A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in ... Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and ...
"Kinetics of catechol estrogen-estrogen receptor dissociation: a possible factor underlying differences in catechol estrogen ... 2-Methoxyestradiol Estrogen conjugate Lipoidal estrogen Oettel M, Schillinger E (6 December 2012). Estrogens and Antiestrogens ... Okatani Y, Fishman J (July 1986). "Inhibition of the preovulatory prolactin surge in the rat by catechol estrogens: functional ... 2-OHE1 is the most abundant catechol estrogen in the body. 2-Hydroxyestrone is not significantly uterotrophic in bioassays, ...
3,4-catechol estrogens and estriol as primary substrates". The Journal of Biological Chemistry. 265 (14): 7900-6. doi:10.1016/ ... UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in ... regulating the level and activity of these potent estrogen metabolites. This enzyme is located on the endoplasmic reticulum and ...
... is also metabolized via hydroxylation into catechol estrogens. In the liver, it is non-specifically metabolized by ... As such, estradiol is the main estrogen in the body, although the roles of estrone and estriol as estrogens are said not to be ... Women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency. The estrogen receptor, ... Estradiol affects target tissues mainly by interacting with two nuclear receptors called estrogen receptor α (ERα) and estrogen ...
... and in conjugated estrogens (Premarin) and conjugated estriol (Progynon, Emmenin). Catechol estrogen Lipoidal estradiol Steroid ... An estrogen conjugate is a conjugate of an endogenous estrogen. They occur naturally in the body as metabolites of estrogens ... Estrogen conjugates have been used as pharmaceutical estrogens, as in estrone sulfate as estropipate (piperazine estrone ... Estrogen conjugates include sulfate and/or glucuronide conjugates of estradiol, estrone, and estriol: Sulfated: Estrone 3- ...
Michnovicz JJ, Galbraith RA (February 1991). "Cimetidine inhibits catechol estrogen metabolism in women". Metabolism. 40 (2): ... estrogen action [16]. Another possible mechanism includes decreased 2-hydroxylation of estrogen leading to elevated serum ... although increased levels of estrogens due to inhibition of estrogen metabolism is another possible mechanism. Cimetidine has ... The gynecomastia associated with cimetidine is thought to be due to blockade of ARs in the breasts, which results in estrogen ...
Aside from sulfate conjugation, EE is mainly metabolized by hydroxylation into catechol estrogens. This is mainly by 2- ... EE is an estrogen similarly to natural estrogens like estradiol and conjugated estrogens (Premarin) and synthetic estrogens ... EE is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. It is a ... 3. Estrogen preparations and combination preparations]" [Estrogen therapy in practice. 3. Estrogen preparations and combination ...
Catechol estrogen Estradiol undecanoate Estrogen conjugate Steroid sulfate Michael Oettel; Ekkehard Schillinger (6 December ... LE2 are estrogens but do not bind to the estrogen receptor, instead acting as prohormones of estradiol. Relative to estradiol, ... Endogenous long-lived estrogens". Ann. N. Y. Acad. Sci. 595 (1): 74-92. Bibcode:1990NYASA.595...74H. doi:10.1111/j.1749- ... It has been hypothesized that LE2 may serve as a store of estrogen for when estradiol levels become low. LE2 are highly ...
... one of the two estrogen receptors (ERs). Catechol estrogen Estrogen conjugate Lipoidal estradiol List of estrogen esters § ... Estradiol disulfate (also known as E2DS or estradiol 3,17β-disulfate) is an endogenous estrogen conjugate and metabolite of ... Estradiol disulfate has 0.0004% of the relative binding affinity of estradiol for the estrogen receptor alpha (ERα), ... "Biological Properties of Estrogen Sulfates", Chemical and Biological Aspects of Steroid Conjugation, Berlin, Heidelberg: ...
Catechol estrogen Estradiol glucuronide Estradiol sulfate Estrogen conjugate Estrone glucuronide Estrone sulfate Lipoidal ... Estriol sulfate was a component, along with estriol glucuronide, of the early pharmaceutical estrogens Progynon and Emmenin. ... Estrogens, Human metabolites, Sulfate esters, All stub articles, Steroid stubs). ...
Estrogen conjugate Estradiol glucuronide Estrone glucuronide Estradiol sulfate Estrone sulfate Lipoidal estradiol Catechol ... 274-. ISBN 978-0-412-27060-4. Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens II: ... steroidal estrogen and a glucuronic acid (β-D-glucopyranuronic acid) conjugate of estriol. It is found in the urine of women as ... Estrogens, Glucuronide esters, Hormones of the hypothalamus-pituitary-gonad axis, Hormones of the pregnant female, Human ...
Catechol estrogen Estrogen conjugate Lipoidal estrogen "Human Metabolome Database: Showing metabocard for Estriol 3-sulfate 16- ... Estrogens, Glucuronide esters, Human metabolites, Phenol esters, Sulfate esters, All stub articles, Steroid stubs). ... and was a component of the early pharmaceutical estrogens Progynon and Emmenin. ...
August 2006). "Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of ... ER+ cancer cells (that is, cancer cells that have estrogen receptors) depend on estrogen for their growth, so they can be ... Some breast cancers require estrogen to continue growing. They can be identified by the presence of estrogen receptors (ER+) ... If hormone replacement is necessary after breast cancer, estrogen-only therapy or estrogen therapy with an intrauterine device ...
