Exoribonucleases exist in all kingdoms of life, the bacteria, archaea, and eukaryotes. Exoribonucleases are involved in the ... Hydrolytic exoribonucleases are classified under EC number 3.1 and phosphorolytic exoribonucleases under EC number 2.7.7. As ... exoribonucleases. Exoribonucleases can use either water to cleave the nucleotide-nucleotide bond (which is called hydrolytic ... Exoribonucleases can be single proteins (such as RNase D or RNase PH) but also can be complexes of multiple proteins, such as ...

... exoribonuclease (misleading), 5'-exoribonuclease) is an enzyme. This enzyme catalyses the following chemical reaction ... Exoribonuclease+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.1.13). ... Exoribonuclease II (EC 3.1.13.1, ribonuclease II, ribonuclease Q, BN ribonuclease, Escherichia coli exo-RNase II, RNase II, ... 5'-3' exoribonuclease 2 Nossal NG, Singer MF (March 1968). "The processive degradation of individual polyribonucleotide chains ...

Exoribonuclease+H at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.1.13). ... Exoribonuclease H (EC 3.1.13.2) is an enzyme. This enzyme catalyses the following chemical reaction 3'-end directed ...

... (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the ...

5′-3′ exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5′ to 3′ ... Li Y, Yamane D, Lemon SM (May 2015). "Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C ... "Entrez Gene: 5'-3' exoribonuclease 1". Bashkirov VI, Scherthan H, Solinger JA, Buerstedde JM, Heyer WD (February 1997). "A ... mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates". The Journal of Cell Biology. 136 (4): ...

A member of the larger DEDD family of exoribonucleases, RNAse T plays a key role in the maturation of tRNA as well as the ... Kelly KO, Deutscher MP (October 1992). "The presence of only one of five exoribonucleases is sufficient to support the growth ... Li Z, Pandit S, Deutscher MP (January 1999). "Maturation of 23S ribosomal RNA requires the exoribonuclease RNase T". RNA. 5 (1 ... Deutscher MP, Marlor CW, Zaniewski R (July 1984). "Ribonuclease T: new exoribonuclease possibly involved in end-turnover of ...

Zuo Y, Deutscher MP (March 2001). "Exoribonuclease superfamilies: structural analysis and phylogenetic distribution". Nucleic ...

... exoribonucleases. RNA polymerase II is known to be in effect during transcriptional termination; it works with a 5' exonuclease ... "The coronavirus proofreading exoribonuclease mediates extensive viral recombination". PLOS Pathogens. 17 (1): e1009226. doi: ...

PNPase: a phosphorolytic exo-ribonuclease that degrades RNA. Its chain has 421 amino acids and its molecular mass is 47 kDa. ... the phosphorolytic exo-ribonuclease PNPase, the ATP-dependent RNA helicase (RhIB) and a glycolytic enzyme enolase. The RNA ... what is known is that in the first place the endoribonucleases can cleave the substrates so that later the exoribonucleases can ... the performance of polymerase PAP is needed to simplify the reduction by exoribonucleases such as PNPase. Finally, the scraps ...

... is one of the seven exoribonucleases identified in E. coli. It is a 3'-5' exoribonuclease which has been shown to be ... Zuo Y, Wang Y, Malhotra A (July 2005). "Crystal structure of Escherichia coli RNase D, an exoribonuclease involved in ...

They are classified into exoribonucleases and endoribonucleases based on their degradative activities. Ribonuclease E (RNase E ...

The exosome is primarily a 3'-5' exoribonuclease, meaning that it degrades RNA molecules from their 3' end. Exoribonucleases ... One of these is Rrp44, a hydrolytic RNase, which belongs to the RNase R family of hydrolytic exoribonucleases (nucleases that ... In archaea, the Rrp41 subunit of the complex is a phosphorolytic exoribonuclease. Three copies of this protein are present in ... Harlow, LS; Kadziola, A; Jensen, KF; Larsen, S (2004). "Crystal structure of the phosphorolytic exoribonuclease RNase PH from ...

