... (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an ... March 2013). "Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with ... February 2003). "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain". ... Li Y, Wang H, Lu H, Hua S (2016). "Regulation of Memory T Cells by Interleukin-23". International Archives of Allergy and ...
In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The ... "Entrez Gene: IL23R interleukin 23 receptor". Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002 ... The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. ... Borgiani P, Perricone C, Ciccacci C, Romano S, Novelli G, Biancone L, Petruzziello C, Pallone F (Sep 2007). "Interleukin-23R ...
"Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein is also known as IL-23p19. ... "Entrez Gene: IL23A interleukin 23, alpha subunit p19". Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. ( ... Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. The IL- ...
"Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 ... Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B- ... Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (dendritic cells, macrophages). It promotes the ... IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which ...
Interleukin-12 p40 also serves as a subunit of interleukin 23. GRCh38: Ensembl release 89: ENSG00000113302 - Ensembl, May 2017 ... IL-12B is a common subunit of interleukin 12 and interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that ... "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): ... "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated ...
... family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T ... IL-17 is unique in that it bears no resemblance to other known interleukins. Furthermore, IL-17 bears no resemblance to any ... Miossec P, Korn T, Kuchroo VK (August 2009). "Interleukin-17 and type 17 helper T cells". The New England Journal of Medicine. ... Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL (January 2003). "Interleukin-23 promotes a distinct CD4 T cell ...
Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 ... 1998). "Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 ... "Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... 1995). "Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist". Eur. J. Immunol. 25 (1): 200-6. doi:10.1002/eji ...
... now called interleukin-1 alpha and interleukin-1 beta. IL-1β is a member of the interleukin 1 family of cytokines. This ... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". European Cytokine ... interleukin 1 beta convertase) to form mature IL-1β. The fever-producing property of human leukocytic pyrogen (interleukin 1) ... "Entrez Gene: IL1B interleukin 1, beta". Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH (August 2009). " ...
... interleukin 1, interleukin 6 and some members of the colony-stimulating factor family. IL-17F can also induce expression of ... Interleukin 17F (IL-17F) is signaling protein that is in human is encoded by the IL17F gene and is considered a pro- ... The interleukin 17 family members are among the effector cytokines of Th17 immune response. This immune response protects hosts ... IL-17F is highly (55%) homologous to interleukin-17A (IL-17A). These two molecules bind to the same receptors and are very ...
30 (2). Hanžel J, D'Haens GR (April 2020). "Anti-interleukin-23 agents for the treatment of ulcerative colitis". Expert Opinion ... that targets IL-23. This drug was developed by MedImmune. Statement On A Nonproprietary Name Adopted By The USAN Council - ...
Interferon-gamma and interleukin-12 pathway defects and human disease. Cytokine Growth Factor Rev. 2000;11(4):321-333. Newport ... Inherited disorders of the interleukin-12/23-interferon gamma axis. In: Ochs HD, Smith CIE, Puck JM, e eds. Primary ...
Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ (2006). "Interleukin-23 drives innate and T ... "A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated ... identified the critical role played by the cytokine IL-23 in driving pathology in the intestine Work from the Powrie lab. ...
July 2015). "Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal ... March 2008). "Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens". Nature Medicine. ... January 2014). "Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway ... August 2014). "Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus ...
... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw ... Its receptors were similarly renamed: Interleukin 8 receptor, alpha - CXCR1 Interleukin 8 receptor, beta - CXCR2 GRCh38: ... Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types ... In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 ...
Catalan-Dibene, Jovani; McIntyre, Laura L.; Zlotnik, Albert (October 2018). "Interleukin 30 to Interleukin 40". Journal of ... Interleukin 40, or IL-40, also known with other name C17orf99 is encoded by gene that do not belong to any cytokine superfamily ... Interleukin-40 is a promising biomarker associated with type 2 diabetes mellitus risk. Immunol Lett. 2023 Feb;254:1-5. doi: ... The expression of IL-40, an interleukin involved in immune regulation, has been found to be elevated in the synovial fluid of ...
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...
Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl M (February 2007). "A human interleukin-12/ ... 15 (4): 215-23. doi:10.1016/S1044-5323(03)00047-2. PMID 14690046. Putnam FW, Liu YS, Low TL (April 1979). "Primary structure of ... 96 (1): 9-23. doi:10.1182/blood.V96.1.9. PMID 10891425. Archived from the original on 29 April 2010. Retrieved 31 March 2007. ... Helsby MA, Fenn JR, Chalmers AD (23 August 2013). "Reporting research antibody use: how to increase experimental ...
