Glucagon-like peptide-1
Mojsov, S; Weir, G C; Habener, J F (1987-02-01). "Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon ... intervening peptide-2 (IP-2) and glucagon-like peptide-2 (GLP-2). Initially, GLP-1 was thought to correspond to proglucagon (72 ... "Structural requirements for biological activity of glucagon-like peptide-I". International Journal of Peptide and Protein ... 2 producing glicentin-related pancreatic peptide (GRPP), glucagon, intervening peptide-1 (IP-1) and major proglucagon fragment ...
Glucagon-like peptide-1 receptor
The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas and on neurons of the ... Glucagon-like peptide-1 (GLP-1) is a hormone consisting of 30 amino acids. It is released by intestinal L cells when nutrients ... glucagon-like+peptide+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the ... October 2016). "Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes". ...
Glucagon-like peptide-1 receptor agonist
... s, also known as GLP-1 receptor agonists (GLP-1-RA), incretin mimetics, or GLP-1 ... Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (September 2016). "The glucagon-like peptide-1 analogue ... Das A, Geetha KM, Hazarika I (29 August 2019). "Contemporary Updates on the Physiology of Glucagon like Peptide-1 and Its ... Pinto LC, Falcetta MR, Rados DV, Leitão CB, Gross JL (20 February 2019). "Glucagon-like peptide-1 receptor agonists and ...
Glucagon-like peptide-2 receptor
"Entrez Gene: Glucagon-like peptide 2 receptor". Burrin DG, Petersen Y, Stoll B, Sangild P (Mar 2001). "Glucagon-like peptide 2 ... Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. ... Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17. The ... Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. ...
Free fatty acid receptor 2
... glucagon-like peptide-1) and PYY (i.e., peptide YY) into the blood. GLP-1 stimulates pancreatic beta cells to secrete insulin ... "Glucagon-like peptide 1 (GLP-1)". Molecular Metabolism. 30: 72-130. doi:10.1016/j.molmet.2019.09.010. PMC 6812410. PMID ... Since insulin causes cells to take up blood glucose and glucagon causes the liver to release glucose into the blood, FFAR2 ... and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in ...
Secretin family
... like other peptide hormones, as part of a larger precursor (preproglucagon), which is cleaved to produce glucagon, glucagon- ... Glucagon/gastric inhibitory polypeptide/secretin/vasoactive intestinal peptide hormones are a family of evolutionarily related ... Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide, ... "Glucagon and related peptides. Molecular structure and biological specificity". Annals of the New York Academy of Sciences. 527 ...
Semaglutide
It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. It can be administered by ... April 2010). "Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell ... Semaglutide is a glucagon-like peptide-1 receptor agonist. The most common side effects include nausea, vomiting, diarrhea, ... By mimicking the action of the incretin glucagon-like peptide-1 (GLP-1), it increases the production of insulin, the hormone ...
Albiglutide
... (trade names Eperzan in Europe and Tanzeum in the US) is a glucagon-like peptide-1 agonist (GLP-1 agonist) drug ... Madsbad S (April 2016). "Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists". Diabetes, Obesity & ... PMID 18812476.[permanent dead link] Baggio LL, Drucker DJ (2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". KEGG ... a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes". The Journal of Clinical Endocrinology and ...
Amylin Pharmaceuticals
Garber, Alan J. (2011-05-01). "Long-Acting Glucagon-Like Peptide 1 Receptor Agonists". Diabetes Care. 34 (Supplement 2): S279- ... John Eng licensed to Amylin exendin-4, a peptide he had isolated in the venom of a Gila monster. Exendin-4 is similar to the ... which is responsible for regulating insulin and glucagon release. Unlike human GLP-1, however, exendin-4 has a half-life of ... "FDA Approves Symlin for Type 1 and Type 2 Diabetes". 2005-03-18. Retrieved 2017-05-26. "Dr. John Eng's Research Found That The ...
Taspoglutide
... is a former experimental drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), that was under investigation for ... Baggio LL, Drucker DJ (2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". "Ipsen's Partner Roche Announces That ... Glucagon-like peptide-1 receptor agonists, Abandoned drugs, All stub articles, Gastrointestinal system drug stubs). ... 36-L-argininamide derivative of the amino acid sequence 7-36 of human glucagon-like peptide I. Incretin "Ipsen: Roche Moves ...
