"Combination Therapy & Drug Resistance , Sima Lev's lab". www.weizmann.ac.il. 2017-08-09. Retrieved 2023-03-31. "Cell Signaling ... Multi-modal combination therapies are often used in cancer treatment to leverage different treatment approaches and reduce the ... high-throughput screening with a library of chemotherapies and small molecule inhibitors to identify combination therapies for ... likelihood that drug-resistant cancer cells develop. Lev combines ...

Lange, Joep (1995). "Combination Antiretroviral Therapy". Drugs. 49 (Supplement 1): 32-37. doi:10.2165/00003495-199500491-00008 ... During the mid-1990s, Lange began advocating for the use of combination therapy in the management of HIV/AIDS. He argued that ... He found that a baby's chance of contracting HIV falls to less than 1% if they receive anti-retroviral drugs while being nursed ... He was also a founding editor of the medical journal, Antiviral Therapy. In 2006 he became Professor of Medicine at the ...

"Combination Therapy and Drug Interactions". In Levy RH, Mattson RH, Meldrum BS, Perucca E (eds.). Antiepileptic drugs (5th ed ... Center for Drug Evaluation and Research. "Drug Interactions & Labeling - Drug Development and Drug Interactions: Table of ... "Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". FDA. 26 May 2021. Park JY, Kim KA, Kim ... Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. ...

Basanta D, Gatenby RA, Anderson AR (April 2012). "Exploiting evolution to treat drug resistance: combination therapy and the ... Adaptive therapy is an evolutionary therapy that aims to maintain or reduce tumor volume by employing minimum effective drug ... Resistance to one drug can lead to unwanted cross-resistance to some other drugs and "collateral" sensitivity to yet other ... In the evolutionary double bind, one drug causes increased susceptibility of the evolving cancer to another drug. Some have ...

"Near-Infrared Absorbing Polymeric Nanoparticles as a Versatile Drug Carrier for Cancer Combination Therapy". Advanced ... PSS NPs can not only serve as PTAs but also as a drug carrier to load various types of drugs, such as SN38, chemotherapy drugs ... Nam J, Son S, Ochyl LJ, Kuai R, Schwendeman A, Moon JJ (March 2018). "Chemo-photothermal therapy combination elicits anti-tumor ... Photomedicine Light Therapy Hyperthermia therapy Experimental cancer treatment Maeda H, Wu J, Sawa T, Matsumura Y, Hori K ( ...

A Matter of Combination Therapy". Cancers. 10 (12): 483. doi:10.3390/cancers10120483. PMC 6315347. PMID 30518036. Wang C, Wang ... Although the mechanisms behind cancer drug resistance are poorly understood, potential causes include: target alteration, drug ... Shi J, Wang E, Milazzo JP, Wang Z, Kinney JB, Vakoc CR (June 2015). "Discovery of cancer drug targets by CRISPR-Cas9 screening ... Targeted cancer therapies are designed to target the specific genes, proteins, or environments contributing to tumor cell ...

... have been found to cause lethal mutagenesis of the HIV-1 virus when used combination therapy. These two drugs are FDA approved ... and Steven Patterson found a novel combination therapy for rendering the HIV-1 virus harmless by using a combination therapy of ... "Exploiting Drug Repositioning for Discovery of a Novel HIV Combination Therapy". Journal of Virology. 84 (18): 9301-9308. doi: ... "Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs". ScienceDaily. Retrieved April 25 ...

... by combining rabbit serum therapy with the use of sulfa drugs. This combination became the lead treatment of meningitis until ... The combined use of the antiserum, sulfa drugs, and antibiotics significantly lowered the mortality rate from Hib. In the ...

Target combination of multitarget drugs and combination therapies; ■ Cross-links of most TTD target and drug entries to the ... nucleic acid drug, cell therapy, gene therapy and vaccine. Small molecule: the most common medications in the pharmaceutical ... Drug scaffolds for drugs/leads; ■ Target validation information (drug-target-disease); ■ Quantitative structure activity ... Successful target: targeted by at least one approved drug; Clinical trial target: not targeted by any approved drug, but ...

"Combination Therapy Targets Pancreatic Cancer Stem Cells". NCI Cancer Bulletin. 6 (8). 21 April 2009. Archived from the ... "Combination Chemotherapy With CS-1008 to Treat Ovarian Cancer" at ClinicalTrials.gov "Drug Dictionary: CS-1008". National ... The drug targets member 10b of the tumor necrosis factor receptor superfamily (TNFRSF10B, better known as death receptor 5 or ... v t e v t e (Articles with short description, Short description is different from Wikidata, Drugs not assigned an ATC code, ...

