It binds to the p-40 subunit of both IL-12 and IL-23 so that they subsequently cannot bind to their receptors. As of January ... The antibody targets a subunit of human interleukin 12 and interleukin 23, which are naturally occurring proteins that regulate ... Specifically, it blocks interleukin IL-12 and IL-23 which help activate certain T-cells. ... Koutruba N, Emer J, Lebwohl M (April 2010). "Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the ...

... which work by targeting the p40 subunit. However, the p40 subunit is also present in Interleukin 12 (IL-12) and causes serious ... Alphabody CMPX-1023 has been successfully developed to target the p19 subunit of Interleukin 23 (IL-23) and has entered ... "Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab". Nat. Biotechnol. 29 (7): 615- ...

... which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in ... EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and ... Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded ... Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel ...

"Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 ... is a protein subunit that in humans is encoded by the IL12B gene. IL-12B is a common subunit of interleukin 12 and interleukin ... "Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic ... This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of ...

IL12 is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred ... Wang KS, Frank DA, Ritz J (May 2000). "Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up ... Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B- ... Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (dendritic cells, macrophages). It promotes the ...

... may refer to: Interleukin-12 subunit beta Neutrophil cytosolic factor 4 Ribosomal protein SA Brazilian patrol boat Grajaú ( ... a smartphone Kel-Tec P-40, a pistol Nonidet P-40, a detergent P-40 APPLE mine, a Vietnamese mine P-40 radar, a Soviet radar ... P40) Carro Armato P 40, an Italian tank Curtiss P-40 Warhawk, an American military aircraft Percival Prentice, a British ... Papyrus 40, a biblical manuscript Phosphorus-40, an isotope of phosphorus ThinkPad P40 Yoga, a laptop P40, a Nissan P engine ...

... p40 homodimer: a potent IL-12 antagonist". Eur. J. Immunol. 25 (1): 200-6. doi:10.1002/eji.1830250133. PMID 7843232. S2CID ... is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name of its human gene. IL-12Rβ1 ... 1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad ... This protein binds to interleukin-12 (IL-12) with a low affinity, and is part of the IL-12 receptor complex. This protein forms ...

On regulatory B-cells, IL-35 signals through the IL-12Rβ2 and IL-27Rα subunits. EBI3 is a homologue to IL-12 p40 and to the ... Interleukin 35 (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family. Member of IL-12 family - IL- ... June 2014). "Interleukin-35 induces regulatory B cells that suppress autoimmune disease". Nature Medicine. 20 (6): 633-41. doi: ... Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40- ...

Interleukins are a cytokine that play a major role in the immune system. IL-12 and IL-23 help with the activation and ... Interleukin antagonists, the most recent class of biologics available for use in IBD, inhibit the action of IL-12 and IL-23 by ... binding to the p40 protein subunit that is found on both of these cytokines. Ustekinumab was approved by the FDA in 2009 for ... Given this, a variety of biological therapies (such as TNF inhibitors and interleukin antagonists) have been developed for the ...

This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad ... The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is ... Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene. ... "Entrez Gene: IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)". ...

Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less ... Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. The IL- ... Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein is also known as IL-23p19. ... "Entrez Gene: IL23A interleukin 23, alpha subunit p19". Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. ( ...

The IL-23 heterodimer binds the receptor complex: the p19 subunit binds IL-23R while the p40 subunit binds IL-12RB1. Receptor ... Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an ... February 2003). "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain". ... Cauli A, Piga M, Floris A, Mathieu A (2015-10-01). "Current perspective on the role of the interleukin-23/interleukin-17 axis ...

Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (Feb 1996). "A novel interleukin-12 p40- ... Trombetta ES, Simons JF, Helenius A (Nov 1996). "Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, ... conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit". The Journal of Biological Chemistry ... 30 (12): 3098-104. doi:10.1021/bi00226a017. PMID 1826090. Jacob CA, Bodmer D, Spirig U, Battig P, Marcil A, Dignard D, Bergeron ...

Similar to subunit p40 of IL-12 which competitively bind to IL-12 receptor (IL-12R) complex, IL-30 most likely binds to IL-27 ... Interleukin 30 (IL-30) forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus it is also called IL27 ... September 2006). "Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic ... Catalan-Dibene J, McIntyre LL, Zlotnik A (October 2018). "Interleukin 30 to Interleukin 40". Journal of Interferon & Cytokine ...

Structurally, IL-23 is a heterodimer with two subunits, p19 and p40. The p40 subunit is also shared with IL-12, a cytokine that ... Tildrakizumab is a humanized IgG1/k monoclonal antibody that selectively binds to the p19 subunit of the interleukin-23 (IL-23 ... Treatments targeting the p40 subunit block both IL-23 and IL-12 and have been associated with an increased risk of infections. ... Tildrakizumab was designed to block interleukin-23 (IL-23), a cytokine that plays a key role in managing the immune system and ...

... is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the ... Renauld JC, Goethals A, Houssiau F, Merz H, Van Roost E, Van Snick J (Jun 1990). "Human P40/IL-9. Expression in activated CD4+ ... Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ...

Ward AC, Monkhouse JL, Hamilton JA, Csar XF (November 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine ... Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP ... Ravichandran KS, Burakoff SJ (January 1994). "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL- ... Wang J, Auger KR, Jarvis L, Shi Y, Roberts TM (May 1995). "Direct association of Grb2 with the p85 subunit of ...

"A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in ... and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell ... van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (April 1999). "The DNA-binding subunit p140 of replication ... Chen M, Pan ZQ, Hurwitz J (April 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 ( ...

Interleukin-23 is known to induce the production of interleukin-17 and interleukin-22. Interleukin-22 works in combination with ... Efalizumab is a monoclonal antibody that specifically targets the CD11a subunit of LFA-1. It also blocks the adhesion molecules ... p40, which is the target of the FDA-approved ustekinumab. In 2017 the US FDA approved guselkumab for plaque psoriasis. There ... such as interleukin-36γ, tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-22. These secreted ...

Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind ... The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent ... "Association of the interleukin-4 receptor alpha chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells". ... Lapouge K, Smith SJ, Groemping Y, Rittinger K (Mar 2002). "Architecture of the p40-p47-p67phox complex in the resting state of ...