Glucose-dependent insulinotropic polypeptide
GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins, which stimulate ... Meier JJ, Nauck MA (2005). "Glucagon-like peptide 1(GLP-1) in biology and pathology". Diabetes/Metabolism Research and Reviews ... Thorens B (Dec 1995). "Glucagon-like peptide-1 and control of insulin secretion". Diabète & Métabolisme. 21 (5): 311-8. PMID ... It has traditionally been named gastrointestinal inhibitory peptide or gastric inhibitory peptide and was found to decrease the ...
Liraglutide
... is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics. It works by ... Shyangdan DS, Royle P, Clar C, Sharma P, Waugh N, Snaith A (October 2011). "Glucagon-like peptide analogues for type 2 diabetes ... Liraglutide has been shown to lead to greater weight loss than other glucagon-like peptide analogues. At exposures eight times ... Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) agonist, derived from human GLP-1-(7-37), a less common form of ...
Omarigliptin
Dupre J, Behme MT, Hramiak IM, McFarlane P, Williamson MP, Zabel P, McDonald TJ (June 1995). "Glucagon-like peptide I reduces ... Behme MT, Dupré J, McDonald TJ (April 2003). "Glucagon-like peptide 1 improved glycemic control in type 1 diabetes". BMC ... which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying and decreases blood ... Regulatory Peptides. 128 (2): 159-65. doi:10.1016/j.regpep.2004.06.001. PMID 15780435. S2CID 9151210. ...
Drug discovery
Shyangdan DS, Royle P, Clar C, Sharma P, Waugh N, Snaith A (October 2011). "Glucagon-like peptide analogues for type 2 diabetes ... Ciemny M, Kurcinski M, Kamel K, Kolinski A, Alam N, Schueler-Furman O, Kmiecik S (May 2018). "Protein-peptide docking: ... 9 (10): 430-1. doi:10.1016/S1359-6446(04)03069-7. PMID 15109945. Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, ... 9 (1): 1-4. doi:10.1021/cc060033w. PMID 17206823. Zheng W, Thorne N, McKew JC (November 2013). "Phenotypic screens as a renewed ...
Peptide therapeutics
May 2006). "Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon ... "Self-assembling peptides improve the stability of glucagon-like peptide-1 by forming a stable and sustained complex". Molecular ... peptide therapeutics mimic such functions. Peptide Therapeutics are seen as relatively safe and well-tolerated as peptides can ... units to the peptide to help with peptide delivery to target sites. The introduction of carbohydrates to peptides can alter the ...
Glucagon-like peptide receptor
Glucagon-like peptide 2 receptor (GLP-2R) - binds glucagon-like peptide 2 (GLP-2) Glucagon receptor v t e (Articles lacking ... The glucagon-like peptide receptors (GLPRs) include the following two receptors: Glucagon-like peptide 1 receptor (GLP-1R) - ...
Penetration enhancer
"Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist". Science Translational Medicine. 10 ... Oral delivery of peptides. 106: 277-319. doi:10.1016/j.addr.2016.06.005. hdl:10197/7800. ISSN 0169-409X. PMID 27320643. ( ... There are also reports on the use of cell penetrating peptides and chitosan as penetration enhancers in ocular drug delivery. ... Maher, Sam; Mrsny, Randall J.; Brayden, David J. (2016-11-15). "Intestinal permeation enhancers for oral peptide delivery". ...
Eriocitrin
... but increased glucagon-like peptide 1 (GLP-1) by (17%) (P ≤ .05). At the end of the placebo period, there was a 13% increase in ... glucagon (−6.5%), C-peptide (−5%), hsCRP (−12%), interleukin-6 (−13%), TNFα (−11%), lipid peroxidation (−17%), systolic blood ... in reducing hyperglycemia by increasing glucagon-like peptide 1 and downregulates systemic inflammation. This double-blind, ... Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized ...
Robert Margolskee
"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proceedings of the National Academy ... 28 (1): 58-63. doi:10.1038/88270. PMID 11326277. Perez, C.; Huang, L.; Rong, M.; Kozak, J.A.; Preuss, A.K.; Zhang, H.; Max, M ... "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1". Proceedings of the National ...
Danuglipron
June 2022). "A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor". Journal of Medicinal Chemistry. 65 ( ... "Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among ... Glucagon-like peptide-1 receptor agonists, Nitriles, Fluoroarenes, Pyridines, Ethers, Piperidines, Oxetanes, Benzimidazoles, ... Danuglipron is a small-molecule GLP-1 agonist developed by Pfizer that, in an oral formulation, is under investigation as a ...