... (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In ... Interleukin-6 has been shown to interact with interleukin-6 receptor, glycoprotein 130, and Galectin-3. There is considerable ... Other cytokines that signal through receptors containing gp130 are Interleukin 11 (IL-11), Interleukin 27 (IL-27), ciliary ... "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". The Journal of ...
... (IL-38) is a member of the interleukin-1 (IL-1) family and the interleukin-36 (IL-36) subfamily. It is important ... Jung, MY; Kang, SW; Kim, SK; Kim, H-J; Yun, DH; Yim, S-V; Hong, SJ; Chung, J-H (2010-02-09). "The interleukin-1 family gene ... Yuan, X. L.; Li, Y.; Pan, X. H.; Zhou, M.; Gao, Q. Y.; Li, M. C. (May 2016). "Production of recombinant human interleukin-38 ... Also serum levels of IL-17 and interleukin-22 were lower in these mice what approves in vitro observation that IL-38 could ...
Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against ... 2004). "Interleukin-28 and 29 (IL-28 and IL-29): new cytokines with anti-viral activities". International Journal of ... Protein pages needing a picture, Genes on human chromosome 19, Interleukins). ... 113 (23): 5868-77. doi:10.1182/blood-2008-11-190520. PMC 2700323. PMID 19304955. Morrow MP, Yan J, Pankhong P, Shedlock DJ, ...
... (IL-24) is a protein in the interleukin family, a type of cytokine signaling molecule in the immune system. In ... This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing ... March 2016). "The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated ... Wang M, Tan Z, Zhang R, Kotenko SV, Liang P (March 2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric ...
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 ( ... "Entrez Gene: interleukin 29 (interferon". Wang JM, Huang AF, Xu WD, Su LC (December 2019). "Insights into IL-29: Emerging role ... Pagliaccetti NE, Eduardo R, Kleinstein SH, Mu XJ, Bandi P, Robek MD (October 2008). "Interleukin-29 functions cooperatively ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 19, Interleukins, Cytokines, ...
Interleukin-1 family Interleukin 18 Interleukin 18 receptor Interleukin 18 binding protein Inflammation Carcinogenesis GRCh38: ... Interleukin 37 (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for ... April 2018). "The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis". ... interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382-384. doi:10.1006/geno.1994.1076. PMID ...
Together with Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony- ... February 2014). "Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co- ... Liew FY, McInnes IB (November 2002). "Role of interleukin 15 and interleukin 18 in inflammatory response". Annals of the ... December 2007). "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis ...
"Entrez Gene: IL7 interleukin 7". Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a ... Aspinall R, Henson S, Pido-Lopez J, Ngom PT (2004). "Interleukin-7: an interleukin for rejuvenating the immune system". Ann. N ... "Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal ... Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by ...
... (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family ... Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils ... "Entrez Gene: Interleukin 33". Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, et al. (November 2010). "IL- ... Casciaro M, Cardia R, Di Salvo E, Tuccari G, Ieni A, Gangemi S (May 2019). "Interleukin-33 Involvement in Nonsmall Cell Lung ...
... (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is encoded by two distinct ... Iwasaki Y, Fujio K, Okamura T, Yamamoto K (January 2015). "Interleukin-27 in T cell immunity". International Journal of ... Yoshida H, Hunter CA (April 2015). "The immunobiology of interleukin-27". Annual Review of Immunology. 33 (1): 417-43. doi: ... Aparicio-Siegmund S, Garbers C (October 2015). "The biology of interleukin-27 reveals unique pro- and anti-inflammatory ...
Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annual Review of ... Media related to Interferons or interleukin-10 (IL-10) at Wikimedia Commons Interleukin-10 at the U.S. National Library of ... Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor". Annual ... "Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin ...
... (IL20) is a protein that is in humans encoded by the IL20 gene which is located in close proximity to the IL-10 ... "Entrez Gene: Interleukin 20". Kragstrup TW, Greisen SR, Nielsen MA, Rhodes C, Stengaard-Pedersen K, Hetland ML, et al. (March ... Overview of all the structural information available in the PDB for UniProt: Q9NYY1 (Interleukin-20) at the PDBe-KB. This ... Hsu YH, Chang MS (May 2014). "The therapeutic potential of anti-interleukin-20 monoclonal antibody". Cell Transplantation. 23 ( ...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein ... February 2014). "Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co- ... Interleukin-2 (Aldesleukin). Date accessed: 07 Nov 10. Shi VY, Tran K, Patel F, Leventhal J, Konia T, Fung MA, Wilken R, Garcia ... 2018-07-26). "Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional ...