Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit ( ... alpha subunit is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene. The IL-15 receptor is ... "Identification of an interleukin-15alpha receptor-binding site on human interleukin-15". J. Biol. Chem. 279 (23): 24313-22. doi ... This may be due to effects of the respective alpha chains, which are unique to each receptor, the kinetics and affinity of ...

... is a subunit for the interleukin-10 receptor. IL10RA, is its human gene. IL10RA has also ... Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Interleukin 10 receptor, alpha subunit ... IL10RA interleukin 10 receptor, alpha". Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A receptor for ... Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". ...

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... "Entrez Gene: IL11RA interleukin 11 receptor, alpha". Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ... 1996). "The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping". Genomics. 32 (1): ...

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 ... Interleukin 5 receptor alpha subunit has been shown to interact with: Interleukin 5, Janus kinase 2, Protein unc-119 homolog, ... The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for ... Interleukin-5 receptor subunit alpha) at the PDBe-KB. This article incorporates text from the United States National Library of ...

1998). "Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and ... 2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. 345 (3): 741-7. doi:10.1042/ ... 1999). "Tip60 interacts with human interleukin-9 receptor alpha-chain". Biochem. Biophys. Res. Commun. 263 (1): 149-55. doi: ... Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also ...

... alpha subunit and shares common beta and gamma subunits with the IL-2 receptor. PDB: 2B5I​Wang X, Rickert M, Garcia KC ( ... November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science. 310 ... Receptors,+Interleukin-15 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (CS1 maint: date and ... Interleukin-15 receptor is a type I cytokine receptor, binding interleukin-15. It consists of an interleukin 15 receptor, ...

Due to sharing of receptor subunits between IL-2 and IL-15, both of these cytokines have similar downstream effects including ... all share the same receptor alpha chain which looks like mammalian IL-15Rα. In fish, as in mammals, IL-15 appears to stimulate ... Together with Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony- ... May 1994). "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor". Science. 264 ( ...

He defined the IL-2 receptor subunits IL-2R beta and IL-2R alpha using the first reported anticytokine monoclonal antibody ( ... "The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T- ... He studied the role played by the receptor for interleukin-2 (IL-2) on the growth, differentiation and regulation of normal and ... was an American immunologist who has worked on therapeutic monoclonal antibodies to the IL-2 receptor, Interleukin 15 (IL-15), ...

"Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's". ... Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70- ... "Entrez Gene: IL2RB interleukin 2 receptor, beta". Boyman O, Sprent J (February 17, 2012). "The role of interleukin-2 during ... Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in ...

... 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is ... The receptors can both bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1 receptor antagonist). The crystal ... Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ...

... interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor ... Stein B, Yang MX (September 1995). "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ... Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types ...

IL-17RA/RC receptor complex is composed of both alpha helices and beta sheets and its extracellular part contains two ... and second other family subunit, thus forming heteromeric receptor binding different ligands. IL-17A, a founding member of IL- ... Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory ... "Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E". Immunity. 35 (4): 611-21. ...

"IL10RA - Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human)". www.uniprot.org. Retrieved 2015-10-13. " ... "IL10RB - Interleukin-10 receptor subunit beta precursor - Homo sapiens (Human)". www.uniprot.org. Retrieved 2015-10-13. "hcdm, ... Retrieved 2015-10-15. "hcdm, Human Cell Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-15. "hcdm, Human Cell ... Retrieved 2015-10-15. "hcdm, Human Cell Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-15. "hcdm, Human Cell ...

Normally, when the interleukin binds to the trimeric receptor protein containing the alpha, beta, and gamma subunits, the ... which is a common subunit of the individual receptors for Interleukin 2, Interleukin 4, Interleukin 7, Interleukin 9, ... The most important receptors for X-SCID are those for Interleukin 2, Interleukin 4, Interleukin 7, and Interleukin 15. ... This gene encodes the interleukin receptor common gamma chain protein, which is a cytokine receptor sub-unit that is part of ...

... encoding interferon alpha/beta receptor 2 IFNGR2: encoding interferon gamma receptor 2 IL10RB: encoding interleukin-10 receptor ... encoding enzyme subunit ATP synthase-coupling factor 6, mitochondrial ATP5PO: encoding enzyme subunit ATP synthase subunit O, ... encoding alpha-1 chain of collagen VI COL6A2: encoding alpha-2 chain of collagen VI COL18A1: encoding alpha-1 chain of collagen ... encoding glutamate receptor ionotropic, kainate 1 H2BC12L: encoding histone H2B type F-S HLCS: encoding enzyme holocarboxylase ...

