1988). "Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes". ... Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... Dolby TW, Devuono J, Croce CM (1981). "Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B ... Rabbitts TH, Forster A, Milstein CP (1982). "Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta ...

"Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends". ...

"Depletion of the predominant B-cell population in immunoglobulin mu heavy-chain transgenic mice". Nature. 329 (6134): 71-3. doi ... "Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene ... altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene ... Grosschedl R, Weaver D, Baltimore D, Costantini F (October 1984). "Introduction of a mu immunoglobulin gene into the mouse germ ...

... a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch ... "Association of a single-nucleotide polymorphism in the immunoglobulin mu-binding protein 2 gene with immunoglobulin A ... "Entrez Gene: IGHMBP2 immunoglobulin mu binding protein 2". Grohmann K, Schuelke M, Diers A, Hoffmann K, Lucke B, Adams C, ... "Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type ...

... that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proceedings of the National ...

Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... Fang T, Smith BP, Roman CA (2001). "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain ... and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain ... 1989). "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human ...

"Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene ...

"Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu". Immunity. 19 (2): 203 ... Whereas pol μ is important for heavy-chain rearrangements, pol λ seems to be more important for light-chain rearrangements. The ... Bertocci B, De Smet A, Weill JC, Reynaud CA (July 2006). "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal ... deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo". Immunity. 25 (1): 31-41. doi:10.1016/j.immuni. ...

"Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu". Immunity. 19 (2): 203 ... This is distinct from pol λ, which is involved in heavy chain rearrangements. In polymerase mu mutant mice, hematopoietic cell ... Whole body gamma irradiation of polymerase mu mutant mice indicates that polymerase mu also has a role in double-strand break ... Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA (July 2002). "Association of DNA polymerase mu (pol mu) with Ku and ...

... and the immunoglobulin mu chain form a complex that is transported onto the cell surface". The Journal of Experimental Medicine ... of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to ... On the surface of early preB cells, CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain ... "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression". ...

... binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991 ... a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics. 11 (2): 374-8. doi: ... Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A ... "bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3 ...

"Entrez Gene: IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides". Frutiger S, Hughes ... As cells develop, it seems that expression of the μ-chain becomes necessary for J chain synthesis. The J chain gene is ... "Early expression of human J chain and mu chain gene in the fetal liver". Cell Structure and Function. 18 (5): 297-302. doi: ... mu and J chain expression as a function of B cell differentiation". The Journal of Experimental Medicine. 158 (6): 1993-2006. ...

... mu opioid receptor - mu-chain immunoglobulin - mucin - Muller's ratchet - multiresistance - muscarinic receptor - muscle - ... immunoglobulin - immunoglobulin joining region - immunoglobulin variable region - immunologic receptor - immunology - In vivo ... heavy-chain immunoglobulin - Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus ... gamma-chain immunoglobulin - gamma-delta T-cell antigen receptor - gastrin - gastrointestinal hormone receptor - gastrula - gel ...

... the mutation rate in population genetics A class of Immunoglobulin heavy chain that defines IgM type Antibodies In pharmacology ... Greek Mu / Coptic Mu Mathematical Mu These characters are used only as mathematical symbols. Stylized Greek text should be ... The lowercase letter mu (μ) is used as a special symbol in many academic fields. Uppercase mu is not used, because it appears ... Mu chord Electronic musician Mike Paradinas runs the label Planet Mu which utilizes the letter as its logo, and releases music ...

The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells. In humans, besides the ... "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells". J Biol Chem ... Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J ... The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis ...

The first identified was the μ (or mu) heavy chain that is present in all jawed fish and is the heavy chain for what is thought ... The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In human genome, the IgH ... These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually ... There are five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. They define classes of immunoglobulins: IgG, ...

... immunoglobulin mu-chains MeSH D12.776.124.486.485.705.625 - immunoglobulin j-chains MeSH D12.776.124.486.485.705.750 - ... immunoglobulin mu-chains MeSH D12.776.124.790.651.705.625 - immunoglobulin j-chains MeSH D12.776.124.790.651.705.750 - ... immunoglobulin m MeSH D12.776.124.486.485.114.619.574.500 - immunoglobulin mu-chains MeSH D12.776.124.486.485.114.632 - ... immunoglobulin m MeSH D12.776.124.790.651.114.619.574.500 - immunoglobulin mu-chains MeSH D12.776.124.790.651.114.632 - ...

A mutation of the mu chain within IgM causes autosomal recessive agammaglobulinemia. The presence of IgM or, rarely, IgG is one ... Immunoglobulins are composed of light chains and heavy chains. The light chain (λ or κ) is a protein of ~220 amino acids, ... "Immunoglobulin M an secretory immunoglobulin A: presence of common polypeptide chain different from light chains". Science. 171 ... The J chain is a small (~137 amino acids), acidic protein. As shown, the J chain joins two µ chains via disulfide bonds ...

