Integrins are found in all animals while integrin-like receptors are found in plant cells. Integrins work alongside other ... The following are 16 of the ~24 integrins found in vertebrates: Beta-1 integrins interact with many alpha integrin chains. Gene ... integrins of the β2 family). This α-I domain is the binding site for ligands of such integrins. Those integrins that don't ... Which ligand in the ECM the integrin can bind to is defined by which α and β subunits the integrin is made of. Among the ...

... (p150,95, CR4) is a complement receptor composed of CD11c and CD18. Integrin+alphaXbeta2 at the U.S. ...

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. ... "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)". Gagliani, Nicola; Magnani, Chiara F.; Huber, ...

... (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as ... and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins. αMβ2 is expressed on the surface of many ... Integrin+alphaM at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD ... CD11b, as an integrin molecule on the surface of leukocytes, plays an important role in cell migration, adhesion, and ...

This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen ... Integrin beta-1 is the most abundant beta-integrin expressed and associates with at least 10 different integrin-alpha subunits ... It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 ... The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion. A second integrin beta-1 ...

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha ... For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. ... "Entrez Gene: ITGA6 integrin, alpha 6". De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October ... Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I ...

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the ... "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)". Tani, T T; Mercurio A M (Sep 2001). "PDZ ...

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain ... This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes ... "Entrez Gene: ITGB8 integrin, beta 8". Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH ( ... 2002). "The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1". J. Cell Biol. 157 (3 ...

True homologs of integrins exist in mammals, invertebrates, and some fungi but not in plant cells. Mammalian integrins are ... Integrin-like receptors (ILRs) are found in plants and carry unique functional properties similar to true integrin proteins. ... Integrin-like receptors and integrin-linked kinases together have been implicated in surface adhesion, immune response, and ion ... Most commonly, ILRs resembles the β1 subunit found in integrin proteins. This structural similarity between ILRs and integrins ...

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are ... Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends ... many integrins are known to facilitate signal transduction. In mammals the integrins that include alpha-V are : Overexpression ... that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta ...

... is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as ... The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha ... "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. 272 (23): ... Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation ...

... also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 ... Gardner, Humphrey (2014). "Integrin α1β1". I Domain Integrins. Advances in Experimental Medicine and Biology. 819: 21-39. doi: ... 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp ... 1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but ...

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral ... and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes ... Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: ... The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding ...

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain ... "Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)". Dyer KD, Garcia-Crespo KE, Killoran KE, ... Overview of all the structural information available in the PDB for UniProt: P20702 (Integrin alpha-X) at the PDBe-KB. This ... CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . ...

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". Hadari YR, Arbel-Goren R, Levy Y, ... Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 ...

"Entrez Gene: ITGAD integrin, alpha D". Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d ... 1999). "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1". J. ... Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 - ... 1999). "alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell ...

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes ... "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". Kato, Atsushi; Kawamata ...

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with ... ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and ... "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2 ... "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". Park KR, Inoue T, Ueda M, Hirano T, ...

"Entrez Gene: ITGA8 integrin, alpha 8". Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 ... 1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor ... Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 - ... 2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1". J. Cell Sci. 115 (Pt 23): 4641-8. doi:10.1242/jcs.00145. PMID ...

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins ... integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". The ... March 2006). "Integrin alpha 11 is a novel type I interferon stimulated gene". Cytokine. 33 (6): 352-361. doi:10.1016/j.cyto. ... "Entrez Gene: ITGA11 integrin, alpha 11". Byström B, Carracedo S, Behndig A, Gullberg D, Pedrosa-Domellöf F (November 2009). " ...

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins ... One α and one β subunit associate non-covalently to form 24 unique integrins found in mammals. While some β integrin subunits ... "Entrez Gene: ITGB6 integrin, beta 6". Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". ... May 1996). "Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation ...

Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell- ... Alpha-7 integrin is 128.9 kDa in molecular weight and 1181 amino acids in length. Integrins are heterodimeric integral membrane ... It was shown however that beta-1D integrin appears at embryonic day 11 and alpha-7 integrin does not appear until embryonic day ... The function of alpha-7 integrin, as is the case for most integrins is to mediate cell membrane interactions with extracellular ...

... is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal ... Integrins lack enzymatic activity and depend on adapters to signal proteins. ILK is linked to beta-1 and beta-3 integrin ... Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. Multiple alternatively spliced ... Dedhar S, Williams B, Hannigan G (1999). "Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling". ...

In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in ... Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain, and are crucial for cells to be able ... The beta 2 integrins have also been found in a soluble form, meaning they are not anchored into the plasma membrane of the cell ... "ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]". Verma NK, Kelleher D (August 2017). "Not Just an Adhesion Molecule: ...

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the ... Like all integrin subunits, β7 is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for ... "Entrez Gene: ITGB7 integrin, beta 7". Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti- ... Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (Jan 2012). "Structural specializations of α(4)β(7), an integrin that ...

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers ... Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This ... "Entrez Gene: ITGB4 integrin, beta 4". Aho S, Uitto J (Feb 1998). "Direct interaction between the intracellular domains of ... Suzuki S, Naitoh Y (Mar 1990). "Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in ...

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene. Integrin, beta 5 has been shown to interact with PTK2 ... 1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat ... ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It ... Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 ...

This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function- ... ITGAL gene encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ...

Høye AM, Couchman JR, Wewer UM, Fukami K, Yoneda A (May 2012). "The newcomer in the integrin family: integrin α9 in biology and ... The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell ... Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins ... "Entrez Gene: ITGA9 integrin, alpha 9". Sulimova G, Kutsenko A, Rakhmanaliev E, Udina I, Kompaniytsev A, Protopopov A, Moisjak E ...

... is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin- ... "Entrez Gene: Integrin subunit beta like 1". Retrieved 2018-07-18. Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner ... The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants ...