"Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa". Ewing RM, Chu P, Elisma F, Li H, ... "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 ... "Ovarian Failure Related to Eukaryotic Initiation Factor 2B Mutations". Am. J. Hum. Genet. 72 (6): 1544-50. doi:10.1086/375404. ... ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel ...
"Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa". Anthony TG, Fabian JR, Kimball SR, ... Wang X, Paulin FE, Campbell LE, Gomez E, O'Brien K, Morrice N, Proud CG (Aug 2001). "Eukaryotic initiation factor 2B: ... in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin". The ... "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human". ...
"Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa". Welsh GI, Miyamoto S, Price NT, et al ... 2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544-50. doi:10.1086/ ... "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B ... "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon ...
"Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa". Welsh GI, Miyamoto S, Price NT, et al ... 2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544-50. doi:10.1086/ ... "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B ... "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon ...
eIF-2b is a eukaryotic initiation factor necessary to initiate protein translation. eIF-2b regenerates the GTP-bound form of ... Price N, Proud C (1994). "The guanine nucleotide-exchange factor, eIF-2B". Biochimie. 76 (8): 748-60. doi:10.1016/0300-9084(94) ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the ...
Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene. Eukaryotic ... "Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa". Anthony TG, Fabian JR, Kimball SR, ... "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544-1550. doi:10.1086/375404 ... "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B ...
"A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". The Journal of ... The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic ... Madsen O, Willemsen D, Ursing BM, Arnason U, de Jong WW (Dec 2002). "Molecular evolution of the mammalian alpha 2B adrenergic ... This gene encodes the α2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that ...
"A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 ... Coupry I, Duzic E, Lanier SM (1992). "Factors determining the specificity of signal transduction by guanine nucleotide-binding ... 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene". J. Hum. Genet. 50 (1): 12-20 ... "Common adrenergic receptor polymorphisms as novel risk factors for vasospastic angina". Am. Heart J. 151 (4): 864-9. doi: ...
"A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". The Journal of ...
"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... "Eukaryotic translation initiation factor 2 subunit 2". Uniprot. Archived from the original on 2011-05-03. "Proline-serine- ... It is a eukaryotic translation factor found in species up to bacteria. In animals, it is localized in the cytoplasm and ... It is regulated by numerous transcription factors, including an estrogen receptor transcription factor (ESR2, ES3), leucine ...
Eukaryotic translation initiation factor 2B epsilon (eIF-2B-epsilon) [1] Eukaryotic translation initiation factor 4 gamma (eIF- ... in which at least 11 eukaryotic initiation factors (eIFs) are included. These factors come together to form the pre-initiation ... Koonin EV (1995). "Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B ... "Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ...
... the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families. Proc. Natl. Acad. Sci. USA 95, ... PMID 10485999 Kyrpides, N., and Woese, C. (1998) Universally conserved translation initiation factors. Proc. Natl. Acad. Sci. ... Kyrpides and Ouzounis demonstrated the parallel existence of a large number of bacterial-type transcription factors in archaeal ... PMID 7770911 Kyrpides, N. and Ouzounis, C. (1997) Bacterial sigma-70 transcription factor DNA-binding domains in the archaeon ...
... ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel ... Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene. ... Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary ... "Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa". Chiorini JA, Miyamoto S, Harkin SJ, ...
... guanine nucleotide exchange factors MeSH D12.644.360.325.300.200 - eukaryotic initiation factor-2b MeSH D12.644.360.325.300.300 ... eukaryotic initiation factor-5 MeSH D12.644.360.325.150.500 - ras gtpase-activating proteins MeSH D12.644.360.325.150.500.460 ... epidermal growth factor MeSH D12.644.276.750 - fibroblast growth factors MeSH D12.644.276.750.110 - fibroblast growth factor 1 ... fibroblast growth factor 9 MeSH D12.644.276.750.200 - fibroblast growth factor 10 MeSH D12.644.276.812 - i-kappa b kinase MeSH ...
... eukaryotic initiation factor-2b MeSH D12.776.476.325.300.300 - guanine nucleotide-releasing factor 2 MeSH D12.776.476.325. ... eukaryotic initiation factor-5 MeSH D12.776.476.325.150.500 - ras gtpase-activating proteins MeSH D12.776.476.325.150.500.460 ... stat6 transcription factor MeSH D12.776.476.024.500.500 - tnf receptor-associated factor 1 MeSH D12.776.476.024.500.750 - tnf ... tnf receptor-associated factor 3 MeSH D12.776.476.024.500.937 - tnf receptor-associated factor 5 MeSH D12.776.476.024.500.968 ...
It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2- ... Human genes which encode eIF-2B proteins include: EIF2B1 - alpha subunit (26kDa) EIF2B2 - beta subunit (39kDa) EIF2B3 - gamma ... which leads to a stable eIF2α-P-GDP-eIF2B complex and therefore inhibits translation initiation. ...
... eukaryotic initiation factor-2 MeSH D12.776.835.725.868.374 - eukaryotic initiation factor-2b MeSH D12.776.835.725.868.437 - ... eukaryotic initiation factor-4f MeSH D12.776.835.725.868.500.500 - eukaryotic initiation factor-4a MeSH D12.776.835.725.868.500 ... eukaryotic initiation factor-4e MeSH D12.776.835.725.868.500.875 - Eukaryotic initiation factor 4G MeSH D12.776.835.725.868.750 ... eukaryotic initiation factor-5 MeSH D12.776.835.725.934.374 - prokaryotic initiation factor-1 MeSH D12.776.835.725.934.562 - ...