Catechol estrogen Estradiol sulfate Estriol glucuronide Estriol sulfate Estrogen conjugate Lipoidal estradiol "Human Metabolome ... estrogen glucuronides have much higher water solubility than do unconjugated estrogens like estradiol. Estrogen glucuronides ... As a result, estrogen glucuronides have estrogenic activity via conversion into estrogens. Estradiol 3-glucuronide is a ... It is specifically the C3 glucuronide conjugate of estradiol, the major estrogen in the body. It is formed from estradiol in ...
... is mainly involved in the glucuronidation of hyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17- ... with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives". ...
Catechol estrogen Estradiol glucuronide Estradiol sulfate Estrogen conjugate Estrone glucuronide Estrone sulfate Lipoidal ... As a result, estrogen glucuronides have estrogenic activity via conversion into estrogens. The positional isomer of estriol 16α ... Estrogen glucuronides can be deglucuronidated into the corresponding free estrogens by β-glucuronidase in tissues that express ... Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Handbook of Experimental ...
2013). "Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O- ...
2013). "Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O- ...
Catechol estrogen Estrogen conjugate Lipoidal estradiol List of estrogen esters § Estradiol esters Isobe T, Shiraishi H, Yasuda ... one of the two estrogen receptors (ERs). It shows less than one million-fold lower potency in activating the estrogen receptors ... Estradiol 3-glucuronide 17β-sulfate (E2-3G-17S) is an endogenous estrogen conjugate and metabolite of estradiol. It is related ... Katayama M, Matsuda Y, Shimokawa K, Kaneko S (June 2003). "Simultaneous determination of 16 estrogens, dehydroepiandrosterone ...
... , also known as estra-1,3,5(10)-triene-2,3,16α,17β-tetrol, is an endogenous catechol estrogen and metabolite of ...
... naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via ... "Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E ... 2-methoxyestrone has very low affinity for the estrogen receptor and lacks significant estrogenic activity. 2-Methoxyestradiol ...
"Kinetics of catechol estrogen-estrogen receptor dissociation: a possible factor underlying differences in catechol estrogen ... Similarly to other steroidal estrogens, 2-hydroxyestradiol is an antioxidant, but the catechol estrogens (2- and 4-hydroxylated ... Catechol-O-methyltransferase inhibitors, Estranes, Estrogens, Human metabolites, Selective estrogen receptor modulators, ... 2-Hydroxyestradiol (2-OHE2), also known as estra-1,3,5(10)-triene-2,3,17β-triol, is an endogenous steroid, catechol estrogen, ...
... analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid". Andrology. 1 (2): ...
... , also known as estra-1,3,5(10)-triene-3,4,16α,17β-tetrol, is an endogenous catechol estrogen and metabolite of ... Estrogens, Human metabolites, All stub articles, Steroid stubs). ...
It is hydroxylated into the catechol estrogens 2-hydroxyestradiol and 4-hydroxyestradiol and into estriol (16α-hydroxyestradiol ... "Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells". The Journal of Steroid ... "Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway". Proceedings of ... However, if estrogen homeostasis is imbalanced by an increase in CYP1B1 and a decrease in COMT, a greater degree of genotoxic ...
Catechol-O-methyltransferase, N-acetyltransferase 2, Glutathione S-transferase Mu 1, GSTP1, GSTT, . . . ), to estrogen, ... The estrogen-plus-progestin arm of the Women's Health Initiative (WHI), a randomized controlled trial, which randomized more ... They are more likely to be diagnosed with hormone-receptor positive tumors, with about six out of seven cases being estrogen- ... Heterocyclic amines also have the ability to copy estrogen and in laboratory studies have been found to encourage the growth of ...
Some estrogen metabolites, such as the catechol estrogens 2-hydroxyestradiol, 2-hydroxyestrone, 4-hydroxyestradiol, and 4- ... Estrogen is considered to play a significant role in women's mental health. Sudden estrogen withdrawal, fluctuating estrogen, ... The biological importance of these minor estrogens is not entirely clear. The actions of estrogen are mediated by the estrogen ... estrogen enters passively into the cell where it binds to and activates the estrogen receptor. The estrogen:ER complex binds to ...
... estrogens, catechol MeSH D02.755.166.350.350 - hydroxyestrones MeSH D02.755.166.453 - guaiacol MeSH D02.755.166.453.400 - ...
... estrogens, catechol MeSH D06.472.334.851.437.984.350 - hydroxyestrones MeSH D06.472.334.851.437.988 - estrogens, conjugated ( ... MeSH D06.347.360.315 - estrogen antagonists MeSH D06.347.360.315.300 - estradiol antagonists MeSH D06.347.360.827 - selective ... usp) MeSH D06.472.334.851.437.994 - estrogens, esterified (usp) MeSH D06.472.334.851.437.996 - estrone MeSH D06.472.334.851.687 ... estrogen receptor modulators MeSH D06.472.040.502 - 17-ketosteroids MeSH D06.472.040.502.112 - androstenedione MeSH D06.472. ...
... naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via ... "Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E ... Estrogens, Ethers, Human metabolites, Ketones, Steroid hormones, All stub articles, Steroid stubs). ...
... naturally occurring methoxylated catechol estrogen and metabolite of estradiol that is formed by catechol O-methyltransferase ... "Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E ... Estrogens, Ethers, Human metabolites, Steroid hormones, All stub articles, Steroid stubs). ...