HIF1AN
... alpha subunit inhibitor". Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): ... Dann CE, Bruick RK, Deisenhofer J (2003). "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl ... "Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin ... "Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha". J. ...
HIF1A
The human HIF1A gene encodes for the alpha subunit, HIF1A of the transcription factor hypoxia-inducible factor (HIF1). Its ... "Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit ... is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The ... alpha subunit (basic helix-loop-helix transcription factor)". Wang GL, Jiang BH, Rue EA, Semenza GL (June 1995). "Hypoxia- ...
Hydroxyproline
Hydroxylation of proline has been shown to be involved in targeting Hypoxia-inducible factor (HIF) alpha subunit (HIF-1 alpha) ... 2001). "Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation". Science. ... Alpha-Amino acids, Cyclic amino acids, Pyrrolidines, Gamma hydroxy acids, Non-proteinogenic amino acids, Secondary amino acids ... Under normoxia (normal oxygen conditions) EGLN1[1] protein hydroxylates the proline at the 564 position of HIF-1 alpha, which ...
List of MeSH codes (D12.776.930)
... core binding factor alpha 2 subunit MeSH D12.776.930.155.200.300 - core binding factor alpha 3 subunit MeSH D12.776.930.316. ... hypoxia-inducible factor 1, alpha subunit MeSH D12.776.930.125.750.590 - myod protein MeSH D12.776.930.125.750.595 - myogenic ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.155.200.100 - core binding factor alpha 1 subunit MeSH D12.776.930.155 ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.323.500.500 - hepatocyte nuclear factor 1-alpha MeSH D12.776.930.323. ...
List of MeSH codes (D12.776.260)
... hypoxia-inducible factor 1, alpha subunit MeSH D12.776.260.103.750.590 - myod protein MeSH D12.776.260.103.750.595 - myogenic ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.262.500.500 - hepatocyte nuclear factor 1-alpha MeSH D12.776.260.262. ... hepatocyte nuclear factor 3-alpha MeSH D12.776.260.950.249.750 - hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.235.750.750 - maf transcription factors, small MeSH D12.776.260.235. ...
Hypoxia in fish
Saydur (2007), "Molecular cloning, characterization and expression of two hypoxia-inducible factor alpha subunits, HIF-1α and ... after approximately one week and is therefore likely under genetic control of hypoxia inducible factor hypoxia inducible factor ... Research in mammals has implicated hypoxia inducible factor (HIF) as a key regulator of gene expression changes in response to ... "Evolution and Regulation of the Downstream Gene of Hypoxia-Inducible Factor-1α in Naked Carp (Gymnocypris przewalskii) from ...
HIF3A
"Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit". Drevytska T, Gavenauskas B, Drozdovska S, Nosar V, Dosenko V, ... It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At ... hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 ... "Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha". ...
EGLN1
Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme ... In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... In humans, PHD2 is one of the three isoforms of hypoxia-inducible factor-proline dioxygenase, which is also known as HIF prolyl ... Ozer A, Wu LC, Bruick RK (2005). "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF ...
Pacak-Zhuang syndrome
Mutations in the genes encoding alpha subunits of hypoxia-inducible factors (HIF-alpha) have not previously been identified in ... Jochmanova I, Yang C, Zhuang Z, Pacak K. Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the ... Ocular Manifestations of Hypoxia-Inducible Factor-2A Paranglioma-Somatostatinoma-Polycythemia Syndrome. J Opthal 2014. DOI: ... neurofibromatosis 1 (NF1), or von Hippel-Lindau (VHL) disease. ...
Phyllodes tumor
These proteins include vascular endothelial growth factor (VEGF), Hypoxia-inducible factor-1a, Platelet-derived growth factor, ... Genes that have been associated with a higher incidence of phyllodes tumors include Mediator Complex Subunit 12 (MED12) exon 2 ... Telomerase Reverse Transcriptase (TERT) promoter, and Retinoic Acid Receptor Alpha (RARA); important genes for regulating DNA ... In addition, vascular factors promoting angiogenesis have been shown to further promote growth of these breast masses. ...
EPAS1
... enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ... It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen ... "Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein". The Journal of ... "A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is ...
Alessio Ciulli
E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities". Journal of ... Hypoxia Inducible Factor 1α Protein-Protein Interface". Chemistry & Biology. 19 (10): 1300-1312. doi:10.1016/j.chembiol.2012.08 ... 8 (1): 830. Bibcode:2017NatCo...8..830M. doi:10.1038/s41467-017-00954-1. PMC 5635026. PMID 29018234. Cardote, Teresa A. F.; ...
Pheochromocytoma
Pacak-Zhuang Syndrome Hypoxia-inducible factor 2 alpha (HIF2A) Polycythemia Duodenal somatostatinoma Retinal and choroidal ... Succinate Dehydrogenase Subunit x) MAX (MYC Associated Factor X); TMEM127 (Transmembrane Protein 127) There have been several ... This complication is related to the impact that alpha and beta-adrenoceptor antagonists have on blood vessels combined with the ... Santos JR, Wolf KI, Pacak K (February 2019). "A Necessity, Not a Second Thought: Pre-Operative Alpha-Adrenoceptor Blockade in ...
Hypoxia-inducible factor
... family of transcription factors. The alpha and beta subunit are similar in structure and both contain the following domains: N- ... Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular ... Acker T, Plate KH (2004). "Hypoxia and hypoxia inducible factors (HIF) as important regulators of tumor physiology". Cancer ... "Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases". Current ...