1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases". Cell. 91 (4 ... exoribonucleases". Cell. 91 (4): 457-66. doi:10.1016/S0092-8674(00)80432-8. PMID 9390555. S2CID 16035676. Chen CY, Gherzi R, ...

This exonuclease is XRN2 (5'-3' Exoribonuclease 2) in humans. This model proposes that XRN2 proceeds to degrade the uncapped ...

Another enzyme, a U-specific exoribonuclease, removes the unpaired Us. After editing has made mRNA complementary to gRNA, an ...

... a novel exoribonuclease associated with the human exosome". EMBO J. 29 (14): 2358-67. doi:10.1038/emboj.2010.122. PMC 2910272. ...

Bashkirov VI, Scherthan H, Solinger JA, Buerstedde JM, Heyer WD (February 1997). "A mouse cytoplasmic exoribonuclease (mXRN1p) ... as the cytoplasmic location of the mouse exoribonuclease mXrn1p. It wasn't until 2002 that a glimpse into the nature and ...

"The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy". Autophagy. 14 (5): 898-912. doi:10.1080/ ...

It has been reported that xrRNAs block the progression of 5' to 3' exoribonuclease producing subgenomic RNAs. xrRNA elements ... and the exoribonuclease-resistant RNA elements (xrRNA). Further, unique elements have been observed for specific groups as well ... The exoribonuclease-resistant RNA elements (xrRNA) are described throughout all groups of flaviviruses. Usually, each virus ... "A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA ...

... (EC 3.1.13.3, oligoribonuclease) is an exoribonuclease derived from Flammulina velutipes. This enzyme ...

Körner CG, Wahle E (April 1997). "Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease". The Journal of ...

"High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants". Journal of Virology. 81 (22 ...

... , or Ribonuclease R, is a 3'-->5' exoribonuclease, which belongs to the RNase II superfamily, a group of enzymes that ... For the methodical digestion of eukaryotic linear RNAs, RNase R is a good 3' to 5' exoribonuclease but there are infrequent ... Vincent HA, Deutscher MP (October 2006). "Substrate recognition and catalysis by the exoribonuclease RNase R". The Journal of ... Cheng ZF, Deutscher MP (June 2002). "Purification and characterization of the Escherichia coli exoribonuclease RNase R. ...

Narayanan, N.; Nair, D. T. (2021). "Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and ... and proofreading exoribonuclease from SARS-CoV-2 (Int J Biol Macromol.,2021,168:272). So far, he has been centrally involved in ...

"Structure and function of the 5'-3' exoribonuclease Rat1 and its activating partner Rai1". Nature. 458: 784-788. Sadre-Bazzaz, ... exoribonuclease Rat1 and its activating partner Rai1, the a6b6 holoenzyme of propionyl-coenzyme A carboxylase, human symplekin- ...

... encode a proofreading exoribonuclease (nsp14 in coronaviruses) thought to be required for replication fidelity. Among ... also lack methyltransferases as well as a proofreading exoribonuclease, a domain that is conserved in nidoviruses with larger ... "The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity". Frontiers in ...

... exoribonuclease (ExoN)-the latter being very unusual for an RNA virus. They also encode a superfamily 1 helicase, uridylate- ... "The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity". Frontiers in ...

O-methylation sites at single-base resolution by using RNA exoribonuclease (Mycoplasma genitalium RNase R, MgR) and periodate ... O-methylation sites by an exoribonuclease-enriched chemical method". Science China Life Sciences. 66 (4): 800-818. doi:10.1007/ ...

A novel method, Nm-REP-seq, was developed for enriching 2'-O-Methylations guided by C/D snoRNAs by using RNA exoribonuclease ( ... April 2023). "Single-base resolution mapping of 2'-O-methylation sites by an exoribonuclease-enriched chemical method". Science ...

The protein nsp14 is a 3'-5' exoribonuclease which provides extra fidelity to the replication process. The exoribonuclease ... and exoribonuclease (ExoN). The two SARS-CoV-2 proteases (PLpro and 3CLpro) also interfere with the immune system response to ...