... transcription factor regulating cell cycle progression), TAL1 (a transcription factor), FOG2 (a transcription factor regulator ... GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of ... Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated ... greatly reduced levels of GATA1 as a result of a ribosomal deficiency in translating GATA1 mRNA into GATA1 transcription factor ...

Notable transcription factors implicated in mitotic bookmarking include: BRD4 GATA1 HSP70 TFIID ESRRB Sarge, K. D.; Park-Sarge ... During mitosis, gene transcription is silenced and most transcription factors are removed from chromatin. The term bookmarking ... "Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1". Cell. 150 (4): 725-37. doi:10.1016/j.cell. ... The pause in transcription during mitosis is like closing the book. "Molecular bookmarks" are the factors that allow ...

1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and ... It is a cofactor of the GATA1 transcription factor. GRCh38: Ensembl release 89: ENSG00000179588 - Ensembl, May 2017 GRCm38: ... 2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins ... 2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis". Am. J. Pathol. 167 (3): 849-58 ...

His laboratory cloned the first hematopoietic transcription factor GATA1 (1989). Starting in 2008, Orkin and his colleagues ...

EpoR induced Jak2-Stat5 signaling, together with transcriptional factor GATA-1, induces the transcription of pro-survival ... "Activation of the erythropoietin receptor promoter by transcription factor GATA-1". Proceedings of the National Academy of ... It is known that GATA-1 can induce EpoR expression. In turn, EpoR's PI3-K/AKT signaling pathway augments GATA-1 activity. ... phosphatidylinositol 3-kinase/AKT pathway and STAT transcription factors, phosphotyrosines also serve as docking sites for ...

Vieille-Grosjean I, Huber P (Mar 1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells ... Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is ... The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression ... Transcription factors, All stub articles, Human chromosome 17 gene stubs). ...

2004). "Global regulation of erythroid gene expression by transcription factor GATA-1". Blood. 104 (10): 3136-3147. doi:10.1182 ... 2004). "Global regulation of erythroid gene expression by transcription factor GATA-1". Blood. 104 (10): 3136-3147. doi:10.1182 ... regulation particularly in the cardiovascular system and two binding sites for GATA1 which is a globin transcription factor 1 ... Additional transcription factor binding sites (DNA-protein interaction) predicted include one binding site for MEF2C a monocyte ...

... focussing on the just discovered GATA transcription factors. He found that GATA-1 promotes red blood cell development whereas ... "Regulation and function of transcription factor GATA-1 during red blood cell differentiation". Development. 122 (12): 3839-3850 ... This work led to the discovery of the Id2 transcription factor in DC development. The Id2 gene data sets received accession ... Lewin, Benjamin (January 1991). "Oncogenic conversion by regulatory changes in transcription factors". Cell. 64 (2): 303-312. ...

... has been shown to interact with E2F2, and many transcription factors including GATA1. ENSG00000234507, ENSG00000230678, ... 1997). "Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked ...

"LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 (Suppl 3): 307-312. ... "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". ... "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". ... Wilkinson DA, Neale GA, Mao S, Naeve CW, Goorha RM (January 1997). "Elf-2, a rhombotin-2 binding ets transcription factor: ...

"The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis". Leukemia. 24 (7): 1249-1257. ... "The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in ... "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". The Journal of Biological Chemistry. 273 ... "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". The Journal of Biological Chemistry. 273 ...

1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 Suppl 3: 307-12 ... 2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99-103. ... and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152-7. doi:10.1074/jbc.273.6.3152. PMID ... van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM ...

2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. ...

"Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3". ... Like other BET protein family members, BRD3 associates with acetylated lysine residues on histones and transcription factors. ... BRD3 has been implicated in nucleosome remodeling in the context of transcription. In addition, BRD3 has been shown to interact ... gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene". Gene. 200 (1-2): 177-83. ...

There are two main transcription factors. PU.1 for Erythroid-megakaryocyte lineage and GATA-1, which leads to a lymphoid-primed ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... Other transcription factors include Ikaros (B cell development), and Gfi1 (promotes Th2 development and inhibits Th1) or IRF8 ( ... Mutations in transcription factors are tightly connected to blood cancers, as acute myeloid leukemia (AML) or acute ...

The transcription factor, GATA-1, directly regulates Mfrn1 expression in zebrafish via distal cis-regulatory Mfrn1 elements. In ...