Hanmi Pharm
... a long-acting glucagon-like peptide-1 receptor agonist; an insulin intended to be delivered once per week, and a fixed-dosed ... An exclusive license outside of South Korea and China with Sanofi for Hanmi's Glucagon-like peptide-1 receptor agonist drug ... By around 2010, Hanmi's R&D had two areas of interest: developing longer-lasting peptide and protein therapeutics using its " ... Carroll, John (October 1, 2016). "Following lethal tox report, Boehringer scraps plans for high-speed development, kills $730M ...
Exenatide
... in a similar way to the human peptide glucagon-like peptide-1 (GLP-1); exenatide bears a 50% amino acid homology to GLP-1 and ... Exenatide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics. It works by ... Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (September 2016). "The glucagon-like peptide-1 analogue ... Shyangdan DS, Royle P, Clar C, Sharma P, Waugh N, Snaith A (October 2011). "Glucagon-like peptide analogues for type 2 diabetes ...
Forkhead box protein O1
In pancreatic beta cells FOXO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. When the level of blood ... Buteau J, Spatz ML, Accili D (May 2006). "Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic ... In pancreatic alpha-cells FOXO1 is important in regulating prepro-glucagon expression. ... 11 (1): 6-8. doi:10.1016/S1097-2765(03)00003-0. PMID 12535515. Armoni M, Harel C, Karni S, Chen H, Bar-Yoseph F, Ver MR, Quon ...
Carboxypeptidase E
"Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice". The Journal of ... CPE is involved in the biosynthesis of most neuropeptides and peptide hormones. The production of neuropeptides and peptide ... although for many peptides the action of the proprotein convertases and CPE is sufficient to produce the bioactive peptide. ... For some peptides, additional processing steps, such as C-terminal amidation, are subsequently required to generate the ...
GNAT3
2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proc. Natl. Acad. Sci. U.S. ... A. 193 (1): 21-34. doi:10.1007/s00359-006-0168-8. PMID 17021831. S2CID 25762931. Lambright DG, Noel JP, Hamm HE, Sigler PB ( ... 22 (1-4): 193-203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379. Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. ( ... 2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon". Am. J. Physiol. ...
Anti-obesity medication
Glucagon-like peptide-1 (GLP-1) are peptide incretin hormones involved in blood sugar control. In 2021, one review concluded ... de Luis DA, Gonzalez Sagrado M, Conde R, Aller R, Izaola O (2007). "Decreased basal levels of glucagon-like peptide-1 after ... "Obesity Medication: Gastrointestinal Agents, Other, CNS Stimulants, Anorexiants, Glucagon-like Peptide-1 Agonists, ... Orforglipron is a non-peptide GLP-1 agonist of potential interest because it can be taken orally and is chemically simpler and ...
Proglucagon
Glucagon (53-81) Glucagon-like peptide 1 (GLP-1, 92-128) - first seven residues further cleaved Glucagon-like peptide 2 (GLP-2 ... and two glucagon-like peptides". The Journal of Biological Chemistry. 263 (20): 9746-9751. doi:10.1016/S0021-9258(19)81581-8. ... "Pro-glucagon". PDBe-KB Aggregated Views of Proteins. Wellcome Genome Campus, Hinxton, Cambridgeshire: EMBL-EBI. (Genes on human ... Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in ...
Neointimal hyperplasia
Exendin-4, a glucagon-like peptide-1 receptor (GLP-1) agonist used as drug treatment for type 2 diabetes inhibits neointimal ... a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury". European Journal of ... 101 (1): 18-26. doi:10.1161/01.cir.101.1.18. PMID 10618299. Kay, I. P; Wardeh, A. J; Kozuma, K; Foley, D. P; Knook, A. H. M; ... 159 (1): 27-33. doi:10.1016/j.jconrel.2012.01.008. PMID 22269665. Purcell, C; Tennant, M; McGeachie, J (1997). "Neo-intimal ...
Dulaglutide
It is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment ... Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases insulin secretion by pancreatic ... Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E (February 2014). "Glucagon-like peptide-1 receptor agonists and ... Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas, as glucagon is ...
Hunger (physiology)
For example, ghrelin stimulates appetite, whereas cholecystokinin and glucagon-like peptide-1 (GLP-1) suppress appetite. The ... The hormones peptide YY and leptin can have an opposite effect on the appetite, causing the sensation of being full. Ghrelin ... Leptin is a peptide hormone that affects homeostasis and immune responses. Lowering food intake can lower leptin levels in the ... CCK is key in suppressing hunger because of its role in inhibiting neuropeptide Y. Glucagon and epinephrine levels rise during ...