In general, glycosphingolipids can be categorized into two groups: neutral glycosphingolipids (also called glycosphingolipids) ... Glycosphingolipids are a group of lipids (more specifically, sphingolipids) and are a part of the cell membrane. They consist ... Neutral glycosphingolipids are also important, for example as blood type antigens. Inheritable enzyme defects can lead to ... Glycosphingolipids are a subtype of glycolipids containing the amino alcohol sphingosine. They may be considered as ...

The systematic name of this enzyme class is glycosphingolipid amidohydrolase. This enzyme is also called glycosphingolipid ... In enzymology, a glycosphingolipid deacylase (EC 3.5.1.69) is an enzyme that catalyzes a chemical reaction that cleaves ... Hirabayashi Y, Kimura M, Matsumoto M, Yamamoto K, Kadowaki S, Tochikura T (January 1988). "A novel glycosphingolipid ... which cleaves the linkage between the fatty acid and sphingosine base in glycosphingolipids". Journal of Biochemistry. 103 (1 ...

2007). "Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide". Nature. 449 (7158): 62-67. Bibcode:2007Natur. ... In addition to their role as building blocks of biological membranes, glycosphingolipids have long attracted attention because ... Glucosylceramides (GluCer) are the most widely distributed glycosphingolipids in cells serving as precursors for the formation ... Hakomori, S (2000). "Traveling for the glycosphingolipid path". Glycoconj. J. 17 (7/9): 627-647. doi:10.1023/A:1011086929064. ...

These molecules include cholesterol, triacylglycerides, and glycosphingolipids. The optimum growing range for this species is ...

Research has found that this cucumber secretes a biologically active glycosphingolipid HPG-7 that is a major component of cell ... Hakomori, Senitiroh (January 2003). "Structure, organization, and function of glycosphingolipids in membrane". Current Opinion ...

GNE myopathy is a rare genetic disorder caused by hyposialylated muscle proteins and glycosphingolipids because there is ... "Non-specific accumulation of glycosphingolipids in GNE myopathy". Journal of Inherited Metabolic Disease. 37 (2): -297-308. doi ...

Glycosphingolipids are ceramides with one or more sugar residues joined in a β-glycosidic linkage at the 1-hydroxyl position ( ... Ceramides and glycosphingolipids are N-acyl derivatives of these compounds. The sphingosine backbone is O-linked to a (usually ... Certain complex glycosphingolipids were found to be involved in specific functions, such as cell recognition and signaling. ... The complex glycosphingolipids are hydrolyzed to glucosylceramide and galactosylceramide. These lipids are then hydrolyzed by ...

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell ...

GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of ... GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. ...

Glycosphingolipids: a sub-group of glycolipids based on sphingolipids. Glycosphingolipids are mostly located in nervous tissue ... Globosides: glycosphingolipids with more than one sugar as part of the carbohydrate complex. They have a variety of functions; ... Cerebrosides: a group glycosphingolipids involved in nerve cell membranes. Galactocerebrosides: a type of cerebroseide with ... Hakomori S, Igarashi Y (December 1995). "Functional role of glycosphingolipids in cell recognition and signaling". Journal of ...

"Recognition of bacterial glycosphingolipids by natural killer T cells". Nature. 434 (7032): 520-525. doi:10.1038/nature03407. ...

This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis ... Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L (1991). "Glycosphingolipid glycosyltransferases in human fetal ...

LOS is also found in lactoneoseries glycosphingolipids from human cells. Most meningococci from groups B and C, as well as ...

Lachmann RH, Platt FM (2001). "Substrate reduction therapy for glycosphingolipid storage disorders". Expert Opinion on ... which catalyzes the first step in synthesizing glucose-based glycosphingolipids like GM2 gangliosideM2 As Tay-Sachs disease is a ...

2004). "Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on ... 2004). "Structural basis for glycosphingolipid transfer specificity". Nature. 430 (7003): 1048-53. Bibcode:2004Natur.430.1048M ... "Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers". ... protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids ...

Lachmann RH, Platt FM (2001). "Substrate reduction therapy for glycosphingolipid storage disorders". Expert Opinion on ...

"Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide". Nature. 449 (7158): 62-7. Bibcode:2007Natur.449...62D ...

"Viral glycosphingolipids induce lytic infection and cell death in marine phytoplankton". Science. 326 (5954): 861-865. Bibcode: ... and the production of viral glycosphingolipids as a result of infection from coccolithoviruses in Emiliania huxleyii Reddy CM, ...

Among glycosphingolipids two types of glycans are serving as SeV receptors. The first type is represented by fucosylated ... Ngamukote S, Yanagisawa M, Ariga T, Ando S, Yu RK (December 2007). "Developmental changes of glycosphingolipids and expression ... However, cellular expression of gangliosides, which are sialic acid-containing glycosphingolipids, cannot be evaluated by these ... "Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells". ...

A high correlation was found between glycosphingolipid (GSL) production and caspase activity during the lytic stage in infected ... "Viral Glycosphingolipids Induce Lytic Infection and Cell Death in Marine Phytoplankton". Science. 326 (5954): 861-865. Bibcode: ...

For example glycosphingolipids become ceramides and phospholipids become free fatty acids. spinous layer (stratum spinosum) ... glycosphingolipids, free sterols, phospholipids and catabolic enzymes. Langerhans cells, immunologically active cells, are ...

It is usually considered to be the principal glycosphingolipid in plants. It is a major component of the outer layer of the ... Degradation of glycosphingolipids occurs in the lysosome, which contains digestive enzymes in animal cells. The lysosome breaks ... Cerebrosides is the common name for a group of glycosphingolipids called monoglycosylceramides which are important components ... Galactosylceramide is the principal glycosphingolipid in brain tissue. Galactosylceramides are present in all nervous tissues, ...

... , Gal(α1→3)Gal(β1→4)Glcβ(1→1)Cer, abbreviated as iGb3, is an iso-globo-series of glycosphingolipid, ... iGb3 was discovered in canine and rat intestines among iso-globo-series of glycosphingolipids. First NMR spectrums for standard ... 1983 Jan 7;750(1):214-6. Breimer ME, Hansson GC, Karlsson KA, Leffler H. Glycosphingolipids of rat tissues. Different ... Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004 Dec 3;306(5702):1786-9. Zhou D. The immunological function ...

The lipid component of MFGM is rich in phospholipids, glycosphingolipids, and cholesterol. Phospholipids make up approximately ...

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 ... "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1". Brdicková N, Brdicka T, Andera L, Spicka J ... "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane ... "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking ...

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine ... The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial ...

Rearrangements of glycosphingolipids, phospholipids, as well as cholesterol explains changes in membrane fluidity. Some studies ...

This forms glycosphingolipids, which are important for the localisation of receptors in membranes. Incorrect breakdown of these ... Because both galactose and glucose sugars can be added to the ceramide lipid, we have two groups of glycosphingolipids. ...

This is thought to be due to accumulation of glucosylceramide and complex glycosphingolipids. The role of inflammatory ... "Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease". ...

"Differentiation and Quantification of Diastereomeric Pairs of Glycosphingolipids using Gas-phase Ion Chemistry". Analytical ...