Drug combination database. covers information on more than 1300 drug combinations in either clinical use or different testing ... T has recently highlighted combination therapy as a top research priority in oncology. Combination therapy with two or more ... such as the combination of medications and talk therapy to treat depression). 'Pharmaceutical' combination therapy may be ... Combination Therapy in Oncology , CureMatch". CureMatch Blog. Retrieved 2017-10-03. "Combination Therapies for Cancer - Annual ...

The drug is used in combination with plasma exchange and immunosuppressive therapy. The U.S. Food and Drug Administration (FDA ... "New Drug Therapy Approvals 2019". U.S. Food and Drug Administration. 31 December 2019. Retrieved 15 September 2020. " ... Immune Drug Tackles Microvascular Thrombosis Disorder. February 2016 "FDA approves first therapy for the treatment of adult ... "Drug Trials Snapshots: Cablivi". U.S. Food and Drug Administration (FDA). 11 February 2019. Archived from the original on 23 ...

The Journal of Human Pharmacology and Drug Therapy. 18 (1): 57-62. doi:10.1002/j.1875-9114.1998.tb03827.x. ISSN 0277-0008. PMID ... Several studies also point at the increased effectiveness of combination of two or more sedatives in the treatment of hyper ... "The Crack Epidemic - The History of Crack Cocaine - Drug-Free World". Foundation for a Drug-Free World. Retrieved 2021-05-24. ... This involved the exposure to highly toxic amounts of the drug due to the bursting of cocaine packets being carried within the ...

These are all antimalarial drugs and are still used in artemisinin-combination therapy. After Saigon fell on 30 April 1975, ... As the first line strategy, the troops were given synthetic drugs. Drug combinations using pyrimethamine and dapsone, ... The US Food and Drug Administration approved the drug in 2009. China portal Yunnan Baiyao Drug discovery Antimalarial ... mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-infective Therapy. 7 (8): 999-1013. doi: ...

In addition, antidepressant drugs tend to lose efficacy throughout long-term maintenance therapy. According to data from the ... "Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents ... "Top 200 generic drugs by units in 2010" (PDF). Archived from the original (PDF) on 15 December 2012."Top 200 brand drugs by ... December 1998). "Cognitive behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome". Archives of ...

A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise. The prognosis of nocardiosis is ... In patients who do not respond to sulfonamide treatment, other drugs, such as ampicillin, erythromycin, or minocycline, may be ... even with appropriate therapy. It is one of several conditions that have been called "the great imitator". Cutaneous ... cure rate with appropriate therapy. The cure rate falls to 63% with those infected with disseminated nocardiosis, with only ...

It is used as an injection therapy, often in combination with other drugs. It is used in combination with 5-fluorouracil as a ... Drugs.com. Retrieved 30 September 2018. "Sutent Approval History". www.drugs.com. Drugs.com. Retrieved 30 September 2018. ( ... N-indol-1-amide compound is a possible anti-tumor drug in combination with other anticancer treatment and has an IC50 value of ... In vitro protein binding is 99,5% for both drugs. The drugs are mainly metabolized in the liver by oxidative metabolism of ...

Matsunaga S, Kishi T, Iwata N (2017). "Combination Therapy with Zonisamide and Antiparkinson Drugs for Parkinson's Disease: A ... "Drug Approval Package: Zonegran (Zonisomide) NDA #20-789". U.S. Food and Drug Administration (FDA). 24 December 1999. Archived ... Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M (April 1998). "Prediction of drug-drug interactions of ... In Australia it is marketed as both an adjunctive therapy and monotherapy for partial seizures only. It has been approved for ...

Hormonal therapy may improve responses to antimyoclonic drugs in some people. Some studies have shown that doses of 5- ... Sodium valproate is an alternative therapy for myoclonus and can be used either alone or in combination with clonazepam. Some ... Some drugs being studied in different combinations include clonazepam, sodium valproate, piracetam, and primidone. ... and similar drugs, and is possibly a sign of high and/or rapidly increasing serum levels of these drugs. Myoclonic jerks caused ...

Treatment of infection often involves a combination of antifungal drug therapy and surgical excision. Ochroconis gallopava was ... Also, antifungal drug therapy and surgical excision can be used to treat the infection separately or together. O. gallopava ... These drugs and surgical methods are the most effective when the fungus is yet disseminated into the brain. Survival rate of ... However, both antifungal drugs and surgical excision do not guarantee the perfect cure; there are some reported cases of ...

If the combination of two drugs in combination therapy has an effect lower than the sum of the effects of the two drugs acting ... Shenfield, G. M. (1982). "Fixed combination drug therapy". Drugs. 23 (6): 462-480. doi:10.2165/00003495-198223060-00003. ISSN ... Thus, some drug combinations with additive effect are avoided. Below are commonly seen drug combinations with additive effect ... the drugs will seldom be prescribed together in the same therapy. Drug or chemical combinations with additive effects can cause ...

