigation ... can play a significant triggering role in the signal transduction pathways of ischemic preconditioning leading to reduction of ... also known as ischemic heart disease). Ischemic heart disease, which results from an occlusion of one of the major coronary ...

... before the major ischemic insult. This procedure is known as ischemic preconditioning ("IPC"), and derives its effectiveness, ... Mubagwa K, Flameng W (October 2001). "Adenosine, adenosine receptors and myocardial protection: an updated overview". ... Increased potassium conductance should stabilize membrane potential during ischemic insults, reducing the extent infarct and ...

Myocardial stunning is associated with oxidant radical damage and calcium overload. Contractile abnormalities can occur through ... Halestrap AP, Clarke SJ, Khaliulin I (August 2007). "The role of mitochondria in protection of the heart by preconditioning". ... Opening these channels is beneficial for post-ischemic changes in vasodilation. Other BKCa++ channel openers are reported to ... It is unclear what the specific role of Akt may play in modulating of myocardial function after rottlerin treatment of ...

Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM, Guo S (Nov 2013). "Myocardial loss of IRS1 and ... and inhibition of p38 MAPK activity is in clinical evaluation as a potential therapy to mitigate acute injury in ischemic heart ... via phosphorylation of αβ-Crystallin or induction of Pim-3 during early response to oxidative stress or anoxic preconditioning ... Mitra A, Ray A, Datta R, Sengupta S, Sarkar S (Sep 2014). "Cardioprotective role of P38 MAPK during myocardial infarction via ...

"Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass ... Heusch's research focus is on coronary blood flow and the pathophysiology of myocardial ischemia and reperfusion. He first ... In recent years, he analyzed the signal transduction of ischemic conditioning. The translation of preclinical data to clinical ... Heusch G (1990), "Alpha-adrenergic mechanisms in myocardial ischemia", Circulation (in German), vol. 81, no. 1, pp. 1-13, doi: ...

... rescue and role of complex I in myocardial ischemic injury, and microbial basis of cardiovascular disease. In 1994, Gottlieb ... Huang, C., Andres, A. M., Ratliff, E. P., Hernandez, G., Lee, P., & Gottlieb, R. A. (2011). Preconditioning involves selective ... Gottlieb was the first to suggest that autophagy served a protective role in the setting of myocardial stress. These concepts, ... Her research primarily focuses on the molecular basis of myocardial ischemia/reperfusion injury and on developing ways to ...

March 2018). "Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair ... Insufficient myocardial protection is considered one of the main causes of death in the correction of TOF. There are many ... Ji Q, Mei Y, Wang X, Feng J, Wusha D, Cai J, Zhou Y (2011). "Effect of ischemic postconditioning in correction of tetralogy of ...

The rapid return of myocardial blood supply is critical in order to save the ischemic heart, but it also has the potential to ... Sanada S, Komuro I, Kitakaze M (November 2011). "Pathophysiology of myocardial reperfusion injury: preconditioning, ... Myocardial damage with the resumption of blood flow after an ischemic event is termed "reperfusion injury". The mitochondrial ... "Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection". Journal of ...

Kim HW, Haider HK, Jiang S, Ashraf M (November 2009). "Ischemic preconditioning augments survival of stem cells via miR-210 ... Myocardial infarction is cardiac tissue necrosis that results from occlusion of blood supply via coronary arteries, thereby ... MiRNA-210 in particular, has been studied for its effects in rescuing cardiac function after myocardial infarcts via the up- ... Delivery of miRNA-210 to an ischemic heart improves heart function, possibly by promoting the release of angiogenic factors ...

This leads to less blood reaching the ischemic tissue, which in turn produces the characteristic chest pain. Adenosine used as ... Adenosine is used as an adjunct to thallium (TI 201) or technetium (Tc99m) myocardial perfusion scintigraphy (nuclear stress ... May 2008). Bozza P (ed.). "Anti-inflammatory preconditioning by agonists of adenosine A1 receptor". PLOS ONE. 3 (5): e2107. ... The recommended dose is also reduced by half in patients presenting congestive heart failure, myocardial infarction, shock, ...

Additionally, in patients with ischemic cardiomyopathy, dilated cardiomyopathy and hypertrophic cardiomyopathy, ALC-1 protein ... "A molecular mechanism improving the contractile state in human myocardial hypertrophy". Experimental and Clinical Cardiology. 7 ... "Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1". ... ischemic cardiomyopathy and congenital heart diseases. ALC-1 is a 21.6 kDa protein composed of 197 amino acids. ALC-1 is ...

Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A, Chaitman BR, Leslie S, Stern T; Myocardial ... "all preconditions are fully met assumption", the "quantitative variable limitation" and the "placebo only or conventional ... "Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized ... it was routine for physicians to prescribe hormone replacement therapy for post-menopausal women to prevent myocardial ...