Other cytokines that signal through receptors containing gp130 are Interleukin 11 (IL-11), Interleukin 27 (IL-27), ciliary ... IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation ... Interleukin is the main member of the IL-6 superfamily (Pfam PF00489), which also includes G-CSF, IL23A, and CLCF1. A viral ... Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In ...

The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528-35. doi:10.1074/jbc. ... "Entrez Gene: IL6R interleukin 6 receptor". Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J (Jan 2004). "Direct ... Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 ... Szpirer J, Szpirer C, Rivière M, Houart C, Baumann M, Fey GH, Poli V, Cortese R, Islam MQ, Levan G (1991). "The Interleukin-6- ...

As a signaling molecule, interleukin 11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; ... Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a ... Chen HF, Lin CY, Chao KH, Wu MY, Yang YS, Ho HN (May 2002). "Defective production of interleukin-11 by decidua and chorionic ... Interleukin 11 is manufactured using recombinant DNA technology.[citation needed] It is marketed as a protein therapeutic ...

Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annual Review of ... Media related to Interferons or interleukin-10 (IL-10) at Wikimedia Commons Interleukin-10 at the U.S. National Library of ... Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor". Annual ... "Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin ...

This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them ... "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636-41. doi:10.1006 ... Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this ... Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. ...

... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...

IL-12B is a common subunit of interleukin 12 and interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that ... Interleukin-12 p40 also serves as a subunit of interleukin 23. GRCh38: Ensembl release 89: ENSG00000113302 - Ensembl, May 2017 ... "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): ... "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated ...

Its receptors were similarly renamed: Interleukin 8 receptor, alpha - CXCR1 Interleukin 8 receptor, beta - CXCR2 GRCh38: ... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw ... Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types ... In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 ...

29 (4). Hassan N, Choy E (September 2020). "Interleukin-6 inhibitors". In Scott DL, Galloway J, Cope A, Pratt A, Strand V (eds ... This drug was developed by Ablynx NV to block interleukin-6 receptor. Vobarilizumab has been evaluated in patients with ...

... is a subunit for the interleukin-10 receptor. IL10RA, is its human gene. IL10RA has also ... Interleukin 10 receptor, alpha subunit has been shown to interact with: Interleukin 10 and Janus kinase 1. GRCh38: Ensembl ... "Entrez Gene: IL10RA interleukin 10 receptor, alpha". Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A ... Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". ...

It binds to interleukin-6. Siltuximab has been investigated for the treatment of neoplastic diseases: metastatic renal cell ... October 2010). "A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal ... Siltuximab is a chimeric monoclonal antibody that binds to interleukin-6 (IL-6), preventing binding to soluble and membrane ... Kampan NC, Xiang SD, McNally OM, Stephens AN, Quinn MA, Plebanski M (2018). "Immunotherapeutic Interleukin-6 or Interleukin-6 ...

... interleukin-12 subunit alpha, and interleukin-12 subunit beta; and mouse helper and cytotoxic T cells from releasing the pro- ... inflammatory cytokines interferon gamma, interleukin 17, interleukin-2, and TNF-α. These findings suggest that FFAR4 acts to ... FFAR4 activators inhibited: human eosinophils from secreting a pro-inflammatory cytokine, interleukin 4; mouse RAW 264.7 and ... and interleukin-6; bone marrow-derived mouse dendritic cells from secreting the pro-inflammatory cytokines monocyte ...

It binds to interleukin 6. Hence acting as an Anti-IL-6 therapeutic aimed at inflammatory disease e.g. rheumatoid arthritis (RA ... Walsh N (6 August 2014). "RheumShorts: IL-6 and RA, Life and Death, Surgery in Lupus". Genovese MC, Fleischmann R, Furst D, ...

Interleukin 6 mediates activation of STAT3. The high level of STAT3 was described in isolated CSCs from liver, bone, cervical ... The activation of NFκB leads to increase not only in production of IL-6, TNF-α and SDF-1 but also in delivery of growth factors ... 131 (6): 1365-1375. doi:10.1242/dev.01025. PMID 14973292. Sarkar A, Parikh N, Hearn SA, Fuller MT, Tazuke SI, Schulz C (July ... The main roles have molecules (IL-6, IL-8, TNF-α, NFκB, TGF-β, HIF-1α) which can regulate both processes through regulation of ...

Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Hence, anti-IL6 agents have been sought. ... Yokota S (2003). "Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis". Current Opinion in ... Barton BE (2005). "Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic ... Smolen JS, Maini RN (2006). "Interleukin-6: a new therapeutic target". Arthritis Research & Therapy. 8 (Suppl 2): S5. doi: ...

... interleukin-1, interleukin-2 receptor, tumor necrosis factor alpha, C-reactive protein, and monocyte chemotactic protein-1 all ... including interleukin-1(IL-1; causes inflammatory cascade and abnormal hormone concentration), interleukin-6 (IL-6; activates ... Khandaker GM, Pearson RM, Zammit S, Lewis G, Jones PB (October 2014). "Association of serum interleukin 6 and C-reactive ... March 2009). "Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of ...

Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (1989). "Interleukin-6 triggers the ... Kishimoto T, Akira S, Narazaki M, Taga T (1995). "Interleukin-6 family of cytokines and gp130". Blood. 86 (4): 1243-1254. doi: ... Haan C, Heinrich PC, Behrmann I (January 2002). "Structural requirements of the interleukin-6 signal transducer gp130 for its ... Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11". J. ...

Galiellalactone is additionally a highly selective and potent inhibitor of interleukin-6 (IL-6) signaling in HepG2 cells. IL-6 ... Weidler M, Rether J, Anka T, Erkel G (2000). "Inhibition of interleukin-6 signaling by galiellalactone". FEBS Letters. 48 (1): ... ISBN 978-0-8131-9039-6. Kibby G. (1994). An Illustrated Guide to Mushrooms and Other Fungi of North America. Stamford, ... 1-6. doi:10.1016/S0014-5793(00)02115-3. PMID 4609797. Galiella rufa in Index Fungorum (CS1 Latin-language sources (la), ...

Whisman, Mark A.; Sbarra, David A. (2012). "Marital adjustment and interleukin-6 (IL-6)". Journal of Family Psychology. 26 (2 ... 47 (6): 478-86. doi:10.1016/j.brat.2009.02.012. PMC 2688957. PMID 19286167. Heyman, Richard E. (2001). "Observation of couple ... 65 (5-6): 297-312. doi:10.1007/s11199-011-9968-6. S2CID 145011583. Holt-Lunstad, Julianne; Smith, Timothy B.; Layton, J. ... 32 (6): 754-63. doi:10.5993/AJHB.32.6.19. PMID 18442354. Reczek, Corinne; Umberson, Debra (2012). "Gender, health behavior, and ...

... interleukin-8, and GM-CSF. These activities are G2A-dependent. It is suggested that 9-HODE acts in human skin to block the ... interleukin-6 and keratinocyte chemoattractant, for in vivo studies. G2A is also involved in blood-borne ... 6 (9): 2840-56. doi:10.3390/toxins6092840. PMC 4179163. PMID 25251539. Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC ... up-regulate the expression of CCR9 and CXCR4 and abrogate the release of IL-6 in human monocytes". Toxins. ...

It (OPR-003) targets (and blocks) Interleukin-6. It has undergone a number of early stage clinical trials, e.g. for lymphoma ... p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k- ... It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339. "WHO Drug Information" (PDF ... December 2009). "A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma". Clinical Cancer ...

... and Interleukin-10 (IL-10), as well as TNF-alpha and Interleukin-6 (IL-6). Antidepressants have also been shown to suppress TH1 ... Hong CJ, Yu YW, Chen TJ, Tsai SJ (2005). "Interleukin-6 genetic polymorphism and Chinese major depression". Neuropsychobiology ... "Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin ... "Anti-Inflammatory effects of antidepressants through suppression of the interferon-gamma/interleukin-10 production ratio". ...