N-alpha-acetyltransferase 10
... does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF". The Journal of ... N-alpha-acetyltransferase 10 (NAA10) also known as NatA catalytic subunit Naa10 and arrest-defective protein 1 homolog A (ARD1A ... "Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis". Journal of ... inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha ...
EGLN2
The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen ... the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this ... 2004). "Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors". J. Cell. Biochem. 92 (3): 491-501. doi:10.1002/jcb ... modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343-9. doi:10.1016/ ...
Hydrogen potassium ATPase
... adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes". Pharmacol Res. 76: 157- ... ATP4A ATPase H+/K+ transporting alpha subunit Chourasia, M.; Sastry, G. M.; Sastry. G. N. (2005). "Proton binding sites and ... The H+/K+ ATPase β subunit stabilizes the H+/K+ ATPase α subunit and is required for function of the enzyme. The β subunit ... The α subunit also has a phosphorylation site (Asp385). The gene ATP4B encodes the β subunit of the H+/K+ ATPase, which is a ~ ...
HIF-1 alpha IRES
Lang KJ, Kappel A, Goodall GJ (May 2002). "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that ... is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response ... The hypoxia-inducible factor-1α protein (HIF-1α) ... Page for HIF-1 alpha IRES at Rfam v t e (GO template errors, ... The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap- ...
P4HA2
"The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases". J ... The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer". J Biol Chem. 272 (28): 17342-8. doi: ... a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one ... "Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. ...
Carrie L. Partch
"Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B". ... her first publication focusing on the regulation of IL-15-stimulated TNF-alpha production, a study applicable to patients with ... of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit ... These complexes directly bind to and inhibit the core circadian transcription factor, CLOCK:BMAL1. As PERIOD proteins are ...
Hepatocyte growth factor receptor
MET transcription is activated by hypoxia-inducible factor 1 (HIF1), which is activated by low concentration of intracellular ... The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are ... "Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von ... "Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway". ...
Procollagen-proline dioxygenase
Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond ... Helaakoski T, Vuori K, Myllylä R, Kivirikko KI, Pihlajaniemi T (June 1989). "Molecular cloning of the alpha-subunit of human ... Smith TG, Robbins PA, Ratcliffe PJ (May 2008). "The human side of hypoxia-inducible factor". British Journal of Haematology. ... Karuppagounder SS, Ratan RR (July 2012). "Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another ...
Hydroxylation
Proline hydroxylation is also a vital component of hypoxia response via hypoxia inducible factors. In some cases, proline may ... Other hydroxylating agents include flavins, alpha-ketoglutarate-dependent hydroxylases, and some diiron hydroxylases. The ... multi-subunit enzymes prolyl 4-hydroxylase, prolyl 3-hydroxylase and lysyl 5-hydroxylase, respectively. These reactions require ... 17α-Hydroxylase Cholesterol 7 alpha-hydroxylase Dopamine β-hydroxylase Phenylalanine hydroxylase Tyrosine hydroxylase One ...
Chromosome 11
Srp receptor alpha subunit Suppression of tumorigenicity 2: encoding protein Suppression of tumorigenicity 2 TAF1D: TATA box ... tumor protein 53 inducible protein 11 TRAPPC4: trafficking protein particle complex subunit 4 TRIM34: encoding protein ... Cleavage and polyadenylation specificity factor subunit 7 CPT1A: carnitine palmitoyltransferase 1A (liver) CREBZF encoding ... hypoxia upregulated protein 1 IFITM2 encoding protein Interferon induced transmembrane protein 2 IFT46: intraflagellar ...
PSMA7
This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important ... Proteasome subunit alpha type-7 also known as 20S proteasome subunit alpha-4 is a protein that in humans is encoded by the ... As a component of alpha ring, proteasome subunit alpha type-7 contributes to the formation of heptameric alpha rings and ... This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits ...
MTORC1
Under hypoxic conditions, hypoxia inducible factor one alpha (HIF1A) will stabilize and activate transcription of REDD1, also ... Once the initiation complex is assembled at the 5' cap of mRNA, it will recruit the 40S small ribosomal subunit that is now ... Cytokines like tumor necrosis factor alpha (TNF-alpha) can induce mTOR activity through IKK beta, also known as IKK2. IKK beta ... Upon growth factor binding to the adjacent receptor tyrosine kinase, the adaptor protein GRB2 binds with its SH2 domains. This ...
Phosphofructokinase 2
Walker JE, Saraste M, Runswick MJ, Gay NJ (1982). "Distantly related sequences in the alpha- and beta-subunits of ATP synthase ... "The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6- ... studies have confirmed that modification from multiple transcription factors in the 5' flanking region regulates the amount of ... I-Type: Inducible This isoform's name is a result of its increased expression in response to hypoxic stress; its formation is ...
P4HA1
"The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases". J ... The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer". J. Biol. Chem. 272 (28): 17342-8. doi ... 1997). "Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme ... a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one ...
IDH2
... which accumulates and leads to the inhibition of hypoxia-inducible factor 1α (HIF1α) degradation (inhibition of the HIF prolyl- ... a partially unraveled alpha helix in the semi open form, and an alpha helix in the active form. The mitochondrial form of IDH2 ... It is a homodimer in which each subunit has a Rossmann fold, and a common top domain of interlocking β sheets. Mtb IDH-1 is ... The mitochondrial form of IDH, like most isoforms, is a homodimer, in which two identical monomer subunits form one unit. The ...
EP300
... hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. The p300 ... "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene ... "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5367- ... "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and ...