Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (Mar 1995). "Localization of the human HER4/erbB-4 gene to chromosome 2 ... Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur.387R.509C. ... ErbB-3 and ErbB-4". Oncogene. 15 (23): 2841-8. doi:10.1038/sj.onc.1201458. PMID 9419975. Fiddes RJ, Campbell DH, Janes PW, ...

The JUP gene contains 13 exons spanning 17 kb on chromosome 17q21. Plakoglobin is a member of the catenin family, since it ... Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (Mar 1995). "c-erbB-2 gene product directly ... "Entrez Gene: JUP junction plakoglobin". "Protein sequence of human JUP (Uniprot ID: P14923)". Cardiac Organellar Protein Atlas ... Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. ...

... encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and ... Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (March 1995). "c-erbB-2 gene product directly ... "Entrez Gene: catenin (cadherin-associated protein)". Bush M, Alhanshali BM, Qian S, Stanley CB, Heller WT, Matsui T, et al. ( ... Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is ...

ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also ... and the other members being erbB-1, erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4. All four contain an ... Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. ERBB2, a known proto- ... Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE (September 1998). "ErbB-1 and ErbB-2 acquire distinct ...

The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). It ... "ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo". Cancer Research. 67 (9): 4364-72. doi: ... "Entrez Gene: CCND1 cyclin D1". He Y, Liu Z, Qiao C, Xu M, Yu J, Li G (January 2014). "Expression and significance of Wnt ... "CCND1" Gene". GeneCards. Weizmann Institute of Science. 2013. Retrieved May 6, 2015. Withers DA, Harvey RC, Faust JB, Melnyk O ...

Advantage: Allows for the analysis of specific genes (i.e. driver genes, tumour suppressors). The process is simple with ... Sauter, G; Moch, H; Gasser, T. C.; Mihatsch, M. J.; Waldman, F. M. (1995). "Heterogeneity of chromosome 17 and erbB-2 gene copy ... Similarly, MTOR, a gene encoding a cell regulatory kinase, has shown to be constitutively active, thereby increasing S6 ... It is important to avoid contamination of non-malignant cells to ensure an accurate representation of gene expression and ...

... human gene location in the UCSC Genome Browser. TOB1 human gene details in the UCSC Genome Browser. v t e (Articles with ... Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 ... Protein Tob1 is a protein that in humans is encoded by the TOB1 gene. This gene encodes a member of the tob/btg1 family of anti ... Yoshida Y, Matsuda S, Yamamoto T (May 1997). "Cloning and characterization of the mouse tob gene". Gene. 191 (1): 109-13. doi: ...

Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the ... "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2". Cancer Res. 53 (6): 1403-8 ... As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through ... Davies B, Fried M (1995). "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter ...

1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur. ... 2000). "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA". Gene. 255 (1): ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur.387R.509C. ... The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the ...

Discovery that the gene for the human growth factor receptor 2 (ErbB2) is amplified in around 25% of primary breast tumors and ... Berger MS, Locher GW, Saurer S, Gullick WJ, Waterfield MD, Groner B, Hynes NE (March 1988). "Correlation of c-erbB-2 gene ... Pietrzak M, Shillito R, Hohn T, Potrykus I (July 1986). "Expression in plants of two bacterial antibiotic resistance genes ... Gene. 173 (1 Spec No): 107-111. doi:10.1016/0378-1119(95)00899-3. PMID 8707048. Kaech S, Ludin B, Matus A (1996). "Cytoskeletal ...

"Entrez Gene: Antigen identified by monoclonal antibody Ki-67". Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van ... Bánkfalvi A (November 2000). "Comparative methodological analysis of erbB-2/HER-2 gene dosage, chromosomal copy number and ... Articles with short description, Short description is different from Wikidata, Genes on human chromosome 10, Cell biology, ... Genes to Cells. 7 (12): 1231-42. doi:10.1046/j.1365-2443.2002.00596.x. PMID 12485163. S2CID 6802841. Ki-67+Antigen at the U.S. ...

Beerli RR, Segal DJ, Dreier B, Barbas CF (1998). "Toward controlling gene expression at will: specific regulation of the erbB-2 ... D. Carroll (2008). "Progress and prospects: Zinc-finger nucleases as gene therapy agents". Gene Therapy. 15 (22): 1463-1468. ... Gene therapy Zinc finger nuclease Zinc finger protein Zinc finger protein transcription factor Gommans WM, Haisma HJ, Rots MG ( ... An ongoing clinical trial is evaluating Zinc finger nucleases that disrupt the CCR5 gene in CD4+ human T-cells as a potential ...

Beerli RR, Segal DJ, Dreier B, Barbas CF (1998). "Toward controlling gene expression at will: specific regulation of the erbB-2 ... Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single ... engineered ZF-TFs have therapeutic potential including correction of abnormal gene expression profiles (e.g., erbB-2 ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...

"Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)". "ETV4 Gene - GeneCards , ETV4 Protein , ETV4 ... "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for ... Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (Feb 1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus ... Coutte L, Monté D, Baert J, de Launoit Y (Nov 1999). "Genomic organization of the human e1af gene,a member of Ets transcription ...

Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-221. doi:10.1016/S0378- ... The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning ... "Entrez Gene: PTGES3 Prostaglandin E synthase 3 (cytosolic)". Freeman BC, Yamamoto KR (June 2002). "Disassembly of ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 12, All stub articles, ...

1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur. ... Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-21. doi:10.1016/S0378-1119 ... 1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study ... The human ERBB3 gene is located on the long arm of chromosome 12 (12q13). It is encoded by 23,651 base pairs and translates ...

... genes, erbb MeSH G14.340.024.340.383.500.791.295.300 - genes, erbb-1 MeSH G14.340.024.340.383.500.791.295.305 - genes, erbb-2 ... genes, nef MeSH G14.340.400.500.667 - genes, pol MeSH G14.340.400.500.735 - genes, px MeSH G14.340.400.500.775 - genes, rev ... genes, vif MeSH G14.340.024.340.470.578 - genes, vpr MeSH G14.340.024.340.470.580 - genes, vpu MeSH G14.340.024.340.495 - genes ... genes, insect MeSH G14.340.024.340.359 - genes, lethal MeSH G14.340.024.340.361 - genes, mdr MeSH G14.340.024.340.376 - genes, ...

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). " ... Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (June 2000). "Gene 33/Mig-6, a transcriptionally ... Wick M, Bürger C, Funk M, Müller R (August 1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during ...

Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... A gene for a fifth FGFR protein, FGFR5, has also been identified. In contrast to FGFRs 1-4, it lacks a cytoplasmic tyrosine ... The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor ... In mice, loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the ...

note, a full list of the ligands able to activate EGFR and other members of the ErbB family is given in the ErbB article) ... "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145-54. doi:10.1016/S0378-1119(99) ... ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or ... Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W (September 1998). "Identification of Nck family genes, ...

In humans, the family includes Her1 (EGFR, ErbB1), Her2 (ErbB2), Her3 (ErbB3), and Her4 (ErbB4). The gene symbol, ErbB, is ... Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ... The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB- ...

Mattei MG, Roeckel N, Olsen BR, Apte SS (1997). "Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, ... This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein ... This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. GRCh38: Ensembl release 89: ENSG00000156103 - ... Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene. Proteins of the matrix metalloproteinase ...

Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly ... Genes on human chromosome 19, All stub articles, Human chromosome 19 gene stubs, Tumor suppressor genes). ... The CIC gene was first identified in Drosophila in 2000. It was shown to encode a transcriptional repressor participating in ... Human CIC genome location and CIC gene details page in the UCSC Genome Browser. v t e (CS1 maint: multiple names: authors list ...

Gene-deletion studies in mice indicate that Gata3 (mouse gene equivalent to GATA3) is critical for the embryonic development ... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... GATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). Studies in mice indicate that the gene ... whose gene is located close to the GATA3 gene on the short arm of chromosome 10 at position p14. Various types of mutations ...

Mutations in this gene have been recurrently seen in instances of prostate cancer. Expression of FOXA1 correlates with two EMT ... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... "Entrez Gene: forkhead box A1". Bingle CD, Gowan S (June 1996). "Molecular cloning of the forkhead transcription factor HNF-3 ... Iacobazzi V, Infantino V, Bisaccia F, Castegna A, Palmieri F (July 2009). "Role of FOXA in mitochondrial citrate carrier gene ...

This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene ... 2000). "Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome ... "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10". Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, ... Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene. DEAD box proteins, ...

"Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2". Masood M, Grimm S, El-Bahrawy M, ... "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 ... Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA (September 2000). "The gene for a novel transmembrane protein containing ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 2, All stub articles, ...

It is named after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus. ... Genes on human chromosome 19, Intracellular receptors, Transcription factors, All stub articles, Human chromosome 19 gene stubs ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... Zhang Y, Dufau ML (January 2000). "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing ...

To be processed, a valid Gene ID must exist for the specific gene, or the Gene staff must have assigned an overall Gene ID to ... p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on ... A GeneRIF or Gene Reference Into Function is a short (255 characters or fewer) statement about the function of a gene. GeneRIFs ... The latter case is implemented via records in Gene with the symbol NEWENTRY. Once the Gene ID is identified, only three types ...

"Entrez Gene: GRB7 growth factor receptor-bound protein 7". Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, ... "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer". Biochemical and Biophysical ... These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7, thought to be involved in ... The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor ...