Drug design
... , often referred to as rational drug design or simply rational design, is the inventive process of finding new ... The phrase "drug design" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that ... Ligand-based drug design (or indirect drug design) relies on knowledge of other molecules that bind to the biological target of ... Structure-based drug design (or direct drug design) relies on knowledge of the three dimensional structure of the biological ...
Retrometabolic drug design
In retrometabolic drug design, metabolic reaction information of drugs is used to design parent drugs whose metabolism and ... In the field of drug discovery, retrometabolic drug design is a strategy for the design of safer drugs either using predictable ... Soft drugs and site-specific chemical delivery systems". Adv. Drug Res. 13: 255-331. Retrometabolism-based drug design and ... The concept of retrometabolic drug design encompasses two distinct approaches. One approach is the design of soft drugs (SDs), ...
Drug Design, Development and Therapy
... is a peer-reviewed medical journal covering research on drug design and development ...
Automobile drag coefficient
The drag coefficient is a common measure in automotive design as it pertains to aerodynamics. Drag is a force that acts ... A common way to measure the drag of the vehicle is through the drag area. The reduction of drag in road vehicles has led to ... The two main factors that impact drag are the frontal area of the vehicle and the drag coefficient. The drag coefficient is a ... The force F required to overcome drag is calculated with the drag equation: F = 1 2 × air density × drag coefficient × ...
Antibody-drug conjugate
... s or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. ... Beck A, Goetsch L, Dumontet C, Corvaïa N (March 2020). "Advances in Antibody-Drug Conjugate Design: Current Clinical Landscape ... "Ambrx Collaborates with Merck to Design and Develop Biologic Drug Conjugates". Archived from the original (Press Release) on ... "Approved Drugs > FDA Approves Gemtuzumab Ozogamicin for CD33-positive AML". fda.gov. Silver Spring, USA: U.S. Food and Drug ...
Drag-divergence Mach number
Boppe, C. W., "CFD Drag Prediction for Aerodynamic Design", Technical Status Review on Drag Prediction and Analysis from ... is the drag-divergence Mach number, c l , design {\displaystyle c_{l,{\text{design}}}} is the coefficient of lift of a specific ... have been able to reduce the factor of increase in drag to two or three for modern aircraft designs. Drag-divergence Mach ... The drag-divergence Mach number (not to be confused with critical Mach number) is the Mach number at which the aerodynamic drag ...
Disease-modifying osteoarthritis drug
Drug Design, Development and Therapy. 15: 2921-2945. doi:10.2147/DDDT.S295224. PMC 8273751. PMID 34262259. S2CID 235820469. " ... A disease-modifying osteoarthritis drug (DMOAD) is a disease-modifying drug that would inhibit or even reverse the progression ... anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. Paroxetine has been ... Several approved drugs are being investigated as repurposed agents in the treatment of osteoarhritis such as liraglutide (anti- ...
Molecular drag pump
"New spiral molecular drag stage design for high compression ratio, compact turbomolecular-drag pumps". Journal of Vacuum ... While the molecular drag pumps of Gaede, Holweck, and Siegbahn are functional designs, they have remained relatively uncommon ... A molecular drag pump is a type of vacuum pump that utilizes the drag of air molecules against a rotating surface. The most ... A. Bhatti, J; K. Aijazi, M; Q. Khan, A (2001). "Design characteristics of molecular drag pumps". Vacuum. Elsevier BV. 60 (1-2 ...
Drug discovery
Another method for drug discovery is de novo drug design, in which a prediction is made of the sorts of chemicals that might (e ... "The drug development process. Step 4: FDA drug review". US Food and Drug Administration. 4 January 2018. Retrieved 18 December ... Antitarget Bioinformatics Biomedical informatics Cheminformatics Drug discovery hit to lead Drug metabolism Fragment-based drug ... Drug Interactions", Drug Design Using Machine Learning (1 ed.), Wiley, pp. 21-96, doi:10.1002/9781394167258.ch2, ISBN 978-1-394 ...