IL-5 has been shown to interact with interleukin 5 receptor alpha subunit. The IL-5 receptor is composed of an α and a βc chain ... "Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional ... is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin ... The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte ...

Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain ... 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045 ... "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ... cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R ...

In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The ... "Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen- ... June 2002). "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, ... The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. ...

LIF+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates ... Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ ... receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood. 93 (3): 804-15. doi:10.1182/blood.V93.3.804. PMID ... receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation". ...

"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science. 310 (5751): 1159-63 ... The IL-2 receptor (IL-2R) α subunit binds IL-2 with low affinity (Kd~ 10−8 M). Interaction of IL-2 and CD25 alone does not lead ... Patients are typically treated for five consecutive days, three times a day, for fifteen minutes. The following approximately ... In fish, IL-2 shares a single receptor alpha chain with its related cytokines IL-15 and IL-15-like (IL-15L). This "IL-15Rα" ...

The human protein Interleukin-2 receptor subunit alpha is encoded by a gene called IL2RA with a length around 51,6 kb. ... "IL2RA interleukin 2 receptor subunit alpha [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-01-25. ... Interleukin-2 receptor subunit alpha) at the PDBe-KB. (CS1: long volume value, Articles with short description, Short ... Interleukin-2 receptor alpha chain (also called TAC antigen, P55 and mainly CD25) is a protein involved in assembly of high- ...

Serve H, Hsu YC, Besmer P (1994). "Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of ... Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. ... Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46 ... Zhang S, Broxmeyer HE (1999). "p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, ...

... and co-receptor IL-1 receptor 8 (IL-1R8). The affinity of IL-37b to IL-18R alpha subunit is much lower compared to IL-18. IL- ... Interleukin-1 family Interleukin 18 Interleukin 18 receptor Interleukin 18 binding protein Inflammation Carcinogenesis GRCh38: ... "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor ... April 2002). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but ...

Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, ... priming for IL-12 and tumor necrosis factor alpha production". J. Exp. Med. 181 (2): 537-46. doi:10.1084/jem.181.2.537. PMC ... IL-12B is a common subunit of interleukin 12 and interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that ... Interleukin-12 p40 also serves as a subunit of interleukin 23. GRCh38: Ensembl release 89: ENSG00000113302 - Ensembl, May 2017 ...

IL-10 has been shown to interact with Interleukin 10 receptor, alpha subunit. The receptor complex for IL-10 also requires the ... Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annual Review of ... Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor". Annual ... IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, ...

2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 ... function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits ... 1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also ...

... alpha 1 Interleukin 13 receptor, alpha 1 Karyopherin alpha 1 Laminin, alpha 1 Major histocompatibility complex, class II, DP ... alpha 1 Collagen, type XII, alpha 1 Collagen, type XIII, alpha 1 Collagen, type XIV, alpha 1 Collagen, type XV, alpha 1 ... subunit, alpha 1 Protein kinase, AMP-activated, alpha 1 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), ... alpha 1 Gap junction protein, alpha 1 GDNF family receptor alpha 1 Glutathione S-transferase A1 Glycine receptor, alpha 1 Heat ...

... the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". Journal of Immunology. 167 (1): 1-5. doi: ... "Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step ... The IL-21 receptor (IL-21R) is expressed on the surface of T, B and NK cells. IL-21r is similar in structure to the receptors ... Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent ...

The interleukin 2 receptor subunit gamma (II2rg) domain, which spans from amino acids 2-102 in C22orf15, facilitates the ... This signifies that C22orf15 is evolving rapidly, but not as rapidly as fibrinogen alpha chain. There appears to be a linkage ... "IL2RG interleukin 2 receptor subunit gamma [Homo sapiens (human)]". NCBI Gene. U.S. National Library of Medicine. " ... This protein is a component of various receptors that aid in immune system function. These receptors direct and regulate the ...

... also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor ... Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans ... "Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor". Science. 262 (5141): 1880-3. Bibcode ... "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877-80. ...