Eukaryotic translation initiation factor 4E). eIF4E is a protein involved in directing Eukaryotic ribosomes in cap dependent ... Specifically, 2B, 2C, and 3A proteins interfere with host cell function and the 3D protein encodes as the RNA polymerase. 2A ... Eukaryotic translation initiation factor 4E), which disables cap dependent translation in the host cell.[citation needed] Foot ... Protease 3C and 2A are also responsible for the cleavage of translation initiation eIF4GE and poly-A- binding protein, PABP. ...
It has been proposed that the eukaryotic translation initiation factor EIF-4a is a potential biochemical target for the natural ... The stable transition state in the Diels-Alder reaction (shown with 2a and 2b) has an energy of 9.4kcal/mol, and coupled with ... The biomimetic synthesis of torreyanic acid involved the rapid conversion of aldehyde 3 to syn- and anti-pyrans 2a and 2b via ... Next, a spontaneous Diels-Alder dimerization of 2a and 2b proceeded with complete and regio- and diastereoselectivity to ...
... infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2 ... Harris, J. R.; V. R. Racaniello (2005-05-01). "Amino Acid Changes in Proteins 2B and 3A Mediate Rhinovirus Type 39 Growth in ...
Xi C, Wang L, Yu J, Ye H, Cao L, Gong Z (September 2018). "Inhibition of eukaryotic translation initiation factor 4E is ... For hepatitis C, it is used in combination with other medications such as simeprevir, sofosbuvir, peginterferon alfa-2b or ... May 2016). "Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E". ... March 2023). "Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor ...
... and phosphorylates a translational repressor protein called eukaryotic translation-initiation factor 4E-binding protein 1 ( ... PEGylated interferon-alpha-2b (Pegintron), polyethylene glycol is linked to the interferon molecule to make the interferon last ... As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms-this contains STAT1, STAT2 and a third transcription factor ... They described these observations in a 1959 publication, naming the responsible factor viral inhibitory factor (VIF). It took ...
MyoD regulates HB-EGF (Heparin-binding EGF-like growth factor), a member of the EGF (Epidermal growth factor) family that ... Chen, B; Lim, R W. (Jan 1997). "Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. ... Massari, M. E.; Murre, C. (2000). "Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms". Molecular ... "E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements". Cell. 79 (5): ...
A splice site mutation in the human gene for plasma factor VII that causes severe plasma factor VII deficiency, bleeding ... The effect of NUMT on the higher Eukaryotic organisms was investigated by Caro and his teammates in the rats as a model ... As shown in figure 2b, direct integration of unedited mtDNA fragments into the nuclear genomes is the most plausible and the ... Based on these findings, mtDNA fragments were assumed to act as a mobile genetic element in the initiation of carcinogenesis. ...
... a neurotrophic factor important for long-term memory. Expression of CREB, an activity-dependent transcription factor involved ... Neuromuscular disease Online Mendelian Inheritance in Man (OMIM): 600882 Charcot-Marie-Tooth Disease, Axonal, Type 2B; CMT2B - ... Goll MG, Bestor TH (2005). "Eukaryotic cytosine methyltransferases". Annual Review of Biochemistry. 74: 481-514. doi:10.1146/ ... and counteract apoptosis initiation. Furthermore, HDAC inhibitors are known to prevent SOD1 protein aggregates in vitro. Sodium ...
Chen CY, Sarnow P (April 1995). "Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs". ... 2B, 2C (an ATPase), 3AB, 3A, 3B proteins which comprise the protein complex needed for virus replication. VP0, which is further ... is an important factor that defines which types of cells support poliovirus replication. In mice expressing CD155 (through ... Pelletier J, Sonenberg N (July 1988). "Internal initiation of translation of eukaryotic mRNA directed by a sequence derived ...
2B (2nd ed.). New York: Springer. p. 1108. ISBN 978-0-387-24144-9. British Library no. GBA561951. Euzéby JP (April 1997). "List ... Replication initiation is then referred to being asynchronous. However, asynchrony can be caused by mutations to for instance ... December 2018). "Risk Factors for Detection, Survival, and Growth of Antibiotic-Resistant and Pathogenic Escherichia coli in ... compared to eukaryotic proteins, a substantial number of proteins are modified in E. coli. For instance, Potel et al. (2018) ...
... -2B, which has an insertion of an alternative exon 2. Survivin-Delta-Ex-3, which has exon 3 removed. The removal of ... An example of this is the binding of tumour necrosis factor-alpha (TNF-alpha) to TNF-alpha receptor. An example of a TNF ... A 3.6 fold decrease of survivin mRNA level was observed 16 hours after infection initiation and decreased 6.7 fold 24 hours ... Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with ...
"Phosphorylation of eukaryotic initiation factor-2α promotes the extracellular survival of obligate intracellular parasite ... For instance, for genotype 1 hepatitis C treated with Pegylated interferon-alpha-2a or Pegylated interferon-alpha-2b (brand ... In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic ... Immunity mediated by these two factors may be manifested by: a direct effect upon a pathogen, such as antibody-initiated ...