Yao L, Pan J, Setiadi H, Patel KD, McEver RP (July 1996). "Interleukin 4 or oncostatin M induces a prolonged increase in P- ... Heinrich PC, Horn F, Graeve L, Dittrich E, Kerr I, Müller-Newen G, Grötzinger J, Wollmer A (1998). "Interleukin-6 and related ... OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely ... Taga T, Kishimoto T (1997). "Gp130 and the interleukin-6 family of cytokines". Annu. Rev. Immunol. 15: 797-819. doi:10.1146/ ...

Rohleder N, Aringer M, Boentert M (July 2012). "Role of interleukin-6 in stress, sleep, and fatigue". Annals of the New York ... 18: 6. doi:10.5334/jcr.199. ISSN 1740-3391. PMC 7583716. PMID 33133210. Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP, ... Most people with different schedules than the ordinary one (from 8 AM to 6 PM) might have these symptoms but the difference is ... Partial and total sleep deprivation has been linked to an increase of pro-inflammatory markers, such as IL-6, and a decrease in ...

In this case, some interleukins bind to a specific receptor, which leads to activation of MAPK/ERK pathway. Consequently, the ... "Interleukin-6 Mediates Angiotensinogen Gene Expression during Liver Regeneration". PLOS ONE. 8 (7): e67868. Bibcode:2013PLoSO ... 24 (6): 290-300. doi:10.1016/j.tem.2013.02.001. PMC 3669669. PMID 23499155. Ham, J; Evans, BA (2012). "An emerging role for ... 6 (1): 60-71. PMC 2853051. PMID 20390049. Geldziler, BD; Marcello, MR; Shakes, D. C.; Singson, A (2011). The genetics and cell ...

Some symptoms of myxoma may be associated with the release of interleukin 6 (IL-6) by the myxoma. High levels of IL-6 may be ... Seino Y, Ikeda U, Shimada K (1993). "Increased expression of interleukin 6 mRNA in cardiac myxomas". Br Heart J. 69 (6): 565-7 ... Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B (1990). "Constitutive production of interleukin-6 and ... 1993). "Cardiac myxoma metastasized to the brain: potential role of endogenous interleukin-6". Cardiology. 83 (3): 208-11. doi: ...

Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F (August 2003). "Principles of interleukin (IL)-6-type ... Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I (December 2000). "Non-redundant signal transduction of interleukin-6- ... This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with ... interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced ...

Molecules called pro-inflammatory cytokines, which include interleukin-1 (IL-1), Interleukin-2 (IL-2), interleukin-6 (IL-6), ... and saw how interleukin-1 was released directly into the brain. Interleukin-1 is the same cytokine released when a macrophage ... Besedovsky, H.; del Rey, A.; Sorkin, E.; Dinarello, C. A. (1986-08-08). "Immunoregulatory feedback between interleukin-1 and ... Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP (1998). "The pathophysiologic roles of interleukin-6 in human disease". ...

Interleukin (IL-6) is a signaling protein that has been known to be present during an immune response. The use of the sandwich ... Interleukin (IL-6) can also be bioimmobilized on biosensors. The ability to observe these changes in IL-6 levels is important ... The increase in interleukin levels is directly proportional to the increased death rate in breast cancer patients. PCR paired ... One example of how mutagenesis is used is found in the coupling of site-directed mutagenesis and PCR to reduce interleukin-6 ...

Buchan, G., Barrett, K., Turner, M., Chantry, D., Maini, R. N., and Feldmann, M. (1988). "Interleukin 1 and tumour necrosis ... Turner, M., Chantry, D., Buchan, G., Barrett, K., and Feldmann, M. (1989). "Regulation of expression of human interleukin 1 ... "Excessive production of interleukin 6 (BSF-2) in rheumatoid arthritis." Eur. J. Immunol. 18:1797-1801. ... 18(6):683-693. PMID 28394372 Galloway, A., Saveliev, A., Łukasiak, S., Hodson, D.J., Bolland, D., Balmanno, K., Ahlfors, H., ...