Chiral drugs
Hyneck, M (1990). Chirality in Drug Design and Synthesis. New York: Academic Press, New York. pp. 1-28. Cotzias, George C.; Van ... Hence "chiral drug" does not say whether the drug is racemic (racemic drug), single enantiomer (chiral specific drug) or some ... Drugs that exhibit handedness are referred to as chiral drugs. Chiral drugs that are equimolar (1:1) mixture of enantiomers are ... The table below list selected unichiral drugs used in drug therapy. A company may go in for developing a racemic drug against ...
Ultrasound-triggered drug delivery using stimuli-responsive hydrogels
The design of these drug delivery platforms is specific to each tissue type and its intended use. In the field of cancer, ... Several gene therapy drugs used in hydrogel-based drug delivery systems include CRISPR/Cas9, siRNA, and other RNA-based drugs. ... Future development of drug delivery systems will continue to incorporate ultrasound and smart hydrogel designs. Wichterle, O.; ... suggested that future hydrogel-based delivery platforms will be designed based on the drug payload to optimize the interaction ...
Dirty drug
Hopkins, A; Mason, J; Overington, J (2006). "Can we rationally design promiscuous drugs?". Current Opinion in Structural ... In pharmacology, a dirty drug is an informal term for drugs that may bind to many different molecular targets or receptors in ... There may be instances of advantages to drugs that exhibit multi-receptor activity such as the anti-addictive drug ibogaine ... Selectively non-selective drugs for mood disorders and schizophrenia". Nature Reviews Drug Discovery. 3 (4): 353-9. doi:10.1038 ...
Drug delivery to the brain
Retrometabolic drug design Neuroscience, Purves et al. Sinauer Associates, Inc. 2008. Rubin, L. L., & Staddon, J. M. (1999). ... Drugs can be disguised using more lipophilic elements or structures. This form of the drug will be inactive because of the ... The most promising drug delivery system is using nanoparticle delivery systems, these are systems where the drug is bound to a ... Once the drug cannot pass back through the barrier the drug can be concentrated and made effective for therapeutic use. However ...
Methylestradiol
Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9780120603084. Ojasoo T, Delettré J, Mornon JP, Turpin- ... Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, Tertiary alcohols, ... Unlisted Drugs. Pharmaceutical Section, Special Libraries Association. 1982. Batynid. C. Each dragee contains: normethandrone, ... Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. ...
Norgestrienone
90-. ISBN 978-1-84184-757-3. Lednicer D (4 March 2009). Strategies for Organic Drug Synthesis and Design. John Wiley & Sons. pp ... Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9781483216102. Raynaud JP (1970). "Metabolism of ... Norgestrienone is the generic name of the drug and its INNTooltip International Nonproprietary Name. It is also known by its ... Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. ...
Donald Truhlar
... drug design; nanoparticle structure and energetics; and density functional theory, including the Minnesota Functionals. To date ...
17α-Epiestriol
Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9780120603084. Ojasoo T, Raynaud JP (November 1978). " ...
Pharmacodynamics of estradiol
Raynaud, J.P.; Ojasoo, T.; Bouton, M.M.; Philibert, D. (1979). Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X ... Side Effects of Drugs Annual. Vol. 25. pp. 478-502. doi:10.1016/S0378-6080(02)80047-2. ISBN 9780444506740. ISSN 0378-6080. ... ISBN 978-3-642-60107-1. Stege R, Carlström K, Collste L, Eriksson A, Henriksson P, Pousette A (1988). "Single drug ... ISBN 978-0-12-137250-7. Stege R, Carlström K, Collste L, Eriksson A, Henriksson P, Pousette A (1988). "Single drug ...
Alcuronium chloride
PMID 14793878.{{cite journal}}: CS1 maint: untitled periodical (link) Martin-Smith M (1971), In: Ariens EJ (ed.), "Drug Design ... Drugs with no legal status, Drugboxes which contain changes to verified fields, Allyl compounds, Muscle relaxants, ... Drugs. 4 (3-4): 163-226. doi:10.2165/00003495-197204030-00002. PMID 4264763. S2CID 20303531. Thompson MA (1980). Br. J. Hosp. ...
Biopolymers & Cell
Drug design; Biology of peptides, nucleoside derivatives and modified oligonucleotides Biopolym. Cell is issued bimonthly, with ...