MEP differentiation was found to be contingent upon the transcription factor GATA1, whereas GMP differentiation needs SPI1. ... Transcription factors such as PITX2 must be expressed in stromal cells to support normal HSC function. Like with the AGM, the ... These chimeric transcription factors can result in the improper repression or activation of the target gene, as well as the ... Through various knock-out models, several transcription factors have been found to be essential in this differentiation, such ...

... has been shown to interact with: CBFA2T3, EP300, GATA1, LDB1, LMO1, LMO2, SIN3A, Sp1 transcription factor, and TCF3. ... "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". ... "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". ... Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5 ...

"Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA ... "The structure and transcription of four linked rabbit beta-like globin genes". Cell. 18 (4): 1285-1297. doi:10.1016/0092-8674( ... "Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration". Genome Research. 21 (10): 1659- ...

... factor stimulates the expression of the GATA1 transcription factor which in turn can displace GATA2 transcription factor from ... GATA2 interacts with other transcription factors (viz., RUNX1, SCL/TAL1, GFI1, GFI1b, MYB, IKZF1, Transcription factor PU.1, ... GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It ... Two sites, termed C-ZnF and N-ZnF, of the gene code for two Zinc finger structural motifs of the GATA2 transcription factor. ...

The development of monoblasts occurs when certain transcription factors are activated, crucial ones being PU.1 and GATA1. ... the activation of certain transcription factors. A monoblast matures into a monocyte if the transcription factors PU.1 and C/ ... These cytokines induce the activation of transcription factors which push completion of the monoblast's myeloid cell fate. ... cell lineage Hematopoiesis This image represents the development from a HSC to a monocyte through various transcription factors ...

... describe a forward programming strategy relying on the concurrent exogenous expression of 3 transcription factors: GATA1, FLI1 ... However, brief expression of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully ... Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, et al. (May 2013). "Transcription factor-mediated ... by lineage-instructive approach Injury induced stem cell niches Transcription factors Growth factors Pioneer factors Cellular ...

Two GATA zinc fingers are found in GATA-family transcription factors. However, there are several proteins that only contain a ... For example, the N-terminal Znf of GATA1 binds specifically to a zinc finger from the transcriptional coregulator FOG1 (ZFPM1 ... In molecular biology, GATA zinc fingers are zinc-containing domains found in a number of transcription factors (including ... Evans T, Felsenfeld G (September 1989). "The erythroid-specific transcription factor Eryf1: a new finger protein". Cell. 58 (5 ...

July 1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and ... "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474-82. doi:10.1016/j.ygeno. ... Crossley, M; Brownlee, GG (May 1990). "Disruption of a C/EBP binding site in the factor IX promoter is associated with ... van Vliet, J; Turner, J; Crossley, M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with ...

In human breast cancer cells, knockdown of transcription factor, GATA1, led to increased expression of PRDX5 and inhibition of ... Transcription factor GATA-binding protein 1 can bind to the PRDX5 gene and lead to increased expression of PRDX5. PRDX5 has ... with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of ...

... both of the activator sites must be bound by the transcription factors, GATA1 and another unknown factor. To form a protein, an ... the only known transcription factor that regulates AGGF1 is GATA1. GATA1 binds upstream of the AGGF1 gene promoter at -295 and ... "Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function". The Journal of Biological ... Angiogenic factor with G patch and FHA domains 1 is a protein that in humans is encoded by the AGGF1 gene. AGGF1 is a human ...

"Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in ... Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene. It is involved in ... Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (1995). "Transcription factor NF-E2 is ... Gavva NR, Gavva R, Ermekova K, Sudol M, Shen CJ (1997). "Interaction of WW domains with hematopoietic transcription factor p45/ ...

... of GATA1 mutations that are projected to cause the gene to make GATA1-S but not GATA1 transcription factors. Since these ... In the absence of GATA1, the GATA1-S transcription factor increases the proliferation but not maturation of megakaryoblasts and ... GATA1 and GATA1-S are transcription factors, i.e. nuclear proteins that regulate the expression of genes. The genes targeted by ... "GATA1 GATA binding protein 1 [Homo sapiens (human)] - Gene - NCBI". Fujiwara T (June 2017). "GATA Transcription Factors: Basic ...

Two single nucleotide polymorphisms in the RGS18 gene that interfere with binding of GATA1 and NFE2 transcription factors ...

SPTBN5 The production of spectrin is promoted by the transcription factor GATA1. Some evidence for the role of spectrins in ...