Fructokinase
... (/fruc•to•ki•nase/ [-ki´nas]), also known as D-fructokinase or D-fructose (D-mannose) kinase, is an enzyme (EC 2.7 ... In tomatoes, fructokinase 1 (Frk 1) mRNA is expressed at a constant level during fruit development. However, fructokinase 2 ( ... Unlike phosphofructokinase, fructokinase is not inhibited by ATP. Fructosuria or hepatic fructokinase deficiency is a rare but ... In rat liver cells (hepatocytes), GTP is also a substrate of fructokinase. It can be used at a substantial rate by fructokinase ...
Hepatic fructokinase
Hepatic+fructokinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (Genes on ... Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1- ...
Mesoamerican nephropathy
August 2014). "Fructokinase activity mediates dehydration-induced renal injury". Kidney International. 86 (2): 294-302. doi: ...
Inborn errors of carbohydrate metabolism
The most common is caused by mutations in the gene encoding hepatic fructokinase, an enzyme that catalyzes the first step in ... Inactivation of the hepatic fructokinase results in asymptomatic fructosuria. Hereditary fructose intolerance (HFI) results in ...
Ribokinase
... fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified by the presence of three conserved ... sequence similarity to microbial ribokinases and fructokinases". Proceedings of the National Academy of Sciences of the United ...
Phosphofructokinase
... sequence similarity to microbial ribokinases and fructokinases". Proceedings of the National Academy of Sciences of the United ...
Adenosine kinase
Other members of this family (also known as the RK family) include ribokinase (RK), inosine-guanosine kinase, fructokinase, and ... sequence similarity to microbial ribokinases and fructokinases". Proceedings of the National Academy of Sciences of the United ... characteristics of this enzyme reveal it to be an atypical enzyme that is more closely related to ribokinase and fructokinase ( ...
ADK (gene)
... sequence similarity to microbial ribokinases and fructokinases". Proc Natl Acad Sci U S A. 93 (3): 1232-7. doi:10.1073/pnas. ...
Non-alcoholic fatty liver disease
Unlike the sugar glucose, the enzyme fructokinase rapidly metabolizes fructose. This leads to a decreased level of ...
Fructose 6-phosphate
Fructose is predominantly converted to fructose 1-phosphate by fructokinase following cellular import. The name Neuberg ester ...
Fructolysis
The absence of fructokinase results in the inability to phosphorylate fructose to fructose-1-phosphate within the cell. As a ... The fructokinase reaction occurs quite rapidly in hepatocytes trapping fructose in cells by phosphorylation. On the other hand ... The first step in the metabolism of fructose is the phosphorylation of fructose to fructose 1-phosphate by fructokinase (Km = ... Fructose is initially converted to DHAP and glyceraldehyde by fructokinase and aldolase B. The resultant glyceraldehyde then ...
Hereditary fructose intolerance
After ingestion, fructose is converted to fructose-1-phosphate in the liver by fructokinase. Deficiencies of fructokinase cause ... fructokinase requires adenosine triphosphate (ATP)). The downstream effects of this enzyme block are the inhibition of glucose ...
Aldolase B
When fructose is absorbed, it is phosphorylated by fructokinase to form fructose 1-phosphate. Aldolase B then catalyzes F1P ...
Tumor hypoxia
Along with phospho-fructokinase 1, pyruvate kinase is also allosterically activated by fructose-2,6-bisphosphate. In cancer ... 6-bisphosphate which plays an important role as an allosteric activator of phospho-fructokinase 1 (PFK-1). PFK-1 is an enzyme ...
Fructose 1-phosphate
Because fructokinase has a high Vmax fructose entering cells is quickly phosphorylated to fructose 1-phosphate. In this form it ... It is generated mainly by hepatic fructokinase but is also generated in smaller amounts in the small intestinal mucosa and ...
Zhimin Lu
"The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62". ...
Alpha cell
PKA also phosphorylates phospho-fructokinase 2 (PFK2)/fructose 2,6-biphsophatase (FBPase2), inhibiting PFK2 and activating ...
Fructose
The first step in the metabolism of fructose is the phosphorylation of fructose to fructose 1-phosphate by fructokinase, thus ... In fructolysis, the enzyme fructokinase initially produces fructose 1-phosphate, which is split by aldolase B to produce the ... Fructose and galactose are phosphorylated in the liver by fructokinase (Km= 0.5 mM) and galactokinase (Km = 0.8 mM), ...
Chaetomium globosum
Fructose is usually digested outside the hyphae using fructokinase activity, whereas glucose enters the cell undigested for ...
Inosine kinase
... fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified by the presence of three conserved ... sequence similarity to microbial ribokinases and fructokinases. Proc Natl Acad Sci U S A 1996, 93: 1232-1237. Maj MC, Singh B, ...
Essential fructosuria
Fructokinase (sometimes called ketohexokinase) is the first enzyme involved in the degradation of fructose to fructose-1- ... Essential fructosuria, caused by a deficiency of the enzyme hepatic fructokinase, is a clinically benign condition ...
Phosphofructokinase 2
The family described here bears a resemblance to the ATP-driven phospho-fructokinases, however, they share little sequence ...
List of MeSH codes (D08)
... fructokinases MeSH D08.811.913.696.620.225.850 - phosphofructokinases MeSH D08.811.913.696.620.225.850.500 - ...
List of EC numbers (EC 2)
No Wikipedia article EC 2.7.1.1: hexokinase EC 2.7.1.2: glucokinase EC 2.7.1.3: ketohexokinase EC 2.7.1.4: fructokinase EC 2.7. ...
FRK
... in the Seychelles Fructokinase Funmilayo Ransome-Kuti Fyn-related kinase Martin Frk (born 1993), Czech ice hockey player This ...