... immunoglobulin mu-chains MeSH D12.776.377.715.548.705.625 - immunoglobulin j-chains MeSH D12.776.377.715.548.705.750 - ... immunoglobulin m MeSH D12.776.377.715.548.114.619.574.500 - immunoglobulin mu-chains MeSH D12.776.377.715.548.114.632 - ... immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - immunoglobulin alpha-chains MeSH D12.776.377.715.548.705. ... immunoglobulin delta-chains MeSH D12.776.377.715.548.705.500.370 - immunoglobulin epsilon-chains MeSH D12.776.377.715.548.705. ...

In mammals there are two types of immunoglobulin light chain, which are called lambda (λ) and kappa (κ). However, there is no ... the heavy chain types α (alpha), γ (gamma), δ (delta), ε (epsilon), μ (mu) give rise to IgA, IgG, IgD, IgE, IgM, respectively. ... two identical heavy chains and two identical light chains connected by disulfide bonds. Each chain is a series of domains: ... The N-terminus of each chain is situated at the tip. Each immunoglobulin domain has a similar structure, characteristic of all ...

... gammopathy of undetermined significance Heavy chain diseases Mu heavy chain disease Gamma heavy chain disease Alpha heavy chain ... of bone Extraosseous plasmacytoma Monoclonal immunoglobulin deposition diseases Primary amyloidosis Light chain and heavy chain ...

It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain ... "FCMR Fc mu receptor [Homo sapiens (Human)] - Gene - NCBI". Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang DW, et al ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... Two types of FcεR are known: the high-affinity receptor FcεRI is a member of the immunoglobulin superfamily (it has two Ig-like ...

IGHG4 Heavy chain delta (IgD): IGHD Heavy chain epsilon (IgE): IGHE Heavy chain mu (IgM): IGHM IGHV@ "Human PubMed Reference ... Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the ... immunoglobulin genes: Heavy chain alpha (IgA): IGHA1, IGHA2 Heavy chain gamma (IgG): IGHG1, IGHG2, IGHG3, ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ...

... gamma chain disease (Franklin's disease) mu chain disease delta chain disease The most common type of heavy chain disease is ... "Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain". Blood. 115 (2): 282-8. ... Wahner-Roedler DL, Kyle RA (1992). "Mu-heavy chain disease: presentation as a benign monoclonal gammopathy". Am. J. Hematol. 40 ... These heavy chain disease proteins have various deletions, mainly in their amino-terminal part, which causes the heavy chains ...

There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three ( ... The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by ... CD2 CD4 VCAM1 Smith DK, Xue H (1997). "Sequence profiles of immunoglobulin and immunoglobulin-like domains". J. Mol. Biol. 274 ... Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. ...

M9762/3 Heavy chain disease, NOS Alpha heavy chain disease Mu heavy chain disease Gamma heavy chain disease Franklin disease ... lymphadenopathy M9768/1 T-gamma lymphoproliferative disease M9769/1 Immunoglobulin deposition disease Systemic light chain ...

... immunoglobulin light chain. For diagnosis, the κ and λ free light chains are quantified by immunological methods and the ratio ... or mu (μ) subtypes and two identical light chains which are of the kappa (κ) or lambda (λ) subtypes. Antibodies are classified ... a free κ chain in great excess of a λ chain or a free λ chain in great excess of a κ chain; and d) free γ, δ, or μ heavy chains ... Myeloma protein toxicities include: Monoclonal free light chains, free heavy chains, or a mixture of these chains can deposit ...

... chains of the immunoglobulin light chain loci rearrange in a very similar way, except that the light chains lack a D segment. ... is generated containing the VDJ region of the heavy chain and both the constant mu and delta chains (Cμ and Cδ). (i.e. the ... of immunoglobulin light chain. Each heavy chain or light chain gene contains multiple copies of three different types of gene ... The immunoglobulin heavy locus (IGH@) on chromosome 14, containing the gene segments for the immunoglobulin heavy chain. The ...

... linker protein for immunoglobulin alpha and mu polypeptides INTS12: Integrator complex subunit 12 KDR: Kinase insert domain ... Myosin light chain 5 NAP1L5: encoding protein Nucleosome assembly protein 1 like 5 NDNF: encoding protein Neuron derived ...

Bridges SL (August 1998). "Frequent N addition and clonal relatedness among immunoglobulin lambda light chains expressed in ... DNA polymerase mu and terminal deoxyribonucleotidyl transferase". Journal of Molecular Biology. 339 (2): 395-404. doi:10.1016/j ... Expression and function of terminal deoxynucleotidyl-transferase and discovery of novel DNA polymerase mu]". Seikagaku. The ...