There is also current experimental research on non drug related therapies. Oxymatrine, for example, is a root extract found in ... On November 22, the FDA approved simeprevir for use in combination with peginterferon-alfa and ribavirin. Simeprevir has been ... It has been reported to be the first drug that has demonstrated safety and efficacy to treat certain types of HCV infection ... Because of this mode of spread the key groups at risk are intravenous drug users (IDUs), recipients of blood products and ...

The hormone production of the ovaries currently cannot be sufficiently mimicked by drug therapy. The ovaries produce hormones a ... or a combination.[citation needed] When the ovaries are removed, a woman is at a seven times greater risk of cardiovascular ... Hormone therapy for women with oophorectomies performed before age 45 improves the long-term outcome and all-cause mortality ... Hormone replacement therapy does not always reduce the adverse effects. Oophorectomy is associated with significantly increased ...

Prednisone, the last drug in the CHOP combination therapy is a corticosteroid that acts as an immunosuppressant.[citation ... The most important part of this combination therapy, however, is the synergism between the drugs. While researchers are not ... Although this drug still cannot strictly target cancer cells, cancer cells have a higher average turnover of microtubules ... This also allows for patients to receive lower and fewer doses of the drug and experience fewer side effects. Newer cases are ...

... has become an important drug in the combination therapy for malaria treatment in Africa. It is often used in ... combination with artesunate as a by mouth artemisinin-based combination therapy (ACT) for uncomplicated P. falciparum malaria. ... and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial". Lancet. 358 ... Analytical Profiles of Drug Substances and Excipients. Vol. 21. Academic Press. p. 45. doi:10.1016/S0099-5428(08)60388-3. ISBN ...

"Fixed-dose combination therapy and secondary cardiovascular prevention: rationale, selection of drugs and target population". ... A polypill is a type of drug combination consisting of a single drug product in pill form (i.e., tablet or capsule) and thus ... a pill is a polypill if it contains at least 4 drugs (meaning that fixed-dose combinations of 2 or 3 drugs are not polypills). ... drug products. Physicians in many countries have wide discretion to prescribe customized drug products containing unique drug- ...

Nifurtimox-eflornithine combination treatment (NECT), a combination therapy of nifurtimox and eflornithine, is the first new, ... Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness". PLOS Neglected Tropical ... In 2010, a study investigating the three possible 2-drug combinations of amphotericin B, miltefosine and paromomycin was ... The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and ...

It became a key drug as part of the first combination therapy for treating AIDS. Realizing that this treatment could provide ... By exploring analogs to thymidine for use as antiviral drugs, his research created a new scientific paradigm for antiviral drug ... At the time, it was thought to be difficult to find antiviral drugs with a high therapeutic index, but professor Herbert E. ... The compound was originally named D4T, and Bristol-Myers Squibb developed and marketed this drug under its more common name, ...

"Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy". Cell. 171 ... "Independent drug action and its statistical implications for development of combination therapies". Contemporary Clinical ... An early success was the discovery that the great majority of approved combination cancer therapies exhibit independent action ... Recent work has focused on deep learning as means to further understand complex protein networks and drug mechanisms. The ...

This is the first approved therapy for advanced BCC. 2012: Perjeta (pertuzumab): For use in combination with Herceptin ( ... Protropin, a drug used to treat dwarfism, was Genentech's first marketed drug and its $2 billion in sales has contributed ... Gazyva is the first drug with breakthrough therapy designation to receive FDA approval. 2014: Esbriet (pirfenidone): An anti- ... "UCSF enters drug discovery agreement with Genentech". FierceBiotech. February 19, 2010. Archived from the original on April 4, ...

The drug antibody eribulin combination therapy is a joint venture between Eisai and Merck. The clinical trials combine eribulin ... a liposomal formulation and antibody drug combination therapy, both are for the treatment of solid tumors. The liposomal ... Infobox drug with local INN variant, Drugs with non-standard legal status, ECHA InfoCard ID from Wikidata, Drug has EMA link, ... Approved Drug Products with Therapeutic Equivalence Evaluations. U.S. Food and Drug Administration. "Eribulin". Drug ...

Examples of indications for the drug include hormone therapy and hormonal contraception. In regard to the latter, estradiol ... In addition to single-drug formulations, estradiol cypionate has been marketed in combination with medroxyprogesterone acetate ... estradiol cypionate is used as a form of high-dose estrogen therapy in feminizing hormone therapy for transgender women. The ... High-dose estrogen therapy with estradiol cypionate injections may also cause an increased risk of thromboembolism, changes in ...