SC-8109
Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9780120603084. v t e (Articles with short description, ... Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, ... It is a potent antagonist of the mineralocorticoid receptor and is more potent than the related drug SC-5233 (of which SC-8109 ...
Gestrinone
Raynaud JP, Ojasoo T, Bouton MM, Philibert D (1979). Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN ... THG was banned by the Food and Drug Administration (FDA) in 2003. Gestrinone was introduced for medical use in 1986. Gestrinone ... 57-. ISBN 978-1-316-21414-5. "Helping athletes compete drug-free" (PDF). Canadian Centre for Ethics in Sport. May 2000. p. 34. ... Roy SN, Bhattacharya S (2004). "Benefits and risks of pharmacological agents used for the treatment of menorrhagia". Drug ...
7α-Methylestradiol
Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9780120603084. García-Becerra R, Ordaz-Rosado D, Noé G, ... Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, Abandoned drugs, ... Secondary alcohols, Estranes, Human drug metabolites, Synthetic estrogens, All stub articles, Genito-urinary system drug stubs ...
Science and technology in Uzbekistan
... drug design; and technology, equipment and product design for the oil and gas and chemical industries. These fields were chosen ... This is designed to ensure that there is a demand for the research being undertaken and that the results will lead to products ... Each of these sectors tends to involve large companies equipped with design bureaux and laboratories. There are also ... such as poor-quality drugs. In the region, research spending has hovered around the 0.2-0.3% mark for the past decade but, in ...
Moxestrol
Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9781483216102. Ojasoo T, Raynaud JP (November 1978). " ... Moxestrol is the generic name of the drug and its INNTooltip International Nonproprietary Name. It is also known by its ... 184-. ISBN 978-1-4613-9208-8. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and ... 61-. ISBN 978-1-4831-5308-7. (Articles with short description, Short description matches Wikidata, Drugs with non-standard ...
Trimethyltrienolone
Drug Design. New York, Academic Press. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9780120603084. Kohtz AS, Frye ... Drugs with no legal status, Articles containing unverified chemical infoboxes, Abandoned drugs, Tertiary alcohols, Estranes, ... The drug was under investigation by Roussel Uclaf for potential medical use, but was abandoned in favor of nonsteroidal ... The drug is a derivative of the extremely potent androgen/anabolic steroid metribolone (R-1881; 17α-methyltrenbolone), and has ...
Epiestriol
Drug Design. pp. 169-214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9780120603084. Ojasoo T, Raynaud JP (November 1978). " ... Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, Anti-acne ... The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 899-. ISBN 978-1-4757-2085- ...
Drag count
van Dam, C. P. (2003). "Aircraft design and the importance of drag prediction". CFD-Based Aircraft Drag Prediction and ... A drag count is more user-friendly than the drag coefficient, as the latter is usually much less than 1. A drag count of 200 to ... 1 drag count is equal to a C d {\displaystyle C_{d}} of 0.0001. A drag count Δ C d {\displaystyle \Delta C_{\mathrm {d} }\,} is ... Drag coefficient Zero-lift drag coefficient v t e (CS1 German-language sources (de), Articles needing additional references ...
Drag crisis
Bartran, D. (2018). "The Drag Crisis and Thermowell Design", J. Press. Ves. Tech. 140(4), 044501, Paper No: PVT-18-1002. DOI: ... In fluid dynamics, drag crisis (also known as the Eiffel paradox) is a phenomenon in which drag coefficient drops off suddenly ... The drag coefficient of a sphere will change rapidly from about 0.5 to 0.2 at a Reynolds number in the range of 300000. This ... The drag crisis was observed in 1905[citation needed] by Nikolay Zhukovsky, who guessed that this paradox can be explained by ...
Thenylfentanyl
Isomer Design. Drug Enforcement Administration. October 29, 1985. Archived (PDF) from the original on March 3, 2022. Retrieved ... It was temporarily scheduled by the Drug Enforcement Administration in 1985, due to fears it would be used as a designer drug. ... Drug Enforcement Administration. June 29, 2010. "Fentanyl Synthesis". GPTA India. June 18, 2020. Archived from the original on ... Infobox drug articles with non-default infobox title, Chemical pages without DrugBank identifier, Articles